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Protein Page:
S100A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
S100A1 Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Belongs to the S-100 family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein; Endoplasmic reticulum
Cellular Component: neuron projection; protein complex; sarcoplasmic reticulum; M band; Z disc; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding; ATPase binding
Biological Process: substantia nigra development; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction
Reference #:  P23297 (UniProtKB)
Alt. Names/Synonyms: Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100; S100 alpha; S100 calcium binding protein A1; S100 calcium-binding protein A1; S100 protein, alpha polypeptide; S100-alpha; S100A; S100A1; S10A1
Gene Symbols: S100A1
Molecular weight: 10,546 Da
Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

S100A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y27-p SGKEGDKyKLSKKEL
0 1 K50 SGFLDAQKDVDAVDK
0 1 K57 KDVDAVDKVMKELDE
  mouse

 
Y27 SGQEGDKYKLSKKEL
K50-ub SGFLDVQkDADAVDk
K57-ub kDADAVDkVMKELDE
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