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Protein Page:
ARID4B (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARID4B Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: intracellular; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: genetic imprinting; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis
Reference #:  A2CG63 (UniProtKB)
Alt. Names/Synonyms: 180 kDa Sin3-associated polypeptide; 5930400I17; 6330417L24Rik; 6720480E17Rik; 9330186M13; ARI4B; ARID domain-containing protein 4B; Arid4b; AT rich interactive domain 4B (Rbp1 like); AT rich interactive domain 4B (RBP1-like); AT-rich interactive domain-containing protein 4B; BCAA; BRCAA1; breast cancer-associated antigen; Histone deacetylase complex subunit SAP180; OTTMUSP00000018788; OTTMUSP00000018792; RBBP1L1; RBP1-like protein; Rbp1l1; retinoblastoma binding protein 1-like 1; Sap180; Sin3-associated polypeptide p180
Gene Symbols: Arid4b
Molecular weight: 147,643 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below

ARID4B

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 Y89 KLTDASWYTVVFDDG
0 1 T90 LTDASWYTVVFDDGD
0 1 S105 EKTLRRSSLCLKGER
0 4 T133 TNPEHFGTPVIGKKT
0 1 S273 KTELKEDSSSsEAEE
0 2 S276 LKEDSSSsEAEEEEE
0 6 S295 EKEKEDNssEEEEEI
0 6 S296 KEKEDNssEEEEEIE
0 1 Y335 NKRPVLGYRNLNLFK
0 3 S482 LECIPAQsDEEKEAH
0 1 R506 LEDKDGGRARTEEAF
0 1 A507 EDKDGGRARTEEAFS
0 1 Y655 EKDRDEKYSPKNCKL
0 2 S656 KDRDEKYSPKNCKLR
0 6 S666 NCKLRRLsKsPFQsN
0 3 S668 KLRRLsKsPFQsNPs
0 1 S672 LsKsPFQsNPsPEMV
0 13 S675 sPFQsNPsPEMVSKL
0 1 S758 KEEQSSPsLLEENKV
0 1 T774 TDLVIAKtVSKsPER
0 8 S778 IAKtVSKsPERLRKD
0 29 S790 RKDMEAIsEDtDFEE
0 33 T793 MEAIsEDtDFEEEDE
0 4 F795 AIsEDtDFEEEDEIt
0 1 T802 FEEEDEItKKRKDVK
0 1 T813 KDVKKDTtDKALKPQ
0 1 Y828 TKRGKRRYCSADECL
0 1 A831 GKRRYCSADECLQTG
0 2 T837 SADECLQTGsPGKKE
0 3 S839 DECLQTGsPGKKEDR
0 2 T876 EKSKAKMtPTKKYNG
0 1 S890 GLEEKRKSLRTTSFY
0 2 Y897 SLRTTSFYSGFSEVA
0 1 S898 LRTTSFYSGFSEVAE
0 1 S901 TSFYSGFSEVAEKRI
0 3 S914 RIKLLNNSDERLQNN
0 1 N921 SDERLQNNRAKDRKD
0 1 S1016 RKTEFPSSGSNSVLN
0 3 T1024 GSNSVLNTPPTTPES
0 1 T1028 VLNTPPTTPESPSSV
0 2 S1031 TPPTTPESPSSVTIT
0 2 S1033 PTTPESPSSVTITEA
0 1 S1034 TTPESPSSVTITEAS
0 1 T1038 SPSSVTITEASQQQS
0 2 T1152 NKKKGKGTNssDsEE
0 3 S1154 KKGKGTNssDsEELs
0 7 S1155 KGKGTNssDsEELsA
0 4 S1157 KGTNssDsEELsAGE
0 4 S1161 ssDsEELsAGESVTK
0 7 S1186 MKTHNSKsPARVQsP
0 5 S1192 KsPARVQsPGKGGRN
0 1 S1258 SLKSEVASIDRRRKR
0 1 S1285 SSSSSPSsSSItAAV
0 1 T1289 SPSsSSItAAVMLtL
0 1 T1295 ItAAVMLtLAEPsMs
0 1 S1300 MLtLAEPsMssASQN
0 1 S1302 tLAEPsMssASQNGM
0 1 S1303 LAEPsMssASQNGMs
0 1 S1310 sASQNGMsVECR___
  human

