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Protein Page:
Grb10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Grb10 an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; insulin receptor binding
Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of insulin receptor signaling pathway; positive regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; response to insulin stimulus; negative regulation of glycogen biosynthetic process
Reference #:  Q13322 (UniProtKB)
Alt. Names/Synonyms: Grb-10; GRB-IR; GRB10; GRB10 adapter protein; GRB10 adaptor protein; GRBIR; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; maternally expressed gene 1; MEG1; RSS
Gene Symbols: GRB10
Molecular weight: 67,231 Da
Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Grb10

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: S150‑p, S476‑p
molecular association, regulation: Y67‑p
protein stabilization: S104‑p, S150‑p, T155‑p, S428‑p, S476‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 Y67-p NASLESLySACSMQS
1 11 S104-p RSIQPQVsPRQRVQR
0 1 S112-p PRQRVQRsQPVHILA
0 1 T132 EEDQQFRTSSLPAIP
2 4 S150-p PELCGPGsPPVLtPG
0 2 V153 CGPGsPPVLtPGSLP
1 1 T155-p PGsPPVLtPGSLPPS
0 1 G157 sPPVLtPGSLPPSQA
0 2 S158 PPVLtPGSLPPSQAA
0 1 - gap
0 1 - gap
0 1 - gap
0 1 K300-ac IQGFLHVkELGkKSW
0 1 K304-ac LHVkELGkKSWKKLY
0 15 K304-ub LHVkELGkKSWKKLY
0 1 R316-m1 KLYVCLRrSGLYCST
0 1 T388 AEDEQTRTCWMTAFR
0 60 Y404-p LKYGMLLyQNYRIPQ
0 1 K414 YRIPQQRKALLsPFS
0 13 S418-p QQRKALLsPFStPVR
0 15 T422-p ALLsPFStPVRsVsE
0 2 S426-p PFStPVRsVsENSLV
2 5 S428-p StPVRsVsENSLVAM
0 4 S431 VRsVsENSLVAMDFS
2 5 S474-p TRMNILGsQsPLHPS
4 24 S476-p MNILGsQsPLHPSTL
0 1 K508 EESHRIIKQQGLVDG
3701 : Phospho-GRB10 (Tyr67) Antibody
11817 : Phospho-GRB10 (Ser476) (D4E6) Rabbit mAb
  mouse

 
N13 NSSVESLNSACNMQS
S50-p SRGQPQAsPRQKMQR
S58 PRQKMQRSQPVHILR
T76-p EEDQQLRtASLPAIP
S96-p LTGAAPGsPPsVAPs
S99-p AAPGsPPsVAPssLP
A101 PGsPPsVAPssLPPP
S103-p sPPsVAPssLPPPPS
S104-p PPsVAPssLPPPPSQ
T160-p RPGLWTKtTARFsKK
S165-p TKtTARFsKKQPKNQ
K191-ub MPTSQMEkLRLRKDV
K328 IQGFLQVKEVGRKSW
R332 LQVKEVGRKSWKKLY
R332 LQVKEVGRKSWKKLY
R344 KLYVCLRRSGLYYST
T416-p AEDEQIRtCWMTAFR
Y432 LKYGMLLYQNYRIPQ
K441-ub NYRIPQRkGLPPPFN
P445 PQRkGLPPPFNAPMR
A449 GLPPPFNAPMRsVsE
S453-p PFNAPMRsVsENsLV
S455-p NAPMRsVsENsLVAM
S458-p MRsVsENsLVAMDFS
S501-p TRMNILSsQsPLHPS
S503-p MNILSsQsPLHPSTL
K535-ub EESHRIIkQQGLVDG
11817 : Phospho-GRB10 (Ser476) (D4E6) Rabbit mAb
  rat

 
N13 NSSVESLNSACNMQS
S50 SRGQPQASPRQKMQR
S58 PRQKMQRSQPVHIQP
T78 EEDQQLRTSSLPAIP
S98 LAGGAPGSPPSVAPS
S101 GAPGSPPSVAPSSLP
A103 PGSPPSVAPSSLPPP
S105 SPPSVAPSSLPPPPS
S106 PPSVAPSSLPPPPSQ
T137 RPGLWTKTTARFSKR
S142 TKTTARFSKRQPKNQ
K168 IPTSQMEKLRLRKDV
K305 IQGFLQVKEVGRKSW
R309 LQVKEVGRKSWKKLY
R309 LQVKEVGRKSWKKLY
R321 KLYVCLRRSGLYYST
T393 AEDEQIRTCWMTAFR
Y409 LKYGMLLYQNYRIPQ
K419 YRIPQQRKGLAPPFN
P423 QQRKGLAPPFNAPMR
A427 GLAPPFNAPMRSVSE
S431 PFNAPMRSVSENsLV
S433 NAPMRSVSENsLVAM
S436-p MRSVSENsLVAMDFS
S479-p TRMNILSsQsPLHPS
S481-p MNILSsQsPLHPSTL
K513 EESHRIIKQQGLVDG
11817 : Phospho-GRB10 (Ser476) (D4E6) Rabbit mAb
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