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Protein Page:
Gab2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Gab2 an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: integrin-mediated signaling pathway; cell migration; phosphoinositide-mediated signaling; positive regulation of cell proliferation; innate immune response; positive regulation of mast cell degranulation; osteoclast differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q9UQC2 (UniProtKB)
Alt. Names/Synonyms: GAB2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; KIAA0571; pp100
Gene Symbols: GAB2
Molecular weight: 74,458 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Gab2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y614‑p, Y643‑p
cell growth, altered: S159‑p, S210‑p, T391‑p
transcription, altered: Y614‑p, Y643‑p
activity, inhibited: S210‑p, T391‑p
intracellular localization: S210‑p, T391‑p
molecular association, regulation: S159‑p, S210‑p, Y266‑p, Y293‑p, T391‑p, Y452‑p, Y476‑p, Y584‑p, Y614‑p, S623‑p, Y643‑p
phosphorylation: S210‑p, T391‑p, Y643‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S2-p ______MsGGGDVVC
0 29 Y48-p GDPDVLEyyKNDHSK
0 8 Y49-p DPDVLEyyKNDHSKk
0 1 K56-ac yKNDHSKkPLRIINL
0 2 S133-p DSLRNVSsAGHGPRs
0 6 S140-p sAGHGPRssPAELSS
0 9 S141-p AGHGPRssPAELSSs
0 1 S146 RssPAELSSssQHLL
0 4 S148-p sPAELSSssQHLLRE
0 2 S149-p PAELSSssQHLLRER
3 1 S159-p LLRERKSsAPSHsSQ
0 1 S164-p KSsAPSHsSQPTLFt
0 1 T171-p sSQPTLFtFEPPVSN
0 1 Y194-p SAPQEYLyLHQCISR
2 15 S210-p AENARSAsFSQGTRA
0 1 S218-p FSQGTRAsFLMRsDT
0 2 S223-p RAsFLMRsDTAVQKL
0 1 G233 AVQKLAQGNGHCVNG
0 74 Y249-p SGQVHGFysLPKPSR
0 6 S250-p GQVHGFysLPKPSRH
0 20 S264-p HNTEFRDstyDLPRS
0 10 T265-p NTEFRDstyDLPRSL
1 230 Y266-p TEFRDstyDLPRSLA
0 1 T278-p SLASHGHtKGsLTGs
0 1 S281-p SHGHtKGsLTGsEtD
0 3 S285-p tKGsLTGsEtDNEDV
0 4 T287-p GsLTGsEtDNEDVyt
1 180 Y293-p EtDNEDVytFKTPSN
0 7 T294-p tDNEDVytFKTPSNT
0 1 T319-p DNMDVPAtPLsAyQI
0 16 S322-p DVPAtPLsAyQIPRT
0 140 Y324-p PAtPLsAyQIPRTFt
0 2 T331-p yQIPRTFtLDKNHNA
