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gp130 (human)

Overview gp130 gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, cytokine Cellular Component: extracellular space; cell soma; oncostatin-M receptor complex; dendrite; extracellular region; plasma membrane; interleukin-6 receptor complex; external side of plasma membrane Molecular Function: interleukin-11 binding; protein homodimerization activity; interleukin-27 receptor activity; oncostatin-M receptor activity; leukemia inhibitory factor receptor activity; interleukin-6 receptor activity; interleukin-11 receptor activity; protein binding; interleukin-6 receptor binding; interleukin-6 binding; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding Biological Process: glycogen metabolic process; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; JAK-STAT cascade; positive regulation of smooth muscle cell migration; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; reduction of cytosolic calcium ion concentration; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; triacylglycerol mobilization; positive regulation of adaptive immune response; response to nutrient; negative regulation of apoptosis; positive regulation of astrocyte differentiation Reference #:  P40189 (UniProtKB) Alt. Names/Synonyms: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6RB; IL6ST; IL6ST nirs variant 3; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin M receptor; Oncostatin-M receptor subunit alpha Gene Symbols: IL6ST Molecular weight: 103,537 Da Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states CST Pathways:  Jak/Stat/IL-6 Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below gp130 1BJ8 - A=219-325 (human) 1BQU - A/B=122-333 (human) 1I1R - A=23-325 (human) 1N2Q - A/B=23-324 (human) 1P9M - A=23-321 (human) 1PVH - A/C=123-323 (human) 3L5H - A=24-612 (human) 3L5I - A=323-612 (human) 3L5J - A/B=323-610 (human) 4GL9 - J/K/I/L=750-764 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
cell cycle regulation: Y767‑p, Y814‑p, Y905‑p, Y915‑p cell differentiation, altered: Y759‑p transcription, altered: Y759‑p, Y767‑p, Y814‑p, Y905‑p, Y915‑p activation: Y759‑p inhibition: Y759‑p molecular association, regulation: Y759‑p, T890‑p phosphorylation: Y759‑p protein degradation: S782‑p receptor internalization, altered: S782‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		-	gap
0	1		I231	PPHNLSVINSEELSS
0	1		S233	HNLSVINSEELSSIL
0	1		S237	VINSEELSSILKLTW
0	1		S238	INSEELSSILKLTWT
0	2		Y309-p	MKEDGKGyWSDWSEE
0	1		Y322-p	EEASGITyEDRPSKA
0	2		Y396-p	VNLTNDRyLATLTVR
0	1		K649	NKRDLIKKHIWPNVP
0	9		S667-p	KSHIAQWsPHtPPRH
0	10		T670-p	IAQWsPHtPPRHNFN
0	1		S678-p	PPRHNFNsKDQMYSD
0	1		S710-p	PFPEDLKsLDLFKKE
11	3		Y759-p	NTSSTVQySTVVHSG
2	5		Y767-p	STVVHSGyRHQVPSV
0	2		S780-p	SVQVFSRsEsTQPLL
4	1		S782-p	QVFSRsEsTQPLLDS
0	1		T783	VFSRsEsTQPLLDSE
0	1		S789	sTQPLLDSEERPEDL
2	1		Y814-p	GILPRQQyFKQNCsQ
0	1		S820-p	QyFKQNCsQHESSPD
0	1		S839-p	ERSKQVSsVNEEDFV
1	1		T890-p	GQVERFEtVGMEAAt
0	1		T897-p	tVGMEAAtDEGMPKS
2	16		Y905-p	DEGMPKSyLPQTVRQ
2	4		Y915-p	QTVRQGGyMPQ____

	gp130 iso4
-	gap
I65	PPHNLSVINSEELSS
S67	HNLSVINSEELSSIL
S71	VINSEELSSILKLTW
S72	INSEELSSILKLTWT
Y143-p	MKEDGKGyWSDWSEE
Y156	EEASGITYEDKLKNT
-	gap
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
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-	gap
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-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	gp130 iso7
S35-p	SCQRGPYsLVEEILH
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
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-	gap
-	gap
-	gap
-	gap

	mouse
-	gap
T229-p	PPYNLSVtNsEELss
S231-p	YNLSVtNsEELssIL
S235-p	VtNsEELssILKLSW
S236-p	tNsEELssILKLSWV
Y307	IKDSGKGYWSDWSEE
Y320	EEASGTTYEDRPSRP
Y394	VNLTNDRYVASLAAR
K647-u	NKRDLIKkHIWPNVP
S665-p	KSHIAQWsPHtPPRH
T668-p	IAQWsPHtPPRHNFN
S676	PPRHNFNSKDQMYSD
S708	PCPDDLKSVDLFKKE
Y757-p	STASTVQySTVVHSG
Y765	STVVHSGYRHQVPSV
S778-p	SVQVFSRsEstQPLL
S780-p	QVFSRsEstQPLLDs
T781-p	VFSRsEstQPLLDsE
S787-p	stQPLLDsEERPEDL
Y812	EILPRQPYFKQNCSQ
S818	PYFKQNCSQPEACPE
S837	ERSNQVLSGNEEDFV
S889	GQMERFESVGMETTI
I896	SVGMETTIDEEIPKS
Y904	DEEIPKSYLPQTVRQ
Y914	QTVRQGGYMPQ____

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