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Protein Page:
PTP1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTP1B a non-receptor phospho-tyrosine protein phosphatase. Negatively regulates insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor. Also reported to dephosphorylate epidermal growth factor receptor, as well as JAK2 and TYK2, implicating PTP1B in cell growth control and the cellular response to interferon. Note: This description may include information from UniProtKB.
Protein type: Phosphatase; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; early endosome; plasma membrane; cytoplasmic vesicle; cytosol
Molecular Function: protein binding; enzyme binding; ephrin receptor binding; zinc ion binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; protein kinase binding; insulin receptor binding
Biological Process: platelet activation; negative regulation of vascular endothelial growth factor receptor signaling pathway; unfolded protein response; cytokine and chemokine mediated signaling pathway; actin cytoskeleton reorganization; regulation of endocytosis; insulin receptor signaling pathway; regulation of signal transduction; negative regulation of insulin receptor signaling pathway; blood coagulation
Reference #:  P18031 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase 1B; protein tyrosine phosphatase, non-receptor type 1; protein tyrosine phosphatase, placental; Protein-tyrosine phosphatase 1B; PTN1; PTP-1B; PTP1B; PTPN1; Tyrosine-protein phosphatase non-receptor type 1
Gene Symbols: PTPN1
Molecular weight: 49,967 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTP1B

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S286‑p
enzymatic activity, induced: S50‑p, Y66‑p, S286‑p
enzymatic activity, inhibited: S50‑p
molecular association, regulation: S50‑p, Y66‑p, Y152‑p, Y153‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 117 Y20-p SGSWAAIyQDIRHEA
1 53 Y46-p KNKNRNRyRDVsPFD
4 19 S50-p RNRyRDVsPFDHsRI
0 1 S55-p DVsPFDHsRIkLHQE
0 2 K58-ub PFDHsRIkLHQEDND
3 45 Y66-p LHQEDNDyINASLIK
0 1 S118-p NRVMEKGsLKCAQYW
0 1 K131-ac YWPQKEEkEMIFEDT
0 1 K141-ac IFEDTNLkLTLIsED
0 1 S146-p NLkLTLIsEDIkSyy
0 2 K150-ub TLIsEDIkSyyTVRQ
4 1 Y152-p IsEDIkSyyTVRQLE
2 0 Y153-p sEDIkSyyTVRQLEL
0 1 S222-p CSAGIGRsGtFCLAD
0 1 T224-p AGIGRsGtFCLADTC
1 0 S242-p MDKRKDPssVDIKKV
1 0 S243-p DKRKDPssVDIKKVL
0 1 Y271-p ADQLRFSyLAVIEGA
1 0 S286-p KFIMGDSsVQDQWKE
0 5 S295-p QDQWKELsHEDLEPP
0 4 K335 FPNHQWVKEETQEDK
1 0 K335-sm FPNHQWVkEETQEDK
0 1 T338 HQWVkEETQEDKDCP
1 0 K347-sm EDKDCPIkEEkGsPL
0 1 K350-ub DCPIkEEkGsPLNAA
1 10 S352-p PIkEEkGsPLNAAPy
0 1 Y359-p sPLNAAPyGIEsMsQ
0 1 S363-p AAPyGIEsMsQDtEV
0 6 S365-p PyGIEsMsQDtEVRS
0 1 T368-p IEsMsQDtEVRSRVV
2 8 S378-p RSRVVGGsLRGAQAA
2 2 S386-p LRGAQAAsPAKGEPs
1 0 S393-p sPAKGEPsLPEKDED
  mouse

