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Protein Page:
Fgr (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Fgr a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Mitochondrial; TK group; Src family
Cellular Component: cytoskeleton; mitochondrial inner membrane; plasma membrane; mitochondrial intermembrane space; cytosol; actin cytoskeleton
Molecular Function: protein binding; phosphotyrosine binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; ATP binding
Biological Process: integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; response to virus; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; immune response-regulating cell surface receptor signaling pathway; positive regulation of mast cell degranulation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of innate immune response; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; defense response to Gram-positive bacterium; innate immune response; blood coagulation; regulation of protein kinase activity; positive regulation of cell migration; positive regulation of cytokine secretion
Reference #:  P09769 (UniProtKB)
Alt. Names/Synonyms: c-fgr; c-fgr protooncogene; c-src-2 proto-oncogene; c-src2; FGR; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; p55-c-fgr protein; p55-Fgr; p55c-fgr; p58c-fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; SRC2; Tyrosine-protein kinase Fgr
Gene Symbols: FGR
Molecular weight: 59,479 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Fgr

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A13 CKKLEPVATAkEDAG
0 2 K16-ub LEPVATAkEDAGLEG
0 22 Y28-p LEGDFRSyGAADHyG
0 107 Y34-p SyGAADHyGPDPTKA
0 1 S45 PTKARPASSFAHIPN
0 1 I61 SNFSSQAINPGFLDS
0 2 N62 NFSSQAINPGFLDSG
0 8 Y86-p VTLFIALyDYEARTE
0 8 G112 HILNNTEGDWWEARS
0 2 K177-ub IRESETTkGAysLSI
0 285 Y180-p SETTkGAysLSIRDW
0 8 S181-p ETTkGAysLSIRDWD
0 2 M205 YKIRKLDMGGyyItt
0 303 Y208-p RKLDMGGyyIttRVQ
0 86 Y209-p KLDMGGyyIttRVQF
0 2 T211-p DMGGyyIttRVQFNS
0 1 T212-p MGGyyIttRVQFNSV
0 2 S218 ttRVQFNSVQELVQH
0 5 K301-ub KPGTMSPkAFLEEAQ
1 202 Y412-p RLIKDDEyNPCQGSK
0 1 T453-p ILLTELItKGRIPYP
1 170 Y523-p FTSAEPQyQPGDQT_
  mouse

 
S13-p CKKLEPAsKEDVGLE
K14 KKLEPAsKEDVGLEG
Q26 LEGDFRSQTAEERYF
Y32 SQTAEERYFPDPTQG
S43-p PTQGRTSsVFPQPts
T49-p SsVFPQPtsPAFLNT
S50-p sVFPQPtsPAFLNTG
Y74-p VTIFVALyDYEARTG
Y100-p HILNNTEyDWWEARS
K165-ub IRESETTkGAysLSI
Y168-p SETTkGAysLSIRDW
S169-p ETTkGAysLSIRDWD
T193-p YKIRKLDtGGyYITT
Y196-p RKLDtGGyYITTRAQ
Y197 KLDtGGyYITTRAQF
T199 DtGGyYITTRAQFDs
T200 tGGyYITTRAQFDsI
S206-p TTRAQFDsIQDLVRH
K289 KPGTMSPKAFLEEAQ
Y400-p RLIEDNEyNPQQGTK
T441 ILLTELITKGRVPYP
Y511-p FTSTEPQyQPGDQT_
  rat

 
P13 CKKLEPAPKEDVGLE
K14 KKLEPAPKEDVGLEG
Q26 LEGDFRSQGAEERYY
Y32 SQGAEERYYPDPTQG
S43 PTQGRSSSISPQPIS
- gap
S50 SISPQPISPAFLNVG
Y74 VTIFVALYDYEARTG
Y100 HILNNTEYDWWEARS
K165 IRESETTKGAySLSI
Y168-p SETTKGAySLSIRDW
S169 ETTKGAySLSIRDWD
M193 YKIRKLDMGGyyITT
Y196-p RKLDMGGyyITTRAQ
Y197-p KLDMGGyyITTRAQF
T199 DMGGyyITTRAQFES
T200 MGGyyITTRAQFESV
S206 TTRAQFESVQDLVRH
K289 KPGTMSPKAFLEEAQ
Y400-p RLIVDDEyNPQQGTK
T441 ILLTELITKGRVPYP
Y511-p FTSTEPQyQPGDQT_
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