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Protein Page:
EVL (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EVL Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes. Belongs to the Ena/VASP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: focal adhesion; cytoskeleton; cell projection; membrane; lamellipodium; cytoplasm
Molecular Function: protein binding; actin binding; SH3 domain binding; profilin binding
Biological Process: axon guidance; platelet activation; positive regulation of actin filament polymerization; actin filament-based movement; actin polymerization and/or depolymerization; positive regulation of stress fiber formation; barbed-end actin filament capping; protein homotetramerization; actin nucleation
Reference #:  P70429 (UniProtKB)
Alt. Names/Synonyms: AI528774; Ena-vasodilator stimulated phosphoprotein; Ena/vasodilator-stimulated phosphoprotein-like; Ena/VASP-like protein; Evl
Gene Symbols: Evl
Molecular weight: 44,337 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Select Structure to View Below

EVL

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 83 Y16-p ARASVMVyDDTSKKW
0 1 S20 VMVyDDTSKKWVPIK
0 10 Y39-p GFSRINIyHNTASST
0 1 S130 RQVQNGPSPEEMDIQ
0 2 S150 EQQHRQESLERRISA
1 3 S156 ESLERRISATGPILP
0 1 S169 LPPGHPSSAASTTLS
0 2 S240-p VQRPEDAsGGssPsG
0 2 S243-p PEDAsGGssPsGTSK
0 9 S244-p EDAsGGssPsGTSKS
0 1 S246-p AsGGssPsGTSKSDA
0 1 T248 GGssPsGTSKSDANR
0 6 S257-p KSDANRAssGGGGGG
0 2 S258-p SDANRAssGGGGGGL
0 2 S281-p AKRRKAAsQTDKPAD
0 1 S294 ADRKEDESQTEDPsT
0 1 S300-p ESQTEDPsTsPsPGt
0 1 T301 SQTEDPsTsPsPGtR
0 33 S302-p QTEDPsTsPsPGtRA
0 6 S304-p EDPsTsPsPGtRATS
0 1 T307-p sTsPsPGtRATSQPP
0 1 S311 sPGtRATSQPPNSSE
0 22 S327-p GRKPWERsNsVEKPV
0 88 S329-p KPWERsNsVEKPVSS
0 6 S335 NsVEKPVSSLLsRtP
0 7 S336 sVEKPVSSLLsRtPs
0 20 S339-p KPVSSLLsRtPsVAK
0 17 T341-p VSSLLsRtPsVAKsP
0 70 S343-p SLLsRtPsVAKsPEA
0 83 S347-p RtPsVAKsPEAKsPL
0 30 S352-p AKsPEAKsPLQSQPH
0 6 S356 EAKsPLQSQPHSRVK
0 1 S360 PLQSQPHSRVKPAGs
0 22 S367-p SRVKPAGsVNDVGLD
0 1 K397 VRELHKVKEEIIDAI
  human

 
Y16-p ARASVMVyDDTsKKW
S20-p VMVyDDTsKKWVPIK
Y39-p GFSRINIyHNTASNT
S130 RQVQNGPSPDEMDIQ
S152-p HQQQRQEsLERRTsA
S158-p EsLERRTsATGPILP
S171-p LPPGHPSsAASAPVS
S242-p VQRPEDAsGGSsPSG
S245 PEDAsGGSsPSGtSK
S246-p EDAsGGSsPSGtSKS
S248 AsGGSsPSGtSKSDA
T250-p GGSsPSGtSKSDANR
S259-p KSDANRAssGGGGGG
S260-p SDANRAssGGGGGGL
S283-p AKRRKAAsQSDKPAE
S296-p AEKKEDEsQMEDPst
S302-p EsQMEDPstsPsPGT
T303-p sQMEDPstsPsPGTR
S304-p QMEDPstsPsPGTRA
S306-p EDPstsPsPGTRAAs
T309 stsPsPGTRAAsQPP
S313-p sPGTRAAsQPPNSSE
S329-p GRKPWERsNsVEKPV
S331-p KPWERsNsVEKPVss
S337-p NsVEKPVssILsRtP
S338-p sVEKPVssILsRtPs
S341-p KPVssILsRtPsVAK
T343-p VssILsRtPsVAKsP
S345-p sILsRtPsVAKsPEA
S349-p RtPsVAKsPEAKsPL
S354-p AKsPEAKsPLQsQPH
S358-p EAKsPLQsQPHsRMK
S362-p PLQsQPHsRMKPAGs
S369-p sRMKPAGsVNDMALD
K399 VRELHKVKEEIIDAI
  rat

 
Y16 ARASVMVYDDTSKKW
S20 VMVYDDTSKKWVPIK
Y39 GFSRINIYHNTASNT
S130-p RQVQNGPsPEEMDIQ
S150-p EQQHRQEsLERRISA
S156 EsLERRISATGPILP
S169 LPPGHPSSAASATFS
S240 VQRPEDASGGSSPSG
S243 PEDASGGSSPSGTSK
S244 EDASGGSSPSGTSKS
S246 ASGGSSPSGTSKSDA
T248 GGSSPSGTSKSDANR
S257-p KSDANRAsSGGGGGG
S258 SDANRAsSGGGGGGL
S281 AKRRKAASQTDKPAD
N294 ADRKEDENQTEDPST
S300 ENQTEDPSTsPSPGS
T301 NQTEDPSTsPSPGSR
S302-p QTEDPSTsPSPGSRA
S304 EDPSTsPSPGSRATS
S307 STsPSPGSRATSQPP
S311 SPGSRATSQPPNSSE
S327 GRKPWERSNsVEKPV
S329-p KPWERSNsVEKPVSS
S335 NsVEKPVSSLLSRVK
S336 sVEKPVSSLLSRVKP
S339 KPVSSLLSRVKPAGs
- gap
- gap
- gap
- gap
- gap
- gap
S346-p SRVKPAGsVNDVGLD
K376-ac VRELHKVkEEIIDAI
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