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Protein Page:
DAB1 (human)

Overview
DAB1 an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: neuron projection; cell soma; membrane; apical part of cell; perinuclear region of cytoplasm; postsynaptic density; cytosol; brush border
Molecular Function: phosphoinositide 3-kinase binding
Biological Process: response to drug; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; Golgi localization; cerebellum structural organization; ventral spinal cord development; negative regulation of cell adhesion; adult walking behavior; small GTPase mediated signal transduction; radial glia guided migration of Purkinje cell; positive regulation of protein kinase activity; negative regulation of astrocyte differentiation; dendrite development; midgut development; negative regulation of axonogenesis; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
Reference #:  O75553 (UniProtKB)
Alt. Names/Synonyms: DAB1; Disabled homolog 1; disabled homolog 1 (Drosophila)
Gene Symbols: DAB1
Molecular weight: 63,775 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DAB1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y220‑p, Y232‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S90 QKIFLTISFGGIKIF
5 0 Y185 KQCEQAVYQTILEED
10 1 Y198-p EDVEDPVyQYIVFEA
4 0 Y200 VEDPVyQYIVFEAGH
11 2 Y220-p PETEENIyQVPTSQK
12 15 Y232-p SQKKEGVyDVPKSQP
1 0 L279 ATKAVTQLELFGDMS
1 0 T418 AMFQGPLTPLATVPG
3 0 S433 TSDSTRSSPQTDKPR
1 0 T503 DISQLNLTPVTSTTP
1 0 T509 LTPVTSTTPSTNSPP
1 0 S514 STTPSTNSPPTPAPR
1 0 T517 PSTNSPPTPAPRQSs
7 0 S524-p TPAPRQSsPSKSSAS
1 0 S548 IFEEGFESPSKSEEQ
1 0 S583 EPSGDNISPQAGS__
3327 : Phospho-Dab1 (Tyr220) Antibody
3325 : Phospho-Dab1 (Tyr232) Antibody
  mouse

► Hide Isoforms
 
S90 QKIFLTISFGGIKIF
Y185-p KQCEQAVyQTILEED
Y198-p EDVEDPVyQyIVFEA
Y200-p VEDPVyQyIVFEAGH
Y220-p PETEENIyQVPTSQK
Y232-p SQKKEGVyDVPKSQP
L279 KVSAVTQLELFGDMS
T418 AMFQGPLTPLATVPG
S433 TNDSARSSPQSDKPR
T503 DISQLNLTPVTSTTP
T509 LTPVTSTTPSTNSPP
S514 STTPSTNSPPTPAPR
T517 PSTNSPPTPAPRQSs
S524-p TPAPRQSsPSKSSAS
S548 IFEEGFESPSKSEEQ
S583 EPSGDNISPQDGS__
3327 : Phospho-Dab1 (Tyr220) Antibody
3325 : Phospho-Dab1 (Tyr232) Antibody
  DAB1 iso2  
S90 QKIFLTISFGGIKIF
Y185-p KQCEQAVyQTILEED
Y198-p EDVEDPVyQyIVFEA
Y200-p VEDPVyQyIVFEAGH
Y220-p PETEENIyQVPTSQK
Y232-p SQKKEGVyDVPKSQP
L246 PVSAVTQLELFGDMS
T385-p AMFQGPLtPLATVPG
S400-p TNDSARSsPQSDKPR
T470-p DISQLNLtPVTSTtP
T476-p LtPVTSTtPSTNsPP
S481-p STtPSTNsPPtPAPR
T484-p PSTNsPPtPAPRQSs
S491-p tPAPRQSsPSKSSAS
S515-p IFEEGFEsPSKSEEQ
S550-p EPSGDNIsPQDGS__
  DAB1 iso3  
S90 QKIFLTISFGGIKIF
Y185 KQCEQAVYQTILEED
Y198 EDVEDPVYQYIVFEA
Y200 VEDPVYQYIVFEAGH
Y220 PETEENIYQVPTSQK
Y232 SQKKEGVYDVPKSQP
S246-p PVSSLVQsPAAERAE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
S90-p QKIFLTIsFGGIKIF
Y185 KQCEQAVYQTILEED
Y198 EDVEDPVYQYIVFEA
Y200 VEDPVYQYIVFEAGH
Y220 PETEENIYQVPTSQK
Y232-p SQKKEGVyDVPKSQP
L246 PVSAVTQLELFGDMS
T385 AMFQGPLTPLATVPG
S400-p TNDSARSsPQSDKPR
T470 DISQLNLTPVTSTTP
T476 LTPVTSTTPSTNSPP
S481 STTPSTNSPPTPAPR
T484 PSTNSPPTPAPRQSs
S491-p TPAPRQSsPSKSSAS
S515 IFEEGFESPSKSEEQ
S550 EPSGDNISPQDGS__
  pig

