a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Note: This description may include information from UniProtKB.
Biological Process: establishment and/or maintenance of chromatin architecture; viral reproduction; positive regulation of cell size; positive regulation of translation; positive regulation of protein binding; apoptosis; positive regulation of proteolysis; regulation of cell cycle; positive regulation of axon extension; heart development; response to glucocorticoid stimulus; positive regulation of collagen biosynthetic process; regulation of angiotensin metabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; protein kinase B signaling cascade; response to glucose stimulus; positive regulation of interferon type I production; G2/M transition of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; positive regulation of DNA binding; response to drug; nervous system development; skeletal muscle development; somitogenesis; Notch signaling pathway; response to retinoic acid; internal peptidyl-lysine acetylation; transcription, DNA-dependent; positive regulation of protein import into nucleus, translocation; liver development; protein-DNA complex assembly; organ morphogenesis; response to ethanol; gut development; positive regulation of protein secretion; response to estrogen stimulus; response to hypoxia; response to cobalt ion; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; response to calcium ion; N-terminal peptidyl-lysine acetylation; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.