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Protein Page:
Caldesmon (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Caldesmon a cytoskeletal protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells. May act as a bridge between myosin and actin filaments. Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin binding protein
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: cytoskeleton; myofibril; plasma membrane; actin cap; cytosol; actin cytoskeleton
Molecular Function: calmodulin binding; myosin binding; tropomyosin binding; actin binding
Biological Process: muscle contraction; cell motility
Reference #:  Q05682 (UniProtKB)
Alt. Names/Synonyms: CAD; CALD1; Caldesmon; caldesmon 1; CDM; H-CAD; HCAD; L-CAD; LCAD; MGC21352; NAG22
Gene Symbols: CALD1
Molecular weight: 93,231 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Caldesmon

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S714‑p, S744‑p, S759‑p, S789‑p
cytoskeletal reorganization: S714‑p, S744‑p, S759‑p, S789‑p
intracellular localization: S759‑p, S789‑p
molecular association, regulation: S759‑p
protein conformation: S759‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 - gap
0 6 - gap
0 1 - gap
2 0 - gap
1 15 Y27-p LEAERIAyQRNDDDE
1 2 S58-p RQKQEEEsLGQVTDQ
3 3 S73-p VEVNAQNsVPDEEAK
0 1 T83-p DEEAKTTttNtQVEG
0 1 T84-p EEAKTTttNtQVEGD
0 2 T86-p AKTTttNtQVEGDDE
0 1 K119 QEALERQKEFDPTIT
0 1 T126 KEFDPTITDAsLsLP
0 2 S129-p DPTITDAsLsLPSRR
0 2 S131-p TITDAsLsLPSRRMQ
0 2 T141-p SRRMQNDtAENETTE
0 1 T146 NDtAENETTEKEEKs
0 1 K152 ETTEKEEKsESRQER
0 1 S153-p TTEKEEKsESRQERy
0 1 Q157 EEKsESRQERyEIEE
1 4 Y160-p sESRQERyEIEETET
0 1 Y172-p TETVTKSyQKNDWRD
0 1 K197 KEEEEEEKPKRGsIG
0 1 K199 EEEEEKPKRGsIGEN
0 29 S202-p EEKPKRGsIGENQVE
0 1 K427-ac EKKAQEDkLQTAVLK
0 1 K464 TFKKEEIKDEKIKKD
0 2 S493-p KGFTEVKsQNGEFMT
0 1 K502 NGEFMTHKLKHTENT
0 1 K504 EFMTHKLKHTENTFs
1 9 S511-p KHTENTFsRPGGRAs
0 2 - gap
0 8 S518-p sRPGGRAsVDtKEAE
0 1 T521-p GGRAsVDtKEAEGAP
0 1 K522 GRAsVDtKEAEGAPQ
1 0 - gap
1 0 - gap
0 12 K534-ac APQVEAGkRLEELRR
0 18 T546-p LRRRRGEtESEEFEK
0 1 K569 ALELEELKKKREERR
0 1 K605 EEEKRRLKEEIERRR
0 2 S628-p KMPEDGLsDDKKPFK
0 1 K632 DGLsDDKKPFKCFTP
1 0 T638 KKPFKCFTPkGSsLk
0 1 K640-ac PFKCFTPkGSsLkIE
2 3 S643-p CFTPkGSsLkIEERA
0 2 K645-ac TPkGSsLkIEERAEF
0 1 K655 ERAEFLNKsVQKssG
1 8 S656-p RAEFLNKsVQKssGV
0 1 S660-p LNKsVQKssGVKStH
0 1 S661-p NKsVQKssGVKStHQ
0 1 T666-p KssGVKStHQAAIVS
1 0 - gap
1 0 - gap
1 0 S673 tHQAAIVSKIDsRLE
0 1 K674 HQAAIVSKIDsRLEQ
2 1 S677-p AIVSKIDsRLEQyTs
