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STAT5B (human)

Overview STAT5B transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleoplasm; cytosol Molecular Function: signal transducer activity; protein binding; double-stranded DNA binding; calcium ion binding; transcription factor activity; glucocorticoid receptor binding Biological Process: positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; response to lipopolysaccharide; positive regulation of multicellular organism growth; female pregnancy; 2-oxoglutarate metabolic process; sequestering of lipid; allantoin metabolic process; natural killer cell differentiation; regulation of steroid metabolic process; acute-phase response; T cell homeostasis; Peyer's patch development; isoleucine metabolic process; positive regulation of natural killer cell proliferation; valine metabolic process; development of secondary female sexual characteristics; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; negative regulation of apoptosis; lactation; transcription from RNA polymerase II promoter; succinate metabolic process; oxaloacetate metabolic process; positive regulation of smooth muscle cell proliferation; progesterone metabolic process; positive regulation of mitotic cell cycle; positive regulation of activated T cell proliferation; fatty acid metabolic process; response to estradiol stimulus; positive regulation of natural killer cell differentiation; luteinization; development of secondary male sexual characteristics; creatinine metabolic process; positive regulation of gamma-delta T cell differentiation; regulation of cell adhesion; negative regulation of erythrocyte differentiation; cytokine and chemokine mediated signaling pathway; regulation of multicellular organism growth; citrate metabolic process; positive regulation of cell motility; positive regulation of natural killer cell mediated cytotoxicity; liver development; creatine metabolic process; cellular response to hormone stimulus; response to hypoxia; positive regulation of B cell differentiation; positive regulation of inflammatory response Reference #:  P51692 (UniProtKB) Alt. Names/Synonyms: Signal transducer and activator of transcription 5B; STA5B; STAT5; STAT5B; transcription factor STAT5B Gene Symbols: STAT5B Molecular weight: 89,866 Da Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  Jak/Stat/IL-6 Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STAT5B

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 245590 604260  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: Y699‑p transcription, altered: Y699‑p, Y725‑p, S731‑p, Y740‑p, Y743‑p transcription, induced: S193‑p activation: Y699‑p, S731‑p inhibition: Y740‑p, Y743‑p molecular association, regulation: S193‑p, Y699‑p phosphorylation: Y699‑p, Y725‑p, Y740‑p, Y743‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K84-a	GEDGFLLkIKLGHyA
0	261		Y90-p	LkIKLGHyAtQLQNT
0	4		T92-p	IKLGHyAtQLQNTYD
0	201		Y114-p	RCIRHILyNEQRLVR
0	5		S128-p	REANNGSsPAGsLAD
0	1		S132-p	NGSsPAGsLADAMSQ
0	1		K164-u	DTENELKkLQQTQEy
0	2		Y171-p	kLQQTQEyFIIQYQE
1	8		S193-p	FGPLAQLsPQERLSR
0	1		K232-u	YRVELAEkHQKTLQL
0	1		K242-u	KTLQLLRkQQTIILD
0	1		T372-p	NPPQVKAtIIsEQQA
0	1		S375-p	QVKAtIIsEQQAkSL
0	1		K380-u	IIsEQQAkSLLkNEN
0	3		K384-a	QQAkSLLkNENTRND
0	2		Y392-p	NENTRNDySGEILNN
0	3		Y665-p	DRLGDLNyLIyVFPD
0	5		Y668-p	GDLNyLIyVFPDRPK
1	0		Y679	DRPKDEVYSKyytPV
0	5		Y682-p	KDEVYSKyytPVPCE
0	50		Y683-p	DEVYSKyytPVPCES
0	3		T684-p	EVYSKyytPVPCESA
0	2		T692-p	PVPCESAtAKAVDGy
31	2222		Y699-p	tAKAVDGyVKPQIKQ
3	1		Y725-p	AGGGSATyMDQAPsP
10	0		S731-p	TyMDQAPsPAVCPQA
4	0		Y740-p	AVCPQAHyNMyPQNP
4	0		Y743-p	PQAHyNMyPQNPDSV

	mouse
K84	GEDGFLLKIKLGHYA
Y90	LKIKLGHYATQLQST
T92	IKLGHYATQLQSTYD
Y114-p	RCIRHILyNEQRLVR
S128-p	REANNGSsPAGSLAD
S132	NGSsPAGSLADAMSQ
K164	DTENELKKLQQTQEy
Y171-p	KLQQTQEyFIIQYQE
N193	FAQLGQLNPQERMSR
K232	YRVELAEKHQKTLQL
K242	KTLQLLRKQQTIILD
T372	NPPQVKATIISEQQA
S375	QVKATIISEQQAKSL
K380	IISEQQAKSLLKNEN
K384	QQAKSLLKNENTRND
Y392	NENTRNDYSGEILNN
Y665	DRLGDLNYLIYVFPD
Y668	GDLNYLIYVFPDRPK
Y679	DRPKDEVYSKYYTPV
Y682	KDEVYSKYYTPVPCE
Y683	DEVYSKYYTPVPCEP
T684	EVYSKYYTPVPCEPA
T692	PVPCEPATAKAADGy
Y699-p	TAKAADGyVKPQIKQ
Y724	DAGSGATYMDQAPsP
S730-p	TYMDQAPsPVVCPQA
Y739	VVCPQAHYNMYPPNP
Y742	PQAHYNMYPPNPDSV

	rat
K84	GEDGFLLKIKLGHyA
Y90-p	LKIKLGHyATQLQNT
T92	IKLGHyATQLQNTYD
Y114	RCIRHILYNEQRLVR
S128	REANNGSSPAGSLAD
S132	NGSSPAGSLADAMSQ
K164	DTESELKKLQQTQEY
Y171	KLQQTQEYFIIQYQE
N193	FAQLAQLNPQERMSR
K232	YRVELAEKHQKTLQL
K242	KTLQLLRKQQTIILD
T372	NPPQVKATIISEQQA
S375	QVKATIISEQQAKSL
K380	IISEQQAKSLLKNEN
K384	QQAKSLLKNENTRND
Y392	NENTRNDYSGEILNN
Y665	DRLGDLNYLIYVFPD
Y668	GDLNYLIYVFPDRPK
Y679-p	DRPKDEVySKYYTPV
Y682	KDEVySKYYTPVPCE
Y683	DEVySKYYTPVPCER
T684	EVySKYYTPVPCERA
T692	PVPCERATAKAADGy
Y699-p	TAKAADGyVKPQIKQ
Y724-p	DAGSGATyMDQAPsP
S730-p	TyMDQAPsPVVCPQA
Y739	VVCPQAHYNMYPQNP
Y742	PQAHYNMYPQNPDSV

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