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Fgr (human)

Overview Fgr a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Mitochondrial; Kinase, protein; TK group; Src family Cellular Component: cytoskeleton; mitochondrial inner membrane; plasma membrane; mitochondrial intermembrane space; cytosol; actin cytoskeleton Molecular Function: phosphotyrosine binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; ATP binding Biological Process: integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; response to virus; positive regulation of phosphoinositide 3-kinase activity; immune response-regulating cell surface receptor signaling pathway; positive regulation of mast cell degranulation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of innate immune response; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; defense response to Gram-positive bacterium; innate immune response; blood coagulation; regulation of protein kinase activity; positive regulation of cytokine secretion; positive regulation of cell migration Reference #:  P09769 (UniProtKB) Alt. Names/Synonyms: c-fgr; c-fgr protooncogene; c-src-2 proto-oncogene; c-src2; FGR; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; p55-c-fgr protein; p55-Fgr; p55c-fgr; p58c-fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; SRC2; Tyrosine-protein kinase Fgr Gene Symbols: FGR Molecular weight: 59,479 Da Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Fgr

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		A13	CKKLEPVATAkEDAG
0	2		K16-u	LEPVATAkEDAGLEG
0	22		Y28-p	LEGDFRSyGAADHyG
0	107		Y34-p	SyGAADHyGPDPTKA
0	1		N62	NFSSQAINPGFLDSG
0	9		Y86-p	VTLFIALyDYEARTE
0	8		G112	HILNNTEGDWWEARS
0	2		K177-u	IRESETTkGAysLSI
0	278		Y180-p	SETTkGAysLSIRDW
0	7		S181-p	ETTkGAysLSIRDWD
0	2		M205	YKIRKLDMGGyyItt
0	308		Y208-p	RKLDMGGyyIttRVQ
0	90		Y209-p	KLDMGGyyIttRVQF
0	2		T211-p	DMGGyyIttRVQFNS
0	1		T212-p	MGGyyIttRVQFNSV
0	2		S218	ttRVQFNSVQELVQH
0	5		K301-u	KPGTMSPkAFLEEAQ
1	202		Y412-p	RLIKDDEyNPCQGSK
0	1		T453-p	ILLTELItKGRIPYP
1	172		Y523-p	FTSAEPQyQPGDQT_

	mouse
S13-p	CKKLEPAsKEDVGLE
K14	KKLEPAsKEDVGLEG
Q26	LEGDFRSQTAEERYF
Y32	SQTAEERYFPDPTQG
S50-p	SVFPQPTsPAFLNTG
Y74-p	VTIFVALyDYEARTG
Y100-p	HILNNTEyDWWEARS
K165-u	IRESETTkGAysLSI
Y168-p	SETTkGAysLSIRDW
S169-p	ETTkGAysLSIRDWD
T193-p	YKIRKLDtGGyYITT
Y196-p	RKLDtGGyYITTRAQ
Y197	KLDtGGyYITTRAQF
T199	DtGGyYITTRAQFDs
T200	tGGyYITTRAQFDsI
S206-p	TTRAQFDsIQDLVRH
K289	KPGTMSPKAFLEEAQ
Y400-p	RLIEDNEyNPQQGTK
T441	ILLTELITKGRVPYP
Y511-p	FTSTEPQyQPGDQT_

	rat
P13	CKKLEPAPKEDVGLE
K14	KKLEPAPKEDVGLEG
Q26	LEGDFRSQGAEERYY
Y32	SQGAEERYYPDPTQG
S50	SISPQPISPAFLNVG
Y74	VTIFVALYDYEARTG
Y100	HILNNTEYDWWEARS
K165	IRESETTKGAySLSI
Y168-p	SETTKGAySLSIRDW
S169	ETTKGAySLSIRDWD
M193	YKIRKLDMGGyyITT
Y196-p	RKLDMGGyyITTRAQ
Y197-p	KLDMGGyyITTRAQF
T199	DMGGyyITTRAQFES
T200	MGGyyITTRAQFESV
S206	TTRAQFESVQDLVRH
K289	KPGTMSPKAFLEEAQ
Y400-p	RLIVDDEyNPQQGTK
T441	ILLTELITKGRVPYP
Y511-p	FTSTEPQyQPGDQT_

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