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Protein Page:
HDAC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC1 a transcriptional regulator of the histone deacetylase family, subfamily 1. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; EC 3.5.1.98; Hydrolase
Cellular Component: nucleoplasm; protein complex; Sin3 complex; histone deacetylase complex; cytoplasm; nuclear chromatin; nucleolus; NuRD complex; nucleus; cytosol
Molecular Function: deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; nucleosomal DNA binding; enzyme binding; transcription activator binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor activity; transcription factor binding
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; nerve growth factor receptor signaling pathway; viral reproduction; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; negative regulation of cell cycle; odontogenesis of dentine-containing teeth; chromatin remodeling; protein amino acid deacetylation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; ATP-dependent chromatin remodeling; epidermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle; circadian regulation of gene expression; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; blood coagulation; negative regulation of apoptosis
Reference #:  Q13547 (UniProtKB)
Alt. Names/Synonyms: DKFZp686H12203; GON-10; HD1; HDAC1; Histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1
Gene Symbols: HDAC1
Molecular weight: 55,103 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HDAC1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S421‑p, S423‑p
molecular association, regulation: S421‑p, S423‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T7 _MAQTQGTRRkVCYY
0 1 K10-ub QTQGTRRkVCYYYDG
0 4 K66-ub ANAEEMTkYHSDDYI
0 1 K74-ac YHSDDYIkFLRSIRP
0 6 K74-ub YHSDDYIkFLRSIRP
0 8 Y87-p RPDNMSEySkQMQRF
0 75 K89-ub DNMSEySkQMQRFNV
0 4 K126-ub ASAVKLNkQQTDIAV
1 0 K218-ac LRDIGAGkGkyYAVN
1 3 K220-ac DIGAGkGkyYAVNyP
0 5 Y221-p IGAGkGkyYAVNyPL
0 1 Y226-p GkyYAVNyPLRDGID
0 1 K242-ub ESYEAIFkPVMSKVM
0 1 S290-p KCVEFVKsFNLPMLM
0 4 K361-ub NTNEYLEkIkQRLFE
0 2 K363-ub NEYLEkIkQRLFENL
1 307 S393-p EDAIPEEsGDEDEDD
0 1 S406-p DDPDKRIsICssDkR
0 2 S409-p DKRIsICssDkRIAC
0 1 S410-p KRIsICssDkRIACE
0 28 K412-ac IsICssDkRIACEEE
0 1 K412 IsICssDKRIACEEE
2 73 S421-p IACEEEFsDsEEEGE
1 69 S423-p CEEEFsDsEEEGEGG
2 0 K432-ac EEGEGGRkNssNFkk
0 1 K432-me EEGEGGRkNssNFkk
0 6 S434-p GEGGRkNssNFkkAk
0 1 S435-p EGGRkNssNFkkAkR
1 0 K438-ac RkNssNFkkAkRVkt
1 0 K439-ac kNssNFkkAkRVktE
1 0 K441-ac ssNFkkAkRVktEDE
2 0 K444-sm FkkAkRVktEDEKEK
0 3 T445-p kkAkRVktEDEKEKD
2 0 K476-sm KPEAKGVkEEVKLA_
  mouse

 
T7-p _MAQTQGtKRKVCYY
K10 QTQGtKRKVCYYYDG
K66 ANAEEMTKYHSDDYI
K74 YHSDDYIKFLRSIRP
K74-ub YHSDDYIkFLRSIRP
Y87-p RPDNMSEySkQMQRF
K89-ub DNMSEySkQMQRFNV
K126 ASAVKLNKQQTDIAV
K218 LRDIGAGKGKyYAVN
K220 DIGAGKGKyYAVNYP
Y221-p IGAGKGKyYAVNYPL
Y226 GKyYAVNYPLRDGID
K242 ESYEAIFKPVMSKVM
S290 KCVEFVKSFNLPMLM
K361-ub NTNEYLEkIKQRLFE
K363 NEYLEkIKQRLFENL
S393-p EDAIPEEsGDEDEED
S406-p EDPDKRIsICsSDkR
S409-p DKRIsICsSDkRIAC
S410 KRIsICsSDkRIACE
K412-ac IsICsSDkRIACEEE
K412-ub IsICsSDkRIACEEE
S421-p IACEEEFsDsDEEGE
S423-p CEEEFsDsDEEGEGG
K432-ac EEGEGGRkNSSNFKK
K432 EEGEGGRKNSSNFKK
S434 GEGGRkNSSNFKKAK
S435 EGGRkNSSNFKKAKR
K438 RkNSSNFKKAKRVKt
K439 kNSSNFKKAKRVKtE
K441 SSNFKKAKRVKtEDE
K444 FKKAKRVKtEDEKEK
T445-p KKAKRVKtEDEKEKD
K476 KPEAKGVKEEVKLA_
  rat

 
T7 _MAQTQGTKRKVCYY
K10 QTQGTKRKVCYYYDG
K66 ANAEEMTKYHSDDYI
K74 YHSDDYIKFLRSIRP
K74 YHSDDYIKFLRSIRP
Y87 RPDNMSEYSKQMQRF
K89 DNMSEYSKQMQRFNV
K126 ASAVKLNKQQTDIAV
K218 LRDIGAGKGKYYAVN
K220 DIGAGKGKYYAVNYP
Y221 IGAGKGKYYAVNYPL
Y226 GKYYAVNYPLRDGID
K242 ESYEAIFKPVMSKVM
S290 KCVEFVKSFNLPMLM
K361 NTNEYLEKIKQRLFE
K363 NEYLEKIKQRLFENL
S393-p EDAIPEEsGDEDEED
S406 EDPDKRISICSsDKR
S409 DKRISICSsDKRIAC
S410-p KRISICSsDKRIACE
K412 ISICSsDKRIACEEE
K412 ISICSsDKRIACEEE
S421-p IACEEEFsDsDEEGE
S423-p CEEEFsDsDEEGEGG
K432 EEGEGGRKNSSNFKK
K432 EEGEGGRKNSSNFKK
S434 GEGGRKNSSNFKKAK
S435 EGGRKNSSNFKKAKR
K438 RKNSSNFKKAKRVKT
K439 KNSSNFKKAKRVKTE
K441 SSNFKKAKRVKTEDE
K444 FKKAKRVKTEDEKEK
T445 KKAKRVKTEDEKEKD
K476 KPEAKGVKEEVKMA_
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