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Gab2 (human)

Overview Gab2 an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: cytoplasm; plasma membrane; cytosol Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding; SH3/SH2 adaptor activity; phosphatidylinositol-3,4-bisphosphate binding; transmembrane receptor protein tyrosine kinase adaptor protein activity Biological Process: phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation; osteoclast differentiation; transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  Q9UQC2 (UniProtKB) Alt. Names/Synonyms: GAB2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; KIAA0571; pp100 Gene Symbols: GAB2 Molecular weight: 74,458 Da Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Gab2 2VWF - B=508-522 (human) 2W0Z - B=350-358 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2VWF 2W0Z  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: Y614‑p, Y643‑p cell growth, altered: S159‑p, S210‑p, T391‑p transcription, altered: Y614‑p, Y643‑p inhibition: S210‑p, T391‑p intracellular localization: S210‑p, T391‑p molecular association, regulation: S159‑p, S210‑p, Y266‑p, Y293‑p, T391‑p, Y452‑p, Y476‑p, Y584‑p, Y614‑p, S623‑p, Y643‑p phosphorylation: S210‑p, T391‑p, Y643‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	29		Y48-p	GDPDVLEyyKNDHSK
0	7		Y49-p	DPDVLEyyKNDHSKk
0	1		K56-a	yKNDHSKkPLRIINL
0	2		S133-p	DSLRNVSsAGHGPRs
0	5		S140-p	sAGHGPRssPAELSS
0	4		S141-p	AGHGPRssPAELSSs
0	2		S148-p	sPAELSSssQHLLRE
0	1		S149-p	PAELSSssQHLLRER
3	2		S159-p	LLRERKSsAPSHsSQ
0	1		S164-p	KSsAPSHsSQPTLFt
0	1		T171-p	sSQPTLFtFEPPVSN
0	1		Y194-p	SAPQEYLyLHQCISR
2	9		S210-p	AENARSAsFSQGTRA
0	1		S218-p	FSQGTRAsFLMRsDT
0	1		S223-p	RAsFLMRsDTAVQKL
0	73		Y249-p	SGQVHGFysLPKPSR
0	4		S250-p	GQVHGFysLPKPSRH
0	17		S264-p	HNTEFRDstyDLPRS
0	10		T265-p	NTEFRDstyDLPRSL
1	228		Y266-p	TEFRDstyDLPRSLA
0	1		T278-p	SLASHGHtKGsLTGS
0	1		S281-p	SHGHtKGsLTGSEtD
0	2		T287-p	GsLTGSEtDNEDVyt
1	170		Y293-p	EtDNEDVytFKTPSN
0	6		T294-p	tDNEDVytFKTPSNT
0	14		S322-p	DVPATPLsAyQIPRT
0	130		Y324-p	PATPLsAyQIPRTFt
0	1		T331-p	yQIPRTFtLDKNHNA
0	2		T385-p	NSRSVAAtIPRRNtL
1	51		T391-p	AtIPRRNtLPAMDNS
0	9		S404-p	NSRLHRAssCEtyEy
0	12		S405-p	SRLHRAssCEtyEyP
0	3		T408-p	HRAssCEtyEyPQRG
0	264		Y409-p	RAssCEtyEyPQRGG
0	3		Y411-p	ssCEtyEyPQRGGES
0	1		S448-p	GRSDSTNsEDNyVPM
4	27		Y452-p	STNsEDNyVPMNPGS
0	28		S472-p	MERAGDNsQsVyIPM
0	19		S474-p	RAGDNsQsVyIPMsP
1	193		Y476-p	GDNsQsVyIPMsPGA
0	3		S480-p	QsVyIPMsPGAHHFD
0	5		S488-p	PGAHHFDsLGyPSTT
0	4		Y491-p	HHFDsLGyPSTTLPV
0	27		S543-p	IDELPFKsPITKSWs
0	1		S548	FKsPITKSWsRANHT
0	2		S550-p	sPITKSWsRANHTFN
0	47		Y563-p	FNSSSSQyCRPISTQ
1	0		Y584-p	SGDSEENyVPMQNPV
0	2		S611-p	APKKSTGsVDyLALD
5	47		Y614-p	KSTGsVDyLALDFQP
0	5		S622-p	LALDFQPssPsPHRK
1	15		S623-p	ALDFQPssPsPHRKP
0	6		S625-p	DFQPssPsPHRKPsT
1	1		S631-p	PsPHRKPsTSSVtsD
0	1		T632	sPHRKPsTSSVtsDE
0	1		T636-p	KPsTSSVtsDEKVDy
0	3		S637-p	PsTSSVtsDEKVDyV
3	173		Y643-p	tsDEKVDyVQVDKEK

