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Protein Page:
caldesmon (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
caldesmon a cytoskeletal protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells. May act as a bridge between myosin and actin filaments. Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin binding protein
Cellular Component: cytoskeleton; myofibril; cell soma; postsynaptic density; plasma membrane; actin filament; cytosol; actin cap; actin cytoskeleton
Molecular Function: calmodulin binding; myosin binding; actin binding; tropomyosin binding
Biological Process: actin filament bundle formation; muscle contraction; positive regulation of protein binding; cell motility
Reference #:  Q05682 (UniProtKB)
Alt. Names/Synonyms: CAD; CALD1; Caldesmon; caldesmon 1; CDM; H-CAD; HCAD; L-CAD; LCAD; MGC21352; NAG22
Gene Symbols: CALD1
Molecular weight: 93,231 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

caldesmon
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell motility, altered: S714‑p, S744‑p, S759‑p, S789‑p
cytoskeletal reorganization: S714‑p, S744‑p, S759‑p, S789‑p
intracellular localization: S759‑p, S789‑p
molecular association, regulation: S759‑p
protein conformation: S759‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 - gap
0 3 R12 ERRRELRRQKREEMR
2 0 A26 RLEAERIAyQRNDDD
1 15 Y27-p LEAERIAyQRNDDDE
1 0 S58 RQKQEEESLGQVTDQ
3 1 S73-p VEVNAQNsVPDEEAK
0 1 T83-p DEEAKTTttNtQVEG
0 1 T84-p EEAKTTttNtQVEGD
0 2 T86-p AKTTttNtQVEGDDE
0 1 K119 QEALERQKEFDPTIT
0 1 T126 KEFDPTITDASLSLP
0 1 T141 SRRMQNDTAENETTE
0 1 T146 NDTAENETTEKEEKS
0 1 Q157 EEKSESRQERyEIEE
0 3 Y160-p SESRQERyEIEETET
0 1 Y172-p TETVTKSyQKNDWRD
0 1 K199 EEEEEKPKRGsIGEN
0 16 S202-p EEKPKRGsIGENQVE
0 1 K427-a EKKAQEDkLQTAVLK
0 2 S493-p KGFTEVKsQNGEFMT
0 1 K504 EFMTHKLKHTENTFS
1 6 S511 KHTENTFSRPGGRAs
0 2 - gap
0 3 S518-p SRPGGRAsVDTKEAE
1 0 - gap
1 0 - gap
0 11 K534-a APQVEAGkRLEELRR
0 17 T546-p LRRRRGEtESEEFEK
1 0 T638 KKPFKCFTPkGSsLk
