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Protein Page:
RhoB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RhoB a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein; G protein, monomeric, Rho
Chromosomal Location of Human Ortholog: 2p24
Cellular Component: late endosome membrane; plasma membrane; endosome membrane; cytosol; nucleus; cleavage furrow
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding
Biological Process: axon guidance; platelet activation; transformed cell apoptosis; positive regulation of apoptosis; apoptosis; cytokinesis; Rho protein signal transduction; negative regulation of cell cycle; positive regulation of angiogenesis; regulation of small GTPase mediated signal transduction; protein transport; GTP catabolic process; small GTPase mediated signal transduction; endosome to lysosome transport; angiogenesis; blood coagulation; cell adhesion
Reference #:  P62745 (UniProtKB)
Alt. Names/Synonyms: Aplysia RAS-related homolog 6; ARH6; ARHB; h6; MST081; MSTP081; oncogene RHO H6; ras homolog gene family, member B; Rho cDNA clone 6; Rho-related GTP-binding protein RhoB; RHOB; RHOH6
Gene Symbols: RHOB
Molecular weight: 22,123 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RhoB

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S185‑p
activity, inhibited: S185‑p
molecular association, regulation: S185‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y34-p KDEFPEVyVPTVFEN
0 8 Y66-p DTAGQEDyDRLRPLS
0 5 K118-ub PIILVANkKDLRSDE
0 1 T129-p RSDEHVRtELARMkQ
0 18 K135-ub RtELARMkQEPVRTD
0 1 T141 MkQEPVRTDDGRAMA
0 10 Y154 MAVRIQAYDYLECSA
0 1 K162 DYLECSAKTKEGVRE
1 0 S185-p ALQKRYGsQNGCINC
  mouse

 
Y34 KDEFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K118-ub PIILVANkKDLRSDE
T129 RSDEHVRTELARMkQ
K135-ub RTELARMkQEPVRtD
T141-p MkQEPVRtDDGRAMA
Y154-p MAVRIQAyDYLECSA
K162-ub DYLECSAkTKEGVRE
S185 ALQKRYGSQNGCINC
  rat

 
Y34 KDEFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K118 PIILVANKKDLRSDE
T129 RSDEHVRTELARMkQ
K135-ub RTELARMkQEPVRTD
T141 MkQEPVRTDDGRAMA
Y154-p MAVRIQAyDYLECSA
K162 DYLECSAKTKEGVRE
S185 ALQKRYGSQNGCINC
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