a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein, monomeric; G protein
Chromosomal Location of Human Ortholog: 2p24
Cellular Component: focal adhesion; late endosome membrane; early endosome; plasma membrane; endosome membrane; nucleus; cytosol; cleavage furrow
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding
Biological Process: platelet activation; axon guidance; transformed cell apoptosis; positive regulation of apoptosis; apoptosis; metabolic process; cytokinesis; Rho protein signal transduction; negative regulation of cell cycle; intracellular protein transport; regulation of small GTPase mediated signal transduction; positive regulation of angiogenesis; small GTPase mediated signal transduction; endosome to lysosome transport; angiogenesis; cell adhesion; blood coagulation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.