0 1 K640-a PFKCFTPkGSsLkIE
2 2 S643-p CFTPkGSsLkIEERA
0 1 K645-a TPkGSsLkIEERAEF
0 1 K655 ERAEFLNKsVQKSSG
1 3 S656-p RAEFLNKsVQKSSGV
1 0 Q668 SGVKSTHQAAIVSKI
1 0 A669 GVKSTHQAAIVSKID
1 0 S673 THQAAIVSKIDsRLE
2 0 S677-p AIVSKIDsRLEQyTs
1 70 Y682-p IDsRLEQyTsAIEGT
1 1 S684-p sRLEQyTsAIEGTKS
1 0 S700 KPTKPAASDLPVPAE
5 0 S714-p EGVRNIKsMWEKGNV
0 5 S723-p WEKGNVFssPtAAGt
2 7 S724-p EKGNVFssPtAAGtP
0 5 T726-p GNVFssPtAAGtPNk
3 10 T730-p ssPtAAGtPNkEtAG
0 1 K733-a tAAGtPNkEtAGLKV
0 1 K733-u tAAGtPNkEtAGLKV
1 3 T735-p AGtPNkEtAGLKVGV
5 0 S744-p GLKVGVSsRINEWLT
0 1 T751 sRINEWLTktPDGNk
0 1 K752-a RINEWLTktPDGNks
2 9 T753-p INEWLTktPDGNksP
0 1 K758-a TktPDGNksPAPKPs
7 7 S759-p ktPDGNksPAPKPsD
0 2 S765-p ksPAPKPsDLRPGDV
0 6 K775 RPGDVSSKRNLWEKQ
1 1 S783-p RNLWEKQsVDKVTsP
15 6 S789-p QsVDKVTsPtKV___
0 1 T791-p VDKVTsPtKV_____
  caldesmon iso2  
- gap
R12 ERRRELRRQKREEMR
A26 RLEAERIAYQRNDDD
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVTDQ
S73 VEVNAQNSVPDEEAK
T83 DEEAKTTTTNTQVEG
T84 EEAKTTTTNTQVEGD
T86 AKTTTTNTQVEGDDE
K119 QEALERQKEFDPTIT
T126 KEFDPTITDASLSLP
T141 SRRMQNDTAENETTE
T146 NDTAENETTEKEEKS
Q157 EEKSESRQERYEIEE
Y160 SESRQERYEIEETET
Y172 TETVTKSYQKNDWRD
K199 EEEEEKPKRGsIGEN
S202-p EEKPKRGsIGENQGE
- gap
S264 KGFTEVKSQNGEFMT
K275 EFMTHKLKHTENTFS
S282 KHTENTFSRPGGRAS
- gap
S289 SRPGGRASVDTKEAE
- gap
- gap
K305 APQVEAGKRLEELRR
T317 LRRRRGETESEEFEK
T409 KKPFKCFTPKGSSLK
K411 PFKCFTPKGSSLKIE
S414 CFTPKGSSLKIEERA
K416 TPKGSSLKIEERAEF
K426 ERAEFLNKSVQKSSG
S427 RAEFLNKSVQKSSGV
Q439 SGVKSTHQAAIVSKI
A440 GVKSTHQAAIVSKID
S444 THQAAIVSKIDSRLE
S448 AIVSKIDSRLEQyTS
Y453-p IDSRLEQyTSAIEGT
S455 SRLEQyTSAIEGTKS
S471 KPTKPAASDLPVPAE
S485 EGVRNIKSMWEKGNV
S494 WEKGNVFSSPTAAGT
S495 EKGNVFSSPTAAGTP
T497 GNVFSSPTAAGTPNK
T501 SSPTAAGTPNKETAG
K504 TAAGTPNKETAGLKV
K504 TAAGTPNKETAGLKV
T506 AGTPNKETAGLKVGV
S515 GLKVGVSSRINEWLT
T522 SRINEWLTKTPDGNK
K523 RINEWLTKTPDGNKS
T524 INEWLTKTPDGNKSP
K529 TKTPDGNKSPAPKPS
S530 KTPDGNKSPAPKPSD
S536 KSPAPKPSDLRPGDV
K546 RPGDVSSKRNLWEKQ
