a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; four-way junction DNA binding; recombinase activity; double-stranded DNA binding; chromatin binding; single-stranded DNA binding; single-stranded DNA-dependent ATPase activity; ATP binding; endodeoxyribonuclease activity
Biological Process: response to drug; DNA unwinding during replication; meiosis; regulation of protein amino acid phosphorylation; mitotic recombination; response to toxin; strand invasion; DNA repair; double-strand break repair via homologous recombination; DNA recombination; telomere organization and biogenesis; DNA recombinase assembly; meiotic recombination; double-strand break repair; positive regulation of DNA ligation; response to DNA damage stimulus; protein homooligomerization; response to X-ray
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.