► Hide Isoforms
 
S90 QKIFLTISFGGIKIF
Y185-p KQCEQAVyQTILEED
Y198-p EDVEDPVyQyIVFEA
Y200-p VEDPVyQyIVFEAGH
Y220 PETEENIYQVPTSQK
Y232-p SQKKEGVyDVPKSQP
L246 PVSAVTQLELFGDMS
T385 AMFQGPLTPLATVPA
S400 TGDSARSSPQTDKPR
T470 DISQLNLTPVTSTTP
T476 LTPVTSTTPSTNSPP
S481 STTPSTNSPPTPAPR
T484 PSTNSPPTPAPRQTS
S491 TPAPRQTSPSKSSAS
S515 IFEEGFESPSKSEEQ
S550 EPSGDNISPQAGS__
  DAB1 iso1  
S90 QKIFLTISFGGIKIF
Y185-p KQCEQAVyQVPTSQK
- gap
- gap
- gap
Y197-p SQKKEGVyDVPKSQP
L244 ATKAVTQLELFGDMS
T383 AMFQGPLTPLATVPA
S398 TGDSARSSPQTDKPR
T468 DISQLNLTPVTSTTP
T474 LTPVTSTTPSTNSPP
S479 STTPSTNSPPTPAPR
T482 PSTNSPPTPAPRQTS
S489 TPAPRQTSPSKSSAS
S513 IFEEGFESPSKSEEQ
- gap
  chicken

► Hide Isoforms
 
S90 QKIFLTVSFGGIKIF
Y185-p KQCEQAVyQTILEED
Y198-p EDVEDPVyQyIVFEA
Y200-p VEDPVyQyIVFEAGH
Y220-p PETEENIyQVPTSQK
Y232-p SQKKEGVyDVPKSQP
L246 PVSAVTQLELFGDMS
A385 AMFQGTIAPIATVPP
S400 TSDSNRSSPQTDRPR
T470 DISQLNLTPVTSTTP
T476 LTPVTSTTPSTNSPP
S481 STTPSTNSPPTPAPR
T484 PSTNSPPTPAPRQSs
S491-p TPAPRQSsPSKSSAS
S515 LFEEGFESPSKSEEQ
S546 EPTGDTISPQVGS__
  DAB1 iso2  
S90 QKIFLTVSFGGIKIF
Y185 KQCEQAVYQVPTSQK
- gap
- gap
- gap
Y197 SQKKEGVYDVPKSQP
L230 VTQAVTQLELFGDMS
A369 AMFQGTIAPIATVPP
S384 TSDSNRSSPQTDRPR
T454 DISQLNLTPVTSTTP
T460 LTPVTSTTPSTNSPP
S465 STTPSTNSPPTPAPR
T468 PSTNSPPTPAPRQSs
S475-p TPAPRQSsPSKSSAS
S499 LFEEGFESPSKSEEQ
S530 EPTGDTISPQVGS__
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