S554 RNLWEKQSVDKVTSP
S560 QSVDKVTSPTKV___
T562 VDKVTSPTKV_____
  caldesmon iso3  
S7 _MLGGSGSHGRRsLA
S12-p SGSHGRRsLAALSQI
A20 LAALSQIAyQRNDDD
Y21-p AALSQIAyQRNDDDE
S52 RQKQEEESLGQVTDQ
S67 VEVNAQNSVPDEEAK
T77 DEEAKTTTTNTQVEG
T78 EEAKTTTTNTQVEGD
T80 AKTTTTNTQVEGDDE
K113 QEALERQKEFDPTIT
T120 KEFDPTITDASLSLP
T135 SRRMQNDTAENETTE
T140 NDTAENETTEKEEKS
Q151 EEKSESRQERYEIEE
Y154 SESRQERYEIEETET
Y166 TETVTKSYQKNDWRD
K193 EEEEEKPKRGsIGEN
S196-p EEKPKRGsIGENQGE
- gap
S258 KGFTEVKSQNGEFMT
K269 EFMTHKLKHTENTFS
S276 KHTENTFSRPGGRAS
- gap
S283 SRPGGRASVDTKEAE
- gap
- gap
K299 APQVEAGKRLEELRR
T311 LRRRRGETESEEFEK
T403 KKPFKCFTPKGSSLK
K405 PFKCFTPKGSSLKIE
S408 CFTPKGSSLKIEERA
K410 TPKGSSLKIEERAEF
K420 ERAEFLNKSVQKSSG
S421 RAEFLNKSVQKSSGV
Q433 SGVKSTHQAAIVSKI
A434 GVKSTHQAAIVSKID
S438 THQAAIVSKIDSRLE
S442 AIVSKIDSRLEQYTS
Y447 IDSRLEQYTSAIEGT
S449 SRLEQYTSAIEGTKS
S465 KPTKPAASDLPVPAE
S479 EGVRNIKSMWEKGNV
S488 WEKGNVFSSPTAAGT
S489 EKGNVFSSPTAAGTP
T491 GNVFSSPTAAGTPNK
T495 SSPTAAGTPNKETAG
K498 TAAGTPNKETAGLKV
K498 TAAGTPNKETAGLKV
T500 AGTPNKETAGLKVGV
S509 GLKVGVSSRINEWLT
T516 SRINEWLTKTPDGNK
K517 RINEWLTKTPDGNKS
T518 INEWLTKTPDGNKSP
K523 TKTPDGNKSPAPKPS
S524 KTPDGNKSPAPKPSD
S530 KSPAPKPSDLRPGDV
K540 RPGDVSSKRNLWEKQ
S548 RNLWEKQSVDKVTSP
S554 QSVDKVTSPTKV___
T556 VDKVTSPTKV_____
  caldesmon iso4  
- gap
R12 ERRRELRRQKREEMR
A26 RLEAERIAYQRNDDD
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVTDQ
S73 VEVNAQNSVPDEEAK
T83 DEEAKTTTTNTQVEG
T84 EEAKTTTTNTQVEGD
T86 AKTTTTNTQVEGDDE
K119 QEALERQKEFDPTIT
T126 KEFDPTITDASLSLP
T141 SRRMQNDTAENETTE
T146 NDTAENETTEKEEKS
Q157 EEKSESRQERYEIEE
Y160 SESRQERYEIEETET
Y172 TETVTKSYQKNDWRD
K199 EEEEEKPKRGsIGEN
S202-p EEKPKRGsIGENQIK
- gap
S238 KGFTEVKSQNGEFMT
K249 EFMTHKLKHTENTFS
S256 KHTENTFSRPGGRAS
- gap
S263 SRPGGRASVDTKEAE
- gap
- gap
K279 APQVEAGKRLEELRR
T291 LRRRRGETESEEFEK
T383 KKPFKCFTPKGSSLK
K385 PFKCFTPKGSSLKIE
S388 CFTPKGSSLKIEERA
K390 TPKGSSLKIEERAEF
K400 ERAEFLNKSVQKSSG
S401 RAEFLNKSVQKSSGV
Q413 SGVKSTHQAAIVSKI
