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TSC2 (human)

Overview TSC2 a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; Nuclear receptor co-regulator; GTPase activating protein, misc.; Tumor suppressor Cellular Component: TSC1-TSC2 complex; Golgi apparatus; growth cone; cell soma; membrane; perinuclear region of cytoplasm; cytoskeletal part; cytoplasm; dendrite; caveola; nucleus; cytosol Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; GTPase activator activity; phosphatase binding Biological Process: negative regulation of MAP kinase activity; phosphoinositide 3-kinase cascade; regulation of insulin receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of cell cycle; protein heterooligomerization; heart development; negative regulation of cell size; negative regulation of cell proliferation; protein localization; cell projection organization and biogenesis; positive chemotaxis; protein import into nucleus; regulation of endocytosis; protein kinase B signaling cascade; acute-phase response; cell cycle arrest; protein homooligomerization; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; negative regulation of TOR signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; negative regulation of protein kinase B signaling cascade; endocytosis; vesicle-mediated transport; regulation of small GTPase mediated signal transduction; insulin-like growth factor receptor signaling pathway; neural tube closure; response to hypoxia; insulin receptor signaling pathway; negative regulation of protein kinase activity; negative regulation of phosphoinositide 3-kinase cascade Reference #:  P49815 (UniProtKB) Alt. Names/Synonyms: FLJ43106; LAM; TSC2; TSC4; Tuberin; tuberous sclerosis 2; Tuberous sclerosis 2 protein Gene Symbols: TSC2 Molecular weight: 200,608 Da Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TSC2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 191092 191100 606690  |  Source  |  NURSA  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: S939‑p, T1462‑p transcription, altered: S939‑p, T1462‑p inhibition: S939‑p, T1462‑p, S1798‑p intracellular localization: S939‑p, S981‑p molecular association, regulation: S664‑p, S939‑p, S981‑p, S1254‑p phosphorylation: S939‑p, T1462‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K7-a	_MAKPTSkDSGLkEK
