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Protein Page:
FRS2 (human)

Overview
FRS2 an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: membrane; integral to plasma membrane; plasma membrane; endosome
Molecular Function: protein binding; neurotrophin TRKA receptor binding; phosphatase activator activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding; fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; activation of MAPK activity; gastrulation with mouth forming second; regulation of epithelial cell proliferation; G-protein coupled receptor protein signaling pathway; induction of an organ; determination of anterior/posterior axis, embryo; neuroblast proliferation; forebrain development; insulin receptor signaling pathway; innate immune response; optic placode formation involved in camera-type eye; transmembrane receptor protein tyrosine phosphatase signaling pathway
Reference #:  Q8WU20 (UniProtKB)
Alt. Names/Synonyms: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
Gene Symbols: FRS2
Molecular weight: 57,029 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below

FRS2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T49-p DTELILYtRKRDSVK
0 1 Y59-p RDSVKWHyLCLRRYG
0 16 T125-p VERNNHQtELEVPRt
0 29 T132-p tELEVPRtPRtPttP
0 30 T135-p EVPRtPRtPttPGFA
0 10 T137-p PRtPRtPttPGFAAQ
0 20 T138-p RtPRtPttPGFAAQN
0 2 Y150-p AQNLPNGyPRyPsFG
0 1 Y153-p LPNGyPRyPsFGDAS
0 1 S155-p NGyPRyPsFGDASSH
0 3 S169-p HPSSRHPsVGSARLP
0 1 S172 SRHPsVGSARLPsVG
0 14 S177-p VGSARLPsVGEESTH
3 7 Y196-p AEEQVHTyVNTTGVQ
0 3 S211-p EERKNRTsVHVPLEA
0 1 S221-p VPLEARVsNAESstP
0 1 S226-p RVsNAESstPKEEPS
0 4 T227-p VsNAESstPKEEPSS
0 1 Y290-p NTEWDTGyDSDERRD
0 1 S300-p DERRDAPsVNKLVyE
2 175 Y306-p PsVNKLVyENINGLs
0 1 S313-p yENINGLsIPSASGV
0 3 T326-p GVRRGRLtstSTSDT
0 52 S327-p VRRGRLtstSTSDTQ
0 11 T328-p RRGRLtstSTSDTQN
0 1 T330 GRLtstSTSDTQNIN
0 8 T344-p NNSAQRRtALLNyEN
2 81 Y349-p RRtALLNyENLPsLP
0 3 S354-p LNyENLPsLPPVWEA
0 5 S365-p VWEARKLsRDEDDNL
0 1 T376 DDNLGPKTPSLNGYH
2 23 Y392-p NLDPMHNyVNtENVT
0 2 T395-p PMHNyVNtENVTVPA
0 1 S403-p ENVTVPAsAHKIEYS
0 3 S428-p NFDIRRPsLEHRQLN
2 0 Y436-p LEHRQLNyIQVDLEG
0 2 T455-p DNPQTPKtPTtPLPQ
0 5 T458-p QTPKtPTtPLPQtPt
0 7 T463-p PTtPLPQtPtRRtEL
0 1 T465-p tPLPQtPtRRtELyA
0 1 T468-p PQtPtRRtELyAVID
0 12 Y471-p PtRRtELyAVIDIER
0 18 S503-p SRKTRHNstDLPM__
0 11 T504-p RKTRHNstDLPM___
3864 : Phospho-FRS2-alpha (Tyr196) Antibody
3861 : Phospho-FRS2-alpha (Tyr436) Antibody
  mouse

