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Rad17 (human)

Overview Rad17 a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. Binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. Phosphorylated and activated after DNA damage, inducing cell cycle G2 arrest. Eight alternatively spliced variants have been reported. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: nucleoplasm; chromosome, telomeric region; nucleolus; nucleus Molecular Function: protein binding; nucleoside-triphosphatase activity; ATP binding Biological Process: regulation of phosphorylation; negative regulation of DNA replication; mitotic cell cycle checkpoint; DNA damage checkpoint; DNA replication checkpoint; DNA repair; DNA replication; cell cycle checkpoint; response to DNA damage stimulus Reference #:  O75943 (UniProtKB) Alt. Names/Synonyms: CCYC; cell cycle checkpoint protein (RAD17); Cell cycle checkpoint protein RAD17; FLJ41520; hRad17; R24L; RAD1 homolog; RAD17; RAD17 homolog (S. pombe); Rad17-like protein; RAD17SP; RAD24; RF-C activator 1 homolog; RF-C/activator 1 homolog Gene Symbols: RAD17 Molecular weight: 77,055 Da Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rad17

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	Sites Implicated In
cell cycle regulation: S646‑p, S656‑p cell growth, altered: S646‑p, S656‑p molecular association, regulation: S646‑p, S656‑p phosphorylation: S646‑p, S656‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T55-p	RRKNGPStLESSRFP
0	1		S71-p	RKRGNLSsLEQIYGL
0	1		S81-p	QIYGLENsKEYLsEN
0	2		S86-p	ENsKEYLsENEPWVD
0	1		T304-p	KFLNRIVtIEANKNG
0	1		S335-p	GCSGDIRsAINSLQF
0	6		S359-p	RPRKKGMsLKsDAVL
0	1		S362-p	KKGMsLKsDAVLsKS
0	1		S367-p	LKsDAVLsKSKRRKK
8	0		S646-p	ETWSLPLsQNSASEL
7	0		S656-p	SASELPAsQPQPFSA

	mouse
T55	RRKYLPSTLESNRLS
S70	ARKRGRLSLEQTHGL
S80	QTHGLETSRERLSDN
S85	ETSRERLSDNEPWVD
T303	KFLNRIVTIEASKNG
S334	GCSGDIRSAINSLQF
S358	WSKKKRMSLKSDAAI
S361	KKRMSLKSDAAISKS
S366	LKSDAAISKSKQKKK
S647	ETWSLPLSQNSGSDL
S657	SGSDLPASQPQPFSS

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