0	1		K12-a	TSkDSGLkEKFKILL
0	1		T23-p	KILLGLGtPRPNPRS
0	1		K69-a	GQICEVAkTKkFEEH
0	1		K72-u	CEVAkTKkFEEHAVE
0	1		K144-u	HERLEVFkALTDNGR
0	1		S188-p	VNLVKFNsCYLDEYI
0	1		S403	DQNEFHGSQERYFEL
0	1		Y407	FHGSQERYFELVERC
0	2		K438-u	AQSIHPAkDGWIQNL
1	1		S540-p	KVMARSLsPPPELEE
4	3		S664-p	KKTSGPLsPPTGPPG
0	1		K707	ESDWKVLKLVLGRLP
0	2		T760-p	APEGFSRtDLHLAVV
0	4		K914-u	DFVPFITkGLRSNVL
0	2		S923	LRSNVLLSFDDtPEk
0	15		T927-p	VLLSFDDtPEkDsFR
0	2		K930-u	SFDDtPEkDsFRARs
0	3		S932-p	DDtPEkDsFRARsts
0	2		S937-p	kDsFRARstsLNERP
0	2		T938-p	DsFRARstsLNERPK
15	58		S939-p	sFRARstsLNERPKs
0	3		S946-p	sLNERPKsLRIARPP
1	1		S960-p	PKQGLNNsPPVKEFK
3	21		S981-p	AFRCRSIsVSEHVVR
0	1		K1043	SNFTAVPKRSPVGEF
1	2		S1096-p	QSGPESSssPGVHVR
1	4		S1097-p	SGPESSssPGVHVRQ
1	17		S1130-p	GARDRVRsMsGGHGL
2	24		S1132-p	RDRVRsMsGGHGLRV
1	7		S1155-p	QFLGSATsPGPRTAP
0	1		Y1186-p	EKTNLAAyVPLLTQG
1	0		T1203	EILVRRPTGNTSWLM
0	1		Y1250-p	EHRDTALyKsLsVPA
0	5		S1252-p	RDTALyKsLsVPAAS
4	20		S1254-p	TALyKsLsVPAASTA
0	7		S1269	KPPPLPRSNTVASFS
1	1		T1271	PPLPRSNTVASFSSL
0	2		S1304	AVVMEEGSPGEVPVL
0	2		S1337-p	TDAYSRSssVSsQEE
0	1		S1338-p	DAYSRSssVSsQEEK
1	1		S1341-p	SRSssVSsQEEKsLH
0	29		S1346-p	VSsQEEKsLHAEELV
1	97		S1364-p	IPIERVVssEGGRPs
0	15		S1365-p	PIERVVssEGGRPsV
2	26		S1371-p	ssEGGRPsVDLsFQP
1	8		S1375-p	GRPsVDLsFQPsQPL
2	1		S1379-p	VDLsFQPsQPLsKss
2	1		S1383-p	FQPsQPLsKssssPE
1	5		S1385-p	PsQPLsKssssPELQ
1	2		S1386-p	sQPLsKssssPELQt
6	12		S1387-p	QPLsKssssPELQtL
1	7		S1388-p	PLsKssssPELQtLQ
0	1		T1393-p	sssPELQtLQDILGD
1	19		S1411-p	KADVGRLsPEVKARs
2	5		S1418-p	sPEVKARsQsGtLDG
3	5		S1420-p	EVKARsQsGtLDGEs
0	1		T1422-p	KARsQsGtLDGEsAA
0	1		S1427-p	sGtLDGEsAAWSASG
0	1		S1449-p	EGPLPSSsPRsPsGL
0	1		S1452-p	LPSSsPRsPsGLRPR
0	5		S1454-p	SSsPRsPsGLRPRGy
0	3		Y1461-p	sGLRPRGytISDSAP
38	47		T1462-p	GLRPRGytISDSAPs
0	3		S1469-p	tISDSAPsRRGKRVE
