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Protein Page:
TSC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TSC2 a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator; GAPs, misc.; GAPs; Tumor suppressor
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: TSC1-TSC2 complex; Golgi apparatus; growth cone; membrane; cell soma; perinuclear region of cytoplasm; dendrite; cytoplasm; caveola; nucleus; cytosol
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; GTPase activator activity; phosphatase binding
Biological Process: negative regulation of MAP kinase activity; phosphoinositide 3-kinase cascade; negative regulation of Wnt receptor signaling pathway; regulation of insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of cell cycle; protein heterooligomerization; heart development; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; negative regulation of cell proliferation; positive regulation of Ras GTPase activity; protein localization; positive chemotaxis; cell projection organization and biogenesis; protein import into nucleus; regulation of endocytosis; acute-phase response; protein kinase B signaling cascade; cell cycle arrest; protein homooligomerization; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; negative regulation of TOR signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; endocytosis; vesicle-mediated transport; insulin-like growth factor receptor signaling pathway; neural tube closure; insulin receptor signaling pathway; response to hypoxia; negative regulation of protein kinase activity; innate immune response; negative regulation of phosphoinositide 3-kinase cascade
Reference #:  P49815 (UniProtKB)
Alt. Names/Synonyms: FLJ43106; LAM; TSC2; TSC4; Tuberin; tuberous sclerosis 2; Tuberous sclerosis 2 protein
Gene Symbols: TSC2
Molecular weight: 200,608 Da
Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TSC2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S939‑p, T1462‑p
transcription, altered: S939‑p, T1462‑p
activity, inhibited: S939‑p, T1462‑p, S1798‑p
intracellular localization: S939‑p, S981‑p
molecular association, regulation: S664‑p, S939‑p, S981‑p, S1254‑p
