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Protein Page:
NMDAR2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NMDAR2A a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell surface; endoplasmic reticulum; integral to plasma membrane; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; calcium channel activity; N-methyl-D-aspartate selective glutamate receptor activity
Biological Process: response to drug; synaptic transmission, glutamatergic; startle response; positive regulation of apoptosis; glutamate signaling pathway; response to amphetamine; regulation of synaptic plasticity; sensory perception of pain; sleep; dopamine metabolic process; memory; synaptic transmission; protein localization; response to ethanol; learning and/or memory; neurogenesis; transport; ionotropic glutamate receptor signaling pathway; directional locomotion; response to wounding; visual learning; regulation of sensory perception of pain; negative regulation of protein catabolic process; regulation of excitatory postsynaptic membrane potential; serotonin metabolic process
Reference #:  Q12879 (UniProtKB)
Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; GRIN2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; NMDAR2A; NMDE1; NR2A
Gene Symbols: GRIN2A
Molecular weight: 165,283 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NMDAR2A

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y1105‑p, Y1267‑p, Y1325‑p, Y1387‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S274-p LIPKEFPsGLIsVsy
0 1 S278-p EFPsGLIsVsyDDWD
0 1 S280-p PsGLIsVsyDDWDYS
0 1 Y281-p sGLIsVsyDDWDYSL
0 1 Y393-p RHAVWPRyKSFSDCE
0 1 K438 RNTVPCRKFVKINNS
0 1 K453 TNEGMNVKKCCKGFC
0 1 Y502 GMIGEVVYQRAVMAV
1 0 S511 RAVMAVGSLTINEER
0 2 Y730-p GKLDAFIyDAAVLNy
0 1 Y737-p yDAAVLNyKAGRDEG
0 1 T749-p DEGCKLVtIGSGYIF
0 1 K880-m1 GVHIEEKkKSPDFNL
0 4 S882 HIEEKkKSPDFNLTG
0 3 T888 KSPDFNLTGSQSNML
0 3 S890 PDFNLTGSQSNMLKL
0 1 S892 FNLTGSQSNMLKLLR
2 0 S900-p NMLKLLRsAKNIssM
0 1 K902 LKLLRsAKNIssMsN
0 1 S905-p LRsAKNIssMsNMNs
0 4 S906-p RsAKNIssMsNMNss
0 4 S908-p AKNIssMsNMNssRM
0 2 S912-p ssMsNMNssRMDsPK
0 2 S913-p sMsNMNssRMDsPKR
0 4 S917-p MNssRMDsPKRAADF
1 6 S929-p ADFIQRGsLIMDMVS
0 1 S936 sLIMDMVSDkGNLMy
0 1 K938-ub IMDMVSDkGNLMySD
1 134 Y943-p SDkGNLMySDNRSFQ
0 3 S944 DkGNLMySDNRSFQG
0 2 S948 LMySDNRSFQGKESI
0 1 K952 DNRSFQGKESIFGDN
0 2 N976 NRQKDNLNNYVFQGQ
0 1 Y978 QKDNLNNYVFQGQHP
0 7 S1025 VDSIRQDSLSQNPVS
0 4 S1059 LPEEMAHSDISETSN
0 4 S1062 EMAHSDISETSNRAT
0 1 S1065 HSDISETSNRATCHR
0 1 N1066 SDISETSNRATCHRE
0 3 S1099 SKYPKDCSEVERTyL
0 3 T1104 DCSEVERTyLKTKSS
2 12 Y1105-p CSEVERTyLKTKSSS
1 3 Y1118-p SSPRDKIyTIDGEKE
