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Protein Page:
FADD (human)

Overview
FADD an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: neuron projection; CD95 death-inducing signaling complex; cytosol; lipid raft
Molecular Function: identical protein binding; protein binding; protease binding; death receptor binding; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding
Biological Process: viral reproduction; positive regulation of apoptosis; apoptosis; positive regulation of T cell mediated cytotoxicity; positive regulation of proteolysis; protein heterooligomerization; T cell differentiation in the thymus; toll-like receptor 3 signaling pathway; positive regulation of activated T cell proliferation; positive regulation of interleukin-8 production; T cell homeostasis; positive regulation of macrophage differentiation; defense response to virus; toll-like receptor 4 signaling pathway; positive regulation of adaptive immune response; spleen development; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; thymus development; MyD88-independent toll-like receptor signaling pathway; positive regulation of tumor necrosis factor production; lymph node development; positive regulation of interferon-gamma production; induction of apoptosis via death domain receptors; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q13158 (UniProtKB)
Alt. Names/Synonyms: FADD; Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Protein FADD
Gene Symbols: FADD
Molecular weight: 23,279 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FADD

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S194‑p
apoptosis, induced: S194‑p, S203‑p
apoptosis, inhibited: S194‑p
carcinogenesis, altered: S194‑p
cell cycle regulation: S194‑p
intracellular localization: S194‑p
phosphorylation: S203‑p
protein conformation: S194‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S41-p RKLERVQsGLDLFSM
0 2 Y133-p IDSIEDRyPRNLtER
0 1 T138-p DRyPRNLtERVRESL
0 1 T157-p NTEKENAtVAHLVGA
0 1 S190-p ARDLQNRsGAMsPMs
12 16 S194-p QNRsGAMsPMsWNSD
0 1 S197-p sGAMsPMsWNSDAsT
1 0 S203-p MsWNSDAsTSEAS__
0 2 - gap
2781 : Phospho-FADD (Ser194) Antibody (Human Specific)
  mouse

 
S41 RKLERVQSGLDLFTV
Y133 MDGIEEKYPRSLSER
S138 EKYPRSLSERVRESL
S157 NAEKKNASVAGLVKA
S187 AQESVSKSENMsPVL
S191-p VSKSENMsPVLRDST
L194 SENMsPVLRDSTVSS
S200 VLRDSTVSSSEtP__
T204-p STVSSSEtP______
2785 : Phospho-FADD (Ser191) Antibody (Mouse Specific)
  rat

 
S41-p RKLERVQsGLDLFSV
Y133 IDGIEERYPRSLSDR
- under review  
S157 NVEKENASVAGLVKA
S190 AQGSVSKSDDTSSAL
S194 VSKSDDTSSALRDST
L197 SDDTSSALRDSTVSF
S203 ALRDSTVSFSEtP__
T207-p STVSFSEtP______
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