 
Y20 AGNWAAIYQDIRHEA
Y46-p KNKNRNRyRDVsPFD
S50-p RNRyRDVsPFDHSRI
S55 DVsPFDHSRIKLHQE
K58 PFDHSRIKLHQEDND
Y66 LHQEDNDYINASLIK
S118 NRIMEKGSLKCAQYW
K131 YWPQQEEKEMVFDDT
K141 VFDDTGLKLTLISED
S146 GLKLTLISEDVKSYY
K150 TLISEDVKSYYTVRQ
Y152 ISEDVKSYYTVRQLE
Y153 SEDVKSYYTVRQLEL
S222 CSAGIGRSGTFCLAD
T224 AGIGRSGTFCLADTC
S242 MDKRKDPSSVDIKKV
S243 DKRKDPSSVDIKKVL
Y271 ADQLRFSYLAVIEGA
S286 KFIMGDSSVQDQWKE
S295-p QDQWKELsREDLDLP
S335-p FSSHQWVsEETCGDE
S335 FSSHQWVSEETCGDE
T338 HQWVsEETCGDEDSL
R347 GDEDSLAREEGRAQS
- gap
- gap
H358 RAQSSAMHSVSSMsP
S362 SAMHSVSSMsPDTEV
S364-p MHSVSSMsPDTEVRR
T367 VSSMsPDTEVRRRMV
G377 RRRMVGGGLQSAQAS
V385 LQSAQASVPTEEELS
S392 VPTEEELSSTEEEHK
  rat

 
Y20 AGNWAAIYQDIRHEA
Y46 KNKNRNRYRDVSPFD
S50 RNRYRDVSPFDHSRI
S55 DVSPFDHSRIKLHQE
K58 PFDHSRIKLHQEDND
Y66 LHQEDNDYINASLIK
S118 NRIMEKGSLKCAQYW
K131 YWPQKEEKEMVFDDT
K141 VFDDTNLKLTLISED
S146 NLKLTLISEDVKSYY
K150 TLISEDVKSYYTVRQ
Y152 ISEDVKSYYTVRQLE
Y153 SEDVKSYYTVRQLEL
S222 CSAGIGRSGTFCLAD
T224 AGIGRSGTFCLADTC
S242 MDKRKDPSSVDIKKV
S243 DKRKDPSSVDIKKVL
Y271 ADQLRFSYLAVIEGA
S286 KFIMGDSSVQDQWKE
S295 QDQWKELSHEDLEPP
S335 FSNHQWVSEEsCEDE
S335 FSNHQWVSEEsCEDE
S338-p HQWVSEEsCEDEDIL
- gap
- gap
- gap
H358 RAPSIAVHSMSSMSQ
S362 IAVHSMSSMSQDTEV
S364 VHSMSSMSQDTEVRK
T367 MSSMSQDTEVRKRMV
G377 RKRMVGGGLQSAQAS
V385 LQSAQASVPTEEELS
S392 VPTEEELSPTEEEQK
  chicken

 
Y20 AASWAAIYQDIRHEA
Y46 RNKNRNRYRDVSPFD
S50 RNRYRDVSPFDHSRI
S55 DVSPFDHSRIKLNQG
K58 PFDHSRIKLNQGDND
Y66-p LNQGDNDyINASLIK
S118 NRVMEKGSIKCAQYW
K131 YWPRKEEKEMFFEDT
K141 FFEDTNLKLTLISED
S146 NLKLTLISEDIKSyy
K150 TLISEDIKSyyTVRQ
Y152-p ISEDIKSyyTVRQLE
Y153-p SEDIKSyyTVRQLEL
S222 CSAGIGRSGTFCLVD
T224 AGIGRSGTFCLVDTC
S242 MDKRKDPSSVDVKQV
S243 DKRKDPSSVDVKQVL
Y271 ADQLRFSYLAVIEGA
S286 KFIMGDASVQEQWKE
S295 QEQWKELSNEDLDPP
E338 FPKHQVVEEEIRCSV
E338 FPKHQVVEEEIRCSV
I341 HQVVEEEIRCSVSTA
- gap
- gap
- gap
L363 RVFSSVPLITDSTSQ
S367 SVPLITDSTSQDTEI
S369 PLITDSTSQDTEIRR
T372 TDSTSQDTEIRRRTV
N382 RRRTVGENLHVTAHK
E390 LHVTAHKEESKSESV
S396 KEESKSESVEEDDEN
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