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Protein Page:
CDCP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDCP1 a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: plasma membrane; extracellular region; integral to membrane
Reference #:  Q9H5V8 (UniProtKB)
Alt. Names/Synonyms: CD318; CDCP1; CUB domain containing protein 1; CUB domain-containing protein 1; Membrane glycoprotein gp140; SIMA135; Subtractive immunization M plus HEp3-associated 135 kDa protein; Transmembrane and associated with src kinases; TRASK
Gene Symbols: CDCP1
Molecular weight: 92,932 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDCP1

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: Y734‑p
intracellular localization: Y734‑p
molecular association, regulation: Y734‑p, Y762‑p
phosphorylation: Y734‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S9-p AGLNCGVsIALLGVL
0 1 K71-ub HITMLSIkSGERIVF
0 1 S142-p IGLELQFsIPRLRQI
0 1 S164-p DGVTHSIsGRIDAtV
0 1 T170-p IsGRIDAtVVRIGTF
0 1 S184-p FCSNGTVsRIKMQEG
0 1 S210-p PRNVSGFsIANRSSI
0 1 K296-ub TTNPEVFkLEDKQPG
0 1 K343-ub HPQNESNkIYVVDLS
0 1 S458-p LVPKDRLsLVLVPAQ
0 1 K542-ub VSFIPYFkEEGVFTV
0 1 K554-ub FTVTPDTkSKVYLRT
0 1 S575-p LPSLTSVsWNIsVPR
0 1 S579-p TSVsWNIsVPRDQVA
0 1 T660-p LLFSVTLtPRTVDLT
0 1 K700-ub KKKKKTNkGPAVGIy
2 321 Y707-p kGPAVGIyNDNINTE
0 9 S731-p KGRKDNDsHVyAVIE
7 15 Y734-p KDNDsHVyAVIEDTM
2 3 Y743-p VIEDTMVyGHLLQDS
3 3 Y762-p LQPEVDTyRPFQGTM
0 1 S775-p TMGVCPPsPPTICSR
0 1 K787-ub CSRAPTAkLATEEPP
0 21 S797-p TEEPPPRsPPEsESE
0 1 S801-p PPRsPPEsESEPytF
1 98 Y806-p PEsESEPytFsHPNN
0 6 T807-p EsESEPytFsHPNNG
0 2 S809-p ESEPytFsHPNNGDV
13111 : Phospho-CDCP1 (Tyr707) Antibody
9050 : Phospho-CDCP1 (Tyr734) Antibody
13093 : Phospho-CDCP1 (Tyr743) Antibody
13024 : Phospho-CDCP1 (Tyr806) Antibody
  mouse

 
S9 AHSACGFSVALLGAL
R71 HITELIIRPGERKSF
A142 IGLELQFATPRLRQI
S164 DGVTHSISGHIDATE
T170 ISGHIDATEVRIGTF
S184 FCSNGTVSRIKMQEG
S210 RRNVSGFSIANRSSI
R296 TTNPEVFRLEDKQPG
K343 RPQDESNKTYMVDLS
S458 LVPKDKLSLMLVPGQ
K542 VSYTPYFKEEGIFTV
K554 FTVTPDTKNKVYLRS
S575 LPALSSVSWNISVPS
S579 SSVSWNISVPSNQVA
T660 LLFWVTLTPRTVDLA
K698 KKKKKVDKGPAVGIy
Y705-p KGPAVGIyNGNVNTQ
S728 KGRKDNDSHVYAVIE
Y731 KDNDSHVYAVIEDTM
Y740 VIEDTMVYGHLLQDS
Y759 IQPEVDTYRPFQGPM
T772 PMGDCPPTPPPLFSR
K784 FSRTPTAKFTAEELA
S794 AEELAPSSPPESESE
S798 APSSPPESESEPYTF
Y803 PESESEPYTFSHPNK
T804 ESESEPYTFSHPNKG
S806 ESEPYTFSHPNKGEI
9050 : Phospho-CDCP1 (Tyr734) Antibody
  rat

 
S9 ARSACGFSVALLGTL
R71 HVTELTIRPGERKSF
A142 IGLELQFATPRLRQI
S164 DGVTHSISGHIDATE
T170 ISGHIDATEVRIGTF
S184 FCSNGTVSRIKMQEG
S210 PRNISGFSIANRSSI
R296 TTNPEVFRLEDQQPG
I343 RPQNESNITYMVDLS
G458 LVPKDRLGLMLVPGQ
K542 VSLIPYFKEEGIFTV
K554 FTVTPDSKNKVYLRS
S575 LPALSSVSWNISVPS
S579 SSVSWNISVPSNQVA
T660 LLFWVTLTPRTVDLT
K698 KKKKKVDKGPAVGIy
Y705-p KGPAVGIyNGNANTQ
S728 KRRKDNDSHVYAVIE
Y731 KDNDSHVYAVIEDTM
Y740 VIEDTMVYGHLLQDS
Y759 IQAEVDTYRPFQGPM
T772 PMGDCPPTPPPIFSR
K784 FSRTPTAKFTADKLA
S794 ADKLAPSSPPESESE
S798 APSSPPESESEPYTF
Y803 PESESEPYTFSHPNK
T804 ESESEPYTFSHPNKG
S806 ESEPYTFSHPNKGEV
9050 : Phospho-CDCP1 (Tyr734) Antibody
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