1 71 Y682-p IDsRLEQyTsAIEGT
1 3 S684-p sRLEQyTsAIEGTKS
0 1 K693 IEGTKSAKPtKPAAS
0 1 T695-p GTKSAKPtKPAASDL
1 0 S700 KPtKPAASDLPVPAE
0 1 K713 AEGVRNIKsMWEKGN
5 0 S714-p EGVRNIKsMWEKGNV
0 7 S723-p WEKGNVFssPtAAGt
2 11 S724-p EKGNVFssPtAAGtP
0 7 T726-p GNVFssPtAAGtPNk
3 16 T730-p ssPtAAGtPNkEtAG
0 1 K733-ac tAAGtPNkEtAGLKV
0 1 K733-ub tAAGtPNkEtAGLKV
1 6 T735-p AGtPNkEtAGLKVGV
5 0 S744-p GLKVGVSsRINEWLT
0 1 T751 sRINEWLTktPDGNk
0 2 K752-ac RINEWLTktPDGNks
2 15 T753-p INEWLTktPDGNksP
0 1 K758-ac TktPDGNksPAPKPs
7 14 S759-p ktPDGNksPAPKPsD
0 1 K763 GNksPAPKPsDLRPG
0 5 S765-p ksPAPKPsDLRPGDV
0 1 S773-p DLRPGDVsSKRNLWE
0 6 K775 RPGDVsSKRNLWEKQ
0 1 K781 SKRNLWEKQsVDKVt
1 2 S783-p RNLWEKQsVDKVtsP
0 1 T788-p KQsVDKVtsPtKV__
17 12 S789-p QsVDKVtsPtKV___
0 2 T791-p VDKVtsPtKV_____
  Caldesmon iso2  
- gap
- gap
- gap
- gap
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVTDQ
S73 VEVNAQNSVPDEEAK
T83 DEEAKTTTTNTQVEG
T84 EEAKTTTTNTQVEGD
T86 AKTTTTNTQVEGDDE
K119 QEALERQKEFDPTIT
T126 KEFDPTITDASLSLP
S129 DPTITDASLSLPSRR
S131 TITDASLSLPSRRMQ
T141 SRRMQNDTAENETTE
T146 NDTAENETTEKEEKS
K152 ETTEKEEKSESRQER
S153 TTEKEEKSESRQERY
- gap
Y160 SESRQERYEIEETET
Y172 TETVTKSYQKNDWRD
K197 KEEEEEEKPKRGsIG
K199 EEEEEKPKRGsIGEN
S202-p EEKPKRGsIGENQGE
- gap
K235 TFKKEEIKDEKIKKD
S264 KGFTEVKSQNGEFMT
K273 NGEFMTHKLKHTENT
K275 EFMTHKLKHTENTFS
S282 KHTENTFSRPGGRAS
- gap
S289 SRPGGRASVDTKEAE
T292 GGRASVDTKEAEGAP
K293 GRASVDTKEAEGAPQ
- gap
- gap
K305 APQVEAGKRLEELRR
T317 LRRRRGETESEEFEK
K340 ALELEELKKKREERR
K376 EEEKRRLKEEIERRR
S399 KMPEDGLSDDKKPFK
K403 DGLSDDKKPFKCFTP
T409 KKPFKCFTPKGSSLK
K411 PFKCFTPKGSSLKIE
S414 CFTPKGSSLKIEERA
K416 TPKGSSLKIEERAEF
K426 ERAEFLNKSVQKSSG
S427 RAEFLNKSVQKSSGV
S431 LNKSVQKSSGVKSTH
S432 NKSVQKSSGVKSTHQ
T437 KSSGVKSTHQAAIVS
- gap
- gap
S444 THQAAIVSKIDSRLE
K445 HQAAIVSKIDSRLEQ
S448 AIVSKIDSRLEQyTS
Y453-p IDSRLEQyTSAIEGT
S455 SRLEQyTSAIEGTKS
K464 IEGTKSAKPTKPAAS
T466 GTKSAKPTKPAASDL
S471 KPTKPAASDLPVPAE
K484 AEGVRNIKSMWEKGN
S485 EGVRNIKSMWEKGNV
S494 WEKGNVFSSPTAAGT
S495 EKGNVFSSPTAAGTP
T497 GNVFSSPTAAGTPNK
T501 SSPTAAGTPNKETAG
K504 TAAGTPNKETAGLKV
K504 TAAGTPNKETAGLKV
T506 AGTPNKETAGLKVGV
S515 GLKVGVSSRINEWLT
T522 SRINEWLTKTPDGNK
K523 RINEWLTKTPDGNKS
T524 INEWLTKTPDGNKSP
K529 TKTPDGNKSPAPKPS
S530 KTPDGNKSPAPKPSD
K534 GNKSPAPKPSDLRPG
S536 KSPAPKPSDLRPGDV
S544 DLRPGDVSSKRNLWE
K546 RPGDVSSKRNLWEKQ
K552 SKRNLWEKQSVDKVT
S554 RNLWEKQSVDKVTSP
T559 KQSVDKVTSPTKV__
S560 QSVDKVTSPTKV___
T562 VDKVTSPTKV_____
  Caldesmon iso3  
S7-p _MLGGSGsHGRRsLA
S12-p SGsHGRRsLAALsQI