A414 GVKSTHQAAIVSKID
S418 THQAAIVSKIDSRLE
S422 AIVSKIDSRLEQyTS
Y427-p IDSRLEQyTSAIEGT
S429 SRLEQyTSAIEGTKS
S445 KPTKPAASDLPVPAE
S459 EGVRNIKSMWEKGNV
S468 WEKGNVFSSPTAAGT
S469 EKGNVFSSPTAAGTP
T471 GNVFSSPTAAGTPNK
T475 SSPTAAGTPNKETAG
K478 TAAGTPNKETAGLKV
K478 TAAGTPNKETAGLKV
T480 AGTPNKETAGLKVGV
S489 GLKVGVSSRINEWLT
T496 SRINEWLTKTPDGNK
K497 RINEWLTKTPDGNKS
T498 INEWLTKTPDGNKSP
K503 TKTPDGNKSPAPKPS
S504 KTPDGNKSPAPKPSD
S510 KSPAPKPSDLRPGDV
K520 RPGDVSSKRNLWEKQ
S528 RNLWEKQSVDKVTSP
S534 QSVDKVTSPTKV___
T536 VDKVTSPTKV_____
  mouse

► Hide Isoforms 		 
- gap
- gap
A26 RLEAERIAYQRNDDD
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVTDQ
S73 VEAHVQNSVPDEESK
S83 DEESKPASSNTQVEG
S84 EESKPASSNTQVEGD
T86 SKPASSNTQVEGDEE
K119-u QEALERQkEFDPTIt
T126-p kEFDPTItDGSLSGP
S141-p SRRMQNDsAENEtAE
T146-p NDsAENEtAEGEEKR
S157-p EEKRESRsGRyEVEE
Y160-p RESRsGRyEVEETEV
Y172 TEVVIKSYQKNSYQD
K197-u EEEQEKLkGGSLGEN
S200 QEKLkGGSLGENQVE
- gap
A470 KGFTEVKAQNGEFMT
K481 EFMTHKLKQTENAFS
S488 KQTENAFSRSGGRAS
- gap
S495 SRSGGRASGDKEAEG
- gap
- gap
K510 APQVEAGKRLEELRR
T522 LRRRRGETENEEFEK
T614 KKPFKCFTPKGSsLK
K616 PFKCFTPKGSsLKIE
S619-p CFTPKGSsLKIEERA
K621 TPKGSsLKIEERAEF
K631-u ERAEFLNkSVQKSGV
S632 RAEFLNkSVQKSGVR
Q643 SGVRSTHQAAVVSKI
A644 GVRSTHQAAVVSKID
S648 THQAAVVSKIDSRLE
S652 AVVSKIDSRLEQyTN
Y657-p IDSRLEQyTNAIEGT
N659 SRLEQyTNAIEGTKA
S675 KPMKPAASDLPVPAE
S689 EGVRNIKSMWEKGSV
S698-p WEKGSVFsAPsASGt
A699 EKGSVFsAPsASGtP
S701-p GSVFsAPsASGtPNK
T705-p sAPsASGtPNKETAG
K708 sASGtPNKETAGLKV
K708 sASGtPNKETAGLKV
T710 SGtPNKETAGLKVGV
S719 GLKVGVSSRINEWLt
T726-p SRINEWLtKsPDGNK
K727 RINEWLtKsPDGNKs
S728-p INEWLtKsPDGNKsP
K733 tKsPDGNKsPAPKPS
S734-p KsPDGNKsPAPKPSD
S740 KsPAPKPSDLRPGDV
K750-a RPGDVSGkRNLWEKQ
S758-p RNLWEKQsVDKVTsP
S764-p QsVDKVTsPTKV___
T766 VDKVTsPTKV_____
  caldesmon iso5  
S7-p _MLSGSGsQGRRCLA
C12 SGsQGRRCLATLSQI
A20 LATLSQIAYQRNDDD
Y21 ATLSQIAYQRNDDDE
S52 RQKQEEESLGQVTDQ
S67 VEAHVQNSVPDEESK
S77 DEESKPASSNTQVEG
S78 EESKPASSNTQVEGD
T80 SKPASSNTQVEGDEE
