a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; STE group; STE20 family; PAKA subfamily
Molecular Function: collagen binding; transferase activity; protein serine/threonine kinase activity; protein binding; nucleotide binding; Rac GTPase binding; kinase activity; protein kinase binding; catalytic activity; ATP binding; protein kinase activity
Biological Process: positive regulation of JNK activity; exocytosis; wound healing; apoptosis; metabolic process; protein amino acid autophosphorylation; positive regulation of estrogen receptor signaling pathway; regulation of mitotic cell cycle; amygdala development; receptor clustering; protein amino acid phosphorylation; Rho protein signal transduction; response to organic substance; regulation of apoptosis; positive regulation of stress fiber formation; stress-activated protein kinase signaling pathway; dendrite development; neuromuscular junction development; cell migration; positive regulation of peptidyl-serine phosphorylation; cellular response to insulin stimulus; branching morphogenesis of a tube; regulation of gene expression; regulation of MAPKKK cascade; regulation of actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; response to hypoxia; activation of protein kinase activity; positive regulation of protein amino acid phosphorylation; actin cytoskeleton organization and biogenesis; phosphorylation; neurite morphogenesis; positive regulation of cell migration
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.