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Protein Page:
NMDAR2A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NMDAR2A a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral
Cellular Component: presynaptic membrane; postsynaptic membrane; cell surface; integral to plasma membrane; postsynaptic density; plasma membrane; terminal button; cell junction; outer membrane-bounded periplasmic space; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: voltage-gated cation channel activity; neurotransmitter binding; glutamate receptor binding; protein binding; glutamate binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity; cell adhesion molecule binding; protein kinase binding; ATPase binding
Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; positive regulation of apoptosis; rhythmic process; response to other organism; sensory perception of pain; dopamine metabolic process; response to carbohydrate stimulus; synaptic transmission; protein localization; learning and/or memory; transport; response to methylmercury; response to wounding; visual learning; serotonin metabolic process; response to drug; regulation of action potential; glutamate signaling pathway; response to amphetamine; hippocampus development; sleep; response to cocaine; memory; response to ethanol; neurogenesis; spinal cord development; directional locomotion; cerebral cortex development; regulation of sensory perception of pain; response to calcium ion; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process
Reference #:  Q12879 (UniProtKB)
Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; GRIN2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; NMDAR2A; NMDE1; NR2A
Gene Symbols: GRIN2A
Molecular weight: 165,283 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NMDAR2A
Protein Structure Not Found.


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Sites Implicated In
activation: Y1105‑p, Y1267‑p, Y1325‑p, Y1387‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K438 RNTVPCRKFVKINNS
0 1 K453 TNEGMNVKKCCKGFC
0 1 Y502 GMIGEVVYQRAVMAV
1 0 S511 RAVMAVGSLTINEER
0 1 Y730-p GKLDAFIyDAAVLNy
0 1 Y737-p yDAAVLNyKAGRDEG
0 1 T749-p DEGCKLVtIGSGYIF
0 3 S882 HIEEKKKSPDFNLTG
0 3 T888 KSPDFNLTGSQSNML
0 3 S890 PDFNLTGSQSNMLKL
0 1 S892 FNLTGSQSNMLKLLR
2 0 S900-p NMLKLLRsAKNIssM
0 1 K902 LKLLRsAKNIssMsN
0 1 S905-p LRsAKNIssMsNMNs
0 4 S906-p RsAKNIssMsNMNss
0 4 S908-p AKNIssMsNMNssRM
0 2 S912-p ssMsNMNssRMDsPK
0 2 S913-p sMsNMNssRMDsPKR
0 4 S917-p MNssRMDsPKRAADF
1 6 S929-p ADFIQRGsLIMDMVS
0 1 S936 sLIMDMVSDkGNLMy
0 1 K938-u IMDMVSDkGNLMySD
1 134 Y943-p SDkGNLMySDNRSFQ
0 1 S944 DkGNLMySDNRSFQG
0 1 S948 LMySDNRSFQGKESI
0 1 K952 DNRSFQGKESIFGDN
0 7 Y978 QKDNLNNYVFQGQHP
0 7 S1025 VDSIRQDSLSQNPVS
0 4 S1059 LPEEMAHSDISETSN
0 4 S1062 EMAHSDISETSNRAT
0 1 S1065 HSDISETSNRATCHR
0 1 N1066 SDISETSNRATCHRE
2 15 Y1105-p CSEVERTyLKTKSSS
1 0 Y1118-p SSPRDKIyTIDGEKE
1 20 Y1184-p GLSNNDQyKLySKHF
1 43 Y1187-p NNDQyKLySKHFTLK
0 2 S1198 FTLKDKGSPHSETSE
0 1 S1201 KDKGSPHSETSERYR
0 1 S1204 GSPHSETSERYRQNS
0 1 T1223 SCLSNMPTYSGHFTM
0 38 Y1224 CLSNMPTYSGHFTMR
4 2 S1232 SGHFTMRSPFKCDAC
0 1 K1235 FTMRSPFKCDACLRM
2 30 Y1246-p CLRMGNLyDIDEDQM
3 24 Y1267-p PATGEQVyQQDWAQN
0 1 S1291-p LRISRQHsYDNIVDK
0 15 Y1292 RISRQHsYDNIVDKP
2 86 Y1325-p RLLEGNFyGSLFSVP
0 1 S1333 GSLFSVPSSKLSGKK
0 1 S1334 SLFSVPSSKLSGKKS
0 1 K1340 SSKLSGKKSSLFPQG
0 1 K1352 PQGLEDSKRSKSLLP
0 14 H1371 DNPFLHSHRDDQRLV
2 9 Y1387-p GRCPSDPyKHSLPSQ
0 12 Y1400-p SQAVNDSyLRSSLRS
1 0 S1416 ASYCSRDSRGHNDVy
0 1 N1420 SRDSRGHNDVyISEH
1 13 Y1423-p SRGHNDVyISEHVMP
0 8 Y1431 ISEHVMPYAANKNNM
0 7 Y1439 AANKNNMYSTPRVLN
0 1 S1449 PRVLNSCSNRRVYKK
0 9 S1459 RVYKKMPSIESDV__
1 1 S1462 KKMPSIESDV_____
4206 : Phospho-NMDAR2A (Tyr1246) Antibody
  mouse