K113 QEALERQKEFDPTIT
T120 KEFDPTITDGSLSGP
S135 SRRMQNDSAENETAE
T140 NDSAENETAEGEEKR
S151 EEKRESRSGRYEVEE
Y154 RESRSGRYEVEETEV
Y166 TEVVIKSYQKNSYQD
K191 EEEQEKLKGGsLGEN
S194-p QEKLKGGsLGENQIK
- gap
A230 KGFTEVKAQNGEFMT
K241-u EFMTHKLkQTENAFs
S248-p kQTENAFsPsRSGGR
S250-p TENAFsPsRSGGRAs
S257-p sRSGGRAsGDKEAEG
- gap
- gap
K272-a APQVEAGkRLEELRR
T284-p LRRRRGEtENEEFEK
T376 KKPFKCFTPKGSSLK
K378 PFKCFTPKGSSLKIE
S381 CFTPKGSSLKIEERA
K383 TPKGSSLKIEERAEF
K393 ERAEFLNKSVQKSGV
S394 RAEFLNKSVQKSGVR
Q405 SGVRSTHQAAVVSKI
A406 GVRSTHQAAVVSKID
S410 THQAAVVSKIDSRLE
S414 AVVSKIDSRLEQYTN
Y419 IDSRLEQYTNAIEGT
N421 SRLEQYTNAIEGTKA
S437 KPMKPAASDLPVPAE
S451 EGVRNIKSMWEKGSV
S460 WEKGSVFSAPSASGT
A461 EKGSVFSAPSASGTP
S463 GSVFSAPSASGTPNK
T467 SAPSASGTPNKETAG
K470 SASGTPNKETAGLKV
K470 SASGTPNKETAGLKV
T472 SGTPNKETAGLKVGV
S481 GLKVGVSSRINEWLT
T488 SRINEWLTKSPDGNK
K489 RINEWLTKSPDGNKS
S490 INEWLTKSPDGNKSP
K495 TKSPDGNKSPAPKPS
S496 KSPDGNKSPAPKPSD
S502 KSPAPKPSDLRPGDV
K512 RPGDVSGKRNLWEKQ
S520 RNLWEKQSVDKVTSP
S526 QSVDKVTSPTKV___
T528 VDKVTSPTKV_____
  rat

 
S7 _MLSRSGSQGRRCLA
C12 SGSQGRRCLATLSQI
A20 LATLSQIAYQRNDDD
Y21 ATLSQIAYQRNDDDE
S52 RQKQEEESLGQVTDQ
S67 VEAHVQNSAPDEESK
T77 DEESKPATANAQVEG
A78 EESKPATANAQVEGD
A80 SKPATANAQVEGDEE
K113 QEALERQKEFDPTIT
T120 KEFDPTITDGSLSVP
S135 SRRMQNNSAENETAE
T140 NNSAENETAEGEEKG
S151 EEKGESRSGRYEMEE
Y154 GESRSGRYEMEETEV
Y166 TEVVITSYQKNSYQD
K192 EEEEEKLKGGNLGEN
N195 EEKLKGGNLGENQIK
- gap
A231 KGFTEVKAQNGEFMT
K242 EFMTHKLKQTENAFs
S249-p KQTENAFsPSRSGGR
S251 TENAFsPSRSGGRAs
S258-p SRSGGRAsGDKEAEG
- gap
- gap
K273 APQVEAGKRLEELRR
T285 LRRRRGETESEEFEK
T377 KKPFKCFTPKGSSLK
K379 PFKCFTPKGSSLKIE
S382 CFTPKGSSLKIEERA
K384 TPKGSSLKIEERAEF
K394 ERAEFLNKSVQKSGV
S395 RAEFLNKSVQKSGVK
Q406 SGVKSTHQAAVVSKI
A407 GVKSTHQAAVVSKID
S411 THQAAVVSKIDSRLE
S415 AVVSKIDSRLEQYTN
Y420 IDSRLEQYTNAIEGT
N422 SRLEQYTNAIEGTKA
S438 KPMKPAASDLPVPAE
S452 EGVRNIKSMWEKGSV
S461 WEKGSVFSsPSASGt
S462-p EKGSVFSsPSASGtP
S464 GSVFSsPSASGtPNK
T468-p SsPSASGtPNKETAG
