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Protein Page:
Pin1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Pin1 a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2-M transition of the cell cycle. Has two distinct functional domains: an N-terminal WW domain and a C-terminal PPlase domain. Pin1 interacts with a series of mitotic phosphoproteins, including Plk1, cdc25C and cdc27, catalyzing pSer-Pro or pThr/Pro cis/trans isomerizations. Displays a preference for an acidic residue n-terminal to the isomerized proline bond. Note: This description may include information from UniProtKB.
Protein type: EC 5.2.1.8; Nuclear receptor co-regulator; Isomerase
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: nucleoplasm; cytoplasm; nuclear speck; midbody; nucleus
Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; mitogen-activated protein kinase kinase binding; phosphothreonine binding; GTPase activating protein binding; phosphoserine binding
Biological Process: protein peptidyl-prolyl isomerization; protein folding; cytokine and chemokine mediated signaling pathway; positive regulation of ubiquitin-protein ligase activity; regulation of mitosis; innate immune response; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle; regulation of cytokinesis; negative regulation of interferon type I production; positive regulation of Rho GTPase activity
Reference #:  Q13526 (UniProtKB)
Alt. Names/Synonyms: DOD; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; peptidyl-prolyl cis/trans isomerase, NIMA-interacting; peptidylprolyl cis/trans isomerase, NIMA-interacting 1; PIN1; PPIase Pin1; prolyl isomerase; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1; Rotamase Pin1; UBL5
Gene Symbols: PIN1
Molecular weight: 18,243 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Pin1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S16‑p, Y23‑p, S138‑p
intracellular localization: S16‑p, S138‑p
molecular association, regulation: S16‑p, Y23‑p
protein degradation: S16‑p
protein stabilization: S65‑p
ubiquitination: S16‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K6-sm __MADEEkLPPGWEk
0 3 K13-ub kLPPGWEkRMsRSSG
10 1 S16-p PGWEkRMsRSSGRVy
2 4 Y23-p sRSSGRVyYFNHITN
0 1 Y24 RSSGRVyYFNHITNA
0 1 S38-p ASQWERPsGNSSsGG
0 1 S43-p RPsGNSSsGGkNGQG
0 26 K46-ac GNSSsGGkNGQGEPA
1 0 K63-sm RCSHLLVkHsQSRRP
0 3 K63-ub RCSHLLVkHsQSRRP
2 0 S65-p SHLLVkHsQSRRPss
2 0 S71-p HsQSRRPssWRQEKI
0 2 S72-p sQSRRPssWRQEKIT
0 1 K82-ac QEKITRTkEEALELI
0 2 K82-ub QEKITRTkEEALELI
0 1 K97-ub NGYIQKIkSGEEDFE
0 9 S105-p SGEEDFEsLAsQFSD
0 1 S108-p EDFEsLAsQFSDCsS
0 1 S114-p AsQFSDCsSAkARGD
0 3 K117-ub FSDCsSAkARGDLGA
0 1 K132-ub FSRGQMQkPFEDAsF
1 0 S138-p QkPFEDAsFALRTGE
3721 : Phospho-Pin1 (Ser16) Antibody
  mouse

 
K6 __MADEEKLPPGWEk
K13-ub KLPPGWEkRMsRSSG
S16-p PGWEkRMsRSSGRVY
Y23 sRSSGRVYyFNHITN
Y24-p RSSGRVYyFNHITNA
S38 ASQWERPSGGSTVGG
V43 RPSGGSTVGGSSKNG
K48 STVGGSSKNGQGEPA
K65 RCSHLLVKHSQSRRP
K65 RCSHLLVKHSQSRRP
S67 SHLLVKHSQSRRPSS
S73 HSQSRRPSSWRQEKI
S74 SQSRRPSSWRQEKIT
K84 QEKITRSKEEALELI
K84 QEKITRSKEEALELI
K99 NGYIQKIKSGEEDFE
S107 SGEEDFESLASQFSD
S110 EDFESLASQFSDCSS
S116 ASQFSDCSSAkARGD
K119-ub FSDCSSAkARGDLGP
K134 FSRGQMQKPFEDASF
S140 QKPFEDASFALRTGE
3721 : Phospho-Pin1 (Ser16) Antibody
  rat

 
K6 __MADEEKLPSGWEK
K13 KLPSGWEKRMSRSSG
S16 SGWEKRMSRSSGRVY
Y23 SRSSGRVYYFNHITN
Y24 RSSGRVYYFNHITNA
S38 ASQWERPSGGSTVGG
V43 RPSGGSTVGGGSkNG
K48-ac STVGGGSkNGQGEPA
K65 RCSHLLVKHSQSRRP
K65-ub RCSHLLVkHSQSRRP
S67 SHLLVkHSQSRRPSS
S73 HSQSRRPSSWRQEKI
S74 SQSRRPSSWRQEKIT
K84-ac QEKITRSkEEALELI
K84 QEKITRSKEEALELI
K99 NGYIQKIKSGEEDFE
S107 SGEEDFESLASQFSD
S110 EDFESLASQFSDCSS
S116 ASQFSDCSSAKARGD
K119 FSDCSSAKARGDLGA
K134 FSRGQMQKPFEDASF
S140 QKPFEDASFALRTGE
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