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Protein Page:
STAT5B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT5B transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein dimerization activity; signal transducer activity; protein binding; double-stranded DNA binding; calcium ion binding; chromatin binding; transcription factor activity; protein phosphatase binding; glucocorticoid receptor binding
Biological Process: transcription from RNA polymerase II promoter; lactation; succinate metabolic process; oxaloacetate metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; response to lipopolysaccharide; female pregnancy; positive regulation of multicellular organism growth; progesterone metabolic process; positive regulation of mitotic cell cycle; positive regulation of activated T cell proliferation; fatty acid metabolic process; response to estradiol stimulus; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; natural killer cell differentiation; allantoin metabolic process; luteinization; regulation of steroid metabolic process; development of secondary male sexual characteristics; creatinine metabolic process; acute-phase response; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; regulation of cell adhesion; Peyer's patch development; isoleucine metabolic process; negative regulation of erythrocyte differentiation; positive regulation of natural killer cell proliferation; regulation of multicellular organism growth; citrate metabolic process; valine metabolic process; development of secondary female sexual characteristics; positive regulation of cell motility; positive regulation of natural killer cell mediated cytotoxicity; liver development; JAK-STAT cascade; creatine metabolic process; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; response to hypoxia; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; positive regulation of inflammatory response; negative regulation of apoptosis
Reference #:  P51692 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 5B; STA5B; STAT5; STAT5B; transcription factor STAT5B
Gene Symbols: STAT5B
Molecular weight: 89,866 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT5B

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y699‑p
transcription, altered: Y699‑p, S731‑p, Y740‑p, Y743‑p
transcription, induced: S193‑p, Y699‑p, Y725‑p
transcription, inhibited: Y740‑p, Y743‑p
activity, induced: Y699‑p, S731‑p
activity, inhibited: Y740‑p, Y743‑p
molecular association, regulation: S193‑p, Y699‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K84-ac GEDGFLLkIKLGHyA
0 262 Y90-p LkIKLGHyAtQLQNT
0 5 T92-p IKLGHyAtQLQNTYD
0 199 Y114-p RCIRHILyNEQRLVR
0 7 S128-p REANNGSsPAGsLAD
0 2 S132-p NGSsPAGsLADAMSQ
0 1 K164-ub DTENELKkLQQTQEY
0 2 Y171 kLQQTQEYFIIQYQE
1 11 S193-p FGPLAQLsPQERLSR
0 1 K232-ub YRVELAEkHQKTLQL
0 1 K242-ub KTLQLLRkQQTIILD
0 1 K380-ub IISEQQAkSLLkNEN
0 3 K384-ac QQAkSLLkNENTRND
0 2 Y392-p NENTRNDySGEILNN
0 3 Y665-p DRLGDLNyLIyVFPD
0 7 Y668-p GDLNyLIyVFPDRPK
1 0 Y679 DRPKDEVYSKyytPV
0 5 Y682-p KDEVYSKyytPVPCE
0 50 Y683-p DEVYSKyytPVPCES
0 3 T684-p EVYSKyytPVPCESA
0 2 T692-p PVPCESAtAKAVDGy
32 2235 Y699-p tAKAVDGyVKPQIKQ
3 1 Y725-p AGGGSATyMDQAPsP
12 0 S731-p TyMDQAPsPAVCPQA
4 0 Y740-p AVCPQAHyNMyPQNP
4 0 Y743-p PQAHyNMyPQNPDSV
0 1 S787-p QWIPHAQs_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  mouse

 
K84 GEDGFLLKIKLGHYA
Y90 LKIKLGHYATQLQST
T92 IKLGHYATQLQSTYD
Y114-p RCIRHILyNEQRLVR
S128-p REANNGSsPAGsLAD
S132-p NGSsPAGsLADAMSQ
K164 DTENELKKLQQTQEy
Y171-p KLQQTQEyFIIQYQE
N193 FAQLGQLNPQERMSR
K232 YRVELAEKHQKTLQL
K242 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRND
Y392 NENTRNDYSGEILNN
Y665 DRLGDLNYLIYVFPD
Y668 GDLNYLIYVFPDRPK
Y679 DRPKDEVYSKYYTPV
Y682 KDEVYSKYYTPVPCE
Y683 DEVYSKYYTPVPCEP
T684 EVYSKYYTPVPCEPA
T692 PVPCEPATAKAADGy
Y699-p TAKAADGyVKPQIKQ
Y724 DAGSGATYMDQAPsP
S730-p TYMDQAPsPVVCPQA
Y739 VVCPQAHYNMYPPNP
Y742 PQAHYNMYPPNPDSV
S786 QWIPHAQS_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  rat

 
K84 GEDGFLLKIKLGHyA
Y90-p LKIKLGHyATQLQNT
T92 IKLGHyATQLQNTYD
Y114 RCIRHILYNEQRLVR
S128 REANNGSSPAGSLAD
S132 NGSSPAGSLADAMSQ
K164 DTESELKKLQQTQEY
Y171 KLQQTQEYFIIQYQE
N193 FAQLAQLNPQERMSR
K232 YRVELAEKHQKTLQL
K242 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRND
Y392 NENTRNDYSGEILNN
Y665 DRLGDLNYLIYVFPD
Y668 GDLNYLIYVFPDRPK
Y679-p DRPKDEVySKYYTPV
Y682 KDEVySKYYTPVPCE
Y683 DEVySKYYTPVPCER
T684 EVySKYYTPVPCERA
T692 PVPCERATAKAADGy
Y699-p TAKAADGyVKPQIKQ
Y724-p DAGSGATyMDQAPsP
S730-p TyMDQAPsPVVCPQA
Y739 VVCPQAHYNMYPQNP
Y742 PQAHYNMYPQNPDSV
S786 QWIPHAQS_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
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