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Protein Page:
VEGFR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VEGFR1 a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; EC 2.7.1.112; Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; VEGFR family
Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; endosome; receptor complex
Molecular Function: identical protein binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; patterning of blood vessels; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; blood vessel morphogenesis; sprouting angiogenesis; embryonic morphogenesis; cell differentiation; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Reference #:  P17948 (UniProtKB)
Alt. Names/Synonyms: FLT; FLT-1; FLT1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGFR-1; VEGFR1; VGFR1
Gene Symbols: FLT1
Molecular weight: 150,769 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VEGFR1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y794‑p, Y1242‑p, Y1333‑p
cell differentiation, altered: Y794‑p
cell growth, altered: Y1242‑p, Y1333‑p
enzymatic activity, induced: Y1213‑p
molecular association, regulation: Y1169‑p, Y1213‑p, Y1333‑p
phosphorylation: Y794‑p
protein degradation: Y1333‑p
receptor internalization, altered: Y1333‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T218-p VNGHLYKtNYLtHRQ
0 1 T222-p LYKtNYLtHRQTNTI
0 2 K791 KRSSSEIKTDyLSII
2 1 Y794-p SSEIKTDyLSIIMDP
0 1 K819 RLPYDASKWEFARER
1 0 K831-m RERLKLGkSLGRGAF
1 0 K831-m2 RERLKLGkSLGRGAF
0 1 K840 LGRGAFGKVVQASAF
0 1 K850 QASAFGIKKSPTCRT
0 1 K864 TVAVKMLKEGATASE
0 1 Y920-p KYGNLSNyLKSKRDL
0 2 K954 PGLEQGKKPRLDSVT
0 149 Y1048-p FGLARDIyKNPDyVR
0 2 K1049 GLARDIyKNPDyVRK
0 154 Y1053-p DIyKNPDyVRKGDTR
0 2 K1153 RFAELVEKLGDLLQA
0 1 K1153-m2 RFAELVEkLGDLLQA
1 6 Y1169-p VQQDGKDyIPINAIL
0 3 S1207-p APKFNSGsSDDVRyV
4 3 Y1213-p GsSDDVRyVNAFKFM
0 1 K1218 VRyVNAFKFMSLERI
2 3 Y1242-p ATSMFDDyQGDSSTL
0 1 S1263 KRFTWTDSKPKASLK
1 0 Y1327-p CCSPPPDyNSVVLyS
3 0 Y1333-p DyNSVVLySTPPI__
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
  VEGFR1 iso2  
T218 VNGHLYKTNYLTHRQ
T222 LYKTNYLTHRQTNTI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
T219 VNGHLYQTNYLTHRQ
T223 LYQTNYLTHRQTNTI
K792-u KRSSSEVkTDYLSII
Y795 SSEVkTDYLSIIMDP
K820-u RLPYDASkWEFARER
K832 RERLKLGKSLGRGAF
K832 RERLKLGKSLGRGAF
K841-u LGRGAFGkVVQASAF
K851-u QASAFGIkKSPTCRT
K865-u TVAVKMLkEGATASE
Y921 KYGNLSNYLKSKRDL
K955-u PGLEQGQkPRLDSVS
Y1048-p FGLARDIykNPDyVR
K1049-u GLARDIykNPDyVRR
Y1053-p DIykNPDyVRRGDTR
K1153-u RFAELVEkLGDLLQA
K1153 RFAELVEKLGDLLQA
Y1169-p VQQDGKDyIPLNAIL
S1207-p DPHFHSGsSDDVRyV
Y1213-p GsSDDVRyVNAFkFM
K1218-u VRyVNAFkFMSLERI
Y1242-p STSMFEDyQLDTSTL
T1263-p KRFTWTEtKPKASMK
Y1322 CCSPPPDYNSVVLYS
Y1328 DYNSVVLYSSPPA__
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
  rat

 
T218 VNGHLYQTSYLTHRQ
T222 LYQTSYLTHRQTNTI
K791 KRSSSEVKTDYLSII
Y794 SSEVKTDYLSIIMDP
K819 RLPYDASKWEFARER
K831 RERLKLGKSLGRGAF
K831 RERLKLGKSLGRGAF
K840 LGRGAFGKVVQASAF
K850 QASAFGIKKSPTCRT
K864 TVAVKMLKEGATASE
Y920 KYGNLSNYLKSKRDF
K954 PDLEQDQKPRLDSVS
Y1048 FGLARDIYKNPDYVR
K1049 GLARDIYKNPDYVRR
Y1053 DIYKNPDYVRRGDTR
K1153 RFAELVEKLGDLLQA
K1153 RFAELVEKLGDLLQA
Y1169-p VQQDGKDyIPLNAIL
S1207 DPKFHSGSSDDVRYV
Y1213 GSSDDVRYVNAFKFM
K1218 VRYVNAFKFMSLERI
Y1242 ATSMFEDYHLDTSSL
T1263 KRFTWTETKPKASMK
Y1325 CCSPPPDYNSVVLYS
Y1331 DYNSVVLYSSPPA__
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
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