S17-p RRsLAALsQIAyQRN
- gap
Y21-p AALsQIAyQRNDDDE
S52 RQKQEEESLGQVTDQ
S67 VEVNAQNSVPDEEAK
T77 DEEAKTTTTNTQVEG
T78 EEAKTTTTNTQVEGD
T80 AKTTTTNTQVEGDDE
K113 QEALERQKEFDPTIT
T120 KEFDPTITDASLSLP
S123 DPTITDASLSLPSRR
S125 TITDASLSLPSRRMQ
T135 SRRMQNDTAENETTE
T140 NDTAENETTEKEEKS
K146 ETTEKEEKSESRQER
S147 TTEKEEKSESRQERY
- gap
Y154 SESRQERYEIEETET
Y166 TETVTKSYQKNDWRD
K191 KEEEEEEKPKRGsIG
K193 EEEEEKPKRGsIGEN
S196-p EEKPKRGsIGENQGE
- gap
K229 TFKKEEIKDEKIKKD
S258 KGFTEVKSQNGEFMT
K267 NGEFMTHKLKHTENT
K269 EFMTHKLKHTENTFS
S276 KHTENTFSRPGGRAS
- gap
S283 SRPGGRASVDTKEAE
T286 GGRASVDTKEAEGAP
K287 GRASVDTKEAEGAPQ
- gap
- gap
K299 APQVEAGKRLEELRR
T311 LRRRRGETESEEFEK
K334 ALELEELKKKREERR
K370 EEEKRRLKEEIERRR
S393 KMPEDGLSDDKKPFK
K397 DGLSDDKKPFKCFTP
T403 KKPFKCFTPKGSSLK
K405 PFKCFTPKGSSLKIE
S408 CFTPKGSSLKIEERA
K410 TPKGSSLKIEERAEF
K420 ERAEFLNKSVQKSSG
S421 RAEFLNKSVQKSSGV
S425 LNKSVQKSSGVKSTH
S426 NKSVQKSSGVKSTHQ
T431 KSSGVKSTHQAAIVS
- gap
- gap
S438 THQAAIVSKIDSRLE
K439 HQAAIVSKIDSRLEQ
S442 AIVSKIDSRLEQYTS
Y447 IDSRLEQYTSAIEGT
S449 SRLEQYTSAIEGTKS
K458 IEGTKSAKPTKPAAS
T460 GTKSAKPTKPAASDL
S465 KPTKPAASDLPVPAE
K478 AEGVRNIKSMWEKGN
S479 EGVRNIKSMWEKGNV
S488 WEKGNVFSSPTAAGT
S489 EKGNVFSSPTAAGTP
T491 GNVFSSPTAAGTPNK
T495 SSPTAAGTPNKETAG
K498 TAAGTPNKETAGLKV
K498 TAAGTPNKETAGLKV
T500 AGTPNKETAGLKVGV
S509 GLKVGVSSRINEWLT
T516 SRINEWLTKTPDGNK
K517 RINEWLTKTPDGNKS
T518 INEWLTKTPDGNKSP
K523 TKTPDGNKSPAPKPS
S524 KTPDGNKSPAPKPSD
K528 GNKSPAPKPSDLRPG
S530 KSPAPKPSDLRPGDV
S538 DLRPGDVSSKRNLWE
K540 RPGDVSSKRNLWEKQ
K546 SKRNLWEKQSVDKVT
S548 RNLWEKQSVDKVTSP
T553 KQSVDKVTSPTKV__
S554 QSVDKVTSPTKV___
T556 VDKVTSPTKV_____
  Caldesmon iso4  
- gap
- gap
- gap
- gap
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVTDQ
S73 VEVNAQNSVPDEEAK
T83 DEEAKTTTTNTQVEG
T84 EEAKTTTTNTQVEGD
T86 AKTTTTNTQVEGDDE
K119 QEALERQKEFDPTIT
T126 KEFDPTITDASLSLP
S129 DPTITDASLSLPSRR
S131 TITDASLSLPSRRMQ
T141 SRRMQNDTAENETTE
T146 NDTAENETTEKEEKS
K152 ETTEKEEKSESRQER
S153 TTEKEEKSESRQERY
- gap
Y160 SESRQERYEIEETET
Y172 TETVTKSYQKNDWRD
K197 KEEEEEEKPKRGsIG
K199 EEEEEKPKRGsIGEN
S202-p EEKPKRGsIGENQIK
- gap
K209 sIGENQIKDEKIKKD
S238 KGFTEVKSQNGEFMT
K247 NGEFMTHKLKHTENT
K249 EFMTHKLKHTENTFS
S256 KHTENTFSRPGGRAS
- gap
S263 SRPGGRASVDTKEAE
T266 GGRASVDTKEAEGAP
K267 GRASVDTKEAEGAPQ
- gap
- gap
K279 APQVEAGKRLEELRR
T291 LRRRRGETESEEFEK
K314 ALELEELKKKREERR
K350 EEEKRRLKEEIERRR
S373 KMPEDGLSDDKKPFK
K377 DGLSDDKKPFKCFTP
T383 KKPFKCFTPKGSSLK
K385 PFKCFTPKGSSLKIE
S388 CFTPKGSSLKIEERA
K390 TPKGSSLKIEERAEF
