Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Gab2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Gab2 an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding; SH3/SH2 adaptor activity; phosphatidylinositol-3,4-bisphosphate binding; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: phosphoinositide-mediated signaling; positive regulation of signal transduction; positive regulation of cell proliferation; innate immune response; positive regulation of mast cell degranulation; osteoclast differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q9UQC2 (UniProtKB)
Alt. Names/Synonyms: GAB2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; KIAA0571; pp100
Gene Symbols: GAB2
Molecular weight: 74,458 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Gab2

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: Y614‑p, Y643‑p
cell growth, altered: S159‑p, S210‑p, T391‑p
transcription, altered: Y614‑p, Y643‑p
activity, inhibited: S210‑p, T391‑p
intracellular localization: S210‑p, T391‑p
molecular association, regulation: S159‑p, S210‑p, Y266‑p, Y293‑p, T391‑p, Y452‑p, Y476‑p, Y584‑p, Y614‑p, S623‑p, Y643‑p
phosphorylation: S210‑p, T391‑p, Y643‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsGGGDVVC
0 29 Y48-p GDPDVLEyyKNDHSK
0 8 Y49-p DPDVLEyyKNDHSKk
0 1 K56-ac yKNDHSKkPLRIINL
0 2 S133-p DSLRNVSsAGHGPRs
0 5 S140-p sAGHGPRssPAELSS
0 6 S141-p AGHGPRssPAELSSs
0 1 S146 RssPAELSSssQHLL
0 3 S148-p sPAELSSssQHLLRE
0 2 S149-p PAELSSssQHLLRER
3 1 S159-p LLRERKSsAPSHsSQ
0 1 S164-p KSsAPSHsSQPTLFt
0 1 T171-p sSQPTLFtFEPPVSN
0 1 Y194-p SAPQEYLyLHQCISR
2 12 S210-p AENARSAsFSQGTRA
0 1 S218-p FSQGTRAsFLMRsDT
0 2 S223-p RAsFLMRsDTAVQKL
0 74 Y249-p SGQVHGFysLPKPSR
0 5 S250-p GQVHGFysLPKPSRH
0 18 S264-p HNTEFRDstyDLPRS
0 10 T265-p NTEFRDstyDLPRSL
1 227 Y266-p TEFRDstyDLPRSLA
0 1 T278-p SLASHGHtKGsLTGs
0 1 S281-p SHGHtKGsLTGsEtD
0 2 S285-p tKGsLTGsEtDNEDV
0 3 T287-p GsLTGsEtDNEDVyt
1 178 Y293-p EtDNEDVytFKTPSN
0 7 T294-p tDNEDVytFKTPSNT
0 1 T319-p DNMDVPAtPLsAyQI
0 14 S322-p DVPAtPLsAyQIPRT
0 139 Y324-p PAtPLsAyQIPRTFt
0 2 T331-p yQIPRTFtLDKNHNA
0 3 S368-p AETPRWGsPQQRPPI
0 1 S381 PISENSRSVAAtIPR
