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Protein Page:
RhoC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RhoC a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rho
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: plasma membrane; cytosol; nucleus; cleavage furrow
Molecular Function: protein binding; signal transducer activity; GTP binding
Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; apical junction assembly; positive regulation of I-kappaB kinase/NF-kappaB cascade; small GTPase mediated signal transduction; cytokinesis
Reference #:  P08134 (UniProtKB)
Alt. Names/Synonyms: ARH9; ARHC; h9; MGC1448; MGC61427; oncogene RHO H9; ras homolog gene family, member C; RAS-related homolog 9; Rho cDNA clone 9; Rho-related GTP-binding protein RhoC; RHOC; rhoC GTPase; RHOH9; small GTP binding protein RhoC
Gene Symbols: RHOC
Molecular weight: 22,006 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RhoC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T19-p GDGACGKtCLLIVFs
0 2 S26-p tCLLIVFsKDQFPEV
0 9 Y34-p KDQFPEVyVPTVFEN
0 8 Y66-p DTAGQEDyDRLRPLS
0 3 K104-ub EKWTPEVkHFCPNVP
0 5 K118-ub PIILVGNkkDLRQDE
0 3 K119-ub IILVGNkkDLRQDEH
0 4 K135-ub RRELAKMkQEPVRSE
0 3 Y156-p NRISAFGyLECSAKT
  mouse

 
T19-p GDGACGKtCLLIVFs
S26-p tCLLIVFsKDQFPEV
Y34 KDQFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K104-ub EKWTPEVkHFCPNVP
K118-ub PIILVGNkkDLRQDE
K119-ub IILVGNkkDLRQDEH
K135-ub RRELAKMkQEPVRSE
Y156 NRISAFGYLECSAKT
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