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ROR2 (human)

Overview ROR2 a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Ror family Cellular Component: integral to plasma membrane Molecular Function: Wnt-protein binding; frizzled binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: inner ear morphogenesis; somitogenesis; Wnt receptor signaling pathway, planar cell polarity pathway; multicellular organismal development; positive regulation of transcription, DNA-dependent; signal transduction; negative regulation of cell proliferation; Wnt receptor signaling pathway, calcium modulating pathway; JNK cascade; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; cartilage condensation; embryonic genitalia morphogenesis Reference #:  Q01974 (UniProtKB) Alt. Names/Synonyms: BDB; BDB1; MGC163394; neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; NTRKR2; receptor tyrosine kinase-like orphan receptor 2; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2 Gene Symbols: ROR2 Molecular weight: 104,757 Da Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ROR2 3ZZW - A/B=463-751 (human) 4GT4 - A/B=452-753 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3ZZW 4GT4  |  ENZYME  |  DISEASE 113000 268310 602337  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		T438-p	KQKASAStPQRRQLM
0	2		S447-p	QRRQLMAsPsQDMEM
0	3		S449-p	RQLMAsPsQDMEMPL
0	1		S469	QAKLKEISLSAVRFM
0	1		Y488	EDRFGKVYkGHLFGP
0	3		K489-u	DRFGKVYkGHLFGPA
0	1		K512-u	AIKTLKDkAEGPLRE
0	1		Y624-p	ATRNVLVyDKLNVKI
0	1		Y645	REVYAADYyKLLGNS
0	2		Y646-p	EVYAADYyKLLGNSL
0	3		Y666-p	MAPEAIMyGKFSIDS
0	1		Y755-p	AWGNLSNyNSsAQTs
0	1		S758-p	NLSNyNSsAQTsGAS
0	1		S762-p	yNSsAQTsGASNTTQ
0	1		S776	QTSSLSTSPVSNVsN
0	1		S782-p	TSPVSNVsNARYVGP
0	1		Y824-p	LYVPVNGyQPVPAYG
1	0		S864	PKPSSHHSGSGSTST
0	3		Y873-p	SGSTSTGyVTTAPSN

	mouse
T438	KQKASASTPQRRQLM
S447-p	QRRQLMAsPsQDMEM
S449-p	RQLMAsPsQDMEMPL
S469-p	QAKLKEIsLSTVRFM
Y488-p	EDRFGKVyKGHLFGP
K489	DRFGKVyKGHLFGPA
K512	AIKTLKDKAEGPLRE
Y624-p	ATRNVLVyDKLNVRI
Y645-p	REVYSADyyKLMGNS
Y646-p	EVYSADyyKLMGNSL
Y666-p	MSPEAVMyGKFSIDS
Y755	SWGNLSNYNSSAQTS
S758	NLSNYNSSAQTSGAS
S762	YNSSAQTSGASNTTQ
S776-p	QTSSLSTsPVSNVSN
S782	TsPVSNVSNARYMAP
Y824	LYIPVNGYQPVPAYG
S864-p	PKPSSHHsGSGSTST
Y873-p	SGSTSTGyVTTAPSN

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