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SHP-2 (human)

Overview SHP-2 a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines. Note: This description may include information from UniProtKB. Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis Cellular Component: protein complex; mitochondrion; cytoplasm; cytosol Molecular Function: protein domain specific binding; protein binding; phospholipase binding; SH3/SH2 adaptor activity; peptide hormone receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; insulin receptor binding Biological Process: axon guidance; hormone-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPK activity; reproductive process in a multicellular organism; glucose homeostasis; regulation of protein export from nucleus; negative regulation of insulin secretion; regulation of cell adhesion mediated by integrin; ephrin receptor signaling pathway; negative regulation of growth hormone secretion; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of hormone secretion; regulation of multicellular organism growth; negative regulation of cortisol secretion; organ growth; triacylglycerol metabolic process; DNA damage checkpoint; T cell costimulation; insulin receptor signaling pathway; hormone metabolic process; blood coagulation; leukocyte migration Reference #:  Q06124 (UniProtKB) Alt. Names/Synonyms: BPTP3; CFC; MGC14433; NS1; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP-2; Shp2; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11 Gene Symbols: PTPN11 Molecular weight: 68,436 Da Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SHP-2 2SHP - A/B=1-529 (human) 3B7O - A=237-529 (human) 3MOW - A=262-532 (human) 3O5X - A=262-532 (human) 3TKZ - A=1-106 (human) 3TL0 - A=1-106 (human) 4DGP - A=1-532 (human) 4DGX - A=1-532 (human) 1AYA - A/B=4-103 (mouse) 1AYB - A=4-103 (mouse) 1AYC - A=4-103 (mouse) 1AYD - A=4-103 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 4DGP 4DGX  |  ENZYME  |  Phospho3D  |  DISEASE 151100 163950 163955 176876 607785  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: Y546‑p cell motility, altered: Y546‑p, Y584‑p cytoskeletal reorganization: Y546‑p transcription, altered: Y546‑p enzymatic activity, induced: Y546‑p, Y584‑p molecular association, regulation: Y546‑p, Y584‑p phosphorylation: Y584‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S28-p	LTRGVDGsFLARPsK
0	1		S34-p	GsFLARPsKSNPGDF
0	1		S36	FLARPsKSNPGDFTL
0	3		T59-p	THIKIQNtGDyyDLy
0	2084		Y62-p	KIQNtGDyyDLyGGE
1	83		Y63-p	IQNtGDyyDLyGGEK
0	16		Y66-p	tGDyyDLyGGEKFAT
0	1		Y80-p	TLAELVQyYMEHHGQ
0	1		K91	HHGQLKEKNGDVIEL
0	3		T153-p	DFVLSVRtGDDKGES
0	1		S165-p	GESNDGKsKVTHVMI
0	1		K178-a	MIRCQELkyDVGGGE
0	3		Y179-p	IRCQELkyDVGGGER
0	1		K198-a	TDLVEHYkKNPMVET
0	15		Y263-p	QQECKLLysRKEGQR
0	1		S264-p	QECKLLysRKEGQRQ
0	1		K274-a	EGQRQENkNkNRykN
0	1		K276-a	QRQENkNkNRykNIL
1	14		Y279-p	ENkNkNRykNILPFD
0	1		K280-a	NkNkNRykNILPFDH
0	20		S302-p	GDPNEPVsDyINANI
2	56		Y304-p	PNEPVsDyINANIIM
1	0		Y327	NSKPKKSYIATQGCL
0	1		T415-p	QALLQGNtERTVWQY
0	38		Y515-p	MVQTEAQyRFIyMAV
0	13		Y519-p	EAQyRFIyMAVQHYI
21	391		Y546-p	SKRKGHEytNIKysL
0	26		T547-p	KRKGHEytNIKysLA
0	2		Y551-p	HEytNIKysLADQtS
0	1		S552-p	EytNIKysLADQtSG
0	10		T557-p	KysLADQtSGDQsPL
0	8		S562-p	DQtSGDQsPLPPCtP
0	14		T568-p	QsPLPPCtPtPPCAE
0	4		T570-p	PLPPCtPtPPCAEMR
2	9		S580-p	CAEMREDsARVyENV
12	1152		Y584-p	REDsARVyENVGLMQ
1	41		S595-p	GLMQQQKsFR_____