K471 SASGtPNKETAGLKV
K471 SASGtPNKETAGLKV
T473 SGtPNKETAGLKVGV
S482 GLKVGVSSRINEWLT
T489 SRINEWLTKsPDGNK
K490 RINEWLTKsPDGNKs
S491-p INEWLTKsPDGNKsP
K496 TKsPDGNKsPAPKPS
S497-p KsPDGNKsPAPKPSD
S503 KsPAPKPSDLRPGDV
K513 RPGDVSGKRNLWEKQ
S521 RNLWEKQSVDKVTsP
S527-p QSVDKVTsPTKV___
T529 VDKVTsPTKV_____
  rabbit

 
- gap
R12 ERRRELRRQKREEMR
A26 RLEAERIAYQRNDDD
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVADQ
S73 VEVHAQNSVSNEDSK
T83 NEDSKPSTTSTQVEG
T84 EDSKPSTTSTQVEGD
T86 SKPSTTSTQVEGDDE
K119 QEALERQKEFDPTVT
T126 KEFDPTVTDASASLP
T141 SRRMPNDTAENATAE
T146 NDTAENATAEKEAKA
R157 EAKAESRRERYETVE
Y160 AESRRERYETVETKM
E172 TKMVTKSEQKNDWRD
K199 DGEEEKSKQESVGEN
S202 EEKSKQESVGENQVK
- gap
S238 KGFTDVKSQNGEFMT
K249 EFMTHKLKHAENTFS
S256 KHAENTFSPGRSGAR
G258 AENTFSPGRSGARPS
S265 GRSGARPSGDAQEAE
- gap
- gap
K275 AQEAEAGKRLEELRR
T287 LRRRRGETESEEFEK
T379 KKPFKCFTPKGSSLK
K381 PFKCFTPKGSSLKIE
S384 CFTPKGSSLKIEERA
K386 TPKGSSLKIEERAEF
K396 ERAEFLNKSVQKSGV
S397 RAEFLNKSVQKSGVK
Q408 SGVKSTHQAAVVSKI
A409 GVKSTHQAAVVSKID
S413 THQAAVVSKIDSRLE
S417 AVVSKIDSRLEQYTS
Y422 IDSRLEQYTSAIEGT
S424 SRLEQYTSAIEGTKA
S440 KSTKPAASDLPVPAE
S454 EGVRNIKSMWEKGNV
S463 WEKGNVFSAPTASGT
A464 EKGNVFSAPTASGTP
T466 GNVFSAPTASGTPNK
T470 SAPTASGTPNKETAG
K473 TASGTPNKETAGLKV
K473 TASGTPNKETAGLKV
T475 SGTPNKETAGLKVGV
S484 GLKVGVSSRINEWLT
T491 SRINEWLTKTPDGSK
K492 RINEWLTKTPDGSKS
T493 INEWLTKTPDGSKSP
K498 TKTPDGSKSPAPKPS
S499 KTPDGSKSPAPKPSD
S505 KSPAPKPSDLRPGDV
K515 RPGDVSGKRNLWEKQ
S523 RNLWEKQSVDKVTsP
S529-p QSVDKVTsPTKV___
T531 VDKVTsPTKV_____
  chicken

 
- gap
R12 ERRRELRRQKREEMR
S26-p RLEAERLsyQRNDDD
Y27-p LEAERLsyQRNDDDE
S59-p QKEEGDVsGEVTEKS
S73-p SEVNAQNsVAEEETK
T83 EEETKRSTDDEAALL
- gap
- gap
K112 QEALERQKEFDPTIT
T119 KEFDPTITDGSLSVP
V134 SRREVNNVEENEITG
I139 NNVEENEITGKEEKV
Q150 EEKVETRQGRCEIEE
C153 VETRQGRCEIEETET
Y165 TETVTKSYQRNNWRQ
K191 DSEEEKPKEVPTEEN
P194 EEKPKEVPTEENQVD
- gap
A476 RGVPEQKAQNGEREL
K489 ELtTPKLKsTENAFG
- gap
- gap
- gap
T484-p QNGERELtTPKLKsT
S490-p LtTPKLKsTENAFGR
