RAPGEF4 (mouse)

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Protein Page:

RAPGEF4 (mouse)

p	Phosphorylation
a	Acetylation
m	Methylation
m1	Mono-methylation
m2	Di-methylation
m3	Tri-methylation
u	Ubiquitination
s	Sumoylation
n	Neddylation
gl	O-GlcNAc
ga	O-GalNAc
h	Palmitoylation
ad	Adenylylation
sn	S-Nitrosylation
ca	Caspase cleavage

Overview

RAPGEF4 Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.

Protein type: Guanine nucleotide exchange factor, Ras

Cellular Component: protein complex; photoreceptor inner segment; basolateral plasma membrane; dendrite; dendritic spine; excitatory synapse; cytosol; cAMP-dependent protein kinase complex; photoreceptor outer segment; membrane; axon; cytoplasm; apical plasma membrane; plasma membrane; intracellular

Molecular Function: protein binding; Ras GTPase binding; guanyl-nucleotide exchange factor activity; nucleotide binding; protein complex binding; cAMP-dependent protein kinase regulator activity; cAMP binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: regulation of protein amino acid phosphorylation; exocytosis; regulation of dendrite development; signal transduction; positive regulation of smooth muscle cell migration; negative regulation of synaptic transmission; calcium ion-dependent exocytosis; regulation of exocytosis; cAMP-mediated signaling; regulation of small GTPase mediated signal transduction; regulation of catalytic activity; insulin secretion; small GTPase mediated signal transduction

Reference #: Q9EQZ6 (UniProtKB)

Alt. Names/Synonyms: 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; cAMP-regulated guanine nucleotide exchange factor IIB; Cgef2; EPAC 2; Epac2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; KIAA4040; mKIAA4040; OTTMUSP00000014141; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; Rapgef4; RPGF4

Gene Symbols: Rapgef4

Molecular weight: 115,491 Da

Basal Isoelectric point: 6.45 Predict pI for various phosphorylation states

CST Pathways: GPCRs Signaling to MAPK/Erk | MAPK/Erk in Growth and Differentiation | Regulation of Actin Dynamics

Protein-Specific Antibodies or siRNAs from Cell Signaling Technology^®

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	RAPGEF4

Modification Sites and Domains

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Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment

SS SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.		mouse ► Hide Isoforms

0	1	T121	GESILDNTPRHATIV
0	1	Y150	FKALWEKYRQYMAGL
0	1	Y153	LWEKYRQYMAGLLAP
0	3	K202-u	ITKVPSEkILRAGKI
0	1	S216	ILRIAILSRAPHMIR
0	1	K