	mouse
S28	LTRGVDGSFLARPSK
S34	GSFLARPSKsNPGDF
S36-p	FLARPSKsNPGDFTL
T59	THIKIQNTGDyyDLy
Y62-p	KIQNTGDyyDLyGGE
Y63-p	IQNTGDyyDLyGGEK
Y66-p	TGDyyDLyGGEKFAT
Y80	TLAELVQYYMEHHGQ
K91-u	HHGQLKEkNGDVIEL
T153	DFVLSVRTGDDKGES
S165	GESNDGKSKVTHVMI
K178	MIRCQELKYDVGGGE
Y179	IRCQELKYDVGGGER
K198	TDLVEHYKKNPMVET
Y263	QQECKLLYSRKEGQR
S264	QECKLLYSRKEGQRQ
K274	EGQRQENKNKNRyKN
K276	QRQENKNKNRyKNIL
Y279-p	ENKNKNRyKNILPFD
K280	NKNKNRyKNILPFDH
S302	GDPNEPVSDyINANI
Y304-p	PNEPVSDyINANIIM
Y327-p	NSKPKKSyIATQGCL
T415	QALLQGNTERTVWQY
Y515-p	MVQTEAQyRFIYMAV
Y519	EAQyRFIYMAVQHYI
Y546-p	SKRKGHEytNIKYSL
T547-p	KRKGHEytNIKYSLV
Y551	HEytNIKYSLVDQTS
S552	EytNIKYSLVDQTSG
T557	KYSLVDQTSGDQsPL
S562-p	DQTSGDQsPLPPCTP
T568	QsPLPPCTPTPPCAE
T570	PLPPCTPTPPCAEMR
S580-p	CAEMREDsARVyENV
Y584-p	REDsARVyENVGLMQ
S595	GLMQQQRSFR_____

	rat
S28	LTRGVDGSFLARPSK
S34	GSFLARPSKSNPGDF
S36	FLARPSKSNPGDFTL
T59	THIKIQNTGDyyDLy
Y62-p	KIQNTGDyyDLyGGE
Y63-p	IQNTGDyyDLyGGEK
Y66-p	TGDyyDLyGGEKFAT
Y80	TLAELVQYYMEHHGQ
K91	HHGQLKEKNGDVIEL
T153	DFVLSVRTGDDKGES
S165	GESNDSKSKVTHVMI
K178	MIRCQELKYDVGGGE
Y179	IRCQELKYDVGGGER
K198	TDLVEHYKKNPMVET
Y263	QQECKLLYSRKEGQR
S264	QECKLLYSRKEGQRQ
K274	EGQRQENKNKNRYKN
K276	QRQENKNKNRYKNIL
Y279	ENKNKNRYKNILPFD
K280	NKNKNRYKNILPFDH
S302	GDPNEPVSDYINANI
Y304	PNEPVSDYINANIIM
Y327	NSKPKKSYIATQGCL
T415	QALLQGNTERTVWQY
Y515	MVQTEAQYRFIYMAV
Y519	EAQYRFIYMAVQHYI
Y546-p	SKRKGHEyTNIKYSL
T547	KRKGHEyTNIKYSLV
Y551	HEyTNIKYSLVDQTS
S552	EyTNIKYSLVDQTSG
T557	KYSLVDQTSGDQsPL
S562-p	DQTSGDQsPLPPCTP
T568	QsPLPPCTPtPPCAE
T570-p	PLPPCTPtPPCAEMR
S580	CAEMREDSARVyENV
Y584-p	REDSARVyENVGLMQ
S595	GLMQQQRSFR_____

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