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FRS2 (human)

Overview FRS2 an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: membrane; integral to plasma membrane; plasma membrane; endomembrane system; endosome Molecular Function: protein binding; neurotrophin TRKA receptor binding; phosphatase activator activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding; fibroblast growth factor receptor binding Biological Process: fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; activation of MAPK activity; gastrulation with mouth forming second; regulation of epithelial cell proliferation; G-protein coupled receptor protein signaling pathway; induction of an organ; determination of anterior/posterior axis, embryo; neuroblast proliferation; forebrain development; insulin receptor signaling pathway; optic placode formation involved in camera-type eye; transmembrane receptor protein tyrosine phosphatase signaling pathway Reference #:  Q8WU20 (UniProtKB) Alt. Names/Synonyms: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1 Gene Symbols: FRS2 Molecular weight: 57,029 Da Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation

Select Structure to View Below FRS2 1XR0 - B=11-136 (human)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T49-p	DTELILYtRKRDSVK
0	1		Y59-p	RDSVKWHyLCLRRYG
0	16		T125-p	VERNNHQtELEVPRt
0	29		T132-p	tELEVPRtPRtPttP
0	29		T135-p	EVPRtPRtPttPGFA
0	10		T137-p	PRtPRtPttPGFAAQ
0	19		T138-p	RtPRtPttPGFAAQN
0	2		Y150-p	AQNLPNGyPRYPsFG
0	1		S155-p	NGyPRYPsFGDASSH
0	3		S169-p	HPSSRHPsVGSARLP
0	1		S172	SRHPsVGSARLPsVG
0	13		S177-p	VGSARLPsVGEESTH
3	7		Y196-p	AEEQVHTyVNTTGVQ
0	2		S211-p	EERKNRTsVHVPLEA
0	1		S221-p	VPLEARVsNAESstP
0	1		S226-p	RVsNAESstPKEEPS
0	4		T227-p	VsNAESstPKEEPSS
0	1		Y290-p	NTEWDTGyDSDERRD
2	171		Y306-p	PSVNKLVyENINGLS
0	3		T326-p	GVRRGRLtstSTSDT
0	51		S327-p	VRRGRLtstSTSDTQ
0	11		T328-p	RRGRLtstSTSDTQN
0	8		T344-p	NNSAQRRtALLNyEN
2	80		Y349-p	RRtALLNyENLPsLP
0	3		S354-p	LNyENLPsLPPVWEA
0	3		S365	VWEARKLSRDEDDNL
0	1		T376	DDNLGPKTPSLNGYH
2	23		Y392-p	NLDPMHNyVNtENVT
0	2		T395-p	PMHNyVNtENVTVPA
0	1		S403-p	ENVTVPAsAHKIEYS
0	3		S428-p	NFDIRRPsLEHRQLN
1	0		Y436	LEHRQLNYIQVDLEG
0	2		T455-p	DNPQTPKtPTtPLPQ
0	5		T458-p	QTPKtPTtPLPQtPt
0	7		T463-p	PTtPLPQtPtRRtEL
0	1		T465-p	tPLPQtPtRRtELyA
0	1		T468-p	PQtPtRRtELyAVID
0	12		Y471-p	PtRRtELyAVIDIER
0	17		S503-p	SRKTRHNstDLPM__
0	11		T504-p	RKTRHNstDLPM___

	mouse
T49	DTELILYTRKRDSVK
Y59	RDSVKWHYLCLRRYG
T125	VERSSHQTELEVPRt
T132-p	TELEVPRtPRtPttP
T135-p	EVPRtPRtPttPGLG
T137-p	PRtPRtPttPGLGAQ
T138-p	RtPRtPttPGLGAQN
Y150-p	AQNLPNGyPRYPSFG
S155	NGyPRYPSFGDASSH
S169-p	HPSSRHPsVGsARLP
S172-p	SRHPsVGsARLPsVG
S177-p	VGsARLPsVGEESTH
Y196-p	AEEQVHTyVNTTGVQ
S211-p	EERKNRAsVHVPPEA
S221	VPPEARVSNAESNTP
N226	RVSNAESNTPKEEPS
T227	VSNAESNTPKEEPSN
Y290	NTEWDTGYDSDERRD
Y306-p	PPVNKLVyENINGLS
T326	GVRRGRLTstSTSDT
S327-p	VRRGRLTstSTSDTQ
T328-p	RRGRLTstSTSDTQN
P344	NNSAQRRPALLNyEN
Y349-p	RRPALLNyENLPsLP
S354-p	LNyENLPsLPPVWEA
S365-p	VWEARKLsRDEDDNL
T376-p	DDNLGPKtPSLNGYH
Y392-p	NLDPMHNyVNTENVT
T395	PMHNyVNTENVTVPA
S403	ENVTVPASAHKIDYS
S428-p	NFDIRRPsLEHRQLN
Y436-p	LEHRQLNyIQVDLEG
T455	DNPQTPKTPTTPLPQ
T458	QTPKTPTTPLPQTPT
T463	PTTPLPQTPTRRTEL
T465	TPLPQTPTRRTELYA
T468	PQTPTRRTELYAVID
Y471	PTRRTELYAVIDIER
S503-p	SRKTRHNstDLPM__
T504-p	RKTRHNstDLPM___

	rat
T49	DTELILYTRKRDSVK
Y59	RDSVKWHYLCLRRYG
T125	VERNSHQTELEVPRt
T132-p	TELEVPRtPRtPTtP
T135-p	EVPRtPRtPTtPGLG
T137	PRtPRtPTtPGLGAQ
T138-p	RtPRtPTtPGLGAQS
Y150	AQSLPNGYPRYPSFG
S155	NGYPRYPSFGDASSH
S169	HPSSRHPSVGSARLP
S172	SRHPSVGSARLPSVG
S177	VGSARLPSVGEESTH
Y196	AEEQVHTYVNTTGVQ
S211	EERKNRASVHIPPEA
S221	IPPEARVSNAESNTP
N226	RVSNAESNTPKEEPS
T227	VSNAESNTPKEEPSN
Y290	STEWDTGYDSDERRD
Y306-p	PPVNKLVyENINGLS
T326	GVRRGRLTSTSTSDT
S327	VRRGRLTSTSTSDTQ
T328	RRGRLTSTSTSDTQN
P344	NNSAQRRPALLNyEN
Y349-p	RRPALLNyENLPSLP
S354	LNyENLPSLPPVWEA
S365	VWEARKLSRDEDDNL
T376	DDNLGPKTPSLNGYH
Y392	NLDPMHNYVNTENVT
T395	PMHNYVNTENVTVPA
S403	ENVTVPASAHKIDCS
S428-p	NFDIRRPsLEHRQLN
Y436	LEHRQLNYIQVDLEG
T455	DNPQTPKTPTTPLPQ
T458	QTPKTPTTPLPQTPT
T463	PTTPLPQTPTRRTEL
T465	TPLPQTPTRRTELYA
T468	PQTPTRRTELYAVID
Y471	PTRRTELYAVIDIER
S503	SRKTRHNSTDLPM__
T504	RKTRHNSTDLPM___

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