0	1		K1481	RVERDALKSRATASN
2	1		Y1571-p	NEHGSYRyTEFLTGL
0	1		T1697-p	DMEGLVDtSVAKIVs
0	1		S1704-p	tSVAKIVsDRNLPFV
0	13		Y1736-p	RSNPTDIyPSKWIAR
0	23		Y1760-p	RICEEAAysNPsLPL
0	4		S1761-p	ICEEAAysNPsLPLV
0	2		S1764-p	EAAysNPsLPLVHPP
0	9		Y1788-p	PAEPTPGyEVGQRKR
2	79		S1798-p	GQRKRLIssVEDFTE
0	40		S1799-p	QRKRLIssVEDFTEF

	TSC2 iso3
K7-a	_MAKPTSkDSGLkEK
K12-a	TSkDSGLkEKFKILL
T23	KILLGLGTPRPNPRS
K69	GQICEVAKTKKFEEH
K72	CEVAKTKKFEEHAVE
K144	HERLEVFKALTDNGR
S188	VNLVKFNSCYLDEYI
S403	DQNEFHGSQERYFEL
Y407	FHGSQERYFELVERC
K438	AQSIHPAKDGWIQNL
S540	KVMARSLSPPPELEE
S664	KKTSGPLSPPTGPPG
K707	ESDWKVLKLVLGRLP
T760	APEGFSRTDLHLAVV
K914	DFVPFITKGLRSNVL
S923	LRSNVLLSFDDTPEK
T927	VLLSFDDTPEKDsFR
K930	SFDDTPEKDsFRARs
S932-p	DDTPEKDsFRARsTs
S937-p	KDsFRARsTsLNERP
T938	DsFRARsTsLNERPK
S939-p	sFRARsTsLNERPKR
-	gap
-	gap
-	gap
K999	SNFTAVPKRSPVGEF
S1052	QSGPESSSSPGVHVR
S1053	SGPESSSSPGVHVRQ
S1086-p	GARDRVRsMsGGHGL
S1088-p	RDRVRsMsGGHGLRV
S1111-p	QFLGSATsPGPRTAP
Y1142	EKTNLAAYVPLLTQG
T1159	EILVRRPTGNTSWLM
Y1206	EHRDTALYKSLSVPA
S1208	RDTALYKSLSVPAAS
S1210	TALYKSLSVPAASTA
S1225	KPPPLPRSNTVASFS
T1227	PPLPRSNTVASFSSL
S1260	AVVMEEGSPGEVPVL
S1293	TDAYSRSSSVSSQEE
S1294	DAYSRSSSVSSQEEK
S1297	SRSSSVSSQEEKSLH
S1302	VSSQEEKSLHAEELV
S1320-p	IPIERVVsSEGGRPS
S1321	PIERVVsSEGGRPSV
S1327	sSEGGRPSVDLSFQP
S1331	GRPSVDLSFQPSQPL
S1335	VDLSFQPSQPLSKsS
S1339	FQPSQPLSKsSSSPE
S1341-p	PSQPLSKsSSSPELQ
S1342	SQPLSKsSSSPELQT
S1343	QPLSKsSSSPELQTL
S1344	PLSKsSSSPELQTLQ
T1349	SSSPELQTLQDILGD
S1367	KADVGRLSPEVKARS
S1374	SPEVKARSQSGTLDG
S1376	EVKARSQSGTLDGES
T1378	KARSQSGTLDGESAA
S1383	SGTLDGESAAWSASG
S1405	EGPLPSSSPRSPSGL
S1408	LPSSSPRSPSGLRPR
S1410	SSSPRSPSGLRPRGY
Y1417	SGLRPRGYtISDSAP
T1418-p	GLRPRGYtISDSAPS
S1425	tISDSAPSRRGKRVE
K1437	RVERDALKSRATASN
Y1527	NEHGSYRYTEFLTGL
T1653	DMEGLVDTSVAKIVS
S1660	TSVAKIVSDRNLPFV
Y1692	RSNPTDIYPSKWIAR
Y1716	RICEEAAYSNPSLPL
S1717	ICEEAAYSNPSLPLV
S1720	EAAYSNPSLPLVHPP
Y1744	PAEPTPGYEVGQRKR
S1754-p	GQRKRLIssVEDFTE
S1755-p	QRKRLIssVEDFTEF

	TSC2 iso4
K7	_MAKPTSKDSGLKEK
K12	TSKDSGLKEKFKILL
T23	KILLGLGTPRPNPRS
K69	GQICEVAKTKKFEEH
K72	CEVAKTKKFEEHAVE
K144	HERLEVFKALTDNGR
