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Protein Page:
IKKE (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IKKE a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Inhibitor protein; Kinase, protein; Other group; IKK family
Cellular Component: PML body; cytoplasm; nucleolus; endosome membrane; nucleus; cytosol
Molecular Function: NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production
Reference #:  Q14164 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B kinase epsilon; IKBKE; IKK-E; IKK-epsilon; IKK-i; IKK-related kinase epsilon; IKKE; IKKI; Inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; MGC125294; MGC125295; MGC125297
Gene Symbols: IKBKE
Molecular weight: 80,462 Da
Basal Isoelectric point: 7.91  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IKKE

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: S172‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K154 EEGQSIYKLTDFGAA
4 1 S172-p DDDEKFVsVYGTEEY
1 0 K231-s FGGPRRNkEIMYRIT
0 1 K241 MYRITTEKPAGAIAG
0 1 R508 TLAEVLSRCSQNITE
0 1 K529 SLNRELVKSRDQVHE
0 3 S664-p RAKGAQAsPPPIAPY
0 11 A712 ERLNRVPAPPDV___
8766 : Phospho-IKK-epsilon (S172) (D1B7) Rabbit mAb
  mouse

 
K154-u EEGQSIYkLSDFGAA
S172-p DDDEKFVsVYGTEEY
K231 FGGPRRNKEIMYRIT
K241-u MYRITTEkPAGAISG
K510-u TLSEILSkCSHNVTE
K531-u CLGEELLkNRDQIHE
S665-p SEQGAEVsPQPMAPH
S713-p ERLHRVPsAPDV___
8766 : Phospho-IKK-epsilon (S172) (D1B7) Rabbit mAb
  rat

 
K154 KEGQSIYKLSDFGAA
S172 DDDEKFVSVYGTEEY
K231 FGGPRRNKEIMYRIT
K241 MYRITTEKPAGAISG
K510 TFSEVLSKCSHNVTE
K531 CLVGELLKSRDQIHE
S665 SKQGAEVSPQPMATH
P713 ERLHRVPPTPEV___
8766 : Phospho-IKK-epsilon (S172) (D1B7) Rabbit mAb
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