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Protein Page:
VEGFR-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VEGFR-1 a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; EC 2.7.1.112; TK group; VEGFR family
Cellular Component: Golgi apparatus; extracellular space; integral to plasma membrane; cytoplasm; nucleolus; plasma membrane; nucleus; endosome
Molecular Function: vascular endothelial growth factor receptor activity; identical protein binding; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: regulation of smooth muscle contraction; cell migration; intracellular receptor-mediated signaling pathway; peptidyl-tyrosine phosphorylation; activation of MAPKK activity; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; response to hypoxia; blood vessel morphogenesis; embryonic morphogenesis; sprouting angiogenesis; cell differentiation; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Reference #:  P17948 (UniProtKB)
Alt. Names/Synonyms: FLT; FLT-1; FLT1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGFR-1; VEGFR1; VGFR1
Gene Symbols: FLT1
Molecular weight: 150,769 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VEGFR-1
Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y794‑p, Y1242‑p, Y1333‑p
cell differentiation, altered: Y794‑p
cell growth, altered: Y1242‑p, Y1333‑p
enzymatic activity, induced: Y1213‑p
molecular association, regulation: Y1169‑p, Y1213‑p, Y1333‑p
phosphorylation: Y794‑p
protein degradation: Y1333‑p
receptor internalization, altered: Y1333‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 Y199 FIISNATYKEIGLLT
0 1 T218-p VNGHLYKtNYLtHRQ
0 1 T222-p LYKtNYLtHRQTNTI
0 1 T255-p LVLNCTAtTPLNTRV
0 1 T265-p LNTRVQMtWsYPDEK
0 1 S267-p TRVQMtWsYPDEKNK
0 1 K306-m3 DKMQNKDkGLYTCRV
0 1 Y383-p ATEKSARyLTRGySL
0 1 Y388-p ARyLTRGySLIIKDV
0 1 K410-u YTILLSIkQSNVFKN
0 1 T588-p KFLYRDVtWILLRTV
0 1 T599-p LRTVNNRtMHYSISK
0 1 T618-p ITKEHSItLNLTIMN
0 1 S631-p MNVSLQDsGtYACRA
0 1 T633-p VSLQDsGtYACRARN
0 1 S739-p KATNQKGsVEssAyL
0 1 S742-p NQKGsVEssAyLTVQ
0 1 S743-p QKGsVEssAyLTVQG
0 1 Y745-p GsVEssAyLTVQGTS
0 2 K791 KRSSSEIKTDyLSII
2 1 Y794-p SSEIKTDyLSIIMDP
0 1 Y815-p EQCERLPyDASKWEF
0 1 K819 RLPyDASKWEFARER
1 0 K831-m RERLKLGkSLGRGAF
1 0 K831-m2 RERLKLGkSLGRGAF
0 1 K840 LGRGAFGKVVQASAF
0 1 K850 QASAFGIKKSPTCRT
0 1 K864 TVAVKMLKEGATASE
0 1 Y911-p PLMVIVEyCKYGNLS
0 1 Y920-p KYGNLSNyLKSKRDL
0 1 K932-m1 RDLFFLNkDAALHME
0 1 K942 ALHMEPKKEKMEPGL
0 2 K954 PGLEQGKKPRLDSVT
0 1 S976 SGFQEDKSLSDVEEE
0 1 S978 FQEDKSLSDVEEEED
0 148 Y1048-p FGLARDIyKNPDyVR
0 2 K1049 GLARDIyKNPDyVRK
0 153 Y1053-p DIyKNPDyVRKGDTR
0 2 K1153 RFAELVEKLGDLLQA
1 6 Y1169-p VQQDGKDyIPINAIL
0 1 Y1184 TGNSGFTYSTPAFSE
0 1 S1197-p SEDFFKEsIsAPKFN
0 1 S1199-p DFFKEsIsAPKFNsG
0 1 S1205-p IsAPKFNsGsSDDVR
0 3 S1207-p APKFNsGsSDDVRyV
4 5 Y1213-p GsSDDVRyVNAFKFM
0 1 K1218 VRyVNAFKFMSLERI
2 3 Y1242-p ATSMFDDyQGDSSTL
0 1 S1263 KRFTWTDSKPKASLK
1 0 Y1327-p CCSPPPDyNSVVLyS