phosphorylation: S939‑p, T1462‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K7-ac _MAKPTSkDSGLkEK
0 1 K12-ac TSkDSGLkEKFKILL
0 1 T23-p KILLGLGtPRPNPRS
0 1 K69-ac GQICEVAkTKkFEEH
0 1 K72-ub CEVAkTKkFEEHAVE
0 1 K144-ub HERLEVFkALTDNGR
0 1 S188-p VNLVKFNsCYLDEYI
0 1 S403 DQNEFHGSQERYFEL
0 1 Y407 FHGSQERYFELVERC
0 2 K438-ub AQSIHPAkDGWIQNL
1 1 S540-p KVMARSLsPPPELEE
0 1 S660 RGSEKKTSGPLsPPT
4 5 S664-p KKTSGPLsPPTGPPG
0 1 T667 SGPLsPPTGPPGPAP
0 1 G671 sPPTGPPGPAPAGPA
0 1 K707 ESDWKVLKLVLGRLP
0 2 T760-p APEGFSRtDLHLAVV
0 4 K914-ub DFVPFITkGLRSNVL
0 2 S923 LRSNVLLSFDDtPEk
0 17 T927-p VLLSFDDtPEkDsFR
0 2 K930-ub SFDDtPEkDsFRARs
0 6 S932-p DDtPEkDsFRARsts
0 2 S937-p kDsFRARstsLNERP
0 2 T938-p DsFRARstsLNERPK
16 64 S939-p sFRARstsLNERPKs
0 3 S946-p sLNERPKsLRIARPP
1 2 S960-p PKQGLNNsPPVKEFK
3 25 S981-p AFRCRSIsVSEHVVR
0 1 K1043 SNFTAVPKRSPVGEF
1 2 S1096-p QSGPESSssPGVHVR
1 6 S1097-p SGPESSssPGVHVRQ
1 18 S1130-p GARDRVRsMsGGHGL
2 42 S1132-p RDRVRsMsGGHGLRV
1 8 S1155-p QFLGSATsPGPRTAP
0 1 Y1186-p EKTNLAAyVPLLTQG
1 0 T1203 EILVRRPTGNTSWLM
0 1 Y1250-p EHRDTALyKsLsVPA
0 5 S1252-p RDTALyKsLsVPAAS
4 25 S1254-p TALyKsLsVPAASTA
0 7 S1269 KPPPLPRSNTVASFS
1 2 T1271 PPLPRSNTVASFSSL
0 4 S1304-p AVVMEEGsPGEVPVL
0 2 S1337-p TDAYSRSssVssQEE
0 1 S1338-p DAYSRSssVssQEEK
0 1 S1340-p YSRSssVssQEEKsL
1 1 S1341-p SRSssVssQEEKsLH
0 35 S1346-p VssQEEKsLHAEELV
1 110 S1364-p IPIERVVssEGGRPs
0 16 S1365-p PIERVVssEGGRPsV
2 30 S1371-p ssEGGRPsVDLsFQP
1 9 S1375-p GRPsVDLsFQPsQPL
2 1 S1379-p VDLsFQPsQPLsKss
2 2 S1383-p FQPsQPLsKssssPE
1 5 S1385-p PsQPLsKssssPELQ
1 3 S1386-p sQPLsKssssPELQt
8 14 S1387-p QPLsKssssPELQtL
1 8 S1388-p PLsKssssPELQtLQ
0 2 T1393-p sssPELQtLQDILGD
1 31 S1411-p KADVGRLsPEVKARs
2 7 S1418-p sPEVKARsQsGtLDG
3 9 S1420-p EVKARsQsGtLDGEs
0 1 T1422-p KARsQsGtLDGEsAA
0 1 S1427-p sGtLDGEsAAWSASG
0 1 S1448-p PEGPLPSssPRsPsG
0 2 S1449-p EGPLPSssPRsPsGL
0 3 S1452-p LPSssPRsPsGLRPR
0 5 S1454-p SssPRsPsGLRPRGy
0 3 Y1461-p sGLRPRGytISDsAP
43 52 T1462-p GLRPRGytISDsAPs
0 1 S1466-p RGytISDsAPsRRGK
0 3 S1469-p tISDsAPsRRGKRVE
0 1 K1481 RVERDALKSRATASN
2 1 Y1571-p NEHGSYRyTEFLTGL
