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Protein Page:
FADD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FADD an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: neuron projection; CD95 death-inducing signaling complex; cytosol; lipid raft
Molecular Function: identical protein binding; protein binding; protease binding; death receptor binding; protein complex binding; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding
Biological Process: viral reproduction; apoptosis; positive regulation of proteolysis; positive regulation of apoptosis; positive regulation of T cell mediated cytotoxicity; protein heterooligomerization; T cell differentiation in the thymus; toll-like receptor 3 signaling pathway; positive regulation of activated T cell proliferation; positive regulation of interleukin-8 production; T cell homeostasis; positive regulation of macrophage differentiation; defense response to virus; toll-like receptor 4 signaling pathway; positive regulation of adaptive immune response; spleen development; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; thymus development; MyD88-independent toll-like receptor signaling pathway; positive regulation of tumor necrosis factor production; lymph node development; positive regulation of interferon-gamma production; induction of apoptosis via death domain receptors; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter
Disease: Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations
Reference #:  Q13158 (UniProtKB)
Alt. Names/Synonyms: FADD; Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Protein FADD
Gene Symbols: FADD
Molecular weight: 23,279 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FADD

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S194‑p
apoptosis, induced: S194‑p, S203‑p
apoptosis, inhibited: S194‑p
carcinogenesis, altered: S194‑p
cell cycle regulation: S194‑p
intracellular localization: S194‑p
phosphorylation: S203‑p
protein conformation: S194‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S41-p RKLERVQsGLDLFSM
0 1 K125 QLKVSDTKIDSIEDR
0 2 Y133-p IDSIEDRyPRNLtER
0 1 T138-p DRyPRNLtERVRESL
0 1 T157-p NTEKENAtVAHLVGA
0 2 S190-p ARDLQNRsGAMsPMs
13 19 S194-p QNRsGAMsPMsWNSD
0 1 S197-p sGAMsPMsWNSDAsT
1 0 S203-p MsWNSDAsTSEAS__
0 5 - gap
2781 : Phospho-FADD (Ser194) Antibody (Human Specific)
  mouse

 
S41-p RKLERVQsGLDLFTV
K125 ELKVSEAKMDGIEEK
Y133 MDGIEEKYPRSLSER
S138 EKYPRSLSERVRESL
S157 NAEKKNASVAGLVKA
S187 AQESVSKSENMsPVL
S191-p VSKSENMsPVLRDST
L194 SENMsPVLRDSTVSS
S200 VLRDSTVSSSEtP__
T204-p STVSSSEtP______
2785 : Phospho-FADD (Ser191) Antibody (Mouse Specific)
  rat

 
S41-p RKLERVQsGLDLFSV
K125-ac ELKVSEAkIDGIEER
Y133 IDGIEERYPRSLSDR
S138 ERYPRSLSDRVRETL
S157 NVEKENASVAGLVKA
S190 AQGSVSKSDDTSSAL
S194 VSKSDDTSSALRDST
L197 SDDTSSALRDSTVSF
S203 ALRDSTVSFSEtP__
T207-p STVSFSEtP______
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