0 2 T385-p NSRSVAAtIPRRNtL
1 60 T391-p AtIPRRNtLPAMDNS
0 12 S404-p NSRLHRAssCEtyEy
0 18 S405-p SRLHRAssCEtyEyP
0 3 T408-p HRAssCEtyEyPQRG
0 260 Y409-p RAssCEtyEyPQRGG
0 2 Y411-p ssCEtyEyPQRGGES
0 1 S422-p GGESAGRsAEsMSDG
0 1 S425-p SAGRsAEsMSDGVGS
0 1 S448-p GRSDSTNsEDNyVPM
4 28 Y452-p STNsEDNyVPMNPGS
0 30 S472-p MERAGDNsQsVyIPM
0 20 S474-p RAGDNsQsVyIPMsP
2 189 Y476-p GDNsQsVyIPMsPGA
0 4 S480-p QsVyIPMsPGAHHFD
0 5 S488-p PGAHHFDsLGyPSTT
0 4 Y491-p HHFDsLGyPSTTLPV
0 35 S543-p IDELPFKsPItKSWs
0 2 T546-p LPFKsPItKSWsRAN
0 1 S548 FKsPItKSWsRANHT
0 2 S550-p sPItKSWsRANHTFN
0 47 Y563-p FNSSSSQyCRPISTQ
1 0 Y584-p SGDSEENyVPMQNPV
0 2 S611-p APKKSTGsVDyLALD
7 52 Y614-p KSTGsVDyLALDFQP
0 6 S622-p LALDFQPssPsPHRK
1 17 S623-p ALDFQPssPsPHRKP
0 6 S625-p DFQPssPsPHRKPsT
1 2 S631-p PsPHRKPsTSSVtsD
0 1 T632 sPHRKPsTSSVtsDE
0 1 T636-p KPsTSSVtsDEKVDy
0 4 S637-p PsTSSVtsDEKVDyV
5 191 Y643-p tsDEKVDyVQVDKEK
0 1 T651-p VQVDKEKtQALQNtM
0 1 T657-p KtQALQNtMQEWTDV
3884 : Phospho-Gab2 (Ser159) Antibody
3881 : Phospho-Gab2 (Tyr452) Antibody
3882 : Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb
  mouse

 
S2 ______MSGGGGDDV
Y50 GDPDVLEYYKNEHSK
Y51 DPDVLEYYKNEHSKK
K58 YKNEHSKKPLRIINL
S135 DSLRNLSSASHGPRS
S142 SASHGPRSsPAEFsS
S143-p ASHGPRSsPAEFsSS
S148-p RSsPAEFsSSQHLLR
S150 sPAEFsSSQHLLRER
- gap
S160-p LLRERKSsAPSHsSQ
S165-p KSsAPSHsSQPTLFT
T172 sSQPTLFTFEPPVSS
Y195 SAPQEYLYLHQCISR
S211-p TENARSAsFSQGTRQ
- gap
S220 SQGTRQKSDTAVQKL
Y246-p GGQVHGFySLPKPSR
S247 GQVHGFySLPKPSRH
S261-p HNTEFKDstyDLPRS
T262-p NTEFKDstyDLPRSL
Y263-p TEFKDstyDLPRSLA
T275 SLASHGHTKSsLTGs
S278-p SHGHTKSsLTGsEtD
S282-p TKSsLTGsEtDNEDV
T284-p SsLTGsEtDNEDVyT
Y290-p EtDNEDVyTFKMPSN
T291 tDNEDVyTFKMPSNT
T316-p DNMDVPTtPLSAyQI
S319 DVPTtPLSAyQIPRT
Y321-p PTtPLSAyQIPRTFT
T328 yQIPRTFTLDKNHNA
S365 AETSQWGSIQQRPPI
S378-p PISENSRsVAATIPR
T382 NSRsVAATIPRRNtL
T388-p ATIPRRNtLPAMDNS
S401-p NSRLHRAssCEtyEY
S402-p SRLHRAssCEtyEYP
T405-p HRAssCEtyEYPARG
Y406-p RAssCEtyEYPARGS
Y408 ssCEtyEYPARGSGE
S413 yEYPARGSGESASWS
S416 PARGSGESASWSAEP
S437 GRSNSASSDDNyVPM
Y441-p SASSDDNyVPMNPGS
S461 MERPGDNSQSVYIPM
S463 RPGDNSQSVYIPMSP
Y465 GDNSQSVYIPMSPGP
S469 QSVYIPMSPGPHHFD
