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BMF (human)

Overview BMF May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Cytoskeletal protein Cellular Component: mitochondrial outer membrane; acrosome; plasma membrane; myosin complex; cytosol Molecular Function: protein binding Biological Process: positive regulation of protein homooligomerization; apoptosis Reference #:  Q96LC9 (UniProtKB) Alt. Names/Synonyms: Bcl-2-modifying factor; Bcl2 modifying factor; BMF; FLJ00065 Gene Symbols: BMF Molecular weight: 20,508 Da Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BMF 2VOG - B=126-152 (mouse)

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	Sites Implicated In
apoptosis, inhibited: S77‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
3	0		S74-p	DKATQTLsPAsPSQG
1	0		S77-p	TQTLsPAsPSQGVML
0	1		S109-p	YRLPLPAsFPAVLPI
0	1		L114	PAsFPAVLPIGEQPP

	mouse
S74-p	DKATQTLsPASPSQG
S77	TQTLsPASPSQGVML
S109	YRLPLPASFPAGsPL
S114-p	PASFPAGsPLGEQPP

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