0 1 S1647-p HLGNDFVsIVyNDsG
0 1 Y1650-p NDFVsIVyNDsGEDF
0 1 S1653-p VsIVyNDsGEDFKLG
0 1 S1684-p DYECNLVsLQCRKDM
0 1 T1697-p DMEGLVDtSVAKIVs
0 1 S1704-p tSVAKIVsDRNLPFV
0 15 Y1736-p RSNPTDIyPSKWIAR
0 23 Y1760-p RICEEAAysNPsLPL
0 4 S1761-p ICEEAAysNPsLPLV
0 2 S1764-p EAAysNPsLPLVHPP
0 9 Y1788-p PAEPTPGyEVGQRKR
2 82 S1798-p GQRKRLIssVEDFTE
0 44 S1799-p QRKRLIssVEDFTEF
3615 : Phospho-Tuberin/TSC2 (Ser939) Antibody
3616 : Phospho-Tuberin/TSC2 (Ser1254) Antibody
5584 : Phospho-Tuberin/TSC2 (Ser1387) Antibody
3611 : Phospho-Tuberin/TSC2 (Thr1462) Antibody
3617 : Phospho-Tuberin/TSC2 (Thr1462) (5B12) Rabbit mAb
3614 : Phospho-Tuberin/TSC2 (Tyr1571) Antibody
  TSC2 iso3  
K7 _MAKPTSKDSGLKEK
K12 TSKDSGLKEKFKILL
T23 KILLGLGTPRPNPRS
K69 GQICEVAKTKKFEEH
K72 CEVAKTKKFEEHAVE
K144 HERLEVFKALTDNGR
S188 VNLVKFNSCYLDEYI
S403 DQNEFHGSQERYFEL
Y407 FHGSQERYFELVERC
K438 AQSIHPAKDGWIQNL
S540 KVMARSLSPPPELEE
S660 RGSEKKTSGPLSPPT
S664 KKTSGPLSPPTGPPG
T667 SGPLSPPTGPPGPAP
G671 SPPTGPPGPAPAGPA
K707 ESDWKVLKLVLGRLP
T760 APEGFSRTDLHLAVV
K914 DFVPFITKGLRSNVL
S923 LRSNVLLSFDDTPEK
T927 VLLSFDDTPEKDsFR
K930 SFDDTPEKDsFRARs
S932-p DDTPEKDsFRARsTs
S937-p KDsFRARsTsLNERP
T938 DsFRARsTsLNERPK
S939-p sFRARsTsLNERPKR
- gap
- gap
- gap
K999 SNFTAVPKRSPVGEF
S1052 QSGPESSSSPGVHVR
S1053 SGPESSSSPGVHVRQ
S1086-p GARDRVRsMsGGHGL
S1088-p RDRVRsMsGGHGLRV
S1111-p QFLGSATsPGPRTAP
Y1142 EKTNLAAYVPLLTQG
T1159 EILVRRPTGNTSWLM
Y1206 EHRDTALYKSLSVPA
S1208 RDTALYKSLSVPAAS
S1210 TALYKSLSVPAASTA
S1225 KPPPLPRSNTVASFS
T1227 PPLPRSNTVASFSSL
S1260 AVVMEEGSPGEVPVL
S1293 TDAYSRSSSVSSQEE
S1294 DAYSRSSSVSSQEEK
S1296 YSRSSSVSSQEEKSL
S1297 SRSSSVSSQEEKSLH
S1302 VSSQEEKSLHAEELV
S1320-p IPIERVVsSEGGRPS
S1321 PIERVVsSEGGRPSV
S1327 sSEGGRPSVDLSFQP
S1331 GRPSVDLSFQPSQPL
S1335 VDLSFQPSQPLSKsS
S1339 FQPSQPLSKsSSSPE
S1341-p PSQPLSKsSSSPELQ
S1342 SQPLSKsSSSPELQT
S1343 QPLSKsSSSPELQTL
S1344 PLSKsSSSPELQTLQ
T1349 SSSPELQTLQDILGD
S1367 KADVGRLSPEVKARS
S1374 SPEVKARSQSGTLDG
S1376 EVKARSQSGTLDGES
T1378 KARSQSGTLDGESAA
S1383 SGTLDGESAAWSASG
S1404 PEGPLPSSSPRSPSG
S1405 EGPLPSSSPRSPSGL
S1408 LPSSSPRSPSGLRPR
S1410 SSSPRSPSGLRPRGY
Y1417 SGLRPRGYtISDSAP
T1418-p GLRPRGYtISDSAPS
S1422 RGYtISDSAPSRRGK
