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Protein Page:
ENO3 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ENO3 Appears to have a function in striated muscle development and regeneration. Defects in ENO3 are the cause of glycogen storage disease type 13 (GSD13). A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen- beta particles are detected on ultrastructural analysis. Belongs to the enolase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lyase; EC 4.2.1.11; Carbohydrate Metabolism - glycolysis and gluconeogenesis
Cellular Component: phosphopyruvate hydratase complex; membrane; cytoplasm
Molecular Function: protein homodimerization activity; protein heterodimerization activity; metal ion binding; magnesium ion binding; lyase activity; phosphopyruvate hydratase activity
Biological Process: glycolysis
Reference #:  P21550 (UniProtKB)
Alt. Names/Synonyms: 2-phospho-D-glycerate hydro-lyase; Beta-enolase; Eno-3; Eno3; ENOB; Enolase 3; enolase 3, beta muscle; MSE; Muscle-specific enolase; OTTMUSP00000006349; OTTMUSP00000006350; Skeletal muscle enolase
Gene Symbols: Eno3
Molecular weight: 47,025 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Select Structure to View Below

ENO3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K5-u ___MAMQkIFAREIL
0 1 K28-u EVDLHTAkGRFRAAV
0 2 S37-p RFRAAVPsGAstGIy
0 14 S40-p AAVPsGAstGIyEAL
0 58 T41-p AVPsGAstGIyEALE
1 1889 Y44-p sGAstGIyEALELRD
0 1 K54-u LELRDGDkARYLGKG
0 2 K64-u YLGKGVLkAVEHINk
0 1 K71 kAVEHINKTLGPALL
0 1 K71-u kAVEHINkTLGPALL
0 1 T72 AVEHINkTLGPALLE
0 1 K80-u LGPALLEkkLsVVDQ
0 2 K81-u GPALLEkkLsVVDQE
0 3 S83-p ALLEkkLsVVDQEKV
0 1 K92-u VDQEKVDkFMIELDG
0 2 Y131 AEKGVPLYRHIADLA
0 1 S176 MILPVGASSFkEAMR
0 1 S177 ILPVGASSFkEAMRI
0 1 K179-u PVGASSFkEAMRIGA
0 1 K256-u SEFYRNGkYDLDFKs
0 4 S263-p kYDLDFKsPDDPARH
0 3 K275-u ARHISGEkLGELYKN
0 1 N282 kLGELYKNFIQNYPV
0 4 K326 DLTVTNPKRIAQAVE
0 1 S349 LKVNQIGSVTESIQA
0 1 S353 QIGSVTESIQACKLA
0 1 S362-p QACKLAQsNGWGVMV
0 3 K394-u GLCTGQIkTGAPCRS
0 1 K420-u IEEALGDkAVFAGRK
  human

► Hide Isoforms
 
K5 ___MAMQKIFAREIL
K28 EVDLHTAKGRFRAAV
S37-p RFRAAVPsGAstGIy
S40-p AAVPsGAstGIyEAL
T41-p AVPsGAstGIyEALE
Y44-p sGAstGIyEALELRD
K54 LELRDGDKGRYLGKG
K64 YLGKGVLKAVENINN
N71 KAVENINNtLGPALL
N71 KAVENINNtLGPALL
T72-p AVENINNtLGPALLQ
K80 LGPALLQKKLsVVDQ
K81 GPALLQKKLsVVDQE
S83-p ALLQKKLsVVDQEKV
K92 VDQEKVDKFMIELDG
Y131-p AEKGVPLyRHIADLA
S176-p MILPVGAssFKEAMR
S177-p ILPVGAssFKEAMRI
K179 PVGAssFKEAMRIGA
K256 SEFYRNGKYDLDFKs
S263-p KYDLDFKsPDDPARH
K275 ARHITGEKLGELYKs
S282-p KLGELYKsFIKNYPV
K326-u DLTVTNPkRIAQAVE
S349-p LKVNQIGsVTEsIQA
S353-p QIGsVTEsIQACKLA
S362 QACKLAQSNGWGVMV
K394-u GLCTGQIkTGAPCRS
K420 IEEALGDKAIFAGRK
  ENO3 var1  
K5 ___MAMQKIFAREIL
K28 EVDLHTAKGRFRAAV
S37 RFRAAVPSGASTGIY
S40 AAVPSGASTGIYEAL
T41 AVPSGASTGIYEALE
Y44 SGASTGIYEALELRD
K54 LELRDGDKGRYLGKG
K64 YLGKGVLKAVENINs
S71-p KAVENINsTLGPALL
S71 KAVENINSTLGPALL
T72 AVENINsTLGPALLQ
K80 LGPALLQKKLSVVDQ
K81 GPALLQKKLSVVDQE
S83 ALLQKKLSVVDQEKV
K92 VDQEKVDKFMIELDG
Y131 AEKGVPLYRHIADLA
S176 MILPVGASSFKEAMR
S177 ILPVGASSFKEAMRI
K179 PVGASSFKEAMRIGA
K256 SEFYRNGKYDLDFKS
S263 KYDLDFKSPDDPARH
K275 ARHITGEKLGELYKS
S282 KLGELYKSFIKNYPV
K326 DLTVTNPKRIAQAVE
S349 LKVNQIGSVTESIQA
S353 QIGSVTESIQACKLA
S362 QACKLAQSNGWGVMV
K394 GLCTGQIKTGAPCRS
K420 IEEALGDKAIFAGRK
  rat

 
K5 ___MAMQKIFAREIL
K28 EVDLHTAKGRFRAAV
S37 RFRAAVPSGAsTGIy
S40-p AAVPSGAsTGIyEAL
T41 AVPSGAsTGIyEALE
Y44-p SGAsTGIyEALELRD
K54 LELRDGDKSRYLGKG
K64 YLGKGVLKAVEHINK
K71 KAVEHINKTLGPALL
K71 KAVEHINKTLGPALL
T72 AVEHINKTLGPALLE
K80 LGPALLEKKLSVVDQ
K81 GPALLEKKLSVVDQE
S83 ALLEKKLSVVDQEKV
K92 VDQEKVDKFMIELDG
Y131 AEKGVPLYRHIADLA
S176 MILPVGASSFKEAMR
S177 ILPVGASSFKEAMRI
K179 PVGASSFKEAMRIGA
K256 SEFYRNGKYDLDFKS
S263 KYDLDFKSPDDPARH
K275 ARHISGEKLGELYKS
S282 KLGELYKSFIKNYPV
K326 DLTVTNPKRIAQAVE
S349 LKVNQIGSVTESIQA
S353 QIGSVTESIQACKLA
S362 QACKLAQSNGWGVMV
K394 GLCTGQIKTGAPCRS
K420 IEEALGDKAVFAGRK
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