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EVL (mouse)

Overview EVL Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes. Belongs to the Ena/VASP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: cytoskeleton; focal adhesion; cell projection; lamellipodium; cytoplasm Molecular Function: protein binding; actin binding; SH3 domain binding; profilin binding Biological Process: axon guidance; platelet activation; actin filament-based movement; actin polymerization and/or depolymerization; barbed-end actin filament capping; actin nucleation; protein homotetramerization Reference #:  P70429 (UniProtKB) Alt. Names/Synonyms: AI528774; Ena-vasodilator stimulated phosphoprotein; Ena/vasodilator-stimulated phosphoprotein-like; Ena/VASP-like protein; Evl Gene Symbols: Evl Molecular weight: 44,337 Da Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states

Select Structure to View Below EVL 1QC6 - A/B=1-130 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	82		Y16-p	ARASVMVyDDTSKKW
0	1		S20	VMVyDDTSKKWVPIK
0	10		Y39-p	GFSRINIyHNTASST
0	1		S150	EQQHRQESLERRISA
1	3		S156	ESLERRISATGPILP
0	1		S169	LPPGHPSSAASTTLS
0	1		S243-p	PEDASGGssPSGTSK
0	4		S244-p	EDASGGssPSGTSKS
0	4		S257-p	KSDANRAsSGGGGGG
0	2		S281-p	AKRRKAAsQTDKPAD
0	1		S294	ADRKEDESQTEDPST
0	1		T301	SQTEDPSTsPSPGTR
0	26		S302-p	QTEDPSTsPSPGTRA
0	4		S304	EDPSTsPSPGTRATS
0	1		S311	SPGTRATSQPPNSSE
0	19		S327-p	GRKPWERsNsVEKPV
0	69		S329-p	KPWERsNsVEKPVSS
0	5		S335	NsVEKPVSSLLsRtP
0	7		S336	sVEKPVSSLLsRtPs
0	18		S339-p	KPVSSLLsRtPsVAK
0	17		T341-p	VSSLLsRtPsVAKsP
0	65		S343-p	SLLsRtPsVAKsPEA
0	72		S347-p	RtPsVAKsPEAKsPL
0	25		S352-p	AKsPEAKsPLQSQPH
0	3		S356	EAKsPLQSQPHSRVK
0	1		S360	PLQSQPHSRVKPAGs
0	14		S367-p	SRVKPAGsVNDVGLD

	human
Y16-p	ARASVMVyDDTsKKW
S20-p	VMVyDDTsKKWVPIK
Y39-p	GFSRINIyHNTASNT
S152-p	HQQQRQEsLERRTsA
S158-p	EsLERRTsATGPILP
S171-p	LPPGHPSsAASAPVS
S245	PEDASGGSsPSGTSK
S246-p	EDASGGSsPSGTSKS
S259-p	KSDANRAsSGGGGGG
S283-p	AKRRKAAsQSDKPAE
S296-p	AEKKEDEsQMEDPSt
T303-p	sQMEDPStsPsPGTR
S304-p	QMEDPStsPsPGTRA
S306-p	EDPStsPsPGTRAAs
S313-p	sPGTRAAsQPPNSSE
S329-p	GRKPWERsNsVEKPV
S331-p	KPWERsNsVEKPVss
S337-p	NsVEKPVssILsRtP
S338-p	sVEKPVssILsRtPs
S341-p	KPVssILsRtPsVAK
T343-p	VssILsRtPsVAKsP
S345-p	sILsRtPsVAKsPEA
S349-p	RtPsVAKsPEAKsPL
S354-p	AKsPEAKsPLQsQPH
S358-p	EAKsPLQsQPHsRMK
S362-p	PLQsQPHsRMKPAGs
S369-p	sRMKPAGsVNDMALD

	rat
Y16	ARASVMVYDDTSKKW
S20	VMVYDDTSKKWVPIK
Y39	GFSRINIYHNTASNT
S150	EQQHRQESLERRISA
S156	ESLERRISATGPILP
S169	LPPGHPSSAASATFS
S243	PEDASGGSSPSGTSK
S244	EDASGGSSPSGTSKS
S257	KSDANRASSGGGGGG
S281	AKRRKAASQTDKPAD
N294	ADRKEDENQTEDPST
T301	NQTEDPSTsPSPGSR
S302-p	QTEDPSTsPSPGSRA
S304	EDPSTsPSPGSRATS
S311	SPGSRATSQPPNSSE
S327	GRKPWERSNsVEKPV
S329-p	KPWERSNsVEKPVSS
S335	NsVEKPVSSLLSRVK
S336	sVEKPVSSLLSRVKP
S339	KPVSSLLSRVKPAGS
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S346	SRVKPAGSVNDVGLD

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