S188	VNLVKFNSCYLDEYI
S403	DQNEFHGSQERYFEL
Y407	FHGSQERYFELVERC
K438	AQSIHPAKDGWIQNL
S540	KVMARSLSPPPELEE
S664	KKTSGPLSPPTGPPG
K707	ESDWKVLKLVLGRLP
T760	APEGFSRTDLHLAVV
K914	DFVPFITKGLRSNVL
S923	LRSNVLLSFDDTPEK
T927	VLLSFDDTPEKDSFR
K930	SFDDTPEKDSFRARS
S932	DDTPEKDSFRARSTS
S937	KDSFRARSTSLNERP
T938	DSFRARSTSLNERPK
S939	SFRARSTSLNERPKS
S946	SLNERPKSLRIARPP
S960	PKQGLNNSPPVKEFK
S981	AFRCRSISVSEHVVR
K1043	SNFTAVPKRSPVGEF
S1096	QSGPESSSSPGVHVR
S1097	SGPESSSSPGVHVRQ
S1130-p	GARDRVRsMsGGHGL
S1132-p	RDRVRsMsGGHGLRV
S1155-p	QFLGSATsPGPRTAP
Y1186	EKTNLAAYVPLLTQG
T1203	EILVRRPTGNTSWLM
Y1250	EHRDTALYKSLsVPA
S1252	RDTALYKSLsVPAAS
S1254-p	TALYKSLsVPAASTA
S1269-p	KPPPLPRsNTDSAVV
T1271	PPLPRsNTDSAVVME
S1281-p	AVVMEEGsPGEVPVL
S1314	TDAYSRSSSVSSQEE
S1315	DAYSRSSSVSSQEEK
S1318	SRSSSVSSQEEKSLH
S1323	VSSQEEKSLHAEELV
S1341-p	IPIERVVsSEGGRPS
S1342	PIERVVsSEGGRPSV
S1348	sSEGGRPSVDLSFQP
S1352	GRPSVDLSFQPSQPL
S1356	VDLSFQPSQPLSKsS
S1360	FQPSQPLSKsSSSPE
S1362-p	PSQPLSKsSSSPELQ
S1363	SQPLSKsSSSPELQT
S1364	QPLSKsSSSPELQTL
S1365	PLSKsSSSPELQTLQ
T1370	SSSPELQTLQDILGD
S1388	KADVGRLSPEVKARS
S1395	SPEVKARSQSGTLDG
S1397	EVKARSQSGTLDGES
T1399	KARSQSGTLDGESAA
S1404	SGTLDGESAAWSASG
S1426	EGPLPSSSPRSPSGL
S1429	LPSSSPRSPSGLRPR
S1431	SSSPRSPSGLRPRGY
Y1438	SGLRPRGYTISDSAP
T1439	GLRPRGYTISDSAPS
S1446	TISDSAPSRRGKRVE
K1458	RVERDALKSRATASN
Y1548	NEHGSYRYTEFLTGL
T1674	DMEGLVDTSVAKIVS
S1681	TSVAKIVSDRNLPFV
Y1713	RSNPTDIYPSKWIAR
Y1737	RICEEAAYSNPSLPL
S1738	ICEEAAYSNPSLPLV
S1741	EAAYSNPSLPLVHPP
Y1765	PAEPTPGYEVGQRKR
S1775	GQRKRLISsVEDFTE
S1776-p	QRKRLISsVEDFTEF

	mouse ► Hide Isoforms
K7	_MAKPTSKDSGLKEK
K12	TSKDSGLKEKFKILL
T23	KILLGLGTSRPNPRC
K69	GQICDVAKTKKLEEH
K72	CDVAKTKKLEEHAVE
K144	HERLEVFKALTDNGR
S188	VNLVKFNSCYLDEYI
S403-p	DQNEFHGsQERyYEL
Y407-p	FHGsQERyYELVESY
K438	AQSIHPAKDGWIQNL
S540	KVMARSLSPPPELEE
S664	KKASGPLSPPTGPPS
K707-a	ESDWKVLkLVLSRLP
T760	TPEGFSRTDLHLAVV
K914-u	DFVPYITkGLRSNVL
S923-p	LRSNVLLsFDDtPEk
T927-p	VLLsFDDtPEkDsFR
K930-u	sFDDtPEkDsFRARS
S932-p	DDtPEkDsFRARSTs
S937	kDsFRARSTsLNERP
T938	DsFRARSTsLNERPK
S939-p	sFRARSTsLNERPKs
S946-p	sLNERPKsLRIARAP
S960	PKQGLNNSPPVKEFK
