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Protein Page:
IKKE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IKKE a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; Kinase, protein; Inhibitor protein; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: PML body; cytoplasm; nucleolus; endosome membrane; nucleus; cytosol
Molecular Function: NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; I-kappaB phosphorylation; negative regulation of interferon type I production; toll-like receptor 4 signaling pathway; protein amino acid phosphorylation
Reference #:  Q14164 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B kinase epsilon; IKBKE; IKK-E; IKK-epsilon; IKK-i; IKK-related kinase epsilon; IKKE; IKKI; Inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; MGC125294; MGC125295; MGC125297
Gene Symbols: IKBKE
Molecular weight: 80,462 Da
Basal Isoelectric point: 7.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IKKE

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: S172‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K30 VYKARNKKSGELVAV
0 1 K154 EEGQSIYKLTDFGAA
4 1 S172-p DDDEKFVsVYGTEEY
1 0 K231-sm FGGPRRNkEIMYRIT
0 1 K241 MYRITTEKPAGAIAG
0 1 T463-p RTLEVARtsLLYLSS
0 1 S464-p TLEVARtsLLYLSSS
0 1 T474-p YLSSSLGtERFSsVA
0 1 S479-p LGtERFSsVAGTPEI
1 0 T501-p ELRSRLRtLAEVLSR
0 1 R508 tLAEVLSRCSQNITE
0 1 K529 SLNRELVKSRDQVHE
0 5 S664-p RAKGAQAsPPPIAPy
0 1 Y671-p sPPPIAPyPSPTRKD
0 12 A712 ERLNRVPAPPDV___
8766 : Phospho-IKK-epsilon (S172) (D1B7) Rabbit mAb
  mouse

 
K30-ac VYKARNKkSGEVVAV
K154-ub EEGQSIYkLSDFGAA
S172-p DDDEKFVsVYGTEEY
K231 FGGPRRNKEIMYRIT
K241-ub MYRITTEkPAGAISG
T465 QTLEVTRTALLYLSS
A466 TLEVTRTALLYLSSS
T476 YLSSSLGTERFSSGA
S481 LGTERFSSGAGMPDV
T503 ELRTRLQTLSEILSk
K510-ub TLSEILSkCSHNVTE
K531-ub CLGEELLkNRDQIHE
S665-p SEQGAEVsPQPMAPH
H672 sPQPMAPHPGPDPKD
S713-p ERLHRVPsAPDV___
8766 : Phospho-IKK-epsilon (S172) (D1B7) Rabbit mAb
  rat

 
K30 VYKARNKKSGEVVAV
K154 KEGQSIYKLSDFGAA
S172 DDDEKFVSVYGTEEY
K231 FGGPRRNKEIMYRIT
K241 MYRITTEKPAGAISG
T465 QTLEITRTALLFLSS
A466 TLEITRTALLFLSSS
T476 FLSSSLGTERLSSGA
S481 LGTERLSSGAGMLDI
T503 ELRSRLQTFSEVLSK
K510 TFSEVLSKCSHNVTE
K531 CLVGELLKSRDQIHE
S665 SKQGAEVSPQPMATH
H672 SPQPMATHPGPDPKD
P713 ERLHRVPPTPEV___
8766 : Phospho-IKK-epsilon (S172) (D1B7) Rabbit mAb
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