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Protein Page:
gp130 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
gp130 gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Receptor, cytokine; Membrane protein, integral
Cellular Component: extracellular space; membrane; cell soma; oncostatin-M receptor complex; dendrite; plasma membrane; extracellular region; interleukin-6 receptor complex; external side of plasma membrane
Molecular Function: interleukin-11 binding; protein homodimerization activity; interleukin-27 receptor activity; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; interleukin-6 receptor activity; interleukin-11 receptor activity; protein binding; interleukin-6 receptor binding; interleukin-6 binding; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding
Biological Process: glycogen metabolic process; viral reproduction; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; positive regulation of adaptive immune response; negative regulation of apoptosis; positive regulation of astrocyte differentiation
Reference #:  P40189 (UniProtKB)
Alt. Names/Synonyms: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6RB; IL6ST; IL6ST nirs variant 3; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin M receptor; Oncostatin-M receptor subunit alpha
Gene Symbols: IL6ST
Molecular weight: 103,537 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

gp130

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y767‑p, Y814‑p, Y905‑p, Y915‑p
cell differentiation, altered: Y759‑p
transcription, altered: Y759‑p, Y767‑p, Y814‑p, Y905‑p, Y915‑p
activity, induced: Y759‑p
activity, inhibited: Y759‑p
molecular association, regulation: Y759‑p, T890‑p
phosphorylation: Y759‑p
protein degradation: S782‑p
receptor internalization, altered: S782‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 I231 PPHNLSVINSEELSS
0 1 S233 HNLSVINSEELSSIL
0 1 S237 VINSEELSSILKLTW
0 1 S238 INSEELSSILKLTWT
0 2 Y309-p MKEDGKGyWSDWSEE
0 1 Y322-p EEASGITyEDRPSKA
0 2 Y396-p VNLTNDRyLATLTVR
0 1 K649 NKRDLIKKHIWPNVP
0 1 S661-p NVPDPSKsHIAQWsP
0 13 S667-p KsHIAQWsPHtPPRH
0 14 T670-p IAQWsPHtPPRHNFN
0 1 S678-p PPRHNFNsKDQMYSD
0 2 S710-p PFPEDLKsLDLFKKE
11 3 Y759-p NTSSTVQySTVVHSG
2 5 Y767-p STVVHSGyRHQVPSV
0 3 S780-p SVQVFSRsEsTQPLL
4 2 S782-p QVFSRsEsTQPLLDS
0 1 T783 VFSRsEsTQPLLDSE
0 1 S789 sTQPLLDSEERPEDL
0 1 G804 QLVDHVDGGDGILPR
2 1 Y814-p GILPRQQyFKQNCsQ
0 1 S820-p QyFKQNCsQHESSPD
0 2 S839-p ERSKQVSsVNEEDFV
1 1 T890-p GQVERFEtVGMEAAt
0 1 T897-p tVGMEAAtDEGMPKS
2 17 Y905-p DEGMPKSyLPQTVRQ
2 4 Y915-p QTVRQGGyMPQ____
  gp130 iso4  
- gap
I65 PPHNLSVINSEELSS
S67 HNLSVINSEELSSIL
S71 VINSEELSSILKLTW
S72 INSEELSSILKLTWT
Y143-p MKEDGKGyWSDWSEE
Y156 EEASGITYEDKLKNT
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- under review  
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  gp130 iso7  
S35-p SCQRGPYsLVEEILH
- gap
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- under review  
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  mouse

 
- gap
T229-p PPYNLSVtNsEELss
S231-p YNLSVtNsEELssIL
S235-p VtNsEELssILKLSW
S236-p tNsEELssILKLSWV
Y307 IKDSGKGYWSDWSEE
Y320 EEASGTTYEDRPSRP
Y394 VNLTNDRYVASLAAR
K647-ub NKRDLIKkHIWPNVP
S659 NVPDPSKSHIAQWsP
S665-p KSHIAQWsPHtPPRH
T668-p IAQWsPHtPPRHNFN
S676 PPRHNFNSKDQMYSD
S708 PCPDDLKSVDLFKKE
Y757-p STASTVQySTVVHSG
Y765 STVVHSGYRHQVPSV
S778-p SVQVFSRsEstQPLL
S780-p QVFSRsEstQPLLDs
T781-p VFSRsEstQPLLDsE
S787-p stQPLLDsEERPEDL
G802 QLVDSVDGGDEILPR
Y812 EILPRQPYFKQNCSQ
S818 PYFKQNCSQPEACPE
S837 ERSNQVLSGNEEDFV
S889 GQMERFESVGMETTI
I896 SVGMETTIDEEIPKS
Y904 DEEIPKSYLPQTVRQ
Y914 QTVRQGGYMPQ____
  rat

 
- gap
T230 PPHNLSVTNSEELSS
S232 HNLSVTNSEELSSIL
S236 VTNSEELSSILKLAW
S237 TNSEELSSILKLAWV
Y308 IKENGKGYWSDWSEE
Y321 EEASGTTYEDRPSKA
Y395 VNLTNNRYVASLAAR
K648 NKRDLIKKHIWPNVP
S660 NVPDPSKSHIAQWSP
S666 KSHIAQWSPHTPPRH
T669 IAQWSPHTPPRHNFN
S677 PPRHNFNSKDQMYSD
S709 PCPDDLKSLDLFKKE
Y758 STASTVQYSTVVHSG
Y766 STVVHSGYRHQVPSV
S779 SVQVFSRSESTQPLL
S781 QVFSRSESTQPLLDS
T782 VFSRSESTQPLLDSE
S788 STQPLLDSEERPEDL
S803-p QLVDSVDsGDEILPR
Y813 EILPRQQYFKQSCSQ
S819 QYFKQSCSQPGASPD
S838 ERSSQVPSGSEEDFV
S890 GQIERFESVGMETAM
M897 SVGMETAMDEDISKS
Y905 DEDISKSYLPQTVRQ
Y915 QTVRQGGYMPQ____
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