S981-p	AFRCRSIsVSEHVVR
K1043-u	SNFTAVPkRSPVGEF
S1096	QGGSDSSSDPSTHVR
D1097	GGSDSSSDPSTHVRQ
S1130-p	GARDRVRsMsGGHGL
S1132-p	RDRVRsMsGGHGLRV
S1155	YSPGGSASLGPQTAV
Y1186	EKTNLAAYVPLLTQG
T1203	EILVRRPTGNTSWLM
Q1250	EHGHAPVQVIVSATG
I1252	GHAPVQVIVSATGCT
S1254	APVQVIVSATGCTAK
S1268-p	KPPTLPRsNtVASFS
T1270-p	PTLPRsNtVASFSSL
S1303	AMVLEEGSPGETQVP
S1339	PDTYSRSSSASsQEE
S1340	DTYSRSSSASsQEEK
S1343-p	SRSSSASsQEEKsHL
S1348-p	ASsQEEKsHLEELAA
S1365-p	IPIERAIsSEGARPA
S1366	PIERAIsSEGARPAV
A1372	sSEGARPAVDLSFQP
S1376	ARPAVDLSFQPSQPL
S1380	VDLSFQPSQPLSKsS
S1384	FQPSQPLSKsSssPE
S1386-p	PSQPLSKsSssPELQ
S1387	SQPLSKsSssPELQT
S1388-p	QPLSKsSssPELQTL
S1389-p	PLSKsSssPELQTLQ
T1394	SssPELQTLQDILGD
S1412-p	KIDIGRLsPEAKVRs
S1419-p	sPEAKVRsQsGILDG
S1421-p	EAKVRsQsGILDGEA
I1423	KVRsQsGILDGEAAT
A1428	sGILDGEAATWSATG
S1452	EGPLPSSSPRSPsGL
S1455	LPSSSPRSPsGLRPR
S1457-p	SSSPRSPsGLRPRGY
Y1464	sGLRPRGYtISDSAP
T1465-p	GLRPRGYtISDSAPS
S1472	tISDSAPSRRGKRVE
K1484-a	RVERDNFkSRAAASS
Y1572	NEHGSYRYTEFLTGL
-	gap
-	gap
Y1744	RSNPTDIYPSKWIAR
Y1768	RIREEVHYSNPsLPL
S1769	IREEVHYSNPsLPLM
S1772-p	EVHYSNPsLPLMHPP
Y1795	APEATPTYETGQRKR
S1805-p	GQRKRLIssVDDFTE
S1806-p	QRKRLIssVDDFTEF

	TSC2 iso6
K7	_MAKPTSKDSGLKEK
K12	TSKDSGLKEKFKILL
T23	KILLGLGTSRPNPRC
K69	GQICDVAKTKKLEEH
K72	CDVAKTKKLEEHAVE
K144	HERLEVFKALTDNGR
S188	VNLVKFNSCYLDEYI
S403	DQNEFHGSQERYYEL
Y407	FHGSQERYYELVESY
K438	AQSIHPAKDGWIQNL
S540	KVMARSLSPPPELEE
S664	KKASGPLSPPTGPPS
K707	ESDWKVLKLVLSRLP
T760	TPEGFSRTDLHLAVV
K914	DFVPYITKGLRSNVL
S923	LRSNVLLSFDDtPEK
T927-p	VLLSFDDtPEKDsFR
K930	SFDDtPEKDsFRARS
S932-p	DDtPEKDsFRARSTs
S937	KDsFRARSTsLNERP
T938	DsFRARSTsLNERPK
S939-p	sFRARSTsLNERPKS
S946	sLNERPKSLRIARAP
S960	PKQGLNNSPPVKEFK
S981-p	AFRCRSIsVSEHVVR
K1043	SNFTAVPKRSPVGEF
S1096	QGGSDSSSDPSTHVR
D1097	GGSDSSSDPSTHVRQ
S1130-p	GARDRVRsMsGGHGL
S1132-p	RDRVRsMsGGHGLRV
S1155	YSPGGSASLGPQTAV
Y1186	EKTNLAAYVPLLTQG
T1203	EILVRRPTGNTSWLM
Y1250	EHRDTALYKsLsVPA
S1252-p	RDTALYKsLsVPAAG
S1254-p	TALYKsLsVPAAGTA
S1269-p	KPPTLPRsNTDSAMV
T1271	PTLPRsNTDSAMVLE
S1281	AMVLEEGSPGETQVP
S1317	PDTYSRSSSASSQEE
S1318	DTYSRSSSASSQEEK
S1321	SRSSSASSQEEKSHL
