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Protein Page:
ALDH1A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALDH1A1 Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: GAPs, Ras; Apoptosis; Cofactor and Vitamin Metabolism - retinol; GAPs; EC 1.2.1.36; Oxidoreductase
Cellular Component: cytoplasm; cytosol
Molecular Function: aldehyde dehydrogenase (NAD) activity; androgen binding; Ras GTPase activator activity; retinal dehydrogenase activity
Biological Process: positive regulation of Ras GTPase activity; retinol metabolic process; xenobiotic metabolic process; aldehyde metabolic process; ethanol oxidation
Reference #:  P00352 (UniProtKB)
Alt. Names/Synonyms: acetaldehyde dehydrogenase 1; AL1A1; ALDC; aldehyde dehydrogenase 1 family, member A1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase 1A1; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase, liver cytosolic; ALDH class 1; ALDH-E1; ALDH1; ALDH11; ALDH1A1; ALHDII; MGC2318; PUMB1; RALDH 1; RalDH1; Retinal dehydrogenase 1; retinaldehyde dehydrogenase 1
Gene Symbols: ALDH1A1
Molecular weight: 54,862 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ALDH1A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6-p __MSSSGtPDLPVLL
0 1 K17 PVLLTDLKIQYTKIF
0 1 K17 PVLLTDLKIQYTKIF
0 1 K17 PVLLTDLKIQYTKIF
0 1 K22 DLKIQYTKIFINNEW
0 3 K36 WHDSVSGKKFPVFNP
0 1 K36 WHDSVSGKKFPVFNP
0 1 K36 WHDSVSGKKFPVFNP
0 4 K65-ac EDVDKAVkAArQAFQ
0 1 R68-m2 DKAVkAArQAFQIGS
0 1 R85-m2 RTMDASErGRLLYkL
0 3 K91-ac ErGRLLYkLADLIER
0 5 K91 ErGRLLYKLADLIER
0 1 T105-p RDRLLLAtMESMNGG
0 16 Y119-p GKLYSNAyLNDLAGC
0 2 N121 LYSNAyLNDLAGCIk
0 1 K128-ac NDLAGCIkTLRYCAG
0 2 K128 NDLAGCIKTLRYCAG
0 1 R131 AGCIkTLRYCAGWAD
0 1 K139 YCAGWADKIQGRTIP
0 6 Y154-p IDGNFFTyTRHEPIG
0 1 K193 CGNTVVVKPAEQTPL
0 1 K210 LHVASLIKEAGFPPG
0 2 K252-ac TGSTEVGkLIKEAAG
0 1 K252 TGSTEVGKLIKEAAG
0 2 K255 TEVGkLIKEAAGKSN
0 3 T267-p KSNLKRVtLELGGKS
0 3 R321 SIYDEFVRRSVERAK
0 1 R321 SIYDEFVRRSVERAK
0 1 R321 SIYDEFVRRSVERAK
0 1 K329 RSVERAKKYILGNPL
0 6 T337-p YILGNPLtPGVTQGP
0 1 K348 TQGPQIDKEQYDkIL
0 1 K348 TQGPQIDKEQYDkIL
0 2 K353-ac IDKEQYDkILDLIEs
0 1 K353 IDKEQYDKILDLIEs
0 1 S360-p kILDLIEsGkKEGAk
0 5 K362-ac LDLIEsGkKEGAkLE
0 1 K367-ac sGkKEGAkLECGGGP
0 2 K378 GGGPWGNKGYFVQPT
0 2 K398 TDEMRIAKEEIFGPV
0 3 K410-ac GPVQQIMkFKsLDDV