K400 ERAEFLNKSVQKSSG
S401 RAEFLNKSVQKSSGV
S405 LNKSVQKSSGVKSTH
S406 NKSVQKSSGVKSTHQ
T411 KSSGVKSTHQAAIVS
- gap
- gap
S418 THQAAIVSKIDSRLE
K419 HQAAIVSKIDSRLEQ
S422 AIVSKIDSRLEQYTS
Y427 IDSRLEQYTSAIEGT
S429 SRLEQYTSAIEGTKS
K438 IEGTKSAKPTKPAAS
T440 GTKSAKPTKPAASDL
S445 KPTKPAASDLPVPAE
K458 AEGVRNIKSMWEKGN
S459 EGVRNIKSMWEKGNV
S468 WEKGNVFSSPTAAGT
S469 EKGNVFSSPTAAGTP
T471 GNVFSSPTAAGTPNK
T475 SSPTAAGTPNKETAG
K478 TAAGTPNKETAGLKV
K478 TAAGTPNKETAGLKV
T480 AGTPNKETAGLKVGV
S489 GLKVGVSSRINEWLT
T496 SRINEWLTKTPDGNK
K497 RINEWLTKTPDGNKS
T498 INEWLTKTPDGNKSP
K503 TKTPDGNKSPAPKPS
S504 KTPDGNKSPAPKPSD
K508 GNKSPAPKPSDLRPG
S510 KSPAPKPSDLRPGDV
S518 DLRPGDVSSKRNLWE
K520 RPGDVSSKRNLWEKQ
K526 SKRNLWEKQSVDKVT
S528 RNLWEKQSVDKVTSP
T533 KQSVDKVTSPTKV__
S534 QSVDKVTSPTKV___
T536 VDKVTSPTKV_____
  Caldesmon iso6  
- gap
- gap
- gap
- gap
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVTDQ
S73 VEVNAQNSVPDEEAK
T83 DEEAKTTTTNTQVEG
T84 EEAKTTTTNTQVEGD
T86 AKTTTTNTQVEGDDE
K119 QEALERQKEFDPTIT
T126 KEFDPTITDASLSLP
S129 DPTITDASLSLPSRR
S131 TITDASLSLPSRRMQ
T141 SRRMQNDTAENETTE
T146 NDTAENETTEKEEKS
K152 ETTEKEEKSESRQER
S153 TTEKEEKSESRQERY
- gap
Y160 SESRQERYEIEETET
Y172 TETVTKSYQKNDWRD
K197 KEEEEEEKPKRGsIG
K199 EEEEEKPKRGsIGEN
S202-p EEKPKRGsIGENQGE
- gap
K235 TFKKEEIKDEKIKKD
S264 KGFTEVKSQNGEFMT
K273 NGEFMTHKLKHTENT
K275 EFMTHKLKHTENTFS
S282 KHTENTFSRPGGRAS
- gap
S289 SRPGGRASVDTKEAE
T292 GGRASVDTKEAEGAP
K293 GRASVDTKEAEGAPQ
- gap
- gap
K305 APQVEAGKRLEELRR
T317 LRRRRGETESEEFEK
K340 ALELEELKKKREERR
K376 EEEKRRLKEEIERRR
S399 KMPEDGLSDDKKPFK
K403 DGLSDDKKPFKCFTP
T409 KKPFKCFTPKGSSLK
K411 PFKCFTPKGSSLKIE
S414 CFTPKGSSLKIEERA
K416 TPKGSSLKIEERAEF
K426 ERAEFLNKsVQKsGV
S427-p RAEFLNKsVQKsGVK
S431-p LNKsVQKsGVKSTHQ
- gap
T436 QKsGVKSTHQAAIVS
- gap
- gap
S443 THQAAIVSKIDSRLE
K444 HQAAIVSKIDSRLEQ
S447 AIVSKIDSRLEQYTS
Y452 IDSRLEQYTSAIEGT
S454 SRLEQYTSAIEGTKS
K463 IEGTKSAKPTKPAAS
T465 GTKSAKPTKPAASDL
S470 KPTKPAASDLPVPAE
K483 AEGVRNIKSMWEKGN
S484 EGVRNIKSMWEKGNV
S493 WEKGNVFSSPTAAGT
S494 EKGNVFSSPTAAGTP
T496 GNVFSSPTAAGTPNK
T500 SSPTAAGTPNKETAG
K503 TAAGTPNKETAGLKV
K503 TAAGTPNKETAGLKV
T505 AGTPNKETAGLKVGV
S514 GLKVGVSSRINEWLT
T521 SRINEWLTKTPDGNK
K522 RINEWLTKTPDGNKS
T523 INEWLTKTPDGNKSP
K528 TKTPDGNKSPAPKPS
S529 KTPDGNKSPAPKPSD
K533 GNKSPAPKPSDLRPG
S535 KSPAPKPSDLRPGDV
S543 DLRPGDVSSKRNLWE
K545 RPGDVSSKRNLWEKQ
K551 SKRNLWEKQSVDKVT
S553 RNLWEKQSVDKVTSP
T558 KQSVDKVTSPTKV__
S559 QSVDKVTSPTKV___
T561 VDKVTSPTKV_____
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
- gap