S1425 tISDSAPSRRGKRVE
K1437 RVERDALKSRATASN
Y1527 NEHGSYRYTEFLTGL
S1603 HLGNDFVSIVYNDSG
Y1606 NDFVSIVYNDSGEDF
S1609 VSIVYNDSGEDFKLG
S1640 DYECNLVSLQCRKDM
T1653 DMEGLVDTSVAKIVS
S1660 TSVAKIVSDRNLPFV
Y1692 RSNPTDIYPSKWIAR
Y1716 RICEEAAYSNPSLPL
S1717 ICEEAAYSNPSLPLV
S1720 EAAYSNPSLPLVHPP
Y1744 PAEPTPGYEVGQRKR
S1754-p GQRKRLIssVEDFTE
S1755-p QRKRLIssVEDFTEF
5584 : Phospho-Tuberin/TSC2 (Ser1387) Antibody
  TSC2 iso4  
K7 _MAKPTSKDSGLKEK
K12 TSKDSGLKEKFKILL
T23 KILLGLGTPRPNPRS
K69 GQICEVAKTKKFEEH
K72 CEVAKTKKFEEHAVE
K144 HERLEVFKALTDNGR
S188 VNLVKFNSCYLDEYI
S403 DQNEFHGSQERYFEL
Y407 FHGSQERYFELVERC
K438 AQSIHPAKDGWIQNL
S540 KVMARSLSPPPELEE
S660 RGSEKKTSGPLSPPT
S664 KKTSGPLSPPTGPPG
T667 SGPLSPPTGPPGPAP
G671 SPPTGPPGPAPAGPA
K707 ESDWKVLKLVLGRLP
T760 APEGFSRTDLHLAVV
K914 DFVPFITKGLRSNVL
S923 LRSNVLLSFDDTPEK
T927 VLLSFDDTPEKDSFR
K930 SFDDTPEKDSFRARS
S932 DDTPEKDSFRARSTS
S937 KDSFRARSTSLNERP
T938 DSFRARSTSLNERPK
S939 SFRARSTSLNERPKS
S946 SLNERPKSLRIARPP
S960 PKQGLNNSPPVKEFK
S981 AFRCRSISVSEHVVR
K1043 SNFTAVPKRSPVGEF
S1096 QSGPESSSSPGVHVR
S1097 SGPESSSSPGVHVRQ
S1130-p GARDRVRsMsGGHGL
S1132-p RDRVRsMsGGHGLRV
S1155-p QFLGSATsPGPRTAP
Y1186 EKTNLAAYVPLLTQG
T1203 EILVRRPTGNTSWLM
Y1250 EHRDTALYKSLsVPA
S1252 RDTALYKSLsVPAAS
S1254-p TALYKSLsVPAASTA
S1269-p KPPPLPRsNTDSAVV
T1271 PPLPRsNTDSAVVME
S1281-p AVVMEEGsPGEVPVL
S1314 TDAYSRSSSVSSQEE
S1315 DAYSRSSSVSSQEEK
S1317 YSRSSSVSSQEEKSL
S1318 SRSSSVSSQEEKSLH
S1323 VSSQEEKSLHAEELV
S1341-p IPIERVVsSEGGRPS
S1342 PIERVVsSEGGRPSV
S1348 sSEGGRPSVDLSFQP
S1352 GRPSVDLSFQPSQPL
S1356 VDLSFQPSQPLSKsS
S1360 FQPSQPLSKsSSSPE
S1362-p PSQPLSKsSSSPELQ
S1363 SQPLSKsSSSPELQT
S1364 QPLSKsSSSPELQTL
S1365 PLSKsSSSPELQTLQ
T1370 SSSPELQTLQDILGD
S1388 KADVGRLSPEVKARS
S1395 SPEVKARSQSGTLDG
S1397 EVKARSQSGTLDGES
T1399 KARSQSGTLDGESAA
S1404 SGTLDGESAAWSASG
S1425 PEGPLPSSSPRSPSG
S1426 EGPLPSSSPRSPSGL
S1429 LPSSSPRSPSGLRPR
S1431 SSSPRSPSGLRPRGY
Y1438 SGLRPRGYTISDSAP
T1439 GLRPRGYTISDSAPS
S1443 RGYTISDSAPSRRGK
S1446 TISDSAPSRRGKRVE
K1458 RVERDALKSRATASN
Y1548 NEHGSYRYTEFLTGL
S1624 HLGNDFVSIVYNDSG
Y1627 NDFVSIVYNDSGEDF
S1630 VSIVYNDSGEDFKLG
S1661 DYECNLVSLQCRKDM
T1674 DMEGLVDTSVAKIVS
S1681 TSVAKIVSDRNLPFV
