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merlin (human)

Overview merlin a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; adherens junction; cytoskeleton; extrinsic to membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; plasma membrane; nucleolus; nucleus; cleavage furrow Molecular Function: protein binding; cytoskeletal protein binding Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; Schwann cell proliferation; negative regulation of cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; negative regulation of tyrosine phosphorylation of Stat3 protein; ectoderm development; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; actin cytoskeleton organization and biogenesis; negative regulation of cell migration; negative regulation of JAK-STAT cascade Reference #:  P35240 (UniProtKB) Alt. Names/Synonyms: ACN; BANF; MERL; Merlin; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Neurofibromin-2; NF2; SCH; Schwannomerlin; Schwannomin Gene Symbols: NF2 Molecular weight: 69,690 Da Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below merlin 1H4R - A/B=1-313 (human) 3U8Z - A/D/C/B=18-312 (human) 1ISN - A=18-340 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1H4R 3U8Z  |  Phospho3D  |  DISEASE 101000 162091 607174 607379  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: S518‑p cell cycle regulation: S518‑p cell growth, altered: S518‑p cell motility, altered: S10‑p, S518‑p cytoskeletal reorganization: S10‑p, S518‑p transcription, altered: S518‑p inhibition: S518‑p intracellular localization: S518‑p molecular association, regulation: S518‑p phosphorylation: S518‑p protein conformation: S518‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		S10-p	GAIASRMsFSsLKRK
0	8		S13-p	ASRMsFSsLKRKQPK
0	4		K80-u	AWLKMDKkVLDHDVS
0	1		K159-u	DYDPSVHkRGFLAQE
2	0		T230-p	AIRNKKGtELLLGVD
0	1		K269-u	RNISYSDkEFTIKPL
0	1		K279-a	TIKPLDKkIDVFKFN
2	0		S315-p	MRRRKADsLEVQQMK
0	2		R351-m2	QMREEAErTrDELER
0	2		R353-m2	REEAErTrDELERRL
0	1		K364	ERRLLQMKEEATMAN
0	1		K387-u	TADLLAEkAQITEEE
0	7		K396-u	QITEEEAkLLAQkAA
0	1		K401-u	EAkLLAQkAAEAEQE
0	1		K439	EAEVLALKMAEESER
0	1		T477-p	QKLLEIAtKPTYPPM
20	12		S518-p	DTDMKRLsMEIEKEK
0	1		K543	QEQLNELKTEIEALK
0	4		T581-p	HNTIKKLtLQSAKsR
0	1		S587-p	LtLQSAKsRVAFFEE

	mouse
S10	GAIASRMSFSsLKRK
S13-p	ASRMSFSsLKRKQPK
K80-u	AWLKMDKkVLDHDVS
K159	DYDPSVHKRGFLAQE
T230	TIRNKKGTELLLGVD
K269	RNISYSDKEFTIKPL
K279	TIKPLDKKIDVFKFN
S315	MRRRKADSLEVQQMK
R351	QMREEAERTRDELER
R353	REEAERTRDELERRL
K364-u	ERRLLQMkEEATMAN
K387	TADLLAEKAQITEEE
K396-u	QITEEEAkLLAQKAA
K401	EAkLLAQKAAEAEQE
K439-a	EAEVLALkMAEESER
T477	QKLLEIATKPTYPPM
S518-p	DTDMKRLsMEIEKEK
K543-a	QEQLNELkTEIEALK
T582-p	HNTIKKLtLQSAKSR
S588	LtLQSAKSRVAFFEE

	rat
S6	__IASRMSFSSLKRK
S9	ASRMSFSSLKRKQPK
K76	AWLKMDKKVLDHDVS
K155	DYDPSVHKRGFLAQE
T226	TIRNKKGTELLLGVD
K265	RNISYSDKEFTIKPL
K275	TIKPLDKKIDVFKFN
S311	MRRRKADSLEVQQMK
R347	QMREEAERSRDEPER
R349	REEAERSRDEPERRV
K360	ERRVLHMKEEATMAN
K383	TADLLAEKAQITEEE
K392	QITEEEAKLLAQKAA
K397	EAKLLAQKAAEAEQE
K435	EAEVLALKMAEESER
T473	QKLLEIATKPTYPPM
S514-p	DTDMKRLsMEIEKEK
K539	QEQLNELKTEIEALK
Q577	HNTIKKPQAQGRRPI
-	gap

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