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RhoB (human)

Overview RhoB a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB. Protein type: G protein, monomeric (Rho); Motility/polarity/chemotaxis; G protein Cellular Component: late endosome membrane; plasma membrane; endosome membrane; cytosol; nucleus; cleavage furrow Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding Biological Process: cytokinesis during cell cycle; platelet activation; axon guidance; transformed cell apoptosis; apoptosis; positive regulation of apoptosis; Rho protein signal transduction; negative regulation of cell cycle; positive regulation of angiogenesis; protein transport; regulation of small GTPase mediated signal transduction; GTP catabolic process; small GTPase mediated signal transduction; endosome to lysosome transport; angiogenesis; blood coagulation; cell adhesion Reference #:  P62745 (UniProtKB) Alt. Names/Synonyms: Aplysia RAS-related homolog 6; ARH6; ARHB; h6; MST081; MSTP081; oncogene RHO H6; ras homolog gene family, member B; Rho cDNA clone 6; Rho-related GTP-binding protein RhoB; RHOB; RHOH6 Gene Symbols: RHOB Molecular weight: 22,123 Da Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  SAPK/JNK Signaling Cascades Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RhoB 2FV8 - A=4-187 (human)

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	Sites Implicated In
cytoskeletal reorganization: S185‑p inhibition: S185‑p molecular association, regulation: S185‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		Y34-p	KDEFPEVyVPTVFEN
0	8		Y66-p	DTAGQEDyDRLRPLS
0	5		K118-u	PIILVANkKDLRSDE
0	1		T129-p	RSDEHVRtELARMkQ
0	18		K135-u	RtELARMkQEPVRTD
0	1		T141	MkQEPVRTDDGRAMA
0	10		Y154	MAVRIQAYDYLECSA
0	1		K162	DYLECSAKTKEGVRE
1	0		S185-p	ALQKRYGsQNGCINC

	mouse
Y34	KDEFPEVYVPTVFEN
Y66	DTAGQEDYDRLRPLS
K118-u	PIILVANkKDLRSDE
T129	RSDEHVRTELARMkQ
K135-u	RTELARMkQEPVRtD
T141-p	MkQEPVRtDDGRAMA
Y154-p	MAVRIQAyDYLECSA
K162-u	DYLECSAkTKEGVRE
S185	ALQKRYGSQNGCINC

	rat
Y34	KDEFPEVYVPTVFEN
Y66	DTAGQEDYDRLRPLS
K118	PIILVANKKDLRSDE
T129	RSDEHVRTELARMkQ
K135-u	RTELARMkQEPVRTD
T141	MkQEPVRTDDGRAMA
Y154-p	MAVRIQAyDYLECSA
K162	DYLECSAKTKEGVRE
S185	ALQKRYGSQNGCINC

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