P477 PGPHHFDPLGYPSTA
Y480 HHFDPLGYPSTALPI
S532-p IDELPFKsPVTKsWs
T535 LPFKsPVTKsWsRIN
S537-p FKsPVTKsWsRINHT
S539-p sPVTKsWsRINHTFN
Y552 FNSSSSQYCRPISTQ
Y573 SGDSEENYVPMQNPV
S600 APKKSTGSVDyLALD
Y603-p KSTGSVDyLALDFQP
G611 LALDFQPGsPSPHRK
S612-p ALDFQPGsPSPHRKP
S614 DFQPGsPSPHRKPst
S620-p PSPHRKPstSSVTSD
T621-p SPHRKPstSSVTSDE
T625 KPstSSVTSDEKVDy
S626 PstSSVTSDEKVDyV
Y632-p TSDEKVDyVQVDKEK
T640 VQVDKEKTQALQNTM
T646 KTQALQNTMQEWTDV
3884 : Phospho-Gab2 (Ser159) Antibody
3881 : Phospho-Gab2 (Tyr452) Antibody
3882 : Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb
  rat

 
S2 ______MSGGGGDDV
Y50 GDPDVLEYYKNEHSK
Y51 DPDVLEYYKNEHSKK
K58 YKNEHSKKPLRIINL
S135 DSLRNLSSASHGPRS
S142 SASHGPRSSPAEFSS
S143 ASHGPRSSPAEFSSS
S148 RSSPAEFSSSQHLLR
S150 SPAEFSSSQHLLRER
- gap
S160 LLRERKSSAPSHSSQ
S165 KSSAPSHSSQPTLFT
T172 SSQPTLFTFEPPMTS
Y195 SAPQEYLYLHQCISR
S211 TENSRSASFSQGTRQ
- gap
S220 SQGTRQKSDTAVQKL
Y246 SNQVHGFYSLPKPSR
S247 NQVHGFYSLPKPSRH
S261 HNTEFKDSTyDLPRS
T262 NTEFKDSTyDLPRSL
Y263-p TEFKDSTyDLPRSLA
T275 SLASHGHTKSSLTGS
S278 SHGHTKSSLTGSETD
S282 TKSSLTGSETDNEDV
T284 SSLTGSETDNEDVYT
Y290 ETDNEDVYTFKMPSN
T291 TDNEDVYTFKMPSNT
T316 DNMDVPTTPLSAYQI
S319 DVPTTPLSAYQIPRT
Y321 PTTPLSAYQIPRTFT
T328 YQIPRTFTLDKNHNA
S365 AETPRWGSPQQKPPI
S378 PIGENSRSVAATIPR
T382 NSRSVAATIPRRNTL
T388 ATIPRRNTLPAMDNS
S401 NSRLHRASSCETYEY
S402 SRLHRASSCETYEYP
T405 HRASSCETYEYPTRG
Y406 RASSCETYEYPTRGS
Y408 SSCETYEYPTRGSGE
S413 YEYPTRGSGESASWS
S416 PTRGSGESASWSAES
S437 GRSDSASSDENYVPM
Y441 SASSDENYVPMNPGS
S461 MERAGDNSQSAYIPM
S463 RAGDNSQSAYIPMGP
Y465 GDNSQSAYIPMGPGP
G469 QSAYIPMGPGPHHFD
P477 PGPHHFDPLGYPSTA
Y480 HHFDPLGYPSTALPI
S532 IDELPFKSPVTKSWS
T535 LPFKSPVTKSWSRIN
S537 FKSPVTKSWSRINHT
S539 SPVTKSWSRINHTFN
Y552 FNSSSSQYCRPISTQ
Y573 SGDSEENYVPMQNPV
S600 APRKSTGSVDYLALD
Y603 KSTGSVDYLALDFQP
G611 LALDFQPGSPSPHRK
S612 ALDFQPGSPSPHRKP
S614 DFQPGSPSPHRKPST
S620 PSPHRKPSTSSVTSD
T621 SPHRKPSTSSVTSDE
T625 KPSTSSVTSDEKVDY
S626 PSTSSVTSDEKVDYV
Y632 TSDEKVDYVQVDKEK
T640 VQVDKEKTQALQNTM
T646 KTQALQNTMQEWTDV
3884 : Phospho-Gab2 (Ser159) Antibody
3881 : Phospho-Gab2 (Tyr452) Antibody
3882 : Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.