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Protein Page:
Bcl-6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Bcl-6 a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 3q27
Cellular Component: replication fork; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; chromatin DNA binding; metal ion binding; chromatin binding; transcription factor activity
Biological Process: erythrocyte development; positive regulation of apoptosis; regulation of memory T cell differentiation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; Rho protein signal transduction; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; positive regulation of B cell proliferation; germinal center formation; negative regulation of mast cell cytokine production; inflammatory response; negative regulation of T-helper 2 cell differentiation; regulation of immune response; regulation of Rho GTPase activity; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of cell motility; negative regulation of cell-matrix adhesion; regulation of germinal center formation; negative regulation of T-helper 2 type immune response; negative regulation of Rho protein signal transduction; protein import into nucleus, translocation; B cell differentiation; regulation of inflammatory response; spermatogenesis; negative regulation of cell growth; actin cytoskeleton organization and biogenesis; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; negative regulation of B cell apoptosis
Reference #:  P41182 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; BCL5; BCL6; BCL6A; cys-his2 zinc finger transcription factor; LAZ3; lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; ZBTB27; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51; zinc finger transcription factor BCL6S; ZNF51
Gene Symbols: BCL6
Molecular weight: 78,846 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-6

Protein Structure Not Found.


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Sites Implicated In
protein degradation: S333‑p, S343‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 Y157-p MPQDIMAyRGREVVE
0 1 S260-p VCHSNIYsPKETIPE
0 1 K282-ub YSVAEGLkPAAPSAR
0 1 S307 SKEEERPSSEDEIAL
0 1 S308 KEEERPSSEDEIALH
0 4 S330-p LNRKGLVsPQsPQKs
1 34 S333-p KGLVsPQsPQKsDCQ
0 4 S337-p sPQsPQKsDCQPNsP
1 20 S343-p KsDCQPNsPTESCSS
0 1 T345 DCQPNsPTESCSSKN
0 2 S361-p CILQASGsPPAKSPT
0 1 S366 SGsPPAKSPTDPKAC
1 0 K379-ac ACNWKKYkFIVLNSL
0 1 P395 QNAKPEGPEQAELGR
0 6 S404-p QAELGRLsPRAYTAP
0 2 S457 VNRSMTGSPRSSSES
0 3 T569-p ASHKTVHtGEKPyRC
0 1 Y574-p VHtGEKPyRCNICGA
0 1 T625-p RAHVLIHtGEKPYPC
0 1 T653-p KSHLRIHtGEKPYHC
  mouse

 
Y157 MPHDIMAYRGREVVE
S261 LCHSNIYSPKEAVPE
K283 YSVPEGPKPAVPSAR
S308 SKEEERPSSEDEIAL
S309 KEEERPSSEDEIALH
S331-p LNRKGLVsPQsPQKs
S334-p KGLVsPQsPQKsDCQ
S338-p sPQsPQKsDCQPNsP
S344-p KsDCQPNsPtESCSS
T346-p DCQPNsPtESCSSKN
S362-p CILQASGsPPAKsPT
S367-p SGsPPAKsPTDPKAC
K380 ACNWKKYKFIVLNSL
S396-p QNAKPEGsEQAELGR
S405-p QAELGRLsPRAYPAP
S458-p VNRSLAGsPRSSSES
T570-p ASHKTVHtGEKPYRC
Y575 VHtGEKPYRCNICGA
T626 RAHVLIHTGEKPYPC
T654 KSHLRIHTGEKPYHC
  rat

 
Y157 MPHDVMAYRGREVVE
S261 LCHSNIYSPKEAVPE
K283 YSVTEGPKPAAPSAR
S308-p SKEEERPssEDEIAL
S309-p KEEERPssEDEIALH
S331 LNRKGLVSPQsPQKS
S334-p KGLVSPQsPQKSDCQ
S338 SPQsPQKSDCQPNSP
S344 KSDCQPNSPTESSSS
T346 DCQPNSPTESSSSKN
S362 CILQASGSPPAKSPT
S367 SGSPPAKSPTDPKAC
K380 ACNWKKYKFIVLNSL
S396 QNAKPEGSEQAELGR
S405 QAELGRLSPRAYPAP
S458-p VNRSLAGsPRSSSES
T570 ASHKTVHTGEKPYRC
Y575 VHTGEKPYRCNICGA
T626 RAHVLIHTGEKPYPC
T654 KSHLRIHTGEKPYHC
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