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Protein Page:
BKR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BKR2 a receptor for bradykinin. Bradykinin elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane; endosome
Molecular Function: bradykinin receptor activity; protein binding; protease binding; protein heterodimerization activity; type 1 angiotensin receptor binding; phosphoinositide phospholipase C activity
Biological Process: vasoconstriction; metabolic process; blood circulation; negative regulation of peptidyl-serine phosphorylation; arachidonic acid secretion; vasodilation; response to salt stress; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; smooth muscle contraction; regulation of vasoconstriction; regulation of vascular permeability; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P30411 (UniProtKB)
Alt. Names/Synonyms: B2 bradykinin receptor; B2R; BDKRB2; BK-2; BK-2 receptor; BK2; BKR2; BKRB2; bradykinin receptor B2; BRB2; DKFZp686O088
Gene Symbols: BDKRB2
Molecular weight: 44,461 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
Select Structure to View Below

BKR2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y177‑p, Y347‑p
intracellular localization: Y332‑p
molecular association, regulation: Y332‑p
phosphorylation: Y177‑p, Y347‑p
receptor desensitization, altered: S373‑p
receptor internalization, altered: Y332‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S17-p FLSVREDsVPTTASF
2 2 Y156 MLVSIDRYLALVKtM
2 0 T162-p RYLALVKtMSMGRMR
1 1 Y177-p GVRWAKLysLVIWGC
0 1 S178-p VRWAKLysLVIWGCT
0 1 R267 KEIQTERRATVLVLV
1 0 Y332-p SCLNPLVyVIVGKRF
3 2 Y347-p RKKSWEVyQGVCQKG
0 1 S358-p CQKGGCRsEPIQMEN
2 2 P360 KGGCRsEPIQMENsM
3 2 S366-p EPIQMENsMGTLRTs
1 2 T369 QMENsMGTLRTsIsV
2 2 S373-p sMGTLRTsIsVERQI
2 3 S375-p GTLRTsIsVERQIHK
  mouse

 
- gap
Y157 MLVSIDRYLALVKTM
T163 RYLALVKTMSMGRMR
Y178 GVRWAKLYSLVIWGC
S179 VRWAKLYSLVIWGCT
K268-ub KEVQTERkATVLVLA
Y333 SGLNPLVYVIVGKRF
Y348 RKKSREVYRVLCQKG
G359 CQKGGCMGEPVQMEN
P361 KGGCMGEPVQMENSM
S367 EPVQMENSMGTLRTS
T370 QMENSMGTLRTSIsV
S374 SMGTLRTSIsVERQI
S376-p GTLRTSIsVERQIHK
  rat

 
- gap
Y161-p MLVSIDRyLALVKtM
T167-p RyLALVKtMSMGRMR
Y182 GVRWAKLYSLVIWSC
S183 VRWAKLYSLVIWSCT
K272 KEVQTEKKATVLVLA
Y337 SCLNPLVYVIVGKRF
Y352-p RKKSREVyQAICRKG
G363 CRKGGCMGEsVQMEN
S365-p KGGCMGEsVQMENsM
S371-p EsVQMENsMGtLRTs
T374-p QMENsMGtLRTsIsV
S378-p sMGtLRTsIsVDRQI
S380-p GtLRTsIsVDRQIHK
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