a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; double-stranded DNA binding; damaged DNA binding; ATP binding; single-stranded DNA-dependent ATPase activity; single-stranded DNA binding
Biological Process: DNA unwinding during replication; ATP catabolic process; meiosis; mitotic recombination; DNA repair; double-strand break repair via homologous recombination; DNA recombination; DNA recombinase assembly; double-strand break repair; meiotic recombination; positive regulation of DNA ligation; response to DNA damage stimulus; protein homooligomerization
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.