► Hide Isoforms
 
Y89 KLTDASWytVVFDDG
T90 LTDASWytVVFDDGD
S105 EKTLRRSsLCLKGER
T133 TNPEHFGtPVIGKKT
S273 KTELKEDsSSsEAEE
S276 LKEDsSSsEAEEEEE
S295 EKEKEDNssEEEEEI
S296 KEKEDNssEEEEEIE
Y335 NKRPVLGyRNLNLFK
S483 LESIPTHsDQEKEVN
T507 LDDKDDDttRVDESL
T508 DDKDDDttRVDESLN
Y655 EKDKDEKysPKNCKL
S656 KDKDEKysPKNCKLR
S666 NCKLRRLsKPPFQTN
P668 KLRRLsKPPFQTNPs
T672 LsKPPFQTNPsPEMV
S675 PPFQTNPsPEMVSKL
S758 KEEQNSSSLLEENKV
P774 ADLVISKPVSKsPER
S778 ISKPVSKsPERLRKD
S790 RKDIEVLsEDtDyEE
T793 IEVLsEDtDyEEDEV
Y795 VLsEDtDyEEDEVTK
T801 DyEEDEVTKKRKDVK
T812 KDVKKDTTDKSSKPQ
Y827 IKRGKRRyCNtEECL
T830 GKRRyCNtEECLKtG
T836 NtEECLKtGsPGKKE
S838 EECLKtGsPGKKEEK
T874 EETKAKMtPTKKYNG
S888 GLEEKRKsLRTTGFy
Y895 sLRTTGFysGFsEVA
S896 LRTTGFysGFsEVAE
S899 TGFysGFsEVAEKRI
S912 RIKLLNNsDERLQNs
S919 sDERLQNsRAKDRKD
S1014 RKAEFPSsGSNSVLN
T1022 GSNSVLNtPPTtPEs
T1026 VLNtPPTtPEsPssV
S1029 tPPTtPEsPssVTVt
S1031 PTtPEsPssVTVtEG
S1032 TtPEsPssVTVtEGS
T1036 sPssVTVtEGSRQQS
T1150 NKKKGKGtNssDsEE
S1152 KKGKGtNssDsEELs
S1153 KGKGtNssDsEELsA
S1155 KGtNssDsEELsAGE
S1159 ssDsEELsAGESITK
S1184 MKSHSTKsPARTQSP
S1190 KsPARTQSPGKCGKN
S1256 SLKSEVAsIDRRRKR
S1283 SSSSSPSSSSITAAV
T1287 SPSSSSITAAVMLTL
T1293 ITAAVMLTLAEPSMS
S1298 MLTLAEPSMSSASQN
S1300 TLAEPSMSSASQNGM
S1301 LAEPSMSSASQNGMS
S1308 SASQNGMSVECR___
  ARID4B iso2  
Y89 KLTDASWYTVVFDDG
T90 LTDASWYTVVFDDGD
S105 EKTLRRSSLCLKGER
T133 TNPEHFGTPVIGKKT
S273 KTELKEDSSSSEAEE
S276 LKEDSSSSEAEEEEE
S295 EKEKEDNSSEEEEEI
S296 KEKEDNSSEEEEEIE
Y335 NKRPVLGYRNLNLFK
S483 LESIPTHSDQEKEVN
T507 LDDKDDDTTRVDESL
T508 DDKDDDTTRVDESLN
Y569 EKDKDEKYSPKNCKL
S570 KDKDEKYSPKNCKLR
S580 NCKLRRLSKPPFQTN
P582 KLRRLSKPPFQTNPS
T586 LSKPPFQTNPSPEMV
S589 PPFQTNPSPEMVSKL
S672 KEEQNSSSLLEENKV
P688 ADLVISKPVSKSPER
S692 ISKPVSKSPERLRKD
S704 RKDIEVLSEDtDYEE
T707 IEVLSEDtDYEEDEV
Y709 VLSEDtDYEEDEVTK
T715 DYEEDEVTKKRKDVK
T726 KDVKKDTTDKSSKPQ
Y741 IKRGKRRYCNTEECL
T744 GKRRYCNTEECLKTG
T750 NTEECLKTGSPGKKE
S752 EECLKTGSPGKKEEK
T788 EETKAKMTPTKKYNG
S802 GLEEKRKSLRTTGFY
Y809 SLRTTGFYSGFSEVA
S810 LRTTGFYSGFSEVAE
S813 TGFYSGFSEVAEKRI
S826 RIKLLNNSDERLQNS
S833 SDERLQNSRAKDRKD
S928 RKAEFPSSGSNSVLN
T936 GSNSVLNTPPTTPES
T940 VLNTPPTTPESPSSV
S943 TPPTTPESPSSVTVT
S945 PTTPESPSSVTVTEG
S946 TTPESPSSVTVTEGS
T950 SPSSVTVTEGSRQQS
T1064 NKKKGKGTNSSDSEE
S1066 KKGKGTNSSDSEELS
S1067 KGKGTNSSDSEELSA
S1069 KGTNSSDSEELSAGE
S1073 SSDSEELSAGESITK
S1098 MKSHSTKSPARTQSP
S1104 KSPARTQSPGKCGKN
S1170 SLKSEVASIDRRRKR
S1197 SSSSSPSSSSITAAV
T1201 SPSSSSITAAVMLTL
T1207 ITAAVMLTLAEPSMS
S1212 MLTLAEPSMSSASQN
S1214 TLAEPSMSSASQNGM
S1215 LAEPSMSSASQNGMS
S1222 SASQNGMSVECR___
  rat

