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Protein Page:
MUC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MUC1 a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Actin binding protein; Membrane protein, integral
Cellular Component: extracellular space; cell surface; integral to plasma membrane; Golgi lumen; apical plasma membrane; nuclear chromatin; cytoplasm
Molecular Function: protein binding; p53 binding; transcription cofactor activity
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription from RNA polymerase II promoter in response to stress; cellular protein metabolic process; O-glycan processing; post-translational protein modification; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Reference #:  P15941 (UniProtKB)
Alt. Names/Synonyms: Breast carcinoma-associated antigen DF3; Carcinoma-associated mucin; CD227; DF3 antigen; EMA; Episialin; H23 antigen; H23AG; KL-6; MAM6; MUC-1; MUC-1/SEC; MUC-1/X; MUC1; MUC1-alpha; MUC1-beta; MUC1-CT; MUC1-NT; MUC1/ZD; mucin 1, cell surface associated; mucin 1, transmembrane; Mucin-1; Mucin-1 subunit alpha; Mucin-1 subunit beta; Peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin
Gene Symbols: MUC1
Molecular weight: 122,102 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MUC1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: T1224‑p
cell motility, altered: Y1203‑p, Y1218‑p
activity, induced: Y1203‑p
intracellular localization: Y1203‑p, Y1218‑p
molecular association, regulation: Y1203‑p, T1224‑p, S1227‑p, Y1229‑p, Y1243‑p
receptor internalization, altered: Y1243‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S38 PGGEKETSATQRSSV
0 1 S47 TQRSSVPSSTEKNAV
0 1 S989-ga TTTPASKstPFsIPS
0 1 T990-ga TTPASKstPFsIPSH
0 1 S993-ga ASKstPFsIPSHHsD
0 1 S999-ga FsIPSHHsDtPttLA
0 1 T1001-ga IPSHHsDtPttLASH
0 1 T1003-ga SHHsDtPttLASHst
0 1 T1004-ga HHsDtPttLASHstK
0 1 S1009-ga PttLASHstKTDASS
0 1 T1010-ga ttLASHstKTDASST
0 1 - gap
0 1 T1126 TQFNQYKTEAASRYN
0 1 S1140 NLTISDVSVSDVPFP
0 9 Y1191-p CQCRRKNyGQLDIFP
0 45 T1202-p DIFPARDtyHPMsEy
5 338 Y1203-p IFPARDtyHPMsEyP
0 182 S1207-p RDtyHPMsEyPtyHt
0 341 Y1209-p tyHPMsEyPtyHtHG
0 192 T1211-p HPMsEyPtyHtHGRy
1 447 Y1212-p PMsEyPtyHtHGRyV
0 98 T1214-p sEyPtyHtHGRyVPP
1 55 Y1218-p tyHtHGRyVPPsstD
0 5 S1222-p HGRyVPPsstDRsPy
0 3 S1223-p GRyVPPsstDRsPyE
1 3 T1224-p RyVPPsstDRsPyEK
1 14 S1227-p PPsstDRsPyEKVsA
4 435 Y1229-p sstDRsPyEKVsAGN
0 1 S1233-p RsPyEKVsAGNGGSs
0 3 S1240-p sAGNGGSsLsytNPA
0 2 S1242-p GNGGSsLsytNPAVA
3 81 Y1243-p NGGSsLsytNPAVAA
0 4 T1244-p GGSsLsytNPAVAAT
  MUC1 iso6  
S38-p PGGEKETsATQRSSV
S47-p TQRSSVPsSTEKNAI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T60-p AIPAPTTtKSCRETF
T101 TQFNQYKTEAASRYN
S115 NLTISDVSVSDVPFP
Y166 CQCRRKNYGQLDIFP
T177 DIFPARDTYHPMSEY
Y178 IFPARDTYHPMSEYP
S182 RDTYHPMSEYPTYHT
Y184 TYHPMSEYPTYHTHG
T186 HPMSEYPTYHTHGRY
Y187 PMSEYPTYHTHGRYV
T189 SEYPTYHTHGRYVPP
Y193 TYHTHGRYVPPSSTD
S197 HGRYVPPSSTDRSPy
S198 GRYVPPSSTDRSPyE
T199 RYVPPSSTDRSPyEK
S202 PPSSTDRSPyEKVSA
Y204-p SSTDRSPyEKVSAGN
S208 RSPyEKVSAGNGGSS
S215 SAGNGGSSLSYTNPA
S217 GNGGSSLSYTNPAVA
Y218 NGGSSLSYTNPAVAA
T219 GGSSLSYTNPAVAAT
  mouse

 
S40 SSQDTSSSLASTTTP
H49 ASTTTPVHSSNSDPA
G367 ATTPVSNGTQPSVPS
T368 TTPVSNGTQPSVPSQ
S371 VSNGTQPSVPSQYPV
P377 PSVPSQYPVSPTMAT
S379 VPSQYPVSPTMATTS
T381 SQYPVSPTMATTSSH
M382 QYPVSPTMATTSSHS
S387 PTMATTSSHSTIASS
H388 TMATTSSHSTIASSS
- gap
K502-ac SQLIQHKkEADDYNL
K515-ac NLTISEVkVNEMQFP
Y566 CQCRRKSYGQLDIFP
T577 DIFPTQDTYHPMSEY
Y578 IFPTQDTYHPMSEYP
S582 QDTYHPMSEYPTYHT
Y584 TYHPMSEYPTYHTHG
T586 HPMSEYPTYHTHGRY
Y587 PMSEYPTYHTHGRYV
T589 SEYPTYHTHGRYVPP
Y593 TYHTHGRYVPPGStK
G597 HGRYVPPGStKRSPY
S598 GRYVPPGStKRSPYE
T599-p RYVPPGStKRSPYEE
S602 PPGStKRSPYEEVSA
Y604 GStKRSPYEEVSAGN
S608 RSPYEEVSAGNGSSS
S615 SAGNGSSSLSYTNPA
S617 GNGSSSLSYTNPAVV
Y618 NGSSSLSYTNPAVVT
T619 GSSSLSYTNPAVVTT
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y10 CQCRRKSYGQLDLFP
T21 DLFPTRDTyHPMSEY
Y22-p LFPTRDTyHPMSEYP
S26 RDTyHPMSEYPTyHT
Y28 TyHPMSEYPTyHTHG
T30 HPMSEYPTyHTHGRY
Y31-p PMSEYPTyHTHGRYV
T33 SEYPTyHTHGRYVPP
Y37 TyHTHGRYVPPATTK
A41 HGRYVPPATTKRSPY
T42 GRYVPPATTKRSPYE
T43 RYVPPATTKRSPYEE
S46 PPATTKRSPYEEVST
Y48 ATTKRSPYEEVSTGN
S52 RSPYEEVSTGNGSSG
G59 STGNGSSGLSYTNPA
S61 GNGSSGLSYTNPAVA
Y62 NGSSGLSYTNPAVAT
T63 GSSGLSYTNPAVATT
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