a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Note: This description may include information from UniProtKB.
Molecular Function: lysine N-acetyltransferase activity; zinc ion binding; transcription coactivator activity; transcription factor binding; NF-kappaB binding; androgen receptor binding; protein complex binding; mitogen-activated protein kinase binding; protein C-terminus binding; peroxisome proliferator activated receptor binding; transcription activator binding; p53 binding; chromatin DNA binding; beta-catenin binding; protein binding; histone acetyltransferase activity; DNA binding; acetyltransferase activity; transferase activity, transferring acyl groups; damaged DNA binding; bHLH transcription factor binding; chromatin binding; SMAD binding; nuclear hormone receptor binding; glucocorticoid receptor binding
Biological Process: stimulatory C-type lectin receptor signaling pathway; circadian rhythm; fat cell differentiation; establishment and/or maintenance of chromatin architecture; viral reproduction; regulation of cell cycle; positive regulation of proteolysis; heart development; positive regulation of axon extension; regulation of angiotensin metabolic process; G2/M transition of mitotic cell cycle; positive regulation of DNA binding; nervous system development; somitogenesis; skeletal muscle development; internal peptidyl-lysine acetylation; positive regulation of protein import into nucleus, translocation; protein-DNA complex assembly; organ morphogenesis; response to ethanol; positive regulation of protein secretion; response to estrogen stimulus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; response to calcium ion; transcription from RNA polymerase II promoter; positive regulation of translation; positive regulation of cell size; positive regulation of protein binding; apoptosis; positive regulation of collagen biosynthetic process; positive regulation of transcription of target genes involved in unfolded protein response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; regulation of transcription, DNA-dependent; positive regulation of interferon type I production; protein kinase B signaling cascade; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; Notch signaling pathway; protein stabilization; liver development; memory; protein amino acid acetylation; positive regulation of muscle atrophy; gut development; response to cobalt ion; response to hypoxia; innate immune response; positive regulation of histone acetylation; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; internal protein amino acid acetylation; lung development; N-terminal peptidyl-lysine acetylation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.