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVTDQ
S73 VEAHVQNSVPDEESK
S83 DEESKPASSNTQVEG
S84 EESKPASSNTQVEGD
T86 SKPASSNTQVEGDEE
K119-ub QEALERQkEFDPTIt
T126-p kEFDPTItDGSLSGP
S129 DPTItDGSLSGPSRR
S131 TItDGSLSGPSRRMQ
S141-p SRRMQNDsAENEtAE
T146-p NDsAENEtAEGEEKR
K152 EtAEGEEKRESRsGR
R153 tAEGEEKRESRsGRy
S157-p EEKRESRsGRyEVEE
Y160-p RESRsGRyEVEETEV
Y172 TEVVIKSYQKNSYQD
K195 KEEEEQEKLkGGSLG
K197-ub EEEQEKLkGGSLGEN
S200 QEKLkGGSLGENQVE
R404 EREAPDDRLQTAVPK
K441 AFRKEEIKDEKIKKD
A470 KGFTEVKAQNGEFMT
K479 NGEFMTHKLKQTENA
K481 EFMTHKLKQTENAFS
S488 KQTENAFSRSGGRAs
- gap
S495-p SRSGGRAsGDKEAEG
- gap
K498 GGRAsGDKEAEGAPQ
- gap
- gap
K510 APQVEAGKRLEELRR
T522 LRRRRGETENEEFEK
K545 ALELEELKKKREERR
K581 EEEKRRLKEEIERRR
S604 KMPEDGLSEDKKPFK
K608 DGLSEDKKPFKCFTP
T614 KKPFKCFTPKGSsLK
K616 PFKCFTPKGSsLKIE
S619-p CFTPKGSsLKIEERA
K621 TPKGSsLKIEERAEF
K631-ub ERAEFLNksVQKSGV
S632-p RAEFLNksVQKSGVR
S636 LNksVQKSGVRSTHQ
- gap
T641 QKSGVRSTHQAAVVS
- gap
- gap
S648 THQAAVVSKIDSRLE
K649 HQAAVVSKIDSRLEQ
S652 AVVSKIDSRLEQyTN
Y657-p IDSRLEQyTNAIEGT
N659 SRLEQyTNAIEGTKA
K668 IEGTKASKPMKPAAS
M670 GTKASKPMKPAASDL
S675 KPMKPAASDLPVPAE
K688 AEGVRNIKSMWEKGS
S689 EGVRNIKSMWEKGSV
S698-p WEKGSVFsAPsASGt
A699 EKGSVFsAPsASGtP
S701-p GSVFsAPsASGtPNK
T705-p sAPsASGtPNKETAG
K708 sASGtPNKETAGLKV
K708 sASGtPNKETAGLKV
T710 SGtPNKETAGLKVGV
S719 GLKVGVSSRINEWLt
T726-p SRINEWLtKsPDGNK
K727 RINEWLtKsPDGNKs
S728-p INEWLtKsPDGNKsP
K733 tKsPDGNKsPAPKPS
S734-p KsPDGNKsPAPKPSD
K738 GNKsPAPKPSDLRPG
S740 KsPAPKPSDLRPGDV
S748 DLRPGDVSGkRNLWE
K750-ac RPGDVSGkRNLWEKQ
K756 GkRNLWEKQsVDKVT
S758-p RNLWEKQsVDKVTsP
T763 KQsVDKVTsPtKV__
S764-p QsVDKVTsPtKV___
T766-p VDKVTsPtKV_____
  Caldesmon iso5  
S7-p _MLSGSGsQGRRCLA
C12 SGsQGRRCLATLSQI
S17 RRCLATLSQIAYQRN
- gap
Y21 ATLSQIAYQRNDDDE
S52 RQKQEEESLGQVTDQ
S67 VEAHVQNSVPDEESK
S77 DEESKPASSNTQVEG
S78 EESKPASSNTQVEGD
T80 SKPASSNTQVEGDEE
K113 QEALERQKEFDPTIT
T120 KEFDPTITDGSLSGP
S123 DPTITDGSLSGPSRR
S125 TITDGSLSGPSRRMQ
S135 SRRMQNDSAENETAE
T140 NDSAENETAEGEEKR
K146 ETAEGEEKRESRSGR
R147 TAEGEEKRESRSGRY
S151 EEKRESRSGRYEVEE
Y154 RESRSGRYEVEETEV
Y166 TEVVIKSYQKNSYQD
K189 KEEEEQEKLKGGsLG
K191 EEEQEKLKGGsLGEN
S194-p QEKLKGGsLGENQIK
- gap
K201 sLGENQIKDEKIKKD
A230 KGFTEVKAQNGEFMT
K239 NGEFMTHKLkQTENA
K241-ub EFMTHKLkQTENAFs
S248-p kQTENAFsPsRSGGR
S250-p TENAFsPsRSGGRAs
S257-p sRSGGRAsGDKEAEG
- gap
K260 GGRAsGDKEAEGAPQ
- gap
- gap
K272-ac APQVEAGkRLEELRR
T284-p LRRRRGEtENEEFEK
K307 ALELEELKKKREERR
K343 EEEKRRLKEEIERRR
S366 KMPEDGLSEDKKPFK
K370 DGLSEDKKPFKCFTP
