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LITAF (human)

Overview LITAF Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. Interacts with NEDD4. Interacts with WWOX. Isoform 2 may interact with STAT6. By bacterial lipopolysaccharides (LPS) or p53/TP53. In monocytes by the Bacillus Calmette-Guerin (BCG). Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: Golgi apparatus; lysosomal membrane; plasma membrane Molecular Function: signal transducer activity; protein binding; WW domain binding Biological Process: regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; signal transduction Reference #:  Q99732 (UniProtKB) Alt. Names/Synonyms: FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; LITAF; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; p53-induced gene 7 protein; PIG7; SIMPLE; Small integral membrane protein of lysosome/late endosome; TP53I7; tumor protein p53 inducible protein 7 Gene Symbols: LITAF Molecular weight: 17,107 Da Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LITAF

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 601098 603795  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	3		Y23-p	APSAPPSyEETVAVN
0	1		S31-p	EETVAVNsyyPTPPA
0	3		Y32-p	ETVAVNsyyPTPPAP
0	1		Y33-p	TVAVNsyyPTPPAPM
0	3		Y61-p	KGMNPPSyytQPAPI
0	7		Y62-p	GMNPPSyytQPAPIP
0	1		T63-p	MNPPSyytQPAPIPN
0	1		S105-p	SCNKMIVsQLSYNAG
0	1		-	gap
0	1		-	gap
0	3		K159-u	RALLGTYkRL_____

	LITAF iso3
Y23	APSAPPSYEETVAVN
S31	EETVAVNSYYPTPPA
Y32	ETVAVNSYYPTPPAP
Y33	TVAVNSYYPTPPAPM
Y61	KGMNPPSYYTQPAPI
Y62	GMNPPSYYTQPAPIP
T63	MNPPSYYTQPAPIPN
S105	SCNKMIVSQLSYNAG
S138-p	GTIVALRsFDLLGsC
S144-p	RsFDLLGsCNPPSSA
-	gap

	mouse
Y23	VPTAPPTYEETVGVN
S31	EETVGVNSYYPTPPA
Y32	ETVGVNSYYPTPPAP
Y33	TVGVNSYYPTPPAPM
Y61	KGMNPPSYYTQPVPV
Y62	GMNPPSYYTQPVPVP
T63	MNPPSYYTQPVPVPN
T105	SCSKMIVTQLSYNAG
-	gap
-	gap
K159-u	KALLGTYkRL_____

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