a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric (Rho); Motility/polarity/chemotaxis
Molecular Function: protein domain specific binding; signal transducer activity; protein binding; GTP binding
Biological Process: axon guidance; positive regulation of cell adhesion; positive regulation of translation; response to glucocorticoid stimulus; regulation of dendrite development; positive regulation of caspase activity; small GTPase mediated signal transduction; positive regulation of neuron apoptosis; stress-activated protein kinase signaling pathway; response to glucose stimulus; response to drug; cytokinesis during cell cycle; apical junction assembly; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of I-kappaB kinase/NF-kappaB cascade; response to amino acid stimulus; positive regulation of cell growth; regulation of small GTPase mediated signal transduction; negative regulation of neuron differentiation; response to ethanol; positive regulation of actin filament polymerization; response to mechanical stimulus; positive regulation of vasoconstriction; response to hypoxia; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.