0 2 K412 VQQIMkFKsLDDVIk
0 2 K412 VQQIMkFKsLDDVIk
0 3 S413-p QQIMkFKsLDDVIkR
0 7 K419-ac KsLDDVIkRANNtFy
0 1 K419 KsLDDVIKRANNtFy
0 1 K419 KsLDDVIKRANNtFy
0 7 T424-p VIkRANNtFyGLsAG
0 1 F425 IkRANNtFyGLsAGV
0 67 Y426-p kRANNtFyGLsAGVF
0 1 S429-p NNtFyGLsAGVFTkD
0 2 K435-ac LsAGVFTkDIDKAIT
0 3 K435 LsAGVFTKDIDKAIT
0 67 Y481-p NGRELGEyGFHEYTE
0 1 K490 FHEYTEVKTVTVkIS
0 1 K490 FHEYTEVKTVTVkIS
0 1 K490 FHEYTEVKTVTVkIS
0 1 K495-ac EVKTVTVkISQKNS_
0 2 K495 EVKTVTVKISQKNS_
0 1 K495 EVKTVTVKISQKNS_
0 1 K499 VTVkISQKNS_____
  mouse

 
- gap
K17-ac PAPLADLkIQHTkIF
K17-ub PAPLADLkIQHTkIF
K17-sc PAPLADLkIQHTkIF
K22-ub DLkIQHTkIFINNEW
K36-ac WHNSVSGkKFPVLNP
K36-ub WHNSVSGkKFPVLNP
K36-sc WHNSVSGkKFPVLNP
K65 ADVDKAVKAARQAFQ
R68 DKAVKAARQAFQIGS
R85 RTMDASERGRLLNkL
K91-ac ERGRLLNkLADLMER
K91-ub ERGRLLNkLADLMER
T105 RDRLLLATMEALNGG
Y119 GKVFANAYLsDLGGC
S121-p VFANAYLsDLGGCIk
K128 sDLGGCIKALkYCAG
K128-ub sDLGGCIkALkYCAG
K131-ub GGCIkALkYCAGWAD
K139-ub YCAGWADkIHGQTIP
Y154 SDGDIFTYTRREPIG
K193-ub CGNTVVVkPAEQTPL
K210-ac LHLASLIkEAGFPPG
K252-ac TGSTQVGkLIkEAAG
K252-ub TGSTQVGkLIkEAAG
K255-ub TQVGkLIkEAAGKSN
T267-p KSNLKRVtLELGGKS
K321-ac SVYDEFVkRSVERAK
K321-ub SVYDEFVkRSVERAK
K321-sc SVYDEFVkRSVERAK
K329-ub RSVERAKkYVLGNPL
T337 YVLGNPLTPGINQGP
K348-ac NQGPQIDkEQHDkIL
K348-ub NQGPQIDkEQHDkIL
K353-ac IDkEQHDkILDLIES
K353-ub IDkEQHDkILDLIES
S360 kILDLIESGkKEGAK
K362-ac LDLIESGkKEGAKLE
K367 SGkKEGAKLECGGGR
K378-ub GGGRWGNkGFFVQPT
K398-ub TDEMRIAkEEIFGPV
K410-ac GPVQQIMkFksVDDV
K412-ac VQQIMkFksVDDVIk
K412-ub VQQIMkFksVDDVIk
S413-p QQIMkFksVDDVIkR
K419-ac ksVDDVIkRANNTty
K419-ub ksVDDVIkRANNTty
K419-sc ksVDDVIkRANNTty
T424 VIkRANNTtyGLAAG
T425-p IkRANNTtyGLAAGL
Y426-p kRANNTtyGLAAGLF
A429 NNTtyGLAAGLFTkD
K435-ac LAAGLFTkDLDKAIT
K435-ub LAAGLFTkDLDKAIT
H481 NGRELGEHGLYEYTE
K490-ac LYEYTELkTVAMkIS
K490-ub LYEYTELkTVAMkIS
K490-sc LYEYTELkTVAMkIS
K495 ELkTVAMKISQkNS_
K495-ub ELkTVAMkISQkNS_
K495-sc ELkTVAMkISQkNS_
K499-ub VAMkISQkNS_____
  rat

 
- gap
K17 PAPLANLKIQHTKIF
K17 PAPLANLKIQHTKIF
K17 PAPLANLKIQHTKIF
K22 NLKIQHTKIFINNEW
K36 WHDSVSGKKFPVLNP
K36 WHDSVSGKKFPVLNP
K36 WHDSVSGKKFPVLNP
K65 ADVDKAVKAARQAFQ
R68 DKAVKAARQAFQIGS
R85 RTMDASERGRLLNKL
K91 ERGRLLNKLADLMER
K91 ERGRLLNKLADLMER
T105 RDRLLLATIEAINGG
Y119 GKVFANAYLSDLGGS
S121 VFANAYLSDLGGSIK
K128 SDLGGSIKALKYCAG
