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SREBP-1 iso3
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Transcription factor; DNA binding protein |
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Cellular Component: Golgi membrane; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; integral to membrane; nuclear envelope; cytoplasmic part; nucleus
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Molecular Function: protein dimerization activity; protein binding; sterol response element binding; DNA binding; sequence-specific DNA binding; chromatin binding; protein kinase binding; transcription factor activity
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Biological Process: response to drug; response to food; cholesterol metabolic process; response to glucagon stimulus; response to retinoic acid; response to cAMP; transcription, DNA-dependent; lipid biosynthetic process; positive regulation of cholesterol biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; negative regulation of insulin secretion; regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; chemical signal regulation of heart rate; regulation of fatty acid metabolic process; response to glucose stimulus; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; response to progesterone stimulus; aging; lung development
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Reference #:
P36956-3 (UniProtKB)
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| Alt. Names/Synonyms: BHLHD1; Class D basic helix-loop-helix protein 1; Processed sterol regulatory element-binding protein 1; SRBP1; SREBF1; SREBP-1; SREBP-1c; SREBP1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1 |
| Gene Symbols: SREBF1 |
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Molecular weight: 111,102 Da
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Basal Isoelectric point: 8.57
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Warburg Effect
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