 
K438-a RNTVPCRkFVKINNS
K453-a TNEGMNVkKCCKGFC
Y502-p GMIGEVVyQRAVMAV
S511 RAVMAVGSLTINEER
Y730 GKLDAFIYDAAVLNY
Y737 YDAAVLNYKAGRDEG
T749 DEGCKLVTIGSGYIF
S882-p HIEEKKKsPDFNLtG
T888-p KsPDFNLtGsQsNML
S890-p PDFNLtGsQsNMLKL
S892-p FNLtGsQsNMLKLLR
S900-p NMLKLLRsAkNISNM
K902-u LKLLRsAkNISNMsN
S905 LRsAkNISNMsNMNs
N906 RsAkNISNMsNMNss
S908-p AkNISNMsNMNssRM
S912-p SNMsNMNssRMDsPK
S913-p NMsNMNssRMDsPKR
S917-p MNssRMDsPKRAADF
S929-p ADFIQRGsLIVDMVs
S936-p sLIVDMVsDKGNLIy
K938 IVDMVsDKGNLIysD
Y943-p sDKGNLIysDNRsFQ
S944-p DKGNLIysDNRsFQG
S948-p LIysDNRsFQGkDSI
K952-u DNRsFQGkDSIFGEN
Y978 HKDSLSNYVFQGQHP
S1025-p MESLRQDsLNQNPVS
S1059-p LPEEVAHsDIsETss
S1062-p EVAHsDIsETssRAT
S1065-p HsDIsETssRATCHR
S1066-p sDIsETssRATCHRE
Y1105-p CSEVERTyVKTKASS
Y1118 SSPRDKIYTIDGEKE
Y1184 GLPNNDQYKLyAKHF
Y1187-p NNDQYKLyAKHFTLK
S1198-p FTLKDKGsPHsEGsD
S1201-p KDKGsPHsEGsDRYR
S1204-p GsPHsEGsDRYRQNS
T1223-p SCLSNLPtYSGHFTM
Y1224 CLSNLPtYSGHFTMR
S1232-p SGHFTMRsPFKCDAC
K1235 FTMRsPFKCDACLRM
Y1246-p CLRMGNLyDIDEDQM
Y1267 PATREEAYQQDWSQN
S1291-p LKINRQHsyDNILDK
Y1292-p KINRQHsyDNILDKP
Y1325-p RLLEGNLyGSLFSVP
S1333-p GSLFSVPssKLLGNk
S1334-p SLFSVPssKLLGNkS
K1340-u ssKLLGNkSSLFPQG
K1352-u PQGLEDSkRSKSLLP
Y1371 DNPFLHTYGDDQRLV
Y1387 GRCPSDPYKHSLPSQ
Y1400 SQAVNDSYLRSSLRS
S1416 ASYCSRDSRGHsDVy
S1420-p SRDSRGHsDVyISEH
Y1423-p SRGHsDVyISEHVMP
Y1431 ISEHVMPYAANKNNM
Y1439 AANKNNMYSTPRVLN
S1449-p PRVLNSCsNRRVYKK
S1459-p RVYKKMPsIEsDV__
S1462-p KKMPsIEsDV_____
4206 : Phospho-NMDAR2A (Tyr1246) Antibody
  rat

 
K438 RNTVPCRKFVKINNS
K453 TNEGMNVKKCCKGFC
Y502 GMIGEVVYQRAVMAV
S511-p RAVMAVGsLTINEER
Y730 GKLDAFIYDAAVLNY
Y737 YDAAVLNYKAGRDEG
T749 DEGCKLVTIGSGYIF
S882 HIEEKKKSPDFNLTG
T888 KSPDFNLTGSQSNML
S890 PDFNLTGSQSNMLKL
S892 FNLTGSQSNMLKLLR
S900 NMLKLLRSAKNISNM
K902 LKLLRSAKNISNMSN
S905 LRSAKNISNMSNMNS
N906 RSAKNISNMSNMNSS
S908 AKNISNMSNMNSSRM
S912 SNMSNMNSSRMDSPK
S913 NMSNMNSSRMDSPKR
S917 MNSSRMDSPKRATDF
S929 TDFIQRGSLIVDMVS
S936 SLIVDMVSDKGNLIy
K938 IVDMVSDKGNLIySD
Y943-p SDKGNLIySDNRSFQ
S944 DKGNLIySDNRSFQG
S948 LIySDNRSFQGKDSI
K952 DNRSFQGKDSIFGDN
Y978-p HKDNLSNyVFQGQHP
S1025 MESLRQDSLNQNPVS
S1059 LPEEVAHSDISETSS
S1062 EVAHSDISETSSRAT
S1065 HSDISETSSRATCHR
S1066 SDISETSSRATCHRE
Y1105-p CSDVDRTyMKTKASS
Y1118 SSPRDKIYTIDGEKE
Y1184-p GLPNNDQyKLyAKHF
Y1187-p NNDQyKLyAKHFTLK
S1198 FTLKDKGSPHSEGSD
S1201 KDKGSPHSEGSDRYR
S1204 GSPHSEGSDRYRQNS
T1223 SCLSNLPTySGHFTM
Y1224-p CLSNLPTySGHFTMR
S1232-p SGHFTMRsPFkCDAC
K1235-u FTMRsPFkCDACLRM
Y1246-p CLRMGNLyDIDEDQM
Y1267-p PATREEVyQQDWSQN
S1291 LRINRQHSyDNILDK
Y1292-p RINRQHSyDNILDKP
Y1325-p RLLEGNLyGSLFSVP
S1333 GSLFSVPSSKLLGNK
S1334 SLFSVPSSKLLGNKS
K1340 SSKLLGNKSSLFPQG
K1352 PQGLEDSKRSKSLLP
Y1371-p DNPFLHTyGDDQRLV
Y1387-p GRCPSDPyKHSLPSQ
Y1400-p SQAVNDSyLRSSLRS
S1416-p ASYCSRDsRGHSDVy
S1420 SRDsRGHSDVyISEH
Y1423-p sRGHSDVyISEHVMP
Y1431-p ISEHVMPyAANKNTM
Y1439-p AANKNTMySTPRVLN
S1449 PRVLNSCSNRRVYKK
S1459 RVYKKMPSIESDV__
S1462 KKMPSIESDV_____
4206 : Phospho-NMDAR2A (Tyr1246) Antibody
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