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Protein Page:
P130Cas (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
P130Cas a docking protein containing multiple protein-protein interaction domains. Plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. The amino-terminal SH3 domain regulates its interaction with focal adhesion kinase (FAK) and the FAK-related kinase PYK2 and also with tyrosine phosphatases PTP-1B and PTP-PEST. Overexpression confers antiestrogen resistance on breast cancer cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: ruffle; focal adhesion; cytoplasm; plasma membrane; cytosol
Molecular Function: signal transducer activity; protein binding; protein phosphatase binding; protein kinase binding; SH3 domain binding
Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; antigen receptor-mediated signaling pathway; platelet activation; cell migration; nerve growth factor receptor signaling pathway; actin filament organization; platelet-derived growth factor receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; T cell receptor signaling pathway; regulation of apoptosis; cell proliferation; G-protein coupled receptor protein signaling pathway; B cell receptor signaling pathway; cell division; insulin receptor signaling pathway; regulation of cell growth; vascular endothelial growth factor receptor signaling pathway; blood coagulation; cell adhesion; positive regulation of cell migration
Reference #:  P56945 (UniProtKB)
Alt. Names/Synonyms: BCAR1; breast cancer anti-estrogen resistance 1; Breast cancer anti-estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; CAS1; CASS1; CRK-associated substrate; Crk-associated substrate p130Cas; CRKAS; FLJ12176; FLJ45059; p130cas
Gene Symbols: BCAR1
Molecular weight: 93,372 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  MAPK/Erk in Growth and Differentiation  |  Regulation of Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

P130Cas
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
carcinogenesis, induced: Y128‑p, Y165‑p, Y664‑p
cell adhesion, altered: Y128‑p
cell adhesion, induced: Y165‑p, Y664‑p
cell growth, induced: Y128‑p
cell motility, altered: S139‑p, S437‑p, S639‑p
cell motility, induced: Y128‑p, Y165‑p, Y664‑p
cytoskeletal reorganization: Y165‑p, Y664‑p
intracellular localization: S139‑p, S437‑p, S639‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
1 3 Y12-p NVLAKALyDNVAESP
0 1 Y67-p LKILVGMyDKKPAGP
0 16 Y115-p QPQPDSVyLVPTPSK
3 785 Y128-p SKAQQGLyQVPGPsP
0 2 S134-p LyQVPGPsPQFQsPP