T376 KKPFKCFTPKGSSLK
K378 PFKCFTPKGSSLKIE
S381 CFTPKGSSLKIEERA
K383 TPKGSSLKIEERAEF
K393 ERAEFLNKSVQKSGV
S394 RAEFLNKSVQKSGVR
S398 LNKSVQKSGVRSTHQ
- gap
T403 QKSGVRSTHQAAVVS
- gap
- gap
S410 THQAAVVSKIDSRLE
K411 HQAAVVSKIDSRLEQ
S414 AVVSKIDSRLEQYTN
Y419 IDSRLEQYTNAIEGT
N421 SRLEQYTNAIEGTKA
K430 IEGTKASKPMKPAAS
M432 GTKASKPMKPAASDL
S437 KPMKPAASDLPVPAE
K450 AEGVRNIKSMWEKGS
S451 EGVRNIKSMWEKGSV
S460 WEKGSVFSAPSASGT
A461 EKGSVFSAPSASGTP
S463 GSVFSAPSASGTPNK
T467 SAPSASGTPNKETAG
K470 SASGTPNKETAGLKV
K470 SASGTPNKETAGLKV
T472 SGTPNKETAGLKVGV
S481 GLKVGVSSRINEWLT
T488 SRINEWLTKSPDGNK
K489 RINEWLTKSPDGNKS
S490 INEWLTKSPDGNKSP
K495 TKSPDGNKSPAPKPS
S496 KSPDGNKSPAPKPSD
K500 GNKSPAPKPSDLRPG
S502 KSPAPKPSDLRPGDV
S510 DLRPGDVSGKRNLWE
K512 RPGDVSGKRNLWEKQ
K518 GKRNLWEKQSVDKVT
S520 RNLWEKQSVDKVTSP
T525 KQSVDKVTSPTKV__
S526 QSVDKVTSPTKV___
T528 VDKVTSPTKV_____
  rat

 
S7 _MLSRSGSQGRRCLA
C12 SGSQGRRCLATLSQI
S17 RRCLATLSQIAYQRN
- gap
Y21 ATLSQIAYQRNDDDE
S52 RQKQEEESLGQVTDQ
S67 VEAHVQNSAPDEESK
T77 DEESKPATANAQVEG
A78 EESKPATANAQVEGD
A80 SKPATANAQVEGDEE
K113 QEALERQKEFDPTIT
T120 KEFDPTITDGSLSVP
S123 DPTITDGSLSVPSRR
S125 TITDGSLSVPSRRMQ
S135 SRRMQNNSAENETAE
T140 NNSAENETAEGEEkG
K146-ac ETAEGEEkGESRSGR
G147 TAEGEEkGESRSGRY
S151 EEkGESRSGRYEMEE
Y154 GESRSGRYEMEETEV
Y166 TEVVITSYQKNSYQD
K190-ac EEEEEEEkLKGGNLG
K192 EEEEEkLKGGNLGEN
N195 EEkLKGGNLGENQIk
- gap
K202-ac NLGENQIkDEKIKKD
A231 KGFTEVKAQNGEFMT
K240-ac NGEFMTHkLKQTENA
K242 EFMTHkLKQTENAFs
S249-p KQTENAFsPSRSGGR
S251 TENAFsPSRSGGRAs
S258-p SRSGGRAsGDkEAEG
- gap
K261-ac GGRAsGDkEAEGAPQ
- gap
- gap
K273-ac APQVEAGkRLEELRR
T285 LRRRRGETESEEFEK
K308-ac ALELEELkKKREERR
K344-ac EEEKRRLkEEIERRR
S367 KMPEDGLSEDKkPFK
K371-ac DGLSEDKkPFKCFTP
T377 KkPFKCFTPKGSSLk
K379 PFKCFTPKGSSLkIE
S382 CFTPKGSSLkIEERA
K384-ac TPKGSSLkIEERAEF
K394 ERAEFLNKSVQKSGV
S395 RAEFLNKSVQKSGVK
S399 LNKSVQKSGVKSTHQ
- gap
T404 QKSGVKSTHQAAVVS
- gap
- gap
S411 THQAAVVSkIDSRLE
K412-ac HQAAVVSkIDSRLEQ
S415 AVVSkIDSRLEQYTN
Y420 IDSRLEQYTNAIEGT
N422 SRLEQYTNAIEGTKA
K431-ac IEGTKASkPMKPAAS
M433 GTKASkPMKPAASDL
S438 kPMKPAASDLPVPAE
K451-ac AEGVRNIkSMWEKGS
S452 EGVRNIkSMWEKGSV
S461 WEKGSVFSsPSASGt
S462-p EKGSVFSsPSASGtP
S464 GSVFSsPSASGtPNK
T468-p SsPSASGtPNKETAG
K471 SASGtPNKETAGLKV
K471 SASGtPNKETAGLKV
T473 SGtPNKETAGLKVGV
S482 GLKVGVSSRINEWLT
T489 SRINEWLTksPDGNK
K490-ac RINEWLTksPDGNKs
S491-p INEWLTksPDGNKsP
K496 TksPDGNKsPAPkPS
S497-p ksPDGNKsPAPkPSD
K501-ac GNKsPAPkPSDLRPG
S503 KsPAPkPSDLRPGDV
S511 DLRPGDVSGKRNLWE
K513 RPGDVSGKRNLWEkQ
K519-ac GKRNLWEkQSVDKVT
