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Protein Page:
SREBP-1 iso3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SREBP-1 iso3 Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cytoplasm; integral to membrane; nuclear envelope; cytosol; nucleus
Molecular Function: protein dimerization activity; protein binding; sterol response element binding; DNA binding; sequence-specific DNA binding; protein complex binding; chromatin binding; transcription factor activity; protein kinase binding
Biological Process: response to food; response to drug; cholesterol metabolic process; response to retinoic acid; response to glucagon stimulus; response to cAMP; transcription, DNA-dependent; lipid biosynthetic process; positive regulation of cholesterol biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; cellular response to starvation; negative regulation of insulin secretion; regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; chemical signal regulation of heart rate; regulation of fatty acid metabolic process; response to glucose stimulus; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; response to progesterone stimulus; lung development; aging
Reference #:  P36956-3 (UniProtKB)
Alt. Names/Synonyms: BHLHD1; Class D basic helix-loop-helix protein 1; Processed sterol regulatory element-binding protein 1; SRBP1; SREBF1; SREBP-1; SREBP-1c; SREBP1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1
Gene Symbols: SREBF1
Molecular weight: 111,102 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Select Structure to View Below

SREBP-1 iso3

Protein Structure Not Found.


Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
transcription, inhibited: S314‑p
activity, inhibited: S410‑p
molecular association, regulation: S314‑p
protein degradation: S410‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
1 0 S63-p AGGTDPAsPDTSSPG
0 1 - gap
0 2 S98 QAAPSPLSPPQPAPT
0 1 P102 SPLSPPQPAPTPLKM
0 1 Y110 APTPLKMYPSMPAFs
0 1 P114 LKMYPSMPAFsPGPG
4 1 S117-p YPSMPAFsPGPGIkE
3 0 K123-sm FsPGPGIkEESVPLS
0 2 K256-ub SLLLTAMkTDGATVK
0 1 T275-p SPLVSGTtVQTGPLP
0 1 S312-p INRLAAGskAPASAQ
0 2 K313-ub NRLAAGskAPASAQS
1 0 K324-ac SAQSRGEkRTAHNAI
1 0 K333-ac TAHNAIEkRYRSsIN
1 0 S337 AIEkRYRSsINDKII
4 0 S338-p IEkRYRSsINDKIIE
0 1 K347-ub NDKIIELkDLVVGTE
0 1 K356-ub LVVGTEAkLNKsAVL
0 1 S360-p TEAkLNKsAVLRKAI
0 1 K381 QHSNQKLKQENLSLR
1 6 S396-p TAVHKSKsLKDLVSA
1 0 S402 KsLKDLVSACGSGGN
1 0 K418-sm DVLMEGVkTEVEDTL
3 0 T426-p TEVEDTLtPPPsDAG
2 0 S430-p DTLtPPPsDAGsPFQ
1 0 S434-p PPPsDAGsPFQSsPL
1 0 S439-p AGsPFQSsPLSLGSR
0 1 S455 SGSGGSGSDSEPDSP
0 2 S457 SGGSGSDSEPDSPVF
0 2 K470-ub VFEDSKAkPEQRPSL
0 1 Y567-p SLVLLFVyGEPVTRP
0 24 K587-ub VYFWRHRkQADLDLA
0 1 K675-ub DAALVYHkLHQLHTM
0 7 K924-ub RAALHSFkAARALLG
0 1 S1060-p THQLLDRsLRRRAGP
0 1 K1070-ub RRAGPGGkGGAVAEL
0 7 K1121-ub EAARTLEkLGDRRLL
9874 : Phospho-SREBP-1c (Ser372) Antibody
  SREBP-1 iso3  
- gap
S39 AGGTDPASPDTSSPG
- gap
S74 QAAPSPLSPPQPAPT
P78 SPLSPPQPAPTPLKM
Y86 APTPLKMYPSMPAFS
P90 LKMYPSMPAFSPGPG
S93 YPSMPAFSPGPGIKE
K99 FSPGPGIKEESVPLS
K232 SLLLTAMKTDGATVK
T251 SPLVSGTTVQTGPLP
S288 INRLAAGSKAPASAQ
K289 NRLAAGSKAPASAQS
K300 SAQSRGEKRTAHNAI
K309 TAHNAIEKRYRSsIN
S313 AIEKRYRSsINDKII
S314-p IEKRYRSsINDKIIE
K323 NDKIIELKDLVVGTE
K332 LVVGTEAKLNKSAVL
S336 TEAKLNKSAVLRKAI
K357 QHSNQKLKQENLSLR
S372-p TAVHKSKsLKDLVSA
S378 KsLKDLVSACGSGGN
K394 DVLMEGVKTEVEDTL
T402 TEVEDTLTPPPSDAG
S406 DTLTPPPSDAGsPFQ
S410-p PPPSDAGsPFQSsPL
S415-p AGsPFQSsPLSLGSR
S431 SGSGGSGSDSEPDSP
S433 SGGSGSDSEPDSPVF
K446 VFEDSKAKPEQRPSL
Y543 SLVLLFVYGEPVTRP
K563 VYFWRHRKQADLDLA
K651 DAALVYHKLHQLHTM
K900 RAALHSFKAARALLG
- gap
- gap
- gap
9874 : Phospho-SREBP-1c (Ser372) Antibody
  mouse

