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Protein Page:
NR1I3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NR1I3 Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: ligand-dependent nuclear receptor activity; androgen receptor activity; DNA binding; zinc ion binding; transcription coactivator activity; thyroid hormone receptor activity; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; signal transduction; negative regulation of transcription, DNA-dependent
Reference #:  Q14994 (UniProtKB)
Alt. Names/Synonyms: CAR; CAR1; Constitutive activator of retinoid response; constitutive active receptor; Constitutive active response; Constitutive androstane receptor; MB67; MGC150433; MGC97144; MGC97209; NR1I3; Nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; Orphan nuclear receptor MB67
Gene Symbols: NR1I3
Molecular weight: 39,942 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Select Structure to View Below

NR1I3

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: T38‑p
activity, inhibited: T38‑p
intracellular localization: T38‑p, S192‑p
molecular association, regulation: T38‑p
protein conformation: T38‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
4 0 T38-p CKGFFRRtVSKSIGP
0 1 K41 FFRRtVSKSIGPTCP
0 1 Q101 QAQRRAQQTPVQLSK
0 1 P186 LPVFRSLPIEDQIsL
1 1 S192-p LPIEDQIsLLKGAAV
  mouse

 
T48-p CKGFFRRtVSkTIGP
K51-ub FFRRtVSkTIGPICP
K111-ub QAQRRAEkASLQLNQ
T196-p LPLFRSLtMEDQIsL
S202-p LtMEDQIsLLKGAAV
  rat

 
T48 CKGFFRRTVSKTIGP
K51 FFRRTVSKTIGPICP
K111 QARRRAQKASLQLSQ
T196 LPLFRSLTMEDQISL
S202 LTMEDQISLLKGAAV
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