S1326	ASSQEEKSHLEELAA
S1343-p	IPIERAIsSEGARPA
S1344	PIERAIsSEGARPAV
A1350	sSEGARPAVDLSFQP
S1354	ARPAVDLSFQPSQPL
S1358	VDLSFQPSQPLSKSS
S1362	FQPSQPLSKSSSSPE
S1364	PSQPLSKSSSSPELQ
S1365	SQPLSKSSSSPELQT
S1366	QPLSKSSSSPELQTL
S1367	PLSKSSSSPELQTLQ
T1372	SSSPELQTLQDILGD
S1390-p	KIDIGRLsPEAKVRs
S1397-p	sPEAKVRsQsGILDG
S1399-p	EAKVRsQsGILDGEA
I1401	KVRsQsGILDGEAAT
A1406	sGILDGEAATWSATG
S1430	EGPLPSSSPRSPSGL
S1433	LPSSSPRSPSGLRPR
S1435	SSSPRSPSGLRPRGY
Y1442	SGLRPRGYTISDSAP
T1443	GLRPRGYTISDSAPS
S1450	TISDSAPSRRGKRVE
K1462	RVERDNFKSRAAASS
Y1550	NEHGSYRYTEFLTGL
T1677	DMEGLVDTSVAKIVS
S1684	TSVAKIVSDRNLSFV
Y1716	RSNPTDIYPSKWIAR
Y1740	RIREEVHYSNPsLPL
S1741	IREEVHYSNPsLPLM
S1744-p	EVHYSNPsLPLMHPP
Y1767	APEATPTYETGQRKR
S1777-p	GQRKRLIssVDDFTE
S1778-p	QRKRLIssVDDFTEF

	rat ► Hide Isoforms
K7	_MAKPTSKDSGLKEK
K12	TSKDSGLKEKFKILL
T23	KILLGLGTSRPNPRC
K69	GQICDVAKTKKLEEH
K72	CDVAKTKKLEEHAVE
K144	HERLEVFKALTDNGR
S188	VNLVKFNSCYLDEYI
S403	DQNEFHGSQERYYEL
Y407	FHGSQERYYELVESY
K438	AQSIHPAKDGWIQNL
S540	KVMARSLSPPLELEE
S664	KKASGPLSPPTGPPS
K707	ETDWKVLKLVLSKLP
T760	TPEGFSRTDLHLAVV
K914	DFVPYITKGLRSNVL
S923	LRSNVLLSFDDTPEK
T927	VLLSFDDTPEKDKFR
K930	SFDDTPEKDKFRARS
K932	DDTPEKDKFRARSTs
S937	KDKFRARSTsLNERP
T938	DKFRARSTsLNERPK
S939-p	KFRARSTsLNERPKS
S946	sLNERPKSLRIARAP
S960	PKQGLNNSPPVKEFK
S981	AFRCRSISVSEHVVR
K1043	SNFTAVPKRSPVGEF
S1096	QGGSASSSDPGTHVR
D1097	GGSASSSDPGTHVRQ
S1130-p	GARDRVRsMsGGHGL
S1132-p	RDRVRsMsGGHGLRV
S1155	YTPGGPASLGAQAAP
Y1186	EKANLAAYVPLLTQG
T1203-p	EILVRRPtGNTSWLM
Y1250	EHRDTALYKSLsVPA
S1252	RDTALYKSLsVPAAG
S1254-p	TALYKSLsVPAAGTA
S1269	KPPTLPRSNTVASFS
T1271	PTLPRSNTVASFSSL
S1304	AVVLEEGSPGEAHVP
S1340	PDAYSRSSSASSQEE
S1341	DAYSRSSSASSQEEK
S1344	SRSSSASSQEEKSHL
S1349	ASSQEEKSHLEELAA
S1366	IPIERAISSEGARPt
S1367	PIERAISSEGARPtV
T1373-p	SSEGARPtVDLsFQP
S1377-p	ARPtVDLsFQPsQPL
S1381-p	VDLsFQPsQPLsKSS
S1385-p	FQPsQPLsKSSsSPE
S1387	PsQPLsKSSsSPELQ
S1388	sQPLsKSSsSPELQT
S1389-p	QPLsKSSsSPELQTL
S1390	PLsKSSsSPELQTLQ
T1395	SsSPELQTLQDILGD
S1413	KTDIGRLSPEAKVRS
S1420	SPEAKVRSQSGILDG
S1422	EAKVRSQSGILDGEA
I1424	KVRSQSGILDGEAAT
A1429	SGILDGEAATWSAPG