S521 RNLWEkQSVDKVTsP
T526 kQSVDKVTsPTKV__
S527-p QSVDKVTsPTKV___
T529 VDKVTsPTKV_____
  rabbit

 
- gap
- gap
- gap
- gap
Y27 LEAERIAYQRNDDDE
S58 RQKQEEESLGQVADQ
S73 VEVHAQNSVSNEDSK
T83 NEDSKPSTTSTQVEG
T84 EDSKPSTTSTQVEGD
T86 SKPSTTSTQVEGDDE
K119 QEALERQKEFDPTVT
T126 KEFDPTVTDASASLP
S129 DPTVTDASASLPSRR
S131 TVTDASASLPSRRMP
T141 SRRMPNDTAENATAE
T146 NDTAENATAEKEAKA
K152 ATAEKEAKAESRRER
A153 TAEKEAKAESRRERY
- gap
Y160 AESRRERYETVETKM
E172 TKMVTKSEQKNDWRD
K197 REDGEEEKSKQESVG
K199 DGEEEKSKQESVGEN
S202 EEKSKQESVGENQVK
- gap
K209 SVGENQVKDEKIKKD
S238 KGFTDVKSQNGEFMT
K247 NGEFMTHKLKHAENT
K249 EFMTHKLKHAENTFS
S256 KHAENTFSPGRSGAR
G258 AENTFSPGRSGARPS
S265 GRSGARPSGDAQEAE
- gap
- gap
- gap
- gap
K275 AQEAEAGKRLEELRR
T287 LRRRRGETESEEFEK
K310 ALELEELKKKREERR
K346 EEEKRRLKEEIERRR
S369 KMPEDGLSDDKKPFK
K373 DGLSDDKKPFKCFTP
T379 KKPFKCFTPKGSSLK
K381 PFKCFTPKGSSLKIE
S384 CFTPKGSSLKIEERA
K386 TPKGSSLKIEERAEF
K396 ERAEFLNKSVQKSGV
S397 RAEFLNKSVQKSGVK
S401 LNKSVQKSGVKSTHQ
- gap
T406 QKSGVKSTHQAAVVS
- gap
- gap
S413 THQAAVVSKIDSRLE
K414 HQAAVVSKIDSRLEQ
S417 AVVSKIDSRLEQYTS
Y422 IDSRLEQYTSAIEGT
S424 SRLEQYTSAIEGTKA
K433 IEGTKAAKSTKPAAS
T435 GTKAAKSTKPAASDL
S440 KSTKPAASDLPVPAE
K453 AEGVRNIKSMWEKGN
S454 EGVRNIKSMWEKGNV
S463 WEKGNVFSAPTASGT
A464 EKGNVFSAPTASGTP
T466 GNVFSAPTASGTPNK
T470 SAPTASGTPNKETAG
K473 TASGTPNKETAGLKV
K473 TASGTPNKETAGLKV
T475 SGTPNKETAGLKVGV
S484 GLKVGVSSRINEWLT
T491 SRINEWLTKTPDGSK
K492 RINEWLTKTPDGSKS
T493 INEWLTKTPDGSKSP
K498 TKTPDGSKSPAPKPS
S499 KTPDGSKSPAPKPSD
K503 GSKSPAPKPSDLRPG
S505 KSPAPKPSDLRPGDV
S513 DLRPGDVSGKRNLWE
K515 RPGDVSGKRNLWEKQ
K521 GKRNLWEKQSVDKVT
S523 RNLWEKQSVDKVTsP
T528 KQSVDKVTsPTKV__
S529-p QSVDKVTsPTKV___
T531 VDKVTsPTKV_____
  chicken

 
- gap
- gap
- gap
S26-p RLEAERLsyQRNDDD
Y27-p LEAERLsyQRNDDDE
S59-p QKEEGDVsGEVTEKS
S73-p SEVNAQNsVAEEETK
T83 EEETKRSTDDEAALL
- gap
- gap
K112 QEALERQKEFDPTIT
T119 KEFDPTITDGSLSVP
S122 DPTITDGSLSVPSRR
S124 TITDGSLSVPSRREV
V134 SRREVNNVEENEITG
I139 NNVEENEITGKEEKV
K145 EITGKEEKVETRQGR
V146 ITGKEEKVETRQGRC
- gap
C153 VETRQGRCEIEETET
Y165 TETVTKSYQRNNWRQ
K189 EKDSEEEKPKEVPTE
K191 DSEEEKPKEVPTEEN
P194 EEKPKEVPTEENQVD
- gap
K361 KAAEERAKAEKERKA
A406 KKMEEKKAQEEKAQA
K487 ERELtTPKLKsTENA
K489 ELtTPKLKsTENAFG
- gap
- gap
- gap
N450 KKDQVKDNKDKEKAP
K451 KDQVKDNKDKEKAPK
T484-p QNGERELtTPKLKsT
S490-p LtTPKLKsTENAFGR
S510 AANAEAGSEKLKEKQ
- gap
K528 AVELDELKKRREERR
K564 EEEKKRMKEEIERRR
S587 KVPEDGVSEEKKPFK
K591 DGVSEEKKPFKCFsP
S597-p KKPFKCFsPKGSsLK
K599 PFKCFsPKGSsLKIE
S602-p CFsPKGSsLKIEERA
K604 sPKGSsLKIEERAEF