Y1713 RSNPTDIYPSKWIAR
Y1737 RICEEAAYSNPSLPL
S1738 ICEEAAYSNPSLPLV
S1741 EAAYSNPSLPLVHPP
Y1765 PAEPTPGYEVGQRKR
S1775 GQRKRLISsVEDFTE
S1776-p QRKRLISsVEDFTEF
5584 : Phospho-Tuberin/TSC2 (Ser1387) Antibody
  mouse

► Hide Isoforms
 
K7 _MAKPTSKDSGLKEK
K12 TSKDSGLKEKFKILL
T23 KILLGLGTSRPNPRC
K69 GQICDVAKTKKLEEH
K72 CDVAKTKKLEEHAVE
K144 HERLEVFKALTDNGR
S188 VNLVKFNSCYLDEYI
S403-p DQNEFHGsQERyYEL
Y407-p FHGsQERyYELVESY
K438 AQSIHPAKDGWIQNL
S540 KVMARSLSPPPELEE
S660-p RASEKKAsGPLsPPt
S664-p KKAsGPLsPPtGPPs
T667-p sGPLsPPtGPPsPVP
S671-p sPPtGPPsPVPMGPA
K707-ac ESDWKVLkLVLSRLP
T760 TPEGFSRTDLHLAVV
K914-ub DFVPYITkGLRSNVL
S923-p LRSNVLLsFDDtPEk
T927-p VLLsFDDtPEkDsFR
K930-ub sFDDtPEkDsFRARS
S932-p DDtPEkDsFRARSTs
S937 kDsFRARSTsLNERP
T938 DsFRARSTsLNERPK
S939-p sFRARSTsLNERPKs
S946-p sLNERPKsLRIARAP
S960 PKQGLNNSPPVKEFK
S981-p AFRCRSIsVSEHVVR
K1043-ub SNFTAVPkRSPVGEF
S1096 QGGSDSSSDPSTHVR
D1097 GGSDSSSDPSTHVRQ
S1130-p GARDRVRsMsGGHGL
S1132-p RDRVRsMsGGHGLRV
S1155 YSPGGSASLGPQTAV
Y1186 EKTNLAAYVPLLTQG
T1203 EILVRRPTGNTSWLM
Q1250 EHGHAPVQVIVSATG
I1252 GHAPVQVIVSATGCT
S1254 APVQVIVSATGCTAK
S1268-p KPPTLPRsNtVASFS
T1270-p PTLPRsNtVASFSSL
S1303 AMVLEEGSPGETQVP
S1339 PDTYSRSSSASsQEE
S1340 DTYSRSSSASsQEEK
S1342 YSRSSSASsQEEKsH
S1343-p SRSSSASsQEEKsHL
S1348-p ASsQEEKsHLEELAA
S1365-p IPIERAIssEGARPA
S1366-p PIERAIssEGARPAV
A1372 ssEGARPAVDLSFQP
S1376 ARPAVDLSFQPSQPL
S1380 VDLSFQPSQPLSKsS
S1384 FQPSQPLSKsSssPE
S1386-p PSQPLSKsSssPELQ
S1387 SQPLSKsSssPELQT
S1388-p QPLSKsSssPELQTL
S1389-p PLSKsSssPELQTLQ
T1394 SssPELQTLQDILGD
S1412-p KIDIGRLsPEAKVRs
S1419-p sPEAKVRsQsGILDG
S1421-p EAKVRsQsGILDGEA
I1423 KVRsQsGILDGEAAT
A1428 sGILDGEAATWSATG
S1451 PEGPLPSSSPRSPsG
S1452 EGPLPSSSPRSPsGL
S1455 LPSSSPRSPsGLRPR
S1457-p SSSPRSPsGLRPRGY
Y1464 sGLRPRGYtISDSAP
T1465-p GLRPRGYtISDSAPS
S1469 RGYtISDSAPSRRGK
S1472 tISDSAPSRRGKRVE
K1484-ac RVERDNFkSRAAASS
Y1572 NEHGSYRYTEFLTGL
S1648 HLGNDFVSIIYNDSG
Y1651 NDFVSIIYNDSGEDF
S1654 VSIIYNDSGEDFKLG
T1686 DYKCNLLTLQCRKDG
- gap
- gap
Y1744 RSNPTDIYPSKWIAR
Y1768 RIREEVHYSNPsLPL
S1769 IREEVHYSNPsLPLM
S1772-p EVHYSNPsLPLMHPP
Y1795 APEATPTYETGQRKR
S1805-p GQRKRLIssVDDFTE
S1806-p QRKRLIssVDDFTEF
