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Protein Page:
ZFP57 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZFP57 Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Defects in ZFP57 are the cause of transient neonatal diabetes mellitus type 1 (TNDM1). Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to- severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The major cause of TNDM1 is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the transient neonatal diabetes differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene. Over 50% of individuals with transient neonatal diabetes and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features. Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; C2H2-type zinc finger protein
Cellular Component: nuclear heterochromatin
Molecular Function: DNA binding; metal ion binding
Biological Process: genetic imprinting; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA methylation during embryonic development; peripheral nervous system development
Reference #:  Q9NU63 (UniProtKB)
Alt. Names/Synonyms: bA145L22; bA145L22.2; C6orf40; TNDM1; Zfp-57; ZFP57; Zinc finger protein 57 homolog; zinc finger protein 57 homolog (mouse); Zinc finger protein 698; ZNF698
Gene Symbols: ZFP57
Molecular weight: 51,919 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Select Structure to View Below

ZFP57

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y172-p HRRVHLGyRPHSCSV
0 5 K195 SELKRHQKIHQNQEP
0 3 - gap
0 2 R286 GTLCQDARSNSHPVK
0 1 S336 YCFHCSKSFSSFSRL
0 1 S339 HCSKSFSSFSRLVRH
0 1 K354 QQTHWKQKSYLCPIC
0 3 - gap
  mouse

 
Y165 HRRAHLGYRPRSCPE
K188-ub SEVNRHLkVHQNKPA
K229-ub APALKYVkVIQGPVA
R251-m1 GASTLNVrSNSITVV
S300-p QHFCCKEsAHsSNTL
S303-p CCKEsAHsSNTLRMQ
K311-ub SNTLRMQkIYTCPVC
K397-ub ETEGLSGkGRVAPWE
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