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IKK-epsilon (human)

Overview IKK-epsilon a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.10; Inhibitor protein; Kinase, protein; Other group; IKK family Cellular Component: PML body; cytoplasm; nucleolus; endosome membrane; cytosol; nucleus Molecular Function: NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding; protein kinase activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; negative regulation of interferon type I production; protein amino acid phosphorylation; toll-like receptor 4 signaling pathway; Toll signaling pathway Reference #:  Q14164 (UniProtKB) Alt. Names/Synonyms: I-kappa-B kinase epsilon; IKBKE; IKK-E; IKK-epsilon; IKK-i; IKK-related kinase epsilon; IKKE; IKKI; Inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; MGC125294; MGC125295; MGC125297 Gene Symbols: IKBKE Molecular weight: 80,462 Da Basal Isoelectric point: 7.91  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  NF-kB Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IKK-epsilon Substrate Sequence Logo

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	Sites Implicated In
enzymatic activity, induced: S172‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K30	VYKARNKKSGELVAV
0	1		K154	EEGQSIYKLTDFGAA
3	1		S172-p	DDDEKFVsVYGTEEY
1	0		K231-s	FGGPRRNkEIMYRIT
0	1		K241	MYRITTEKPAGAIAG
0	1		T474-p	YLSSSLGtERFSsVA
0	1		S479-p	LGtERFSsVAGTPEI
0	1		R508	TLAEVLSRCSQNITE
0	1		K529	SLNRELVKSRDQVHE
0	1		Y554	LDKMNFIYKQFKKSR
0	2		S664-p	RAKGAQAsPPPIAPy
0	1		Y671-p	sPPPIAPyPSPTRKD
0	11		A712	ERLNRVPAPPDV___

	mouse
K30-a	VYKARNKkSGEVVAV
K154-u	EEGQSIYkLSDFGAA
S172-p	DDDEKFVsVYGTEEY
K231	FGGPRRNKEIMYRIT
K241-u	MYRITTEkPAGAISG
T476	YLSSSLGTERFSSGA
S481	LGTERFSSGAGMPDV
K510-u	TLSEILSkCSHNVTE
K531-u	CLGEELLkNRDQIHE
Y557	LDKMHFIYKQFKKSR
S665	SEQGAEVSPQPMAPH
H672	SPQPMAPHPGPDPKD
S713-p	ERLHRVPsAPDV___

	rat
K30	VYKARNKKSGEVVAV
K154	KEGQSIYKLSDFGAA
S172	DDDEKFVSVYGTEEY
K231	FGGPRRNKEIMYRIT
K241	MYRITTEKPAGAISG
T476	FLSSSLGTERLSSGA
S481	LGTERLSSGAGMLDI
K510	TFSEVLSKCSHNVTE
K531	CLVGELLKSRDQIHE
Y557-p	LDKMHFIyKQFKKSR
S665	SKQGAEVSPQPMATH
H672	SPQPMATHPGPDPKD
P713	ERLHRVPPTPEV___

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