a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, tyrosine (non-receptor); EC 188.8.131.52; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: protein complex; mitochondrion; cytoplasm; cytosol; nucleus
Molecular Function: protein domain specific binding; protein binding; phospholipase binding; SH3/SH2 adaptor activity; peptide hormone receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; D1 dopamine receptor binding; phosphoprotein phosphatase activity; insulin receptor binding
Biological Process: axon guidance; nerve growth factor receptor signaling pathway; hormone-mediated signaling; activation of MAPK activity; heart development; glucose homeostasis; reproductive process in a multicellular organism; negative regulation of insulin secretion; regulation of protein export from nucleus; regulation of cell adhesion mediated by integrin; ephrin receptor signaling pathway; inner ear development; negative regulation of growth hormone secretion; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cytokine and chemokine mediated signaling pathway; positive regulation of hormone secretion; regulation of multicellular organism growth; negative regulation of cortisol secretion; organ growth; genitalia development; triacylglycerol metabolic process; DNA damage checkpoint; T cell costimulation; insulin receptor signaling pathway; hormone metabolic process; innate immune response; brain development; blood coagulation; leukocyte migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.