K128 SDLGGSIKALKYCAG
K131 GGSIKALKYCAGWAD
K139 YCAGWADKIHGQTIP
F154 SDGDIFTFTRREPIG
K193 CGNTVVVKPAEQTPL
K210 LHMASLIKEAGFPPG
K252 TGSTQVGKLIKEAAG
K252 TGSTQVGKLIKEAAG
K255 TQVGKLIKEAAGKSN
T267 KSNLKRVTLELGGKS
R321 SVYDEFVRKSVERAK
R321 SVYDEFVRKSVERAK
R321 SVYDEFVRKSVERAK
K329 KSVERAKKYVLGNPL
T337 YVLGNPLTQGINQGP
K348 NQGPQIDKEQHDKIL
K348 NQGPQIDKEQHDKIL
K353 IDKEQHDKILDLIES
K353 IDKEQHDKILDLIES
S360 KILDLIESGKKEGAK
K362 LDLIESGKKEGAKLE
K367 SGKKEGAKLECGGGR
K378 GGGRWGNKGFFVQPT
K398 TDEMRIAKEEIFGPV
K410 GPVQQIMKFKSIDDV
K412 VQQIMKFKSIDDVIK
K412 VQQIMKFKSIDDVIK
S413 QQIMKFKSIDDVIKR
K419 KSIDDVIKRANNTTy
K419 KSIDDVIKRANNTTy
K419 KSIDDVIKRANNTTy
T424 VIKRANNTTyGLAAG
T425 IKRANNTTyGLAAGV
Y426-p KRANNTTyGLAAGVF
A429 NNTTyGLAAGVFTKD
K435 LAAGVFTKDLDRAIT
K435 LAAGVFTKDLDRAIT
H481 NGRELGEHGLYEYTE
K490 LYEYTELKTVAMKIS
K490 LYEYTELKTVAMKIS
K490 LYEYTELKTVAMKIS
K495 ELKTVAMKISQKNS_
K495 ELKTVAMKISQKNS_
K495 ELKTVAMKISQKNS_
K499 VAMKISQKNS_____
  sheep

 
- gap
Q17 PAPLTNLQFKYTKIF
Q17 PAPLTNLQFKYTKIF
Q17 PAPLTNLQFKYTKIF
K22 NLQFKYTKIFINNEW
K36 WHSSVSGKKFPVFNP
K36 WHSSVSGKKFPVFNP
K36 WHSSVSGKKFPVFNP
K65 EDVDKAVKAARQAFQ
R68 DKAVKAARQAFQIGS
R85 RTMDASERGRLLNKL
K91 ERGRLLNKLADLIER
K91 ERGRLLNKLADLIER
T105 RDRLLLATMEAMNGG
Y119 GKLFSNAYLMDLGGC
M121 LFSNAYLMDLGGCIK
K128 MDLGGCIKTLRYCAG
K128 MDLGGCIKTLRYCAG
R131 GGCIKTLRYCAGWAD
K139 YCAGWADKIQGRTIP
Y154 MDGNFFTYTRSEPVG
K193 CGNTVVVKPAEQTPL
K210 LHMGSLIKEAGFPPG
K252 TGSTEVGKLIKEAAG
K252 TGSTEVGKLIKEAAG
K255 TEVGKLIKEAAGKSN
S267 KSNLKRVSLELGGKS
R321 SIYDEFVRRSVERAK
R321 SIYDEFVRRSVERAK
R321 SIYDEFVRRSVERAK
K329 RSVERAKKYVLGNPL
T337 YVLGNPLTPGVSQGP
K348 SQGPQIDKEQYEKIL
K348 SQGPQIDKEQYEKIL
K353 IDKEQYEKILDLIES
K353 IDKEQYEKILDLIES
S360 KILDLIESGKKEGAK
K362 LDLIESGKKEGAKLE
K367 SGKKEGAKLECGGGP
K378 GGGPWGNKGYFIQPT
K398 TDDMRIAKEEIFGPV
K410 GPVQQIMKFKSLDDV
K412 VQQIMKFKSLDDVIK
K412 VQQIMKFKSLDDVIK
S413 QQIMKFKSLDDVIKR
K419 KSLDDVIKRANNTFY
K419 KSLDDVIKRANNTFY
K419 KSLDDVIKRANNTFY
T424 VIKRANNTFYGLSAG
F425 IKRANNTFYGLSAGI
Y426 KRANNTFYGLSAGIF
S429 NNTFYGLSAGIFTND
N435 LSAGIFTNDIDKAIT
N435 LSAGIFTNDIDKAIT
Y481 NGRELGEYGFHEYTE
K490 FHEYTEVKTVTIKIS
K490 FHEYTEVKTVTIKIS
K490 FHEYTEVKTVTIKIS
K495 EVKTVTIKISQKNS_
K495 EVKTVTIKISQKNS_
K495 EVKTVTIKISQKNS_
K499 VTIKISQKNS_____
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