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Grb10 (human)

Overview Grb10 an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: cytoplasm; plasma membrane; cytosol Molecular Function: protein binding; SH3/SH2 adaptor activity; phospholipid binding; insulin receptor binding Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphorylation; response to insulin stimulus; negative regulation of glycogen biosynthetic process Reference #:  Q13322 (UniProtKB) Alt. Names/Synonyms: Grb-10; GRB-IR; GRB10; GRB10 adapter protein; GRB10 adaptor protein; GRBIR; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; maternally expressed gene 1; MEG1; RSS Gene Symbols: GRB10 Molecular weight: 67,231 Da Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Grb10 1NRV - A/B=487-591 (human) 3HK0 - A/B=164-415 (human) 3M7F - A=514-621 (mouse)

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	Sites Implicated In
inhibition: S150‑p, S476‑p molecular association, regulation: Y67‑p protein stabilization: S104‑p, S150‑p, T155‑p, S428‑p, S476‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		Y67-p	NASLESLySACSMQS
1	7		S104-p	RSIQPQVsPRQRVQR
0	1		T132	EEDQQFRTSSLPAIP
2	4		S150-p	PELCGPGsPPVLtPG
0	2		V153	CGPGsPPVLtPGSLP
1	1		T155-p	PGsPPVLtPGSLPPS
0	1		G157	sPPVLtPGSLPPSQA
0	2		S158	PPVLtPGSLPPSQAA
0	1		-	gap
0	1		-	gap
0	1		-	gap
0	1		K300-a	IQGFLHVkELGkKSW
0	1		K304-a	LHVkELGkKSWKKLY
0	15		K304-u	LHVkELGkKSWKKLY
0	1		R316-m1	KLYVCLRrSGLYCST
0	1		T388	AEDEQTRTCWMTAFR
0	61		Y404-p	LKYGMLLyQNYRIPQ
0	1		Y407	GMLLyQNYRIPQQRK
0	1		K414	YRIPQQRKALLsPFS
0	9		S418-p	QQRKALLsPFStPVR
0	13		T422-p	ALLsPFStPVRSVsE
0	1		S426	PFStPVRSVsENSLV
2	3		S428-p	StPVRSVsENSLVAM
0	4		S431	VRSVsENSLVAMDFS
0	3		S474-p	TRMNILGsQsPLHPS
2	14		S476-p	MNILGsQsPLHPSTL
0	1		K508	EESHRIIKQQGLVDG

	mouse
N13	NSSVESLNSACNMQS
S50-p	SRGQPQAsPRQKMQR
T76-p	EEDQQLRtASLPAIP
S96-p	LTGAAPGsPPsVAPs
S99-p	AAPGsPPsVAPssLP
A101	PGsPPsVAPssLPPP
S103-p	sPPsVAPssLPPPPS
S104-p	PPsVAPssLPPPPSQ
T160-p	RPGLWTKtTARFsKK
S165-p	TKtTARFsKKQPKNQ
K191-u	MPTSQMEkLRLRKDV
K328	IQGFLQVKEVGRKSW
R332	LQVKEVGRKSWKKLY
R332	LQVKEVGRKSWKKLY
R344	KLYVCLRRSGLYYST
T416-p	AEDEQIRtCWMTAFR
Y432	LKYGMLLYQNYRIPQ
Y435	GMLLYQNYRIPQRkG
K441-u	NYRIPQRkGLPPPFN
P445	PQRkGLPPPFNAPMR
A449	GLPPPFNAPMRsVsE
S453-p	PFNAPMRsVsENsLV
S455-p	NAPMRsVsENsLVAM
S458-p	MRsVsENsLVAMDFS
S501-p	TRMNILSsQsPLHPS
S503-p	MNILSsQsPLHPSTL
K535-u	EESHRIIkQQGLVDG

	rat
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K3	_____MEKLRLRKDV
K140	IQGFLQVKEVGRKSW
R144	LQVKEVGRKSWKKLY
R144	LQVKEVGRKSWKKLY
R156	KLYVCLRRSGLYYST
T228	AEDEQIRTCWMTAFR
Y244-p	LKYGMLLyQNyRIPQ
Y247-p	GMLLyQNyRIPQQRK
K254	yRIPQQRKGLAPPFN
P258	QQRKGLAPPFNAPMR
A262	GLAPPFNAPMRSVSE
S266	PFNAPMRSVSENSLV
S268	NAPMRSVSENSLVAM
S271	MRSVSENSLVAMDFS
S314	TRMNILSSQSPLHPS
S316	MNILSSQSPLHPSTL
K348	EESHRIIKQQGLVDG

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