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Bcl-6
a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Transcription factor |
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Cellular Component: nucleolus; replication fork; nucleus
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Molecular Function: protein binding; zinc ion binding; chromatin DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
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Biological Process: erythrocyte development; negative regulation of S phase of mitotic cell cycle; positive regulation of apoptosis; regulation of memory T cell differentiation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; Rho protein signal transduction; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; positive regulation of B cell proliferation; germinal center formation; negative regulation of mast cell cytokine production; negative regulation of T-helper 2 cell differentiation; regulation of immune response; T-helper 2 type immune response; regulation of Rho GTPase activity; transcription, DNA-dependent; positive regulation of cell motility; negative regulation of cell-matrix adhesion; regulation of germinal center formation; negative regulation of T-helper 2 type immune response; negative regulation of Rho protein signal transduction; protein import into nucleus, translocation; B cell differentiation; regulation of inflammatory response; spermatogenesis; negative regulation of cell growth; actin cytoskeleton organization and biogenesis; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; negative regulation of B cell apoptosis
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Reference #:
P41182 (UniProtKB)
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| Alt. Names/Synonyms: B-cell CLL/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; BCL5; BCL6; BCL6A; cys-his2 zinc finger transcription factor; LAZ3; lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; ZBTB27; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51; zinc finger transcription factor BCL6S; ZNF51 |
| Gene Symbols: BCL6 |
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Molecular weight: 78,846 Da
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Basal Isoelectric point: 8.28
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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