3615 : Phospho-Tuberin/TSC2 (Ser939) Antibody
3616 : Phospho-Tuberin/TSC2 (Ser1254) Antibody
5584 : Phospho-Tuberin/TSC2 (Ser1387) Antibody
3611 : Phospho-Tuberin/TSC2 (Thr1462) Antibody
3617 : Phospho-Tuberin/TSC2 (Thr1462) (5B12) Rabbit mAb
3614 : Phospho-Tuberin/TSC2 (Tyr1571) Antibody
  TSC2 iso6  
K7 _MAKPTSKDSGLKEK
K12 TSKDSGLKEKFKILL
T23 KILLGLGTSRPNPRC
K69 GQICDVAKTKKLEEH
K72 CDVAKTKKLEEHAVE
K144 HERLEVFKALTDNGR
S188 VNLVKFNSCYLDEYI
S403 DQNEFHGSQERYYEL
Y407 FHGSQERYYELVESY
K438 AQSIHPAKDGWIQNL
S540 KVMARSLSPPPELEE
S660 RASEKKASGPLSPPT
S664 KKASGPLSPPTGPPS
T667 SGPLSPPTGPPSPVP
S671 SPPTGPPSPVPMGPA
K707 ESDWKVLKLVLSRLP
T760 TPEGFSRTDLHLAVV
K914 DFVPYITKGLRSNVL
S923 LRSNVLLSFDDtPEK
T927-p VLLSFDDtPEKDsFR
K930 SFDDtPEKDsFRARS
S932-p DDtPEKDsFRARSTs
S937 KDsFRARSTsLNERP
T938 DsFRARSTsLNERPK
S939-p sFRARSTsLNERPKS
S946 sLNERPKSLRIARAP
S960 PKQGLNNSPPVKEFK
S981-p AFRCRSIsVSEHVVR
K1043 SNFTAVPKRSPVGEF
S1096 QGGSDSSSDPSTHVR
D1097 GGSDSSSDPSTHVRQ
S1130-p GARDRVRsMsGGHGL
S1132-p RDRVRsMsGGHGLRV
S1155 YSPGGSASLGPQTAV
Y1186 EKTNLAAYVPLLTQG
T1203 EILVRRPTGNTSWLM
Y1250 EHRDTALYKsLsVPA
S1252-p RDTALYKsLsVPAAG
S1254-p TALYKsLsVPAAGTA
S1269-p KPPTLPRsNTDSAMV
T1271 PTLPRsNTDSAMVLE
S1281 AMVLEEGSPGETQVP
S1317 PDTYSRSSSASSQEE
S1318 DTYSRSSSASSQEEK
S1320 YSRSSSASSQEEKSH
S1321 SRSSSASSQEEKSHL
S1326 ASSQEEKSHLEELAA
S1343-p IPIERAIsSEGARPA
S1344 PIERAIsSEGARPAV
A1350 sSEGARPAVDLSFQP
S1354 ARPAVDLSFQPSQPL
S1358 VDLSFQPSQPLSKSS
S1362 FQPSQPLSKSSSSPE
S1364 PSQPLSKSSSSPELQ
S1365 SQPLSKSSSSPELQT
S1366 QPLSKSSSSPELQTL
S1367 PLSKSSSSPELQTLQ
T1372 SSSPELQTLQDILGD
S1390-p KIDIGRLsPEAKVRs
S1397-p sPEAKVRsQsGILDG
S1399-p EAKVRsQsGILDGEA
I1401 KVRsQsGILDGEAAT
A1406 sGILDGEAATWSATG
S1429 PEGPLPSSSPRSPSG
S1430 EGPLPSSSPRSPSGL
S1433 LPSSSPRSPSGLRPR
S1435 SSSPRSPSGLRPRGY
Y1442 SGLRPRGYTISDSAP
T1443 GLRPRGYTISDSAPS
S1447 RGYTISDSAPSRRGK
S1450 TISDSAPSRRGKRVE
K1462 RVERDNFKSRAAASS
Y1550 NEHGSYRYTEFLTGL
S1626 HLGNDFVSIIYNDSG
Y1629 NDFVSIIYNDSGEDF
S1632 VSIIYNDSGEDFKLG
T1664 DYKCNLLTLQCRKDM
T1677 DMEGLVDTSVAKIVS
S1684 TSVAKIVSDRNLSFV
Y1716 RSNPTDIYPSKWIAR
Y1740 RIREEVHYSNPsLPL
S1741 IREEVHYSNPsLPLM
S1744-p EVHYSNPsLPLMHPP
