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Protein Page:
FRS2 (human)

Overview
FRS2 an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: membrane; integral to plasma membrane; plasma membrane; endosome
Molecular Function: protein binding; neurotrophin TRKA receptor binding; phosphatase activator activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding; fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPKK activity; activation of MAPK activity; gastrulation with mouth forming second; regulation of epithelial cell proliferation; G-protein coupled receptor protein signaling pathway; determination of anterior/posterior axis, embryo; induction of an organ; neuroblast proliferation; forebrain development; insulin receptor signaling pathway; innate immune response; optic placode formation involved in camera-type eye; transmembrane receptor protein tyrosine phosphatase signaling pathway
Reference #:  Q8WU20 (UniProtKB)
Alt. Names/Synonyms: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
Gene Symbols: FRS2
Molecular weight: 57,029 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below

FRS2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T49-p DTELILYtRKRDSVK
0 1 Y59-p RDSVKWHyLCLRRYG
0 20 T125-p VERNNHQtELEVPRt
0 31 T132-p tELEVPRtPRtPttP
0 31 T135-p EVPRtPRtPttPGFA
0 11 T137-p PRtPRtPttPGFAAQ
0 21 T138-p RtPRtPttPGFAAQN
0 2 Y150-p AQNLPNGyPRyPsFG
0 2 Y153-p LPNGyPRyPsFGDAS
0 1 S155-p NGyPRyPsFGDASSH
0 3 S169-p HPSSRHPsVGSARLP
0 1 S172 SRHPsVGSARLPsVG
0 20 S177-p VGSARLPsVGEEStH
0 2 T183-p PsVGEEStHPLLVAE
3 10 Y196-p AEEQVHTyVNTtGVQ
0 1 T200-p VHTyVNTtGVQEERK
0 3 S211-p EERKNRTsVHVPLEA
0 1 S221-p VPLEARVsNAESstP
0 1 S226-p RVsNAESstPKEEPS
0 4 T227-p VsNAESstPKEEPSS
0 1 Y290-p NTEWDTGyDSDERRD
0 1 S300-p DERRDAPsVNKLVyE
2 203 Y306-p PsVNKLVyENINGLs
0 1 S313-p yENINGLsIPSASGV
0 3 T326-p GVRRGRLtstSTSDT
0 54 S327-p VRRGRLtstSTSDTQ
0 11 T328-p RRGRLtstSTSDTQN
0 1 T330 GRLtstSTSDTQNIN
0 9 T344-p NNSAQRRtALLNyEN
2 95 Y349-p RRtALLNyENLPsLP
0 4 S354-p LNyENLPsLPPVWEA
0 5 S365-p VWEARKLsRDEDDNL
0 1 T376 DDNLGPKTPsLNGYH
0 1 S378-p NLGPKTPsLNGYHNN
2 25 Y392-p NLDPMHNyVNtENVT
0 2 T395-p PMHNyVNtENVTVPA
0 2 S403-p ENVTVPAsAHKIEYS
0 3 S428-p NFDIRRPsLEHRQLN
2 0 Y436-p LEHRQLNyIQVDLEG
0 2 T455-p DNPQTPKtPTtPLPQ
0 5 T458-p QTPKtPTtPLPQtPt
0 7 T463-p PTtPLPQtPtRRtEL
0 1 T465-p tPLPQtPtRRtELyA
0 1 T468-p PQtPtRRtELyAVID
0 13 Y471-p PtRRtELyAVIDIER
0 18 S503-p SRKTRHNstDLPM__
0 11 T504-p RKTRHNstDLPM___
3864 : Phospho-FRS2-alpha (Tyr196) Antibody
3861 : Phospho-FRS2-alpha (Tyr436) Antibody
  mouse