0 3 S368-p AETPRWGsPQQRPPI
0 1 S381 PISENSRSVAAtIPR
0 2 T385-p NSRSVAAtIPRRNtL
1 64 T391-p AtIPRRNtLPAMDNS
0 15 S404-p NSRLHRAssCEtyEy
0 19 S405-p SRLHRAssCEtyEyP
0 3 T408-p HRAssCEtyEyPQRG
0 262 Y409-p RAssCEtyEyPQRGG
0 2 Y411-p ssCEtyEyPQRGGES
0 1 S422-p GGESAGRsAEsMSDG
0 1 S425-p SAGRsAEsMSDGVGS
0 1 S448-p GRSDSTNsEDNyVPM
5 29 Y452-p STNsEDNyVPMNPGS
0 30 S472-p MERAGDNsQsVyIPM
0 20 S474-p RAGDNsQsVyIPMsP
2 190 Y476-p GDNsQsVyIPMsPGA
0 5 S480-p QsVyIPMsPGAHHFD
0 5 S488-p PGAHHFDsLGyPSTT
0 4 Y491-p HHFDsLGyPSTTLPV
0 38 S543-p IDELPFKsPItKSWs
0 2 T546-p LPFKsPItKSWsRAN
0 1 S548 FKsPItKSWsRANHT
0 2 S550-p sPItKSWsRANHTFN
0 47 Y563-p FNSSSSQyCRPISTQ
1 0 Y584-p SGDSEENyVPMQNPV
0 3 S611-p APKKSTGsVDyLALD
7 54 Y614-p KSTGsVDyLALDFQP
0 7 S622-p LALDFQPssPsPHRK
1 19 S623-p ALDFQPssPsPHRKP
0 6 S625-p DFQPssPsPHRKPst
1 2 S631-p PsPHRKPstsSVtsD
0 2 T632-p sPHRKPstsSVtsDE
0 1 S633-p PHRKPstsSVtsDEK
0 1 S634 HRKPstsSVtsDEKV
0 1 T636-p KPstsSVtsDEKVDy
0 4 S637-p PstsSVtsDEKVDyV
5 194 Y643-p tsDEKVDyVQVDKEK
0 1 T651-p VQVDKEKtQALQNtM
0 1 T657-p KtQALQNtMQEWTDV
3884 : Phospho-Gab2 (Ser159) Antibody
3881 : Phospho-Gab2 (Tyr452) Antibody
3882 : Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb
  Gab2 iso2  
- gap
Y10 GDPDVLEYYKNDHSK
Y11 DPDVLEYYKNDHSKK
K18 YKNDHSKKPLRIINL
S95 DSLRNVSSAGHGPRS
S102 SAGHGPRSSPAELSS
S103 AGHGPRSSPAELSSS
S108 RSSPAELSSSSQHLL
S110 SPAELSSSSQHLLRE
S111 PAELSSSSQHLLRER
S121 LLRERKSSAPSHSSQ
S126 KSSAPSHSSQPTLFT
T133 SSQPTLFTFEPPVSN
Y156 SAPQEYLYLHQCISR
S172 AENARSASFSQGTRA
S180 FSQGTRASFLMRSDT
S185 RASFLMRSDTAVQKL
G195 AVQKLAQGNGHCVNG
Y211 SGQVHGFYSLPKPSR
S212 GQVHGFYSLPKPSRH
S226 HNTEFRDSTYDLPRS
T227 NTEFRDSTYDLPRSL
Y228 TEFRDSTYDLPRSLA
T240 SLASHGHTKGSLTGS
S243 SHGHTKGSLTGSETD
S247 TKGSLTGSETDNEDV
T249 GSLTGSETDNEDVYT
Y255 ETDNEDVYTFKTPSN
T256 TDNEDVYTFKTPSNT
T281 DNMDVPATPLSAYQI
S284 DVPATPLSAYQIPRT
Y286 PATPLSAYQIPRTFT
T293 YQIPRTFTLDKNHNA
S330 AETPRWGSPQQRPPI
S343 PISENSRSVAATIPR
T347 NSRSVAATIPRRNTL
T353 ATIPRRNTLPAMDNS
S366 NSRLHRASSCETYEY
S367 SRLHRASSCETYEYP
T370 HRASSCETYEYPQRG
