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Protein Page:
BKR2 (human)

Overview
BKR2 a receptor for bradykinin. Bradykinin elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane; endosome
Molecular Function: protein binding; bradykinin receptor activity; protease binding; protein heterodimerization activity; type 1 angiotensin receptor binding; phosphoinositide phospholipase C activity
Biological Process: vasoconstriction; metabolic process; blood circulation; negative regulation of peptidyl-serine phosphorylation; arachidonic acid secretion; vasodilation; response to salt stress; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; smooth muscle contraction; regulation of vasoconstriction; regulation of vascular permeability; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P30411 (UniProtKB)
Alt. Names/Synonyms: B2 bradykinin receptor; B2R; BDKRB2; BK-2; BK-2 receptor; BK2; BKR2; BKRB2; bradykinin receptor B2; BRB2; DKFZp686O088
Gene Symbols: BDKRB2
Molecular weight: 44,461 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
Select Structure to View Below

BKR2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y177‑p, Y347‑p
intracellular localization: Y332‑p
molecular association, regulation: Y332‑p
phosphorylation: Y177‑p, Y347‑p
receptor desensitization, altered: S373‑p
receptor internalization, altered: Y332‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 2 Y156 MLVSIDRYLALVKtM
2 0 T162-p RYLALVKtMSMGRMR
1 1 Y177-p GVRWAKLySLVIWGC
1 0 Y332-p SCLNPLVyVIVGKRF
3 2 Y347-p RKKSWEVyQGVCQKG
2 2 P360 KGGCRSEPIQMENsM
3 2 S366-p EPIQMENsMGTLRTs
1 2 T369 QMENsMGTLRTsIsV
2 2 S373-p sMGTLRTsIsVERQI
2 2 S375-p GTLRTsIsVERQIHK
  mouse

 
Y157 MLVSIDRYLALVKTM
T163 RYLALVKTMSMGRMR
Y178 GVRWAKLYSLVIWGC
Y333 SGLNPLVYVIVGKRF
Y348 RKKSREVYRVLCQKG
P361 KGGCMGEPVQMENSM
S367 EPVQMENSMGTLRTS
T370 QMENSMGTLRTSIsV
S374 SMGTLRTSIsVERQI
S376-p GTLRTSIsVERQIHK
  rat

 
Y161-p MLVSIDRyLALVKtM
T167-p RyLALVKtMSMGRMR
Y182 GVRWAKLYSLVIWSC
Y337 SCLNPLVYVIVGKRF
Y352-p RKKSREVyQAICRKG
S365-p KGGCMGEsVQMENsM
S371-p EsVQMENsMGtLRTs
T374-p QMENsMGtLRTsIsV
S378-p sMGtLRTsIsVDRQI
S380-p GtLRTsIsVDRQIHK
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