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Protein Page:
RAPGEF4 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RAPGEF4 Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Ras
Cellular Component: protein complex; photoreceptor inner segment; basolateral plasma membrane; dendrite; dendritic spine; excitatory synapse; cytosol; cAMP-dependent protein kinase complex; photoreceptor outer segment; membrane; axon; cytoplasm; apical plasma membrane; plasma membrane; intracellular
Molecular Function: protein binding; Ras GTPase binding; guanyl-nucleotide exchange factor activity; nucleotide binding; protein complex binding; cAMP-dependent protein kinase regulator activity; cAMP binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: regulation of protein amino acid phosphorylation; regulation of GTPase activity; exocytosis; regulation of dendrite development; positive regulation of smooth muscle cell migration; signal transduction; negative regulation of synaptic transmission; calcium ion-dependent exocytosis; regulation of exocytosis; regulation of Ras GTPase activity; cAMP-mediated signaling; regulation of small GTPase mediated signal transduction; insulin secretion; small GTPase mediated signal transduction
Reference #:  Q9EQZ6 (UniProtKB)
Alt. Names/Synonyms: 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; cAMP-regulated guanine nucleotide exchange factor IIB; Cgef2; EPAC 2; Epac2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; KIAA4040; mKIAA4040; OTTMUSP00000014141; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; Rapgef4; RPGF4
Gene Symbols: Rapgef4
Molecular weight: 115,491 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAPGEF4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 3 K202-u ITKVPSEkILRAGKI
0 1 K283-u QERHFQDkYLFYRFL
0 3 Y348-p VDDLEIIyDELLHIK
0 1 K631-u PELEKIVkQISEDAK
0 1 K645 KAPQKKHKVLLQQFN
0 1 K645-u KAPQKKHkVLLQQFN
0 2 T653-p VLLQQFNtGDERAQK
0 1 S667 KRQPIRGSDEVLFKV
0 1 Y675 DEVLFKVYCIDHtyt
0 1 T680-p KVYCIDHtyttIRVP
0 26 Y681-p VYCIDHtyttIRVPV
0 2 T682-p YCIDHtyttIRVPVA
0 2 T683-p CIDHtyttIRVPVAA
0 1 K693-u VPVAASVkEVISAVA
0 24 Y857-p IAAHCKEyKNLNSFF
0 1 K915-u AYRLTAAkLEPPLIP
0 1 K950-u DNLVNFEkMRMIANT
0 1 K978-u PDAAQANkNHQDVRS
  RAPGEF4 iso3  
K184-u KENVPSEkILRAGKI
K265 QERHFQDKYLFYRFL
Y330 VDDLEIIYDELLHIK
K613 PELEKIVKQISEDAK
K627 KAPQKKHKVLLQQFN
K627 KAPQKKHKVLLQQFN
T635 VLLQQFNTGDERAQK
S649 KRQPIRGSDEVLFKV
Y657 DEVLFKVYCIDHTYT
T662 KVYCIDHTYTTIRVP
Y663 VYCIDHTYTTIRVPV
T664 YCIDHTYTTIRVPVA
T665 CIDHTYTTIRVPVAA
K675 VPVAASVKEVISAVA
Y839 IAAHCKEYKNLNSFF
K897 AYRLTAAKLEPPLIP
K932 DNLVNFEKMRMIANT
K960 PDAAQANKNHQDVRS
  human

 
K202 ITKVPSEKILRAGKI
K283 QEHHFQDKYLFYRFL
Y348 VDDLEIIYEELLHIK
K631 PELEKIVKQISEDAK
K645-a KAPQKKHkVLLQQFN
K645 KAPQKKHKVLLQQFN
T653 VLLQQFNTGDERAQK
S667 KRQPIRGSDEVLFKV
Y675 DEVLFKVYCMDHTYT
T680 KVYCMDHTYTTIRVP
Y681 VYCMDHTYTTIRVPV
T682 YCMDHTYTTIRVPVA
T683 CMDHTYTTIRVPVAT
K693 VPVATSVKEVISAVA
Y857-p IAAHCKEyKNLNSFF
K915 AYRLTVAKLEPPLIP
K950 DNLVNFEKMRMIANT
K978 PDAAQANKNHQDVRS
  rat

 
K202-u ITKVPSEkILRAGKI
- gap
Y306-p ADDLEIIyDELLHIK
K589 AELEKTVKQISEDAK
K603 KAPQKKHKVLLQQFN
K603 KAPQKKHKVLLQQFN
T611 VLLQQFNTGDERAQK
S625-p KRQPIRGsDEVLFKV
Y633-p DEVLFKVyCIDHTyt
T638 KVyCIDHTyttIRVP
Y639-p VyCIDHTyttIRVPV
T640-p yCIDHTyttIRVPVA
T641-p CIDHTyttIRVPVAA
K651 VPVAASVKEVISAVA
Y815 IAAHCKEYKNLNSFF
K873 AYRLTAAKLEPPLIP
K908 DNLVNFEKMRMIANT
K936 PDAAQANKNHQDVRS
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