a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Note: This description may include information from UniProtKB.
Biological Process: circadian rhythm; establishment and/or maintenance of chromatin architecture; positive regulation of cell size; viral reproduction; positive regulation of protein binding; positive regulation of translation; apoptosis; regulation of cell cycle; positive regulation of proteolysis; heart development; positive regulation of axon extension; positive regulation of collagen biosynthetic process; response to glucocorticoid stimulus; regulation of angiotensin metabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to glucose stimulus; positive regulation of interferon type I production; protein kinase B signaling cascade; G2/M transition of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; positive regulation of DNA binding; response to drug; nervous system development; somitogenesis; Notch signaling pathway; skeletal muscle development; internal peptidyl-lysine acetylation; response to retinoic acid; positive regulation of protein import into nucleus, translocation; transcription, DNA-dependent; liver development; protein-DNA complex assembly; organ morphogenesis; response to ethanol; gut development; positive regulation of protein secretion; response to estrogen stimulus; response to cobalt ion; response to hypoxia; innate immune response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; response to calcium ion; internal protein amino acid acetylation; N-terminal peptidyl-lysine acetylation; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.