 
T49 DTELILYTRKRDSVK
Y59 RDSVKWHYLCLRRYG
T125 VERSSHQTELEVPRt
T132-p TELEVPRtPRtPttP
T135-p EVPRtPRtPttPGLG
T137-p PRtPRtPttPGLGAQ
T138-p RtPRtPttPGLGAQN
Y150-p AQNLPNGyPRYPSFG
Y153 LPNGyPRYPSFGDAS
S155 NGyPRYPSFGDASSH
S169-p HPSSRHPsVGsARLP
S172-p SRHPsVGsARLPsVG
S177-p VGsARLPsVGEESTH
T183 PsVGEESTHPLLVAE
Y196-p AEEQVHTyVNTTGVQ
T200 VHTyVNTTGVQEERK
S211-p EERKNRAsVHVPPEA
S221 VPPEARVSNAESNTP
N226 RVSNAESNTPKEEPS
T227 VSNAESNTPKEEPSN
Y290 NTEWDTGYDSDERRD
P300 DERRDVPPVNKLVyE
Y306-p PPVNKLVyENINGLS
S313 yENINGLSIPSASGV
T326 GVRRGRLTstStSDT
S327-p VRRGRLTstStSDTQ
T328-p RRGRLTstStSDTQN
T330-p GRLTstStSDTQNIN
P344 NNSAQRRPALLNyEN
Y349-p RRPALLNyENLPsLP
S354-p LNyENLPsLPPVWEA
S365-p VWEARKLsRDEDDNL
T376-p DDNLGPKtPSLNGYH
S378 NLGPKtPSLNGYHNN
Y392-p NLDPMHNyVNTENVT
T395 PMHNyVNTENVTVPA
S403 ENVTVPASAHKIDYS
S428-p NFDIRRPsLEHRQLN
Y436-p LEHRQLNyIQVDLEG
T455 DNPQTPKTPTTPLPQ
T458 QTPKTPTTPLPQTPT
T463 PTTPLPQTPTRRTEL
T465 TPLPQTPTRRTELYA
T468 PQTPTRRTELYAVID
Y471 PTRRTELYAVIDIER
S503-p SRKTRHNstDLPM__
T504-p RKTRHNstDLPM___
3864 : Phospho-FRS2-alpha (Tyr196) Antibody
  rat

 
T49 DTELILYTRKRDSVK
Y59 RDSVKWHYLCLRRYG
T125 VERNSHQTELEVPRt
T132-p TELEVPRtPRtPTtP
T135-p EVPRtPRtPTtPGLG
T137 PRtPRtPTtPGLGAQ
T138-p RtPRtPTtPGLGAQS
Y150 AQSLPNGYPRYPSFG
Y153 LPNGYPRYPSFGDAS
S155 NGYPRYPSFGDASSH
S169 HPSSRHPSVGSARLP
S172 SRHPSVGSARLPSVG
S177 VGSARLPSVGEESTH
T183 PSVGEESTHPLLVAE
Y196 AEEQVHTYVNTTGVQ
T200 VHTYVNTTGVQEERK
S211 EERKNRASVHIPPEA
S221 IPPEARVSNAESNTP
N226 RVSNAESNTPKEEPS
T227 VSNAESNTPKEEPSN
Y290 STEWDTGYDSDERRD
P300 DERRDVPPVNKLVyE
Y306-p PPVNKLVyENINGLS
S313 yENINGLSIPSASGV
T326 GVRRGRLTSTSTSDT
S327 VRRGRLTSTSTSDTQ
T328 RRGRLTSTSTSDTQN
T330 GRLTSTSTSDTQNIN
P344 NNSAQRRPALLNyEN
Y349-p RRPALLNyENLPSLP
S354 LNyENLPSLPPVWEA
S365-p VWEARKLsRDEDDNL
T376 DDNLGPKTPSLNGYH
S378 NLGPKTPSLNGYHNN
Y392 NLDPMHNYVNTENVT
T395 PMHNYVNTENVTVPA
S403 ENVTVPASAHKIDCS
S428-p NFDIRRPsLEHRQLN
Y436 LEHRQLNYIQVDLEG
T455 DNPQTPKTPTTPLPQ
T458 QTPKTPTTPLPQTPT
T463 PTTPLPQTPTRRTEL
T465 TPLPQTPTRRTELYA
T468 PQTPTRRTELYAVID
Y471 PTRRTELYAVIDIER
S503 SRKTRHNSTDLPM__
T504 RKTRHNSTDLPM___
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