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Protein Page:
Rad17 (human)

Overview
Rad17 a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. Binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. Phosphorylated and activated after DNA damage, inducing cell cycle G2 arrest. Eight alternatively spliced variants have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; chromosome, telomeric region; nucleolus; nucleus
Molecular Function: protein binding; nucleoside-triphosphatase activity; ATP binding
Biological Process: regulation of phosphorylation; negative regulation of DNA replication; mitotic cell cycle checkpoint; DNA damage checkpoint; DNA replication checkpoint; DNA repair; DNA replication; response to DNA damage stimulus
Reference #:  O75943 (UniProtKB)
Alt. Names/Synonyms: CCYC; cell cycle checkpoint protein (RAD17); Cell cycle checkpoint protein RAD17; FLJ41520; hRad17; R24L; RAD1 homolog; RAD17; RAD17 homolog (S. pombe); Rad17-like protein; RAD17SP; RAD24; RF-C activator 1 homolog; RF-C/activator 1 homolog
Gene Symbols: RAD17
Molecular weight: 77,055 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rad17

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S646‑p, S656‑p
cell growth, altered: S646‑p, S656‑p
molecular association, regulation: S646‑p, S656‑p
phosphorylation: S646‑p, S656‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T55-p RRKNGPStLESSRFP
0 2 S71-p RKRGNLSsLEQIYGL
0 1 S81-p QIYGLENsKEYLsEN
0 3 S86-p ENsKEYLsENEPWVD
0 2 T304-p KFLNRIVtIEANKNG
0 1 S335-p GCSGDIRsAINSLQF
0 7 S359-p RPRKKGMsLKsDAVL
0 1 S362-p KKGMsLKsDAVLsKS
0 1 S367-p LKsDAVLsKSKRRKK
0 1 S416-p ASLTELDsPRLPSHL
1 0 T633-p EESLGEPtQATVPET
8 0 S646-p ETWSLPLsQNSASEL
9 0 S656-p SASELPAsQPQPFSA
13404 : Phospho-Rad17 (Ser635) (D6K9P) Rabbit mAb
6981 : Phospho-Rad17 (Ser645) (D5H5) Rabbit mAb
  mouse

 
T55 RRKYLPSTLESNRLS
S70 ARKRGRLSLEQTHGL
S80 QTHGLETSRERLSDN
S85 ETSRERLSDNEPWVD
T303 KFLNRIVTIEASKNG
S334 GCSGDIRSAINSLQF
S358 WSKKKRMSLKSDAAI
S361 KKRMSLKSDAAISKS
S366 LKSDAAISKSKQKKK
S415 APLTELDSPRLPAHL
A631 QEAPGEPAQAAQNAD
S647 ETWSLPLSQNSGSDL
S657 SGSDLPASQPQPFSS
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