1 13 S139-p GPsPQFQsPPAkQTS
0 1 K143-a QFQsPPAkQTSTFSK
7 0 Y165-p PSPATDLyQVPPGPG
1 3 Y179-p GGPAQDIyQVPPsAG
0 1 S184-p DIyQVPPsAGMGHDI
1 5 Y192-p AGMGHDIyQVPPSMD
0 6 Y222-p PTRVGQGyVyEAAQP
0 90 Y224-p RVGQGyVyEAAQPEQ
1 699 Y234-p AQPEQDEyDIPRHLL
0 2 I236 PEQDEyDIPRHLLAP
7 722 Y249-p APGPQDIyDVPPVRG
0 1 S260-p PVRGLLPsQyGQEVy
0 3 Y262-p RGLLPsQyGQEVyDt
2 290 Y267-p sQyGQEVyDtPPMAV
0 24 T269-p yGQEVyDtPPMAVKG
1 299 Y287-p RDPLLEVyDVPPsVE
0 4 S292-p EVyDVPPsVEKGLPP
0 8 S300-p VEKGLPPsNHHAVyD
2 187 Y306-p PsNHHAVyDVPPsVs
0 1 S311-p AVyDVPPsVsKDVPD
0 1 S313-p yDVPPsVsKDVPDGP
0 21 T326-p GPLLREEtyDVPPAF
1 210 Y327-p PLLREEtyDVPPAFA
0 1 S355-p LAAPPPDsPPAEDVy
1 43 Y362-p sPPAEDVyDVPPPAP
0 52 Y372-p PPPAPDLyDVPPGLR
0 85 T385-p LRRPGPGtLyDVPRE
1 438 Y387-p RPGPGtLyDVPRERV
0 1 G403 PPEVADGGVVDsGVy
0 1 S407-p ADGGVVDsGVyAVPP
8 106 Y410-p GVVDsGVyAVPPPAE
0 3 S428-p PAEGKRLsASstGSt
0 1 S431-p GKRLsASstGStRsS
0 1 T432-p KRLsASstGStRsSQ
0 1 T435-p sASstGStRsSQSAS
1 1 S437-p SstGStRsSQSASSL
0 9 H552 LQKMEDVHQTLVAHG
0 2 T554 KMEDVHQTLVAHGQA
0 1 G568 ALDAGRGGSGATLED
1 2 S639-p IQSRPLPsPPKFTSQ
1 1 Y653-p QDSPDGQyENSEGGW
6 26 Y664-p EGGWMEDyDyVHLQG
2 25 Y666-p GWMEDyDyVHLQGKE
0 1 K693 GSITRQGKsQLELQQ
0 1 S694-p SITRQGKsQLELQQL
0 2 K702-u QLELQQLkQFERLEQ
0 1 Y815-p VRSQVTHySNLLCDL
4015 : Phospho-p130 Cas (Tyr165) Antibody
4014 : Phospho-p130 Cas (Tyr249) Antibody
4011 : Phospho-p130 Cas (Tyr410) Antibody
  mouse

 
Y12-p NVLAKALyDNVAESP
Y67 LKILVGMYDKKPVGP
Y119-p QPQSDNVyLVPTPSK
Y132-p SKTQQGLyQAPGPNP
N138 LyQAPGPNPQFQsPP
S143-p GPNPQFQsPPAKQTS
K147 QFQsPPAKQTSTFSK
Y169-p PSPATDLyQVPPGPG
Y183 GSPAQDIYQVPPSAG
S188 DIYQVPPSAGIGHDI
Y196-p AGIGHDIyQVPPSLD
Y226-p PTRVGQGyVyEAAQT
Y228-p RVGQGyVyEAAQTEQ
Y238-p AQTEQDEyDtPRHLL
T240-p TEQDEyDtPRHLLAP
Y253-p APGPQDIyDVPPVRG
N264 PVRGLLPNQyGQEVy
Y266-p RGLLPNQyGQEVyDt
Y271-p NQyGQEVyDtPPMAV
T273-p yGQEVyDtPPMAVKG
Y291-p RDPLLDVyDVPPSVE
S296 DVyDVPPSVEKGLLS
S304 VEKGLLSSSHHSVyD
Y310-p SSSHHSVyDVPPSVS
S315 SVyDVPPSVSKDVPD
S317 yDVPPSVSKDVPDGP
T330-p GPLLREEtyDVPPAF
Y331-p PLLREEtyDVPPAFA
S359 LAAPPPDSPAAEDVy
Y366-p SPAAEDVyDVPPPAP
Y376-p PPPAPDLyDVPPGLR
T389-p LRRPGPGtLyDVPRE
Y391-p RPGPGtLyDVPRERV
S407-p PPEVADGsVVDDGVy
D411 ADGsVVDDGVyAVPP
Y414-p sVVDDGVyAVPPPAE
S432 PTDGKRLSASSTGST
S435 GKRLSASSTGSTRSS
T436 KRLSASSTGSTRSSQ
T439 SASSTGSTRSSQSAS
S441 SSTGSTRSSQSASSL
Y556-p LQKMEDVyQtLVVHG
T558-p KMEDVyQtLVVHGQV
S572-p VLDSGRGsPGFTPED
S643 IQSRPLPSPPKFTSQ
Y657 QDSPDGQYENSEGGW
Y668-p EGGWMEDyDyVHLQG
Y670-p GWMEDyDyVHLQGKE
K697-u GNIMRQGkGQLELQQ