0 3 T1119 SPRDKIyTIDGEKEP
0 4 G1127 IDGEKEPGFHLDPPQ
0 1 S1163-p ENFRKGDstLPMNRN
0 1 T1164-p NFRKGDstLPMNRNP
0 1 S1179-p LHNEEGLsNNDQyKL
1 20 Y1184-p GLsNNDQyKLySKHF
1 43 Y1187-p NNDQyKLySKHFTLK
0 2 S1198 FTLKDKGSPHSETSE
0 1 S1201 KDKGSPHSETSERYR
0 1 S1204 GSPHSETSERYRQNS
0 7 T1223 SCLSNMPTYSGHFTM
0 33 Y1224 CLSNMPTYSGHFTMR
0 1 S1225 LSNMPTYSGHFTMRS
0 1 T1229 PTYSGHFTMRSPFKC
5 7 S1232 SGHFTMRSPFKCDAC
0 1 K1235 FTMRSPFKCDACLRM
2 30 Y1246-p CLRMGNLyDIDEDQM
0 1 T1262 QETGNPATGEQVyQQ
3 25 Y1267-p PATGEQVyQQDWAQN
0 12 S1291-p LRISRQHsYDNIVDK
0 16 Y1292 RISRQHsYDNIVDKP
2 84 Y1325-p RLLEGNFyGSLFSVP
0 2 S1327 LEGNFyGSLFSVPSS
0 1 S1333 GSLFSVPSSKLSGKK
0 1 S1334 SLFSVPSSKLSGKKS
0 1 K1340 SSKLSGKKSSLFPQG
0 1 K1352 PQGLEDSKRSKSLLP
0 1 S1370 SDNPFLHSHRDDQRL
0 5 H1371 DNPFLHSHRDDQRLV
0 8 S1384 LVIGRCPSDPyKHSL
3 13 Y1387-p GRCPSDPyKHSLPSQ
0 2 S1390 PSDPyKHSLPSQAVN
0 1 S1399 PSQAVNDSYLRSSLR
0 7 Y1400 SQAVNDSYLRSSLRS
1 0 S1416 ASYCSRDSRGHNDVy
0 1 N1420 SRDSRGHNDVyISEH
1 13 Y1423-p SRGHNDVyISEHVMP
0 12 Y1431 ISEHVMPYAANKNNM
0 1 N1437 PYAANKNNMYSTPRV
0 9 Y1439 AANKNNMYSTPRVLN
0 1 S1449 PRVLNSCSNRRVYKK
0 9 S1459 RVYKKMPSIESDV__
1 1 S1462 KKMPSIESDV_____
4206 : Phospho-NMDAR2A (Tyr1246) Antibody
  mouse

 
S274 LIPKEFPSGLISVSY
S278 EFPSGLISVSYDDWD
S280 PSGLISVSYDDWDYS
Y281 SGLISVSYDDWDYSL
Y393 RHAVWPRYKSFSDCE
K438-ac RNTVPCRkFVKINNS
K453-ac TNEGMNVkKCCKGFC
Y502-p GMIGEVVyQRAVMAV
S511 RAVMAVGSLTINEER
Y730 GKLDAFIYDAAVLNY
Y737 YDAAVLNYKAGRDEG
T749 DEGCKLVTIGSGYIF
K880 GVHIEEKKKsPDFNL
S882-p HIEEKKKsPDFNLtG
T888-p KsPDFNLtGsQsNML
S890-p PDFNLtGsQsNMLKL
S892-p FNLtGsQsNMLKLLR
S900-p NMLKLLRsAkNISNM
K902-ub LKLLRsAkNISNMsN
S905 LRsAkNISNMsNMNs
N906 RsAkNISNMsNMNss
S908-p AkNISNMsNMNssRM
S912-p SNMsNMNssRMDsPK
S913-p NMsNMNssRMDsPKR
S917-p MNssRMDsPKRAADF
S929-p ADFIQRGsLIVDMVs
S936-p sLIVDMVsDKGNLIy
K938 IVDMVsDKGNLIysD
Y943-p sDKGNLIysDNRsFQ
S944-p DKGNLIysDNRsFQG
S948-p LIysDNRsFQGkDSI
K952-ub DNRsFQGkDSIFGEN
S976 NRHKDSLSNYVFQGQ
Y978 HKDSLSNYVFQGQHP
S1025-p MESLRQDsLNQNPVS
S1059-p LPEEVAHsDIsETss
S1062-p EVAHsDIsETssRAT
S1065-p HsDIsETssRATCHR
S1066-p sDIsETssRATCHRE
S1099 SKYPKDCSEVERTyV
T1104 DCSEVERTyVKTKAS
Y1105-p CSEVERTyVKTKASS
Y1118 SSPRDKIYTIDGEKE
T1119 SPRDKIYTIDGEKEP
S1127 IDGEKEPSFHLDPPQ
S1163 ENFRKGDSTLPMNRN
T1164 NFRKGDSTLPMNRNP
P1179 LHNEDGLPNNDQYKL
Y1184 GLPNNDQYKLyAKHF
Y1187-p NNDQYKLyAKHFTLK
S1198-p FTLKDKGsPHsEGsD
S1201-p KDKGsPHsEGsDRYR
S1204-p GsPHsEGsDRYRQNS
T1223-p SCLSNLPtYSGHFTM
Y1224 CLSNLPtYSGHFTMR
S1225 LSNLPtYSGHFTMRs
T1229 PtYSGHFTMRsPFKC
S1232-p SGHFTMRsPFKCDAC
K1235 FTMRsPFKCDACLRM
Y1246-p CLRMGNLyDIDEDQM
T1262 QETGNPATREEAYQQ
Y1267 PATREEAYQQDWSQN
S1291-p LKINRQHsyDNILDK