	mouse
Y50	GDPDVLEYYKNEHSK
Y51	DPDVLEYYKNEHSKK
K58	YKNEHSKKPLRIINL
S135	DSLRNLSSASHGPRS
S142	SASHGPRSsPAEFSS
S143-p	ASHGPRSsPAEFSSS
S150	sPAEFSSSQHLLRER
-	gap
S160-p	LLRERKSsAPSHsSQ
S165-p	KSsAPSHsSQPTLFT
T172	sSQPTLFTFEPPVSS
Y195	SAPQEYLYLHQCISR
S211-p	TENARSAsFSQGTRQ
-	gap
S220	SQGTRQKSDTAVQKL
Y246-p	GGQVHGFySLPKPSR
S247	GQVHGFySLPKPSRH
S261-p	HNTEFKDstyDLPRS
T262-p	NTEFKDstyDLPRSL
Y263-p	TEFKDstyDLPRSLA
T275	SLASHGHTKSsLTGS
S278-p	SHGHTKSsLTGSEtD
T284-p	SsLTGSEtDNEDVyT
Y290-p	EtDNEDVyTFKMPSN
T291	tDNEDVyTFKMPSNT
S319	DVPTTPLSAyQIPRT
Y321-p	PTTPLSAyQIPRTFT
T328	yQIPRTFTLDKNHNA
T382	NSRSVAATIPRRNtL
T388-p	ATIPRRNtLPAMDNS
S401-p	NSRLHRAssCEtyEY
S402-p	SRLHRAssCEtyEYP
T405-p	HRAssCEtyEYPARG
Y406-p	RAssCEtyEYPARGS
Y408	ssCEtyEYPARGSGE
S437	GRSNSASSDDNyVPM
Y441-p	SASSDDNyVPMNPGS
S461	MERPGDNSQSVYIPM
S463	RPGDNSQSVYIPMSP
Y465	GDNSQSVYIPMSPGP
S469	QSVYIPMSPGPHHFD
P477	PGPHHFDPLGYPSTA
Y480	HHFDPLGYPSTALPI
S532-p	IDELPFKsPVTKsWs
S537-p	FKsPVTKsWsRINHT
S539-p	sPVTKsWsRINHTFN
Y552	FNSSSSQYCRPISTQ
Y573	SGDSEENYVPMQNPV
S600	APKKSTGSVDyLALD
Y603-p	KSTGSVDyLALDFQP
G611	LALDFQPGsPSPHRK
S612-p	ALDFQPGsPSPHRKP
S614	DFQPGsPSPHRKPst
S620-p	PSPHRKPstSSVTSD
T621-p	SPHRKPstSSVTSDE
T625	KPstSSVTSDEKVDy
S626	PstSSVTSDEKVDyV
Y632-p	TSDEKVDyVQVDKEK

	rat
Y50	GDPDVLEYYKNEHSK
Y51	DPDVLEYYKNEHSKK
K58	YKNEHSKKPLRIINL
S135	DSLRNLSSASHGPRS
S142	SASHGPRSSPAEFSS
S143	ASHGPRSSPAEFSSS
S150	SPAEFSSSQHLLRER
-	gap
S160	LLRERKSSAPSHSSQ
S165	KSSAPSHSSQPTLFT
T172	SSQPTLFTFEPPMTS
Y195	SAPQEYLYLHQCISR
S211	TENSRSASFSQGTRQ
-	gap
S220	SQGTRQKSDTAVQKL
Y246	SNQVHGFYSLPKPSR
S247	NQVHGFYSLPKPSRH
S261	HNTEFKDSTyDLPRS
T262	NTEFKDSTyDLPRSL
Y263-p	TEFKDSTyDLPRSLA
T275	SLASHGHTKSSLTGS
S278	SHGHTKSSLTGSETD
T284	SSLTGSETDNEDVYT
Y290	ETDNEDVYTFKMPSN
T291	TDNEDVYTFKMPSNT
S319	DVPTTPLSAYQIPRT
Y321	PTTPLSAYQIPRTFT
T328	YQIPRTFTLDKNHNA
T382	NSRSVAATIPRRNTL
T388	ATIPRRNTLPAMDNS
S401	NSRLHRASSCETYEY
S402	SRLHRASSCETYEYP
T405	HRASSCETYEYPTRG
Y406	RASSCETYEYPTRGS
Y408	SSCETYEYPTRGSGE
S437	GRSDSASSDENYVPM
Y441	SASSDENYVPMNPGS
S461	MERAGDNSQSAYIPM
S463	RAGDNSQSAYIPMGP
Y465	GDNSQSAYIPMGPGP
G469	QSAYIPMGPGPHHFD
P477	PGPHHFDPLGYPSTA
Y480	HHFDPLGYPSTALPI
S532	IDELPFKSPVTKSWS
S537	FKSPVTKSWSRINHT
S539	SPVTKSWSRINHTFN
Y552	FNSSSSQYCRPISTQ
Y573	SGDSEENYVPMQNPV
S600	APRKSTGSVDYLALD
Y603	KSTGSVDYLALDFQP
G611	LALDFQPGSPSPHRK
S612	ALDFQPGSPSPHRKP
S614	DFQPGSPSPHRKPST
S620	PSPHRKPSTSSVTSD
T621	SPHRKPSTSSVTSDE
T625	KPSTSSVTSDEKVDy
S626	PSTSSVTSDEKVDyV
Y632-p	TSDEKVDyVQVDKEK

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