S1453	EGPLPSSSPRSPSGL
S1456	LPSSSPRSPSGLRPR
S1458	SSSPRSPSGLRPRGY
Y1465	SGLRPRGYtISDSAP
T1466-p	GLRPRGYtISDSAPS
S1473	tISDSAPSRRGKRVE
K1485	RVERDNFKSRTAASS
Y1573-p	NEHGSYRyTEFLTGL
T1699	DMEGLVDTSVAKIVS
S1706	TSVAKIVSDRNLSFV
Y1738	RSNPTDIYPSKWIAR
Y1762	RIREEVHYSNPSLPL
S1763	IREEVHYSNPSLPLM
S1766	EVHYSNPSLPLMHPP
Y1790	PTEATPTYETGQRKR
S1800	GQRKRLISSVDDFTE
S1801	QRKRLISSVDDFTEF

	TSC2 iso2
K7	_MAKPTSKDSGLKEK
K12	TSKDSGLKEKFKILL
T23	KILLGLGTSRPNPRC
K69	GQICDVAKTKKLEEH
K72	CDVAKTKKLEEHAVE
K144	HERLEVFKALTDNGR
S188	VNLVKFNSCYLDEYI
S403	DQNEFHGSQERYYEL
Y407	FHGSQERYYELVESY
K438	AQSIHPAKDGWIQNL
S540	KVMARSLSPPLELEE
S664	KKASGPLSPPTGPPS
K707	ETDWKVLKLVLSKLP
T760	TPEGFSRTDLHLAVV
K914	DFVPYITKGLRSNVL
S923	LRSNVLLSFDDTPEK
T927	VLLSFDDTPEKDKFR
K930	SFDDTPEKDKFRARS
K932	DDTPEKDKFRARSTs
S937	KDKFRARSTsLNERP
T938	DKFRARSTsLNERPK
S939-p	KFRARSTsLNERPKS
S946	sLNERPKSRIQTSLT
-	gap
-	gap
K1000	SNFTAVPKRSPVGEF
S1053	QGGSASSSDPGTHVR
D1054	GGSASSSDPGTHVRQ
S1087-p	GARDRVRsMsGGHGL
S1089-p	RDRVRsMsGGHGLRV
S1112	YTPGGPASLGAQAAP
Y1143	EKANLAAYVPLLTQG
T1160	EILVRRPTGNTSWLM
Y1207	EHRDTALYKSLsVPA
S1209	RDTALYKSLsVPAAG
S1211-p	TALYKSLsVPAAGTA
S1226	KPPTLPRSNtVASFS
T1228-p	PTLPRSNtVASFSSL
S1261	AVVLEEGSPGEAHVP
S1297	PDAYSRSSSASSQEE
S1298	DAYSRSSSASSQEEK
S1301	SRSSSASSQEEKSHL
S1306	ASSQEEKSHLEELAA
S1323	IPIERAISSEGARPT
S1324	PIERAISSEGARPTV
T1330	SSEGARPTVDLSFQP
S1334	ARPTVDLSFQPsQPL
S1338-p	VDLSFQPsQPLsKSS
S1342-p	FQPsQPLsKSSsSPE
S1344	PsQPLsKSSsSPELQ
S1345	sQPLsKSSsSPELQT
S1346-p	QPLsKSSsSPELQTL
S1347	PLsKSSsSPELQTLQ
T1352	SsSPELQTLQDILGD
S1370	KTDIGRLSPEAKVRS
S1377	SPEAKVRSQSGILDG
S1379	EAKVRSQSGILDGEA
I1381	KVRSQSGILDGEAAT
A1386	SGILDGEAATWSAPG
S1410	EGPLPSSSPRSPSGL
S1413	LPSSSPRSPSGLRPR
S1415	SSSPRSPSGLRPRGY
Y1422	SGLRPRGYtISDSAP
T1423-p	GLRPRGYtISDSAPS
S1430	tISDSAPSRRGKRVE
K1442	RVERDNFKSRTAASS
Y1530	NEHGSYRYTEFLTGL
T1656	DMEGLVDTSVAKIVS
S1663	TSVAKIVSDRNLSFV
Y1695	RSNPTDIYPSKWIAR
Y1719	RIREEVHYSNPSLPL
S1720	IREEVHYSNPSLPLM
S1723	EVHYSNPSLPLMHPP
Y1747	PTEATPTYETGQRKR
S1757	GQRKRLISSVDDFTE
S1758	QRKRLISSVDDFTEF

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