Y371 RASSCETYEYPQRGG
Y373 SSCETYEYPQRGGES
S384 GGESAGRSAESMSDG
S387 SAGRSAESMSDGVGS
S410 GRSDSTNSEDNYVPM
Y414 STNSEDNYVPMNPGS
S434 MERAGDNSQSVYIPM
S436 RAGDNSQSVYIPMSP
Y438 GDNSQSVYIPMSPGA
S442 QSVYIPMSPGAHHFD
S450 PGAHHFDSLGYPSTT
Y453 HHFDSLGYPSTTLPV
S505 IDELPFKSPITKSWS
T508 LPFKSPITKSWSRAN
S510 FKSPITKSWSRANHT
S512 SPITKSWSRANHTFN
Y525 FNSSSSQYCRPISTQ
Y546 SGDSEENYVPMQNPV
S573 APKKSTGSVDYLALD
Y576 KSTGSVDYLALDFQP
S584 LALDFQPSSPSPHRK
S585 ALDFQPSSPSPHRKP
S587 DFQPSSPSPHRKPST
S593 PSPHRKPSTSSVTSD
T594 SPHRKPSTSSVTSDE
S595 PHRKPSTSSVTSDEK
S596 HRKPSTSSVTSDEKV
T598 KPSTSSVTSDEKVDY
S599 PSTSSVTSDEKVDYV
Y605 TSDEKVDYVQVDKEK
T613 VQVDKEKTQALQNTM
T619 KTQALQNTMQEWTDV
  mouse

 
S2 ______MSGGGGDDV
Y50 GDPDVLEYYKNEHSK
Y51 DPDVLEYYKNEHSKK
K58 YKNEHSKKPLRIINL
S135 DSLRNLSSASHGPRs
S142-p SASHGPRssPAEFsS
S143-p ASHGPRssPAEFsSS
S148-p RssPAEFsSSQHLLR
S150 sPAEFsSSQHLLRER
- gap
S160-p LLRERKSsAPSHsSQ
S165-p KSsAPSHsSQPTLFT
T172 sSQPTLFTFEPPVSS
Y195 SAPQEYLYLHQCISR
S211-p TENARSAsFSQGTRQ
- gap
S220 SQGTRQKSDTAVQKL
S230-p AVQKLAQsNGHCING
Y246-p GGQVHGFySLPKPSR
S247 GQVHGFySLPKPSRH
S261-p HNTEFKDstyDLPRS
T262-p NTEFKDstyDLPRSL
Y263-p TEFKDstyDLPRSLA
T275 SLASHGHTKSsLTGs
S278-p SHGHTKSsLTGsEtD
S282-p TKSsLTGsEtDNEDV
T284-p SsLTGsEtDNEDVyT
Y290-p EtDNEDVyTFKMPSN
T291 tDNEDVyTFKMPSNT
T316-p DNMDVPTtPLsAyQI
S319-p DVPTtPLsAyQIPRT
Y321-p PTtPLsAyQIPRTFT
T328 yQIPRTFTLDKNHNA
S365 AETSQWGSIQQRPPI
S378-p PISENSRsVAATIPR
T382 NSRsVAATIPRRNtL
T388-p ATIPRRNtLPAMDNS
S401-p NSRLHRAssCEtyEY
S402-p SRLHRAssCEtyEYP
T405-p HRAssCEtyEYPARG
Y406-p RAssCEtyEYPARGS
Y408 ssCEtyEYPARGSGE
S413 yEYPARGSGESASWS
S416 PARGSGESASWSAEP
S437 GRSNSASSDDNyVPM
Y441-p SASSDDNyVPMNPGS
S461 MERPGDNSQSVYIPM
S463 RPGDNSQSVYIPMSP
Y465 GDNSQSVYIPMSPGP
S469 QSVYIPMSPGPHHFD
P477 PGPHHFDPLGYPSTA
Y480 HHFDPLGYPSTALPI
S532-p IDELPFKsPVTKsWs
T535 LPFKsPVTKsWsRIN
S537-p FKsPVTKsWsRINHT
S539-p sPVTKsWsRINHTFN
Y552 FNSSSSQYCRPISTQ
Y573 SGDSEENYVPMQNPV
S600-p APKKSTGsVDyLALD
Y603-p KSTGsVDyLALDFQP
G611 LALDFQPGsPSPHRK
S612-p ALDFQPGsPSPHRKP
S614 DFQPGsPSPHRKPst
