a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral
Molecular Function: voltage-gated cation channel activity; neurotransmitter binding; glutamate receptor binding; protein binding; glutamate binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity; cell adhesion molecule binding; protein kinase binding; ATPase binding
Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; positive regulation of apoptosis; rhythmic process; response to other organism; sensory perception of pain; dopamine metabolic process; response to carbohydrate stimulus; synaptic transmission; protein localization; learning and/or memory; transport; response to methylmercury; response to wounding; visual learning; serotonin metabolic process; response to drug; regulation of action potential; glutamate signaling pathway; response to amphetamine; hippocampus development; sleep; response to cocaine; memory; response to ethanol; neurogenesis; spinal cord development; directional locomotion; cerebral cortex development; regulation of sensory perception of pain; response to calcium ion; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.