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Protein Page:
Rad51 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rad51 a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Mitochondrial
Cellular Component: nucleoplasm; nuclear chromosome; lateral element; PML body; condensed nuclear chromosome; mitochondrion; mitochondrial matrix; perinuclear region of cytoplasm; cytoplasm; nucleolus; microtubule organizing center; condensed chromosome; nucleus
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; double-stranded DNA binding; damaged DNA binding; ATP binding; single-stranded DNA-dependent ATPase activity; single-stranded DNA binding
Biological Process: DNA unwinding during replication; ATP catabolic process; meiosis; mitotic recombination; DNA repair; double-strand break repair via homologous recombination; DNA recombination; DNA recombinase assembly; double-strand break repair; meiotic recombination; positive regulation of DNA ligation; response to DNA damage stimulus; protein homooligomerization
Reference #:  Q06609 (UniProtKB)
Alt. Names/Synonyms: BRCA1/BRCA2-containing complex, subunit 5; BRCC5; DNA repair protein RAD51 homolog 1; hRAD51; HsRAD51; HsT16930; RAD51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog A; RAD51 homolog protein; RAD51A; RECA; RecA, E. coli, homolog of; RecA-like protein; recombination protein A
Gene Symbols: RAD51
Molecular weight: 36,966 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rad51

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y315‑p
cell cycle regulation: T309‑p, Y315‑p
DNA repair, induced: T13‑p, S14‑p
molecular association, regulation: T13‑p, Y315‑p
phosphorylation: S14‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 T13-p QLEANADtsVEEESF
2 0 S14-p LEANADtsVEEESFG
1 2 Y54-p HTVEAVAyAPKkELI
0 1 K58-ub AVAyAPKkELINIkG
0 1 K64-ub KkELINIkGISEAKA
0 1 K107-ub IQITTGSkELDKLLQ
0 1 K156-ub DRGGGEGkAMYIDTE
0 1 Y301-p HASTTRLyLRKGRGE
1 0 T309-p LRKGRGEtRICKIyD
3 1 Y315-p EtRICKIyDSPCLPE
  mouse

 
T13 QLEASADTSVEEESF
S14 LEASADTSVEEESFG
Y54 HTVEAVAYAPKKELI
K58 AVAYAPKKELINIKG
K64 KKELINIKGISEAKA
K107 IQITTGSKELDKLLQ
K156 DRGGGEGKAMYIDTE
Y301 HASTTRLYLRKGRGE
T309 LRKGRGETRICKIYD
Y315 ETRICKIYDSPCLPE
  rat

 
T13 QLEANADTSVEEESF
S14 LEANADTSVEEESFG
Y54 HTVEAVAYAPKKELI
K58 AVAYAPKKELINIKG
K64 KKELINIKGISEAKA
K107 IQITTGSKELDKLLQ
K156 DRGGGEGKAMYIDTE
Y301 HASTTRLYLRKGRGE
T309 LRKGRGETRICKIYD
Y315 ETRICKIYDSPCLPE
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