Y1767 APEATPTYETGQRKR
S1777-p GQRKRLIssVDDFTE
S1778-p QRKRLIssVDDFTEF
5584 : Phospho-Tuberin/TSC2 (Ser1387) Antibody
  rat

► Hide Isoforms
 
K7 _MAKPTSKDSGLKEK
K12 TSKDSGLKEKFKILL
T23 KILLGLGTSRPNPRC
K69 GQICDVAKTKKLEEH
K72 CDVAKTKKLEEHAVE
K144 HERLEVFKALTDNGR
S188 VNLVKFNSCYLDEYI
S403 DQNEFHGSQERYYEL
Y407 FHGSQERYYELVESY
K438 AQSIHPAKDGWIQNL
S540 KVMARSLSPPLELEE
S660 RASEKKASGPLSPPT
S664 KKASGPLSPPTGPPS
T667 SGPLSPPTGPPSPVP
S671 SPPTGPPSPVPTGPA
K707 ETDWKVLKLVLSKLP
T760 TPEGFSRTDLHLAVV
K914 DFVPYITKGLRSNVL
S923 LRSNVLLSFDDTPEK
T927 VLLSFDDTPEKDKFR
K930 SFDDTPEKDKFRARS
K932 DDTPEKDKFRARSTs
S937 KDKFRARSTsLNERP
T938 DKFRARSTsLNERPK
S939-p KFRARSTsLNERPKS
S946 sLNERPKSLRIARAP
S960 PKQGLNNSPPVKEFK
S981 AFRCRSISVSEHVVR
K1043 SNFTAVPKRSPVGEF
S1096 QGGSASSSDPGTHVR
D1097 GGSASSSDPGTHVRQ
S1130-p GARDRVRsMsGGHGL
S1132-p RDRVRsMsGGHGLRV
S1155 YTPGGPASLGAQAAP
Y1186 EKANLAAYVPLLTQG
T1203-p EILVRRPtGNTSWLM
Y1250 EHRDTALYKSLsVPA
S1252 RDTALYKSLsVPAAG
S1254-p TALYKSLsVPAAGTA
S1269 KPPTLPRSNTVASFS
T1271 PTLPRSNTVASFSSL
S1304 AVVLEEGSPGEAHVP
S1340 PDAYSRSSSASSQEE
S1341 DAYSRSSSASSQEEK
S1343 YSRSSSASSQEEKSH
S1344 SRSSSASSQEEKSHL
S1349 ASSQEEKSHLEELAA
S1366 IPIERAISSEGARPt
S1367 PIERAISSEGARPtV
T1373-p SSEGARPtVDLsFQP
S1377-p ARPtVDLsFQPsQPL
S1381-p VDLsFQPsQPLsKSS
S1385-p FQPsQPLsKSSsSPE
S1387 PsQPLsKSSsSPELQ
S1388 sQPLsKSSsSPELQT
S1389-p QPLsKSSsSPELQTL
S1390 PLsKSSsSPELQTLQ
T1395 SsSPELQTLQDILGD
S1413-p KTDIGRLsPEAKVRS
S1420 sPEAKVRSQSGILDG
S1422 EAKVRSQSGILDGEA
I1424 KVRSQSGILDGEAAT
A1429 SGILDGEAATWSAPG
S1452 PEGPLPSSSPRSPSG
S1453 EGPLPSSSPRSPSGL
S1456 LPSSSPRSPSGLRPR
S1458 SSSPRSPSGLRPRGY
Y1465 SGLRPRGYtISDSAP
T1466-p GLRPRGYtISDSAPS
S1470 RGYtISDSAPSRRGK
S1473 tISDSAPSRRGKRVE
K1485 RVERDNFKSRTAASS
Y1573-p NEHGSYRyTEFLTGL
S1649 HLGNDFVSIIYNDSG
Y1652 NDFVSIIYNDSGEDF
S1655 VSIIYNDSGEDFKLG
T1686 DYKCNLLTLQCRKDM
T1699 DMEGLVDTSVAKIVS
S1706 TSVAKIVSDRNLSFV
Y1738 RSNPTDIYPSKWIAR
Y1762 RIREEVHYSNPSLPL
S1763 IREEVHYSNPSLPLM
S1766 EVHYSNPSLPLMHPP
Y1790 PTEATPTYETGQRKR
S1800 GQRKRLISSVDDFTE
S1801 QRKRLISSVDDFTEF
3615 : Phospho-Tuberin/TSC2 (Ser939) Antibody
3616 : Phospho-Tuberin/TSC2 (Ser1254) Antibody