G698 NIMRQGkGQLELQQL
K706-u QLELQQLkQFERLEQ
Y819 VRSQVTHYSNLLCDL
4015 : Phospho-p130 Cas (Tyr165) Antibody
4014 : Phospho-p130 Cas (Tyr249) Antibody
4011 : Phospho-p130 Cas (Tyr410) Antibody
  rat

► Hide Isoforms 		 
Y106 NVLAKALYDNVAESP
Y161 LKILVGMYDKKPAAP
Y213 QPQPDNVYLVPTPSK
Y226-p SKTQQGLyQAPGPNP
N232 LyQAPGPNPQFQSPP
S237 GPNPQFQSPPAKQTS
K241 QFQSPPAKQTSTFSK
Y263-p PSPATDLyQVPPGPG
Y277-p GSPAQDIyQVPPSAG
S282 DIyQVPPSAGTGHDI
Y290-p AGTGHDIyQVPPSLD
Y320 PTRVGQGYVYEASQA
Y322 RVGQGYVYEASQAEQ
Y332-p SQAEQDEyDTPRHLL
T334 AEQDEyDTPRHLLAP
Y347-p APGSQDIyDVPPVRG
N358 PVRGLLPNQYGQEVy
Y360 RGLLPNQYGQEVyDT
Y365-p NQYGQEVyDTPPMAV
T367 YGQEVyDTPPMAVKG
Y385-p RDPLLDVyDVPPSVE
S390 DVyDVPPSVEKGLPP
S398 VEKGLPPSNHHSVyD
Y404-p PSNHHSVyDVPPSVS
S409 SVyDVPPSVSKDVPD
S411 yDVPPSVSKDVPDGP
T424 GPLLREETYDVPPAF
Y425 PLLREETYDVPPAFA
S453 LAAPPPDSPPAEDVY
Y460 SPPAEDVYDVPPPAP
Y470 PPPAPDLYDVPPGLR
T483 LRRPGPGTLyDVPRE
Y485-p RPGPGTLyDVPRERV
S501 PPEVADGSVIDDGVy
D505 ADGSVIDDGVyAVPP
Y508-p SVIDDGVyAVPPPAE
S526 PTDGKRLSASSTGST
S529 GKRLSASSTGSTRSS
T530 KRLSASSTGSTRSSQ
T533 SASSTGSTRSSQSAS
S535 SSTGSTRSSQSASSL
Y650-p LQKMEDVyQTLVVHG
T652 KMEDVyQTLVVHGQV
G666 VLDSGRGGPGFTLDD
S737 IQSRPLPSPPKFTSQ
Y751-p QDSPDGQyENSEGGW
Y762-p EGGWMEDyDyVHLQG
Y764-p GWMEDyDyVHLQGKE
K791 GNIVRQGKGQLELQQ
G792 NIVRQGKGQLELQQL
K800 QLELQQLKQFERLEQ
Y913 VRSKVTHYSNLLCDL
  P130Cas iso2  
Y12 NVLAKALYDNVAESP
Y67 LKILVGMYDKKPAAP
Y119 QPQPDNVYLVPTPSK
Y132-p SKTQQGLyQAPGPNP
N138 LyQAPGPNPQFQsPP
S143-p GPNPQFQsPPAKQTS
K147 QFQsPPAKQTSTFSK
Y169-p PSPATDLyQVPPGPG
Y183-p GSPAQDIyQVPPSAG
S188 DIyQVPPSAGTGHDI
Y196-p AGTGHDIyQVPPSLD
Y226 PTRVGQGYVYEASQA
Y228 RVGQGYVYEASQAEQ
Y238-p SQAEQDEyDTPRHLL
T240 AEQDEyDTPRHLLAP
Y253-p APGSQDIyDVPPVRG
N264 PVRGLLPNQYGQEVy
Y266 RGLLPNQYGQEVyDT
Y271-p NQYGQEVyDTPPMAV
T273 YGQEVyDTPPMAVKG
Y291-p RDPLLDVyDVPPSVE
S296 DVyDVPPSVEKGLPP
S304 VEKGLPPSNHHSVyD
Y310-p PSNHHSVyDVPPSVS
S315 SVyDVPPSVSKDVPD
S317 yDVPPSVSKDVPDGP
T330 GPLLREETYDVPPAF
Y331 PLLREETYDVPPAFA
S359 LAAPPPDSPPAEDVY
Y366 SPPAEDVYDVPPPAP
Y376 PPPAPDLYDVPPGLR
T389 LRRPGPGTLyDVPRE
Y391-p RPGPGTLyDVPRERV
S407 PPEVADGSVIDDGVy
D411 ADGSVIDDGVyAVPP
Y414-p SVIDDGVyAVPPPAE
S432 PTDGKRLSASSTGST
S435 GKRLSASSTGSTRsS
T436 KRLSASSTGSTRsSQ
T439 SASSTGSTRsSQSAS
S441-p SSTGSTRsSQSASSL
Y556 LQKMEDVYQTLVVHG
T558 KMEDVYQTLVVHGQV
G572 VLDSGRGGPGFTLDD
S643-p IQSRPLPsPPKFTSQ
Y657 QDSPDGQYENSEGGW
Y668 EGGWMEDYDYVHLQG
Y670 GWMEDYDYVHLQGKE
K697 GNIVRQGKGQLELQQ
G698 NIVRQGKGQLELQQL
K706 QLELQQLKQFERLEQ
Y819 VRSKVTHYSNLLCDL
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