 
T49 DTELILYTRKRDSVK
Y59 RDSVKWHYLCLRRYG
T125 VERSSHQTELEVPRt
T132-p TELEVPRtPRtPttP
T135-p EVPRtPRtPttPGLG
T137-p PRtPRtPttPGLGAQ
T138-p RtPRtPttPGLGAQN
Y150-p AQNLPNGyPRYPSFG
Y153 LPNGyPRYPSFGDAS
S155 NGyPRYPSFGDASSH
S169-p HPSSRHPsVGsARLP
S172-p SRHPsVGsARLPsVG
S177-p VGsARLPsVGEESTH
Y196-p AEEQVHTyVNTTGVQ
S211-p EERKNRAsVHVPPEA
S221 VPPEARVSNAESNTP
N226 RVSNAESNTPKEEPS
T227 VSNAESNTPKEEPSN
Y290 NTEWDTGYDSDERRD
P300 DERRDVPPVNKLVyE
Y306-p PPVNKLVyENINGLS
S313 yENINGLSIPSASGV
T326 GVRRGRLTstStSDT
S327-p VRRGRLTstStSDTQ
T328-p RRGRLTstStSDTQN
T330-p GRLTstStSDTQNIN
P344 NNSAQRRPALLNyEN
Y349-p RRPALLNyENLPsLP
S354-p LNyENLPsLPPVWEA
S365-p VWEARKLsRDEDDNL
T376-p DDNLGPKtPSLNGYH
Y392-p NLDPMHNyVNTENVT
T395 PMHNyVNTENVTVPA
S403 ENVTVPASAHKIDYS
S428-p NFDIRRPsLEHRQLN
Y436-p LEHRQLNyIQVDLEG
T455 DNPQTPKTPTTPLPQ
T458 QTPKTPTTPLPQTPT
T463 PTTPLPQTPTRRTEL
T465 TPLPQTPTRRTELYA
T468 PQTPTRRTELYAVID
Y471 PTRRTELYAVIDIER
S503-p SRKTRHNstDLPM__
T504-p RKTRHNstDLPM___
3864 : Phospho-FRS2-alpha (Tyr196) Antibody
  rat

 
T49 DTELILYTRKRDSVK
Y59 RDSVKWHYLCLRRYG
T125 VERNSHQTELEVPRt
T132-p TELEVPRtPRtPTtP
T135-p EVPRtPRtPTtPGLG
T137 PRtPRtPTtPGLGAQ
T138-p RtPRtPTtPGLGAQS
Y150 AQSLPNGYPRYPSFG
Y153 LPNGYPRYPSFGDAS
S155 NGYPRYPSFGDASSH
S169 HPSSRHPSVGSARLP
S172 SRHPSVGSARLPSVG
S177 VGSARLPSVGEESTH
Y196 AEEQVHTYVNTTGVQ
S211 EERKNRASVHIPPEA
S221 IPPEARVSNAESNTP
N226 RVSNAESNTPKEEPS
T227 VSNAESNTPKEEPSN
Y290 STEWDTGYDSDERRD
P300 DERRDVPPVNKLVyE
Y306-p PPVNKLVyENINGLS
S313 yENINGLSIPSASGV
T326 GVRRGRLTSTSTSDT
S327 VRRGRLTSTSTSDTQ
T328 RRGRLTSTSTSDTQN
T330 GRLTSTSTSDTQNIN
P344 NNSAQRRPALLNyEN
Y349-p RRPALLNyENLPSLP
S354 LNyENLPSLPPVWEA
S365-p VWEARKLsRDEDDNL
T376 DDNLGPKTPSLNGYH
Y392 NLDPMHNYVNTENVT
T395 PMHNYVNTENVTVPA
S403 ENVTVPASAHKIDCS
S428-p NFDIRRPsLEHRQLN
Y436 LEHRQLNYIQVDLEG
T455 DNPQTPKTPTTPLPQ
T458 QTPKTPTTPLPQTPT
T463 PTTPLPQTPTRRTEL
T465 TPLPQTPTRRTELYA
T468 PQTPTRRTELYAVID
Y471 PTRRTELYAVIDIER
S503 SRKTRHNSTDLPM__
T504 RKTRHNSTDLPM___
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