a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Note: This description may include information from UniProtKB.
Biological Process: circadian rhythm; establishment and/or maintenance of chromatin architecture; positive regulation of cell size; positive regulation of translation; viral reproduction; positive regulation of protein binding; regulation of cell cycle; apoptosis; positive regulation of proteolysis; heart development; positive regulation of axon extension; positive regulation of collagen biosynthetic process; response to glucocorticoid stimulus; regulation of angiotensin metabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; protein kinase B signaling cascade; positive regulation of interferon type I production; response to glucose stimulus; G2/M transition of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; positive regulation of DNA binding; response to drug; nervous system development; somitogenesis; Notch signaling pathway; skeletal muscle development; response to retinoic acid; internal peptidyl-lysine acetylation; positive regulation of protein import into nucleus, translocation; transcription, DNA-dependent; liver development; protein-DNA complex assembly; organ morphogenesis; response to ethanol; positive regulation of protein secretion; gut development; response to estrogen stimulus; response to hypoxia; response to cobalt ion; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; response to calcium ion; internal protein amino acid acetylation; N-terminal peptidyl-lysine acetylation; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.