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RhoC (human)

Overview RhoC a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB. Protein type: G protein; G protein, monomeric (Rho); Motility/polarity/chemotaxis Cellular Component: axon; plasma membrane; cytosol; nucleus; cleavage furrow Molecular Function: protein domain specific binding; signal transducer activity; protein binding; GTP binding Biological Process: axon guidance; positive regulation of cell adhesion; positive regulation of translation; response to glucocorticoid stimulus; regulation of dendrite development; positive regulation of caspase activity; small GTPase mediated signal transduction; positive regulation of neuron apoptosis; stress-activated protein kinase signaling pathway; response to glucose stimulus; response to drug; cytokinesis during cell cycle; apical junction assembly; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of I-kappaB kinase/NF-kappaB cascade; response to amino acid stimulus; positive regulation of cell growth; regulation of small GTPase mediated signal transduction; negative regulation of neuron differentiation; response to ethanol; positive regulation of actin filament polymerization; response to mechanical stimulus; positive regulation of vasoconstriction; response to hypoxia; positive regulation of cell migration Reference #:  P08134 (UniProtKB) Alt. Names/Synonyms: ARH9; ARHC; h9; MGC1448; MGC61427; oncogene RHO H9; ras homolog gene family, member C; RAS-related homolog 9; Rho cDNA clone 9; Rho-related GTP-binding protein RhoC; RHOC; rhoC GTPase; RHOH9; small GTP binding protein RhoC Gene Symbols: RHOC Molecular weight: 22,006 Da Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RhoC 1Z2C - A/C=1-193 (human) 2GCN - A=1-181 (human) 2GCO - A/B=1-181 (human) 2GCP - A=1-181 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1Z2C 2GCN 2GCO  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	9		Y34-p	KDQFPEVyVPTVFEN
0	8		Y66-p	DTAGQEDyDRLRPLS
0	3		K104-u	EKWTPEVkHFCPNVP
0	5		K118-u	PIILVGNkkDLRQDE
0	3		K119-u	IILVGNkkDLRQDEH
0	4		K135-u	RRELAKMkQEPVRSE
0	3		Y156-p	NRISAFGyLECSAKT

	mouse
Y34	KDQFPEVYVPTVFEN
Y66	DTAGQEDYDRLRPLS
K104-u	EKWTPEVkHFCPNVP
K118-u	PIILVGNkkDLRQDE
K119-u	IILVGNkkDLRQDEH
K135-u	RRELAKMkQEPVRSE
Y156	NRISAFGYLECSAKT

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