an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: perinuclear region of cytoplasm
Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; cerebellum structural organization; Golgi localization; neuron migration; ventral spinal cord development; negative regulation of cell adhesion; adult walking behavior; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; small GTPase mediated signal transduction; negative regulation of astrocyte differentiation; dendrite development; negative regulation of axonogenesis; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.