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Protein Page:
ROR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ROR2 a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Ror family
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: Wnt-protein binding; protein binding; frizzled binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: inner ear morphogenesis; somitogenesis; peptidyl-tyrosine phosphorylation; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; multicellular organismal development; signal transduction; negative regulation of cell proliferation; Wnt receptor signaling pathway, calcium modulating pathway; JNK cascade; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; embryonic genitalia morphogenesis; cartilage condensation
Reference #:  Q01974 (UniProtKB)
Alt. Names/Synonyms: BDB; BDB1; MGC163394; neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; NTRKR2; receptor tyrosine kinase-like orphan receptor 2; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2
Gene Symbols: ROR2
Molecular weight: 104,757 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ROR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T157-ga LFVRLGPtHSPNHNF
0 3 T438-p KQKASAStPQRRQLM
0 4 S447-p QRRQLMAsPsQDMEM
0 6 S449-p RQLMAsPsQDMEMPL
0 1 S469 QAKLKEISLSAVRFM
0 1 Y488 EDRFGKVYkGHLFGP
0 3 K489-ub DRFGKVYkGHLFGPA
0 1 K512-ub AIKTLKDkAEGPLRE
0 1 Y624-p ATRNVLVyDKLNVKI
0 1 Y645 REVYAADYyKLLGNS
0 2 Y646-p EVYAADYyKLLGNSL
0 3 Y666-p MAPEAIMyGKFSIDS
0 1 Y755-p AWGNLSNyNSsAQTs
0 1 S758-p NLSNyNSsAQTsGAS
0 1 S762-p yNSsAQTsGASNTTQ
0 1 S776 QTSSLSTSPVSNVsN
0 1 S782-p TSPVSNVsNARYVGP
0 1 R785 VSNVsNARYVGPKQK
0 1 Y824-p LYVPVNGyQPVPAYG
1 0 S864 PKPSSHHSGSGSTST
0 3 Y873-p SGSTSTGyVTTAPSN
  mouse

 
T157 LYVRLGPTHSPNHNF
T438 KQKASASTPQRRQLM
S447-p QRRQLMAsPsQDMEM
S449-p RQLMAsPsQDMEMPL
S469-p QAKLKEIsLSTVRFM
Y488-p EDRFGKVyKGHLFGP
K489 DRFGKVyKGHLFGPA
K512 AIKTLKDKAEGPLRE
Y624-p ATRNVLVyDKLNVRI
Y645-p REVYSADyyKLMGNS
Y646-p EVYSADyyKLMGNSL
Y666-p MSPEAVMyGKFSIDS
Y755 SWGNLSNYNSSAQTS
S758 NLSNYNSSAQTSGAS
S762 YNSSAQTSGASNTTQ
S776-p QTSSLSTsPVSNVSN
S782 TsPVSNVSNArYMAP
R785-m2 VSNVSNArYMAPKQK
Y824 LYIPVNGYQPVPAYG
S864-p PKPSSHHsGSGSTST
Y873-p SGSTSTGyVTTAPSN
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