 
Y89 KLTDASWYTVVFDDG
T90 LTDASWYTVVFDDGD
S105 EKTLRRSSLCLKGER
T133 TNPEHFGTPVIGKKT
S273 KTELKEDSSSSEAEE
S276 LKEDSSSSEAEEEEE
S295 EKEKEDNSSEEEEEI
S296 KEKEDNSSEEEEEIE
Y335 NKRPVLGYRNLNLFK
S482 LECIPAQSDQEKEAN
T506 LEDKDGATARAEEAL
A507 EDKDGATARAEEALS
Y568 EKDRDEKYSPKNCKL
S569 KDRDEKYSPKNCKLR
S579 NCKLRRLSKSPFQSN
S581 KLRRLSKSPFQSNPS
S585 LSKSPFQSNPSPEMV
S588 SPFQSNPSPEMVSKL
S671 KEELSSPSLLEENKV
T687 PDLVIAKTVSKSPER
S691 IAKTVSKSPERLRKD
S703 RKDVEAIsEDtDFEE
T706 VEAIsEDtDFEEEDE
F708 AIsEDtDFEEEDEIT
T715 FEEEDEITKKRKDVK
T726 KDVKKDTTDKALKPQ
Y742 KTWGKDRYCIQTNCL
Q745 GKDRYCIQTNCLQSG
S751 IQTNCLQSGSPGKKE
S753 TNCLQSGSPGKKEDR
T790 EKSKAKMTPTKKYNG
S804 GLEEKRKSLRTTSFY
Y811 SLRTTSFYSGFSEVA
S812 LRTTSFYSGFSEVAE
S815 TSFYSGFSEVAEKRI
S828 RIKLLNNSDERLQNN
N835 SDERLQNNRAKDRKD
S930 RKTEFPSSGSNSVLN
T938 GSNSVLNTPPTTPES
T942 VLNTPPTTPESPSSV
S945 TPPTTPESPSSVTVT
S947 PTTPESPSSVTVTET
S948 TTPESPSSVTVTETS
T952 SPSSVTVTETSQQQS
T1066 NKKKGKGTNSSDSED
S1068 KKGKGTNSSDSEDLS
S1069 KGKGTNSSDSEDLSA
S1071 KGTNSSDSEDLSAGE
S1075 SSDSEDLSAGESVTK
S1100 MKTHNSKSPARIQSP
S1106 KSPARIQSPGKCGKN
S1172 SLKSEVASIDRRRKR
S1199 SSSSSPSSSSITAAV
T1203 SPSSSSITAAVMLTL
T1209 ITAAVMLTLAEPSMS
S1214 MLTLAEPSMSSASQN
S1216 TLAEPSMSSASQNGM
S1217 LAEPSMSSASQNGMS
S1224 SASQNGMSVECR___
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