► Hide Isoforms
 
T14-p GEAALEQtLAEMCEL
S63 TGDTGPSSPGANSPE
T91-p FLGGPKVtPAPLsPP
S96-p KVtPAPLsPPPsAPA
S100-p APLsPPPsAPAALKM
Y108-p APAALKMyPSVsPFS
S112-p LKMyPSVsPFSPGPG
S115 yPSVsPFSPGPGIKE
K121 FSPGPGIKEEPVPLT
K249-ub SLLLTAVkTDAGATV
- gap
S306 IHRLAAGSkALGSAQ
K307-ub HRLAAGSkALGSAQS
K318 SAQSRGEKRTAHNAI
K327 TAHNAIEKRYRSSIN
S331 AIEKRYRSSINDKIV
S332 IEKRYRSSINDKIVE
K341 NDKIVELKDLVVGTE
K350 LVVGTEAKLNKSAVL
S354 TEAKLNKSAVLRKAI
K375-ub QHSNQKLkQENLTLR
S389 RSAHKSKSLKDLVSA
S395 KSLKDLVSACGSGGG
K411 DVSMEGMKPEVVETL
T419 PEVVETLTPPPSDAG
S423 ETLTPPPSDAGSPSQ
S427 PPPSDAGSPSQSSPL
S432 AGSPSQSSPLSFGSR
S446-p RASSSGGsDsEPDSP
S448-p SSSGGsDsEPDSPAF
K461-ub AFEDSQVkAQRLPSH
Y556 CLALLFVYGEPVTRP
K576-ub VHFWRHRkQADLDLA
K664 DAAVVYHKLHQLHAM
K911-ub RAALYSFkAARALLD
S1047 THQLLDRSLRRRAGS
K1057 RRAGSSGKGGTTAEL
K1108-ub EAARTVEkLGDHRLL
9874 : Phospho-SREBP-1c (Ser372) Antibody
  SREBP-1 iso4  
- gap
S39 TGDTGPSSPGANSPE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K183 SLLLTAVKTDAGATV
- gap
S240 IHRLAAGSKALGSAQ
K241 HRLAAGSKALGSAQS
K252 SAQSRGEKRTAHNAI
K261 TAHNAIEKRYRssIN
S265-p AIEKRYRssINDKIV
S266-p IEKRYRssINDKIVE
K275 NDKIVELKDLVVGTE
K284 LVVGTEAKLNKSAVL
S288 TEAKLNKSAVLRKAI
K309 QHSNQKLKQENLTLR
S323 RSAHKSKSLKDLVsA
S329-p KSLKDLVsACGSGGG
K345 DVSMEGMKPEVVETL
T353 PEVVETLTPPPSDAG
S357 ETLTPPPSDAGSPSQ
S361 PPPSDAGSPSQSSPL
S366 AGSPSQSSPLSFGSR
S380 RASSSGGSDSEPDSP
S382 SSSGGSDSEPDSPAF
K395 AFEDSQVKAQRLPSH
Y490 CLALLFVYGEPVTRP
K510 VHFWRHRKQADLDLA
K598 DAAVVYHKLHQLHAM
K845 RAALYSFKAARALLD
S981 THQLLDRSLRRRAGS
K991 RRAGSSGKGGTTAEL
K1042 EAARTVEKLGDHRLL
9874 : Phospho-SREBP-1c (Ser372) Antibody
  rat