3 0 Y1333-p DyNSVVLySTPPI__
0 1 - gap
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
  VEGFR-1 iso2  
Y199 FIISNATYKEIGLLT
T218 VNGHLYKTNYLTHRQ
T222 LYKTNYLTHRQTNTI
T255 LVLNCTATTPLNTRV
T265 LNTRVQMTWSYPDEK
S267 TRVQMTWSYPDEKNK
K306 DKMQNKDKGLYTCRV
Y383 ATEKSARYLTRGYSL
Y388 ARYLTRGYSLIIKDV
K410 YTILLSIKQSNVFKN
T588 KFLYRDVTWILLRTV
T599 LRTVNNRTMHYSISK
T618 ITKEHSITLNLTIMN
S631 MNVSLQDSGTYACRA
T633 VSLQDSGTYACRARN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T681-p STRNDCTtQSNVKH_
  mouse

 
Y200-p FIIANATyKEIGLLN
T219 VNGHLYQTNYLTHRQ
T223 LYQTNYLTHRQTNTI
T256 LVLNCTATTELNTRV
S266 LNTRVQMSWNYPGKA
N268 TRVQMSWNYPGKATK
K307 NNVESRDKGLYTCRV
Y384 ATLKSARYLVHGYSL
Y389 ARYLVHGYSLIIKDV
K411 YTILLGIKQSRLFKN
T589 KFLYRDITWILLRTV
T600 LRTVNNRTMHHSISK
T619 TTQDYSITLNLVIKN
S632 KNVSLEDSGTYACRA
T634 VSLEDSGTYACRARN
A740 RATNQKGAVESAAYL
S743 NQKGAVESAAYLTVQ
A744 QKGAVESAAYLTVQG
Y746 GAVESAAYLTVQGTS
K792-u KRSSSEVkTDYLSII
Y795 SSEVkTDYLSIIMDP
Y816 EQCERLPYDASkWEF
K820-u RLPYDASkWEFARER
K832 RERLKLGKSLGRGAF
K832 RERLKLGKSLGRGAF
K841-u LGRGAFGkVVQASAF
K851-u QASAFGIkKSPTCRT
K865-u TVAVKMLkEGATASE
Y912 PLMVIVEYCKYGNLS
Y921 KYGNLSNYLKSKRDL
K933 RDLFCLNKDAALHME
K943-u ALHMELKkESLEPGL
K955-u PGLEQGQkPRLDSVS
S976-p SSFPEDRsVsDVEGD
S978-p FPEDRsVsDVEGDED
Y1048-p FGLARDIykNPDyVR
K1049-u GLARDIykNPDyVRR
Y1053-p DIykNPDyVRRGDTR
K1153-u RFAELVEkLGDLLQA
Y1169-p VQQDGKDyIPLNAIL
Y1184-p TRNSSFTySTPTFSE
G1197 SEDLFKDGFADPHFH
A1199 DLFKDGFADPHFHSG
S1205 FADPHFHSGsSDDVR
S1207-p DPHFHSGsSDDVRyV
Y1213-p GsSDDVRyVNAFkFM
K1218-u VRyVNAFkFMSLERI
Y1242-p STSMFEDyQLDTSTL
T1263-p KRFTWTEtKPKASMK
Y1322 CCSPPPDYNSVVLYS
Y1328 DYNSVVLYSSPPA__
- gap
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
  rat

 
Y199 FIIANATYKEIGLLT
T218 VNGHLYQTSYLTHRQ
T222 LYQTSYLTHRQTNTI
T255 LVLNCTVTTDLNTRV
S265 LNTRVQMSWNYPGKA
N267 TRVQMSWNYPGKATK
K306 NNVESRDKGLYTCRV
Y383 ATEKSARYSVHGYSL
Y388 ARYSVHGYSLIIKDV
K410 YTILLGIKQSKLFRN
T588 KFLYRDITWILLRTV
T599 LRTVNNRTMHHSISK
T618 TTQDYSITLNLVIKN
S631 KNVSLEDSGTYACRA
T633 VSLEDSGTYACRARN
V739 RATNQKGVVESSAYL
S742 NQKGVVESSAYLTVQ
S743 QKGVVESSAYLTVQG
Y745 GVVESSAYLTVQGTS
K791 KRSSSEVKTDYLSII
Y794 SSEVKTDYLSIIMDP
Y815 EQCERLPYDASKWEF
K819 RLPYDASKWEFARER
K831 RERLKLGKSLGRGAF
K831 RERLKLGKSLGRGAF
K840 LGRGAFGKVVQASAF
K850 QASAFGIKKSPTCRT
K864 TVAVKMLKEGATASE
Y911 PLMVIVEYCKYGNLS
Y920 KYGNLSNYLKSKRDF
K932 RDFFCLNKDAALHME
K942 ALHMEPKKEKLEPDL
K954 PDLEQDQKPRLDSVS
S976 SGFQEDKSVSDVEGG
S978 FQEDKSVSDVEGGED
Y1048 FGLARDIYKNPDYVR
K1049 GLARDIYKNPDYVRR
Y1053 DIYKNPDYVRRGDTR
K1153 RFAELVEKLGDLLQA
Y1169-p VQQDGKDyIPLNAIL
Y1184 TRNSGFTYSVPTFSE
G1197 SEDFFKDGFTDPKFH
T1199 DFFKDGFTDPKFHSG
S1205 FTDPKFHSGSSDDVR
S1207 DPKFHSGSSDDVRYV
Y1213 GSSDDVRYVNAFKFM
K1218 VRYVNAFKFMSLERI
Y1242 ATSMFEDYHLDTSSL
T1263 KRFTWTETKPKASMK
Y1325 CCSPPPDYNSVVLYS
Y1331 DYNSVVLYSSPPA__
- gap
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
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