Y1292-p KINRQHsyDNILDKP
Y1325-p RLLEGNLyGSLFSVP
S1327 LEGNLyGSLFSVPss
S1333-p GSLFSVPssKLLGNk
S1334-p SLFSVPssKLLGNkS
K1340-ub ssKLLGNkSSLFPQG
K1352-ub PQGLEDSkRSKSLLP
T1370 SDNPFLHTYGDDQRL
Y1371 DNPFLHTYGDDQRLV
S1384 LVIGRCPSDPYKHSL
Y1387 GRCPSDPYKHSLPSQ
S1390 PSDPYKHSLPSQAVN
S1399 PSQAVNDSYLRSSLR
Y1400 SQAVNDSYLRSSLRS
S1416 ASYCSRDSRGHsDVy
S1420-p SRDSRGHsDVyISEH
Y1423-p SRGHsDVyISEHVMP
Y1431 ISEHVMPYAANKNNM
N1437 PYAANKNNMYSTPRV
Y1439 AANKNNMYSTPRVLN
S1449-p PRVLNSCsNRRVYKK
S1459-p RVYKKMPsIEsDV__
S1462-p KKMPsIEsDV_____
4206 : Phospho-NMDAR2A (Tyr1246) Antibody
  rat

 
S274 LIPKEFPSGLISVSY
S278 EFPSGLISVSYDDWD
S280 PSGLISVSYDDWDYS
Y281 SGLISVSYDDWDYSL
Y393 RHAVWPRYKSFSDCE
K438 RNTVPCRKFVKINNS
K453 TNEGMNVKKCCKGFC
Y502 GMIGEVVYQRAVMAV
S511-p RAVMAVGsLTINEER
Y730 GKLDAFIYDAAVLNY
Y737 YDAAVLNYKAGRDEG
T749 DEGCKLVTIGSGYIF
K880 GVHIEEKKKsPDFNL
S882-p HIEEKKKsPDFNLTG
T888 KsPDFNLTGsQSNML
S890-p PDFNLTGsQSNMLKL
S892 FNLTGsQSNMLKLLR
S900 NMLKLLRSAKNISNM
K902 LKLLRSAKNISNMSN
S905 LRSAKNISNMSNMNS
N906 RSAKNISNMSNMNSS
S908 AKNISNMSNMNSSRM
S912 SNMSNMNSSRMDSPK
S913 NMSNMNSSRMDSPKR
S917 MNSSRMDSPKRATDF
S929-p TDFIQRGsLIVDMVS
S936 sLIVDMVSDKGNLIy
K938 IVDMVSDKGNLIysD
Y943-p SDKGNLIysDNRsFQ
S944-p DKGNLIysDNRsFQG
S948-p LIysDNRsFQGKDSI
K952 DNRsFQGKDSIFGDN
S976-p NRHKDNLsNyVFQGQ
Y978-p HKDNLsNyVFQGQHP
S1025-p MESLRQDsLNQNPVS
S1059-p LPEEVAHsDIsETSS
S1062-p EVAHsDIsETSSRAT
S1065 HsDIsETSSRATCHR
S1066 sDIsETSSRATCHRE
S1099-p SKYPKDCsDVDRtyM
T1104-p DCsDVDRtyMKTKAS
Y1105-p CsDVDRtyMKTKASS
Y1118-p SSPRDKIytIDGEKE
T1119-p SPRDKIytIDGEKEP
S1127-p IDGEKEPsFHLDPPQ
S1163 ENFRKGDSTLPMNRN
T1164 NFRKGDSTLPMNRNP
P1179 LHNEDGLPNNDQyKL
Y1184-p GLPNNDQyKLyAKHF
Y1187-p NNDQyKLyAKHFTLK
S1198-p FTLKDKGsPHSEGSD
S1201 KDKGsPHSEGSDRYR
S1204 GsPHSEGSDRYRQNS
T1223-p SCLSNLPtysGHFtM
Y1224-p CLSNLPtysGHFtMR
S1225-p LSNLPtysGHFtMRs
T1229-p PtysGHFtMRsPFkC
S1232-p sGHFtMRsPFkCDAC
K1235-ub FtMRsPFkCDACLRM
Y1246-p CLRMGNLyDIDEDQM
T1262-p QETGNPAtREEVyQQ
Y1267-p PAtREEVyQQDWSQN
S1291-p LRINRQHsyDNILDK
Y1292-p RINRQHsyDNILDKP
Y1325-p RLLEGNLyGsLFSVP
S1327-p LEGNLyGsLFSVPSS
S1333 GsLFSVPSSKLLGNK
S1334 sLFSVPSSKLLGNKS
K1340 SSKLLGNKSSLFPQG
K1352 PQGLEDSKRSKSLLP
T1370-p SDNPFLHtyGDDQRL
Y1371-p DNPFLHtyGDDQRLV
S1384-p LVIGRCPsDPyKHsL
Y1387-p GRCPsDPyKHsLPSQ
S1390-p PsDPyKHsLPSQAVN
S1399-p PSQAVNDsyLRSSLR
Y1400-p SQAVNDsyLRSSLRS
S1416-p ASYCSRDsRGHSDVy
S1420 SRDsRGHSDVyISEH
Y1423-p sRGHSDVyISEHVMP
Y1431-p ISEHVMPyAANKNtM
T1437-p PyAANKNtMySTPRV
Y1439-p AANKNtMySTPRVLN
S1449 PRVLNSCSNRRVYKK
S1459-p RVYKKMPsIEsDV__
S1462-p KKMPsIEsDV_____
4206 : Phospho-NMDAR2A (Tyr1246) Antibody
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