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Protein Page:
LITAF (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
LITAF Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. Interacts with NEDD4. Interacts with WWOX. Isoform 2 may interact with STAT6. By bacterial lipopolysaccharides (LPS) or p53/TP53. In monocytes by the Bacillus Calmette-Guerin (BCG). Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; cytoplasm; plasma membrane; nucleolus; nucleus
Molecular Function: protein binding; signal transducer activity; WW domain binding
Biological Process: regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; negative regulation of NF-kappaB import into nucleus; signal transduction; aging; regulation of cytokine production
Reference #:  Q99732 (UniProtKB)
Alt. Names/Synonyms: FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; LITAF; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; p53-induced gene 7 protein; PIG7; SIMPLE; Small integral membrane protein of lysosome/late endosome; TP53I7; tumor protein p53 inducible protein 7
Gene Symbols: LITAF
Molecular weight: 17,107 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LITAF

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 Y23-p APSAPPSyEETVAVN
0 1 S31-p EETVAVNsyyPTPPA
0 3 Y32-p ETVAVNsyyPTPPAP
0 1 Y33-p TVAVNsyyPTPPAPM
0 3 Y61-p KGMNPPSyyTQPAPI
0 7 Y62-p GMNPPSyyTQPAPIP
0 1 S105-p SCNKMIVsQLSYNAG
0 3 K159-u RALLGTYkRL_____
  LITAF iso3  
Y23 APSAPPSYEETVAVN
S31 EETVAVNSYYPTPPA
Y32 ETVAVNSYYPTPPAP
Y33 TVAVNSYYPTPPAPM
Y61 KGMNPPSYYTQPAPI
Y62 GMNPPSYYTQPAPIP
S105 SCNKMIVSQLSYNAG
- gap
  mouse

 
Y23 VPTAPPTYEETVGVN
S31 EETVGVNSYYPTPPA
Y32 ETVGVNSYYPTPPAP
Y33 TVGVNSYYPTPPAPM
Y61 KGMNPPSYYTQPVPV
Y62 GMNPPSYYTQPVPVP
T105 SCSKMIVTQLSYNAG
K159-u KALLGTYkRL_____
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