K614 ERAEFLNKsAQKSGM
S615-p RAEFLNKsAQKSGMK
S619 LNKsAQKSGMKPAHt
- gap
A624 QKSGMKPAHttAVVs
T626-p SGMKPAHttAVVsKI
T627-p GMKPAHttAVVsKID
S631-p AHttAVVsKIDsRLE
K632 HttAVVsKIDsRLEQ
S635-p AVVsKIDsRLEQyTs
Y640-p IDsRLEQyTsAVVGN
S642-p sRLEQyTsAVVGNKA
K651 VVGNKAAKPAKPAAs
A653 GNKAAKPAKPAAsDL
S658-p KPAKPAAsDLPVPAE
K671 AEGVRNIKsMWEKGN
S672-p EGVRNIKsMWEKGNV
S681 WEKGNVFSsPGGTGt
S682-p EKGNVFSsPGGTGtP
G684 GNVFSsPGGTGtPNK
T688-p SsPGGTGtPNKEtAG
K691 GGTGtPNKEtAGLKV
K691 GGTGtPNKEtAGLKV
T693-p TGtPNKEtAGLKVGV
S702-p GLKVGVSsRINEWLT
T709 sRINEWLTKtPEGNK
K710 RINEWLTKtPEGNKs
T711-p INEWLTKtPEGNKsP
K716 TKtPEGNKsPAPKPS
S717-p KtPEGNKsPAPKPSD
K721 GNKsPAPKPSDLRPG
S723 KsPAPKPSDLRPGDV
S731 DLRPGDVSGKRNLWE
K733 RPGDVSGKRNLWEKQ
K739 GKRNLWEKQsVEKPA
S741-p RNLWEKQsVEKPAAS
S748 sVEKPAASSSKVTAT
S749 VEKPAASSSKVTATG
S750 EKPAASSSKVTATGK
  cow

 
- gap
- gap
- gap
- gap
Y27 LEAERIAYQRNDDDE
L59 QKQEEEALGQVTDQV
S73 VEVNTQNSVPDEEVK
T83 DEEVKTTTTNTQAEG
T84 EEVKTTTTNTQAEGD
T86 VKTTTTNTQAEGDDE
K119 QEALERQKEFDPTIT
T126 KEFDPTITDASLSLS
S129 DPTITDASLSLSSRR
S131 TITDASLSLSSRRMQ
T141 SRRMQNDTTDNETAE
T146 NDTTDNETAEKEGRS
R152 ETAEKEGRSESRQER
S153 TAEKEGRSESRQERQ
- gap
Q160 SESRQERQELEETEI
H172 TEIVTKSHQKNDWME
K197 KEEEEEEKPKPGSIE
K199 EEEEEKPKPGSIEEN
S202 EEKPKPGSIEENQLK
- gap
K209 SIEENQLKDEKTKKD
S237 KGFTEVKSQNGEFMT
K246 NGEFMTHKLKHAENT
K248 EFMTHKLKHAENTFS
S255 KHAENTFSRAGGRVS
- gap
S262 SRAGGRVSEAKEAEG
- gap
K265 GGRVSEAKEAEGTSQ
- gap
- gap
K277 TSQVEAGKRLEELRR
T289 LRRRRGETESEEFEK
K312 ALELEELKKKREERR
K348 EEEKRRLKEEIERRR
S371 KMPEDGLSEDKKPFK
K375 DGLSEDKKPFKCFTP
T381 KKPFKCFTPKGSSLK
K383 PFKCFTPKGSSLKIE
S386 CFTPKGSSLKIEERA
K388 TPKGSSLKIEERAEF
K398 ERAEFLNKSVQKSGV
S399 RAEFLNKSVQKSGVK
S403 LNKSVQKSGVKPTHQ
- gap
T408 QKSGVKPTHQAAVVS
- gap
- gap
S415 THQAAVVSKIDSRLE
K416 HQAAVVSKIDSRLEQ
S419 AVVSKIDSRLEQYTS
Y424 IDSRLEQYTSAIEGT
S426 SRLEQYTSAIEGTKA
K435 IEGTKAAKPTKPAAS
T437 GTKAAKPTKPAASDL
S442 KPTKPAASDLPVPAE
K455 AEGVRNIKSMWEKGN
S456 EGVRNIKSMWEKGNV
S465 WEKGNVFSSPTASGT
S466 EKGNVFSSPTASGTP
T468 GNVFSSPTASGTPNK
T472 SSPTASGTPNKETAG
K475 TASGTPNKETAGLKV
K475 TASGTPNKETAGLKV
T477 SGTPNKETAGLKVGV
S486 GLKVGVSSRINEWLT
T493 SRINEWLTKTPEGSK
K494 RINEWLTKTPEGSKs
T495 INEWLTKTPEGSKsP
K500 TKTPEGSKsPAPKPS
S501-p KTPEGSKsPAPKPSD
K505 GSKsPAPKPSDLRPG
S507 KsPAPKPSDLRPGDV
S515 DLRPGDVSGKRNLWE
K517 RPGDVSGKRNLWEKQ
K523 GKRNLWEKQSVDKVT
S525 RNLWEKQSVDKVTsP
T530 KQSVDKVTsPTKV__
S531-p QSVDKVTsPTKV___
T533 VDKVTsPTKV_____
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