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Protein Page:
CDCP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CDCP1 a transmembrane protein containing three extracellular CUB domains. Overexpressed in some colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: integral to membrane; extracellular region; plasma membrane
Reference #:  Q9H5V8 (UniProtKB)
Alt. Names/Synonyms: CD318; CDCP1; CUB domain containing protein 1; CUB domain-containing protein 1; Membrane glycoprotein gp140; SIMA135; Subtractive immunization M plus HEp3-associated 135 kDa protein; Transmembrane and associated with src kinases; TRASK
Gene Symbols: CDCP1
Molecular weight: 92,932 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDCP1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Sites Implicated In
cell motility, altered: Y734‑p
intracellular localization: Y734‑p
molecular association, regulation: Y734‑p, Y762‑p
phosphorylation: Y734‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p AGLNCGVsIALLGVL
0 1 K71-u HITMLSIkSGERIVF
0 1 S142-p IGLELQFsIPRLRQI
0 1 S164-p DGVTHSIsGRIDAtV
0 1 T170-p IsGRIDAtVVRIGTF
0 1 S184-p FCSNGTVsRIKMQEG
0 1 S210-p PRNVSGFsIANRSSI
0 1 K296-u TTNPEVFkLEDKQPG
0 1 K343-u HPQNESNkIYVVDLS
0 1 K542-u VSFIPYFkEEGVFTV
0 1 K554-u FTVTPDTkSKVYLRT
0 1 S575-p LPSLTSVsWNIsVPR
0 1 S579-p TSVsWNIsVPRDQVA
0 1 K700-u KKKKKTNkGPAVGIy
1 336 Y707-p kGPAVGIyNDNINTE
0 10 S731-p KGRKDNDsHVyAVIE
6 16 Y734-p KDNDsHVyAVIEDTM
1 3 Y743-p VIEDTMVyGHLLQDS
2 3 Y762-p LQPEVDTyRPFQGTM
0 1 K787-u CSRAPTAkLATEEPP
0 20 S797-p TEEPPPRsPPESESE
0 104 Y806-p PESESEPytFsHPNN
0 6 T807-p ESESEPytFsHPNNG
0 2 S809-p ESEPytFsHPNNGDV
13111 : Phospho-CDCP1 (Tyr707) Antibody
9050 : Phospho-CDCP1 (Tyr734) Antibody
13093 : Phospho-CDCP1 (Tyr743) Antibody
13024 : Phospho-CDCP1 (Tyr806) Antibody
  mouse

 
S9 AHSACGFSVALLGAL
R71 HITELIIRPGERKSF
A142 IGLELQFATPRLRQI
S164 DGVTHSISGHIDATE
T170 ISGHIDATEVRIGTF
S184 FCSNGTVSRIKMQEG
S210 RRNVSGFSIANRSSI
R296 TTNPEVFRLEDKQPG
K343 RPQDESNKTYMVDLS
K542 VSYTPYFKEEGIFTV
K554 FTVTPDTKNKVYLRS
S575 LPALSSVSWNISVPS
S579 SSVSWNISVPSNQVA
K698 KKKKKVDKGPAVGIy
Y705-p KGPAVGIyNGNVNTQ
S728 KGRKDNDSHVYAVIE
Y731 KDNDSHVYAVIEDTM
Y740 VIEDTMVYGHLLQDS
Y759 IQPEVDTYRPFQGPM
K784 FSRTPTAKFTAEELA
S794 AEELAPSSPPESESE
Y803 PESESEPYTFSHPNK
T804 ESESEPYTFSHPNKG
S806 ESEPYTFSHPNKGEI
9050 : Phospho-CDCP1 (Tyr734) Antibody
  rat

 
S9 ARSACGFSVALLGTL
R71 HVTELTIRPGERKSF
A142 IGLELQFATPRLRQI
S164 DGVTHSISGHIDATE
T170 ISGHIDATEVRIGTF
S184 FCSNGTVSRIKMQEG
S210 PRNISGFSIANRSSI
R296 TTNPEVFRLEDQQPG
I343 RPQNESNITYMVDLS
K542 VSLIPYFKEEGIFTV
K554 FTVTPDSKNKVYLRS
S575 LPALSSVSWNISVPS
S579 SSVSWNISVPSNQVA
K698 KKKKKVDKGPAVGIy
Y705-p KGPAVGIyNGNANTQ
S728 KRRKDNDSHVYAVIE
Y731 KDNDSHVYAVIEDTM
Y740 VIEDTMVYGHLLQDS
Y759 IQAEVDTYRPFQGPM
K784 FSRTPTAKFTADKLA
S794 ADKLAPSSPPESESE
Y803 PESESEPYTFSHPNK
T804 ESESEPYTFSHPNKG
S806 ESEPYTFSHPNKGEV
9050 : Phospho-CDCP1 (Tyr734) Antibody
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