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CDCP1 (human)

Overview CDCP1 a transmembrane protein containing three extracellular CUB domains. Overexpressed in some colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cell surface Cellular Component: extracellular region; integral to membrane; plasma membrane Reference #:  Q9H5V8 (UniProtKB) Alt. Names/Synonyms: CD318; CDCP1; CUB domain containing protein 1; CUB domain-containing protein 1; Membrane glycoprotein gp140; SIMA135; Subtractive immunization M plus HEp3-associated 135 kDa protein; Transmembrane and associated with src kinases; TRASK Gene Symbols: CDCP1 Molecular weight: 92,932 Da Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDCP1

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	Sites Implicated In
cell motility, altered: Y734‑p intracellular localization: Y734‑p molecular association, regulation: Y734‑p, Y762‑p phosphorylation: Y734‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S9-p	AGLNCGVsIALLGVL
0	1		K71-u	HITMLSIkSGERIVF
0	1		S142-p	IGLELQFsIPRLRQI
0	1		S164-p	DGVTHSIsGRIDAtV
0	1		T170-p	IsGRIDAtVVRIGTF
0	1		S184-p	FCSNGTVsRIKMQEG
0	1		S210-p	PRNVSGFsIANRSSI
0	1		K296-u	TTNPEVFkLEDKQPG
0	1		K343-u	HPQNESNkIYVVDLS
0	1		S458-p	LVPKDRLsLVLVPAQ
0	1		K542-u	VSFIPYFkEEGVFTV
0	1		K554-u	FTVTPDTkSKVYLRT
0	1		S575-p	LPSLTSVsWNIsVPR
0	1		S579-p	TSVsWNIsVPRDQVA
0	1		T660-p	LLFSVTLtPRTVDLT
0	1		K700-u	KKKKKTNkGPAVGIy
0	334		Y707-p	kGPAVGIyNDNINTE
0	10		S731-p	KGRKDNDsHVyAVIE
6	16		Y734-p	KDNDsHVyAVIEDTM
1	3		Y743-p	VIEDTMVyGHLLQDS
2	3		Y762-p	LQPEVDTyRPFQGTM
0	1		S775-p	TMGVCPPsPPTICSR
0	1		K787-u	CSRAPTAkLATEEPP
0	20		S797-p	TEEPPPRsPPESESE
0	103		Y806-p	PESESEPytFsHPNN
0	6		T807-p	ESESEPytFsHPNNG
0	2		S809-p	ESEPytFsHPNNGDV

	mouse
S9	AHSACGFSVALLGAL
R71	HITELIIRPGERKSF
A142	IGLELQFATPRLRQI
S164	DGVTHSISGHIDATE
T170	ISGHIDATEVRIGTF
S184	FCSNGTVSRIKMQEG
S210	RRNVSGFSIANRSSI
R296	TTNPEVFRLEDKQPG
K343	RPQDESNKTYMVDLS
S458	LVPKDKLSLMLVPGQ
K542	VSYTPYFKEEGIFTV
K554	FTVTPDTKNKVYLRS
S575	LPALSSVSWNISVPS
S579	SSVSWNISVPSNQVA
T660	LLFWVTLTPRTVDLA
K698	KKKKKVDKGPAVGIy
Y705-p	KGPAVGIyNGNVNTQ
S728	KGRKDNDSHVYAVIE
Y731	KDNDSHVYAVIEDTM
Y740	VIEDTMVYGHLLQDS
Y759	IQPEVDTYRPFQGPM
T772	PMGDCPPTPPPLFSR
K784	FSRTPTAKFTAEELA
S794	AEELAPSSPPESESE
Y803	PESESEPYTFSHPNK
T804	ESESEPYTFSHPNKG
S806	ESEPYTFSHPNKGEI

	rat
S9	ARSACGFSVALLGTL
R71	HVTELTIRPGERKSF
A142	IGLELQFATPRLRQI
S164	DGVTHSISGHIDATE
T170	ISGHIDATEVRIGTF
S184	FCSNGTVSRIKMQEG
S210	PRNISGFSIANRSSI
R296	TTNPEVFRLEDQQPG
I343	RPQNESNITYMVDLS
G458	LVPKDRLGLMLVPGQ
K542	VSLIPYFKEEGIFTV
K554	FTVTPDSKNKVYLRS
S575	LPALSSVSWNISVPS
S579	SSVSWNISVPSNQVA
T660	LLFWVTLTPRTVDLT
K698	KKKKKVDKGPAVGIy
Y705-p	KGPAVGIyNGNANTQ
S728	KRRKDNDSHVYAVIE
Y731	KDNDSHVYAVIEDTM
Y740	VIEDTMVYGHLLQDS
Y759	IQAEVDTYRPFQGPM
T772	PMGDCPPTPPPIFSR
K784	FSRTPTAKFTADKLA
S794	ADKLAPSSPPESESE
Y803	PESESEPYTFSHPNK
T804	ESESEPYTFSHPNKG
S806	ESEPYTFSHPNKGEV

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