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Protein Page:
EVL (mouse)

Overview
EVL Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes. Belongs to the Ena/VASP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: cytoskeleton; focal adhesion; cell projection; lamellipodium; cytoplasm
Molecular Function: protein binding; actin binding; SH3 domain binding; profilin binding
Biological Process: platelet activation; axon guidance; actin filament-based movement; actin polymerization and/or depolymerization; barbed-end actin filament capping; protein homotetramerization; actin nucleation
Reference #:  P70429 (UniProtKB)
Alt. Names/Synonyms: AI528774; Ena-vasodilator stimulated phosphoprotein; Ena/vasodilator-stimulated phosphoprotein-like; Ena/VASP-like protein; Evl
Gene Symbols: Evl
Molecular weight: 44,337 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Select Structure to View Below

EVL

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 82 Y16-p ARASVMVyDDTSKKW
0 10 Y39-p GFSRINIyHNTASST
1 3 S156 ESLERRISATGPILP
0 1 S243-p PEDASGGssPSGTSK
0 4 S244-p EDASGGssPSGTSKS
0 4 S257-p KSDANRAsSGGGGGG
0 2 S281-p AKRRKAAsQTDKPAD
0 27 S302-p QTEDPSTsPsPGTRA
0 4 S304-p EDPSTsPsPGTRATS
0 19 S327-p GRKPWERsNsVEKPV
0 74 S329-p KPWERsNsVEKPVSS
0 5 S335 NsVEKPVSSLLsRtP
0 7 S336 sVEKPVSSLLsRtPs
0 18 S339-p KPVSSLLsRtPsVAK
0 17 T341-p VSSLLsRtPsVAKsP
0 65 S343-p SLLsRtPsVAKsPEA
0 72 S347-p RtPsVAKsPEAKsPL
0 25 S352-p AKsPEAKsPLQSQPH
0 3 S356 EAKsPLQSQPHSRVK
0 16 S367-p SRVKPAGsVNDVGLD
  human

 
Y16-p ARASVMVyDDTSKKW
Y39-p GFSRINIyHNTASNT
S158-p ESLERRTsATGPILP
S245 PEDASGGSsPSGTSK
S246-p EDASGGSsPSGTSKS
S259-p KSDANRAsSGGGGGG
S283-p AKRRKAAsQSDKPAE
S304-p QMEDPSTsPsPGTRA
S306-p EDPSTsPsPGTRAAS
S329-p GRKPWERsNsVEKPV
S331-p KPWERsNsVEKPVss
S337-p NsVEKPVssILsRtP
S338-p sVEKPVssILsRtPs
S341-p KPVssILsRtPsVAK
T343-p VssILsRtPsVAKsP
S345-p sILsRtPsVAKsPEA
S349-p RtPsVAKsPEAKsPL
S354-p AKsPEAKsPLQsQPH
S358-p EAKsPLQsQPHSRMK
S369-p SRMKPAGsVNDMALD
  rat

 
Y16 ARASVMVYDDTSKKW
Y39 GFSRINIYHNTASNT
S156 ESLERRISATGPILP
S243 PEDASGGSSPSGTSK
S244 EDASGGSSPSGTSKS
S257 KSDANRASSGGGGGG
S281 AKRRKAASQTDKPAD
S302-p QTEDPSTsPSPGSRA
S304 EDPSTsPSPGSRATS
S327 GRKPWERSNsVEKPV
S329-p KPWERSNsVEKPVSS
S335 NsVEKPVSSLLSRVK
S336 sVEKPVSSLLSRVKP
S339 KPVSSLLSRVKPAGS
- gap
- gap
- gap
- gap
- gap
S346 SRVKPAGSVNDVGLD
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