S510 AANAEAGSEKLKEKQ
- gap
S597-p KKPFKCFsPKGSsLK
K599 PFKCFsPKGSsLKIE
S602-p CFsPKGSsLKIEERA
K604 sPKGSsLKIEERAEF
K614 ERAEFLNKsAQKSGM
S615-p RAEFLNKsAQKSGMK
T626-p SGMKPAHttAVVsKI
T627-p GMKPAHttAVVsKID
S631-p AHttAVVsKIDsRLE
S635-p AVVsKIDsRLEQyTs
Y640-p IDsRLEQyTsAVVGN
S642-p sRLEQyTsAVVGNKA
S658-p KPAKPAAsDLPVPAE
S672-p EGVRNIKsMWEKGNV
S681 WEKGNVFSsPGGTGt
S682-p EKGNVFSsPGGTGtP
G684 GNVFSsPGGTGtPNK
T688-p SsPGGTGtPNKEtAG
K691 GGTGtPNKEtAGLKV
K691 GGTGtPNKEtAGLKV
T693-p TGtPNKEtAGLKVGV
S702-p GLKVGVSsRINEWLT
T709 sRINEWLTKtPEGNK
K710 RINEWLTKtPEGNKs
T711-p INEWLTKtPEGNKsP
K716 TKtPEGNKsPAPKPS
S717-p KtPEGNKsPAPKPSD
S723 KsPAPKPSDLRPGDV
K733 RPGDVSGKRNLWEKQ
S741-p RNLWEKQsVEKPAAS
S748 sVEKPAASSSKVTAT
S750 EKPAASSSKVTATGK
  cow

 
- gap
R12 ERRRELRRQKREEMR
A26 RLEAERIAYQRNDDD
Y27 LEAERIAYQRNDDDE
A58 RQKQEEEALGQVTDQ
S73 VEVNTQNSVPDEEVK
T83 DEEVKTTTTNTQAEG
T84 EEVKTTTTNTQAEGD
T86 VKTTTTNTQAEGDDE
K119 QEALERQKEFDPTIT
T126 KEFDPTITDASLSLS
T141 SRRMQNDTTDNETAE
T146 NDTTDNETAEKEGRS
Q157 EGRSESRQERQELEE
Q160 SESRQERQELEETEI
H172 TEIVTKSHQKNDWME
K199 EEEEEKPKPGSIEEN
S202 EEKPKPGSIEENQLK
- gap
S237 KGFTEVKSQNGEFMT
K248 EFMTHKLKHAENTFS
S255 KHAENTFSRAGGRVS
- gap
S262 SRAGGRVSEAKEAEG
- gap
- gap
K277 TSQVEAGKRLEELRR
T289 LRRRRGETESEEFEK
T381 KKPFKCFTPKGSSLK
K383 PFKCFTPKGSSLKIE
S386 CFTPKGSSLKIEERA
K388 TPKGSSLKIEERAEF
K398 ERAEFLNKSVQKSGV
S399 RAEFLNKSVQKSGVK
Q410 SGVKPTHQAAVVSKI
A411 GVKPTHQAAVVSKID
S415 THQAAVVSKIDSRLE
S419 AVVSKIDSRLEQYTS
Y424 IDSRLEQYTSAIEGT
S426 SRLEQYTSAIEGTKA
S442 KPTKPAASDLPVPAE
S456 EGVRNIKSMWEKGNV
S465 WEKGNVFSSPTASGT
S466 EKGNVFSSPTASGTP
T468 GNVFSSPTASGTPNK
T472 SSPTASGTPNKETAG
K475 TASGTPNKETAGLKV
K475 TASGTPNKETAGLKV
T477 SGTPNKETAGLKVGV
S486 GLKVGVSSRINEWLT
T493 SRINEWLTKTPEGSK
K494 RINEWLTKTPEGSKs
T495 INEWLTKTPEGSKsP
K500 TKTPEGSKsPAPKPS
S501-p KTPEGSKsPAPKPSD
S507 KsPAPKPSDLRPGDV
K517 RPGDVSGKRNLWEKQ
S525 RNLWEKQSVDKVTsP
S531-p QSVDKVTsPTKV___
T533 VDKVTsPTKV_____
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