5584 : Phospho-Tuberin/TSC2 (Ser1387) Antibody
3611 : Phospho-Tuberin/TSC2 (Thr1462) Antibody
3617 : Phospho-Tuberin/TSC2 (Thr1462) (5B12) Rabbit mAb
3614 : Phospho-Tuberin/TSC2 (Tyr1571) Antibody
  TSC2 iso2  
K7 _MAKPTSKDSGLKEK
K12 TSKDSGLKEKFKILL
T23 KILLGLGTSRPNPRC
K69 GQICDVAKTKKLEEH
K72 CDVAKTKKLEEHAVE
K144 HERLEVFKALTDNGR
S188 VNLVKFNSCYLDEYI
S403 DQNEFHGSQERYYEL
Y407 FHGSQERYYELVESY
K438 AQSIHPAKDGWIQNL
S540 KVMARSLSPPLELEE
S660 RASEKKASGPLSPPT
S664 KKASGPLSPPTGPPS
T667 SGPLSPPTGPPSPVP
S671 SPPTGPPSPVPTGPA
K707 ETDWKVLKLVLSKLP
T760 TPEGFSRTDLHLAVV
K914 DFVPYITKGLRSNVL
S923 LRSNVLLSFDDTPEK
T927 VLLSFDDTPEKDKFR
K930 SFDDTPEKDKFRARS
K932 DDTPEKDKFRARSTs
S937 KDKFRARSTsLNERP
T938 DKFRARSTsLNERPK
S939-p KFRARSTsLNERPKS
S946 sLNERPKSRIQTSLT
- gap
- gap
K1000 SNFTAVPKRSPVGEF
S1053 QGGSASSSDPGTHVR
D1054 GGSASSSDPGTHVRQ
S1087-p GARDRVRsMsGGHGL
S1089-p RDRVRsMsGGHGLRV
S1112 YTPGGPASLGAQAAP
Y1143 EKANLAAYVPLLTQG
T1160 EILVRRPTGNTSWLM
Y1207 EHRDTALYKSLsVPA
S1209 RDTALYKSLsVPAAG
S1211-p TALYKSLsVPAAGTA
S1226 KPPTLPRSNtVASFS
T1228-p PTLPRSNtVASFSSL
S1261 AVVLEEGSPGEAHVP
S1297 PDAYSRSSSASSQEE
S1298 DAYSRSSSASSQEEK
S1300 YSRSSSASSQEEKSH
S1301 SRSSSASSQEEKSHL
S1306 ASSQEEKSHLEELAA
S1323 IPIERAISSEGARPT
S1324 PIERAISSEGARPTV
T1330 SSEGARPTVDLSFQP
S1334 ARPTVDLSFQPsQPL
S1338-p VDLSFQPsQPLsKSS
S1342-p FQPsQPLsKSSsSPE
S1344 PsQPLsKSSsSPELQ
S1345 sQPLsKSSsSPELQT
S1346-p QPLsKSSsSPELQTL
S1347 PLsKSSsSPELQTLQ
T1352 SsSPELQTLQDILGD
S1370 KTDIGRLSPEAKVRS
S1377 SPEAKVRSQSGILDG
S1379 EAKVRSQSGILDGEA
I1381 KVRSQSGILDGEAAT
A1386 SGILDGEAATWSAPG
S1409 PEGPLPSSSPRSPSG
S1410 EGPLPSSSPRSPSGL
S1413 LPSSSPRSPSGLRPR
S1415 SSSPRSPSGLRPRGY
Y1422 SGLRPRGYtISDSAP
T1423-p GLRPRGYtISDSAPS
S1427 RGYtISDSAPSRRGK
S1430 tISDSAPSRRGKRVE
K1442 RVERDNFKSRTAASS
Y1530 NEHGSYRYTEFLTGL
S1606 HLGNDFVSIIYNDSG
Y1609 NDFVSIIYNDSGEDF
S1612 VSIIYNDSGEDFKLG
T1643 DYKCNLLTLQCRKDM
T1656 DMEGLVDTSVAKIVS
S1663 TSVAKIVSDRNLSFV
Y1695 RSNPTDIYPSKWIAR
Y1719 RIREEVHYSNPSLPL
S1720 IREEVHYSNPSLPLM
S1723 EVHYSNPSLPLMHPP
Y1747 PTEATPTYETGQRKR
S1757 GQRKRLISSVDDFTE
S1758 QRKRLISSVDDFTEF
5584 : Phospho-Tuberin/TSC2 (Ser1387) Antibody
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