► Hide Isoforms
 
- gap
S63 TGDTGPSSPGASSPE
T92 FLGGPKVTPAPLsPP
S97-p KVTPAPLsPPPSAPT
S101 APLsPPPSAPTAVKM
Y109 APTAVKMYPSVPPFS
P113 VKMYPSVPPFSPGPG
S116 YPSVPPFSPGPGIKE
K122 FSPGPGIKEEPVPLT
K249 SLLLTAVKTDTGATM
- gap
- gap
K307 HRLAAGGKALGSAQS
K318 SAQSRGEKRTAHNAI
K327 TAHNAIEKRYRSsIN
S331 AIEKRYRSsINDKIV
S332-p IEKRYRSsINDKIVE
K341 NDKIVELKDLVVGTE
K350 LVVGTEAKLNKSAVL
S354 TEAKLNKSAVLRKAI
K375 QHSNQKLKQENLTLR
S389 RSAHKSKSLKDLVSA
S395 KSLKDLVSACGSGGG
K411 DVSMEGMKPEVVETL
T419 PEVVETLTPPPSDAG
S423 ETLTPPPSDAGSPSQ
S427 PPPSDAGSPSQSSPL
S432 AGSPSQSSPLSLGSR
S446 RGSSSGGSDSEPDSP
S448 SSSGGSDSEPDSPAF
K461 AFEDNQVKAQRLPSH
Y556 CLALLFVYGEPVTRP
K576 VHFWRHRKQADLDLA
K664 DAAVVYHKLHQLHAM
K911 RAALYSFKAARALLD
S1047 THQLLDRSLRRRAGS
K1057 RRAGSSGKGGAAAEL
K1108 EAARTVEKLGDHRLL
9874 : Phospho-SREBP-1c (Ser372) Antibody
  SREBP-1 iso2  
- gap
S39 TGDTGPSSPGASSPE
T68 FLGGPKVTPAPLSPP
S73 KVTPAPLSPPPSAPT
S77 APLSPPPSAPTAVKM
Y85 APTAVKMYPSVPPFS
P89 VKMYPSVPPFSPGPG
S92 YPSVPPFSPGPGIkE
K98-sm FSPGPGIkEEPVPLT
K225 SLLLTAVKTDTGATM
- gap
- gap
K283 HRLAAGGKALGSAQS
K294 SAQSRGEKRTAHNAI
K303 TAHNAIEKRYRSsIN
S307 AIEKRYRSsINDKIV
S308-p IEKRYRSsINDKIVE
K317 NDKIVELKDLVVGTE
K326 LVVGTEAKLNKSAVL
S330 TEAKLNKSAVLRKAI
K351 QHSNQKLKQENLTLR
S365 RSAHKSKSLKDLVSA
S371 KSLKDLVSACGSGGG
K387 DVSMEGMKPEVVETL
T395 PEVVETLTPPPSDAG
S399 ETLTPPPSDAGSPSQ
S403 PPPSDAGSPSQSSPL
S408 AGSPSQSSPLSLGSR
S422 RGSSSGGSDSEPDSP
S424 SSSGGSDSEPDSPAF
K437 AFEDNQVKAQRLPSH
Y532 CLALLFVYGEPVTRP
K552 VHFWRHRKQADLDLA
K640 DAAVVYHKLHQLHAM
K887 RAALYSFKAARALLD
S1023 THQLLDRSLRRRAGS
K1033 RRAGSSGKGGAAAEL
K1084 EAARTVEKLGDHRLL
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