S620-p PSPHRKPstSsVTSD
T621-p SPHRKPstSsVTSDE
S622 PHRKPstSsVTSDEK
S623-p HRKPstSsVTSDEKV
T625 KPstSsVTSDEKVDy
S626 PstSsVTSDEKVDyV
Y632-p TSDEKVDyVQVDKEK
T640 VQVDKEKTQALQNTM
T646 KTQALQNTMQEWTDV
3884 : Phospho-Gab2 (Ser159) Antibody
3881 : Phospho-Gab2 (Tyr452) Antibody
3882 : Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb
  rat

 
S2 ______MSGGGGDDV
Y50 GDPDVLEYYKNEHSK
Y51 DPDVLEYYKNEHSKK
K58 YKNEHSKKPLRIINL
S135 DSLRNLSSASHGPRS
S142 SASHGPRSsPAEFSS
S143-p ASHGPRSsPAEFSSS
S148 RSsPAEFSSSQHLLR
S150 sPAEFSSSQHLLRER
- gap
S160 LLRERKSSAPSHSSQ
S165 KSSAPSHSSQPTLFT
T172 SSQPTLFTFEPPMTS
Y195 SAPQEYLYLHQCISR
S211 TENSRSASFSQGTRQ
- gap
S220 SQGTRQKSDTAVQKL
S230 AVQKLAQSNGHCING
Y246 SNQVHGFYSLPKPSR
S247 NQVHGFYSLPKPSRH
S261 HNTEFKDSTyDLPRS
T262 NTEFKDSTyDLPRSL
Y263-p TEFKDSTyDLPRSLA
T275 SLASHGHTKSSLTGS
S278 SHGHTKSSLTGSETD
S282 TKSSLTGSETDNEDV
T284 SSLTGSETDNEDVYT
Y290 ETDNEDVYTFKMPSN
T291 TDNEDVYTFKMPSNT
T316 DNMDVPTTPLSAYQI
S319 DVPTTPLSAYQIPRT
Y321 PTTPLSAYQIPRTFT
T328 YQIPRTFTLDKNHNA
S365 AETPRWGSPQQKPPI
S378 PIGENSRSVAATIPR
T382 NSRSVAATIPRRNTL
T388 ATIPRRNTLPAMDNS
S401 NSRLHRASSCETYEY
S402 SRLHRASSCETYEYP
T405 HRASSCETYEYPTRG
Y406 RASSCETYEYPTRGS
Y408 SSCETYEYPTRGSGE
S413 YEYPTRGSGESASWS
S416 PTRGSGESASWSAES
S437 GRSDSASSDENYVPM
Y441 SASSDENYVPMNPGS
S461 MERAGDNSQSAYIPM
S463 RAGDNSQSAYIPMGP
Y465 GDNSQSAYIPMGPGP
G469 QSAYIPMGPGPHHFD
P477 PGPHHFDPLGYPSTA
Y480 HHFDPLGYPSTALPI
S532 IDELPFKSPVTKSWS
T535 LPFKSPVTKSWSRIN
S537 FKSPVTKSWSRINHT
S539 SPVTKSWSRINHTFN
Y552 FNSSSSQYCRPISTQ
Y573 SGDSEENYVPMQNPV
S600 APRKSTGSVDYLALD
Y603 KSTGSVDYLALDFQP
G611 LALDFQPGSPSPHRK
S612 ALDFQPGSPSPHRKP
S614 DFQPGSPSPHRKPST
S620 PSPHRKPSTSSVTSD
T621 SPHRKPSTSSVTSDE
S622 PHRKPSTSSVTSDEK
S623 HRKPSTSSVTSDEKV
T625 KPSTSSVTSDEKVDY
S626 PSTSSVTSDEKVDYV
Y632 TSDEKVDYVQVDKEK
T640 VQVDKEKTQALQNTM
T646 KTQALQNTMQEWTDV
3884 : Phospho-Gab2 (Ser159) Antibody
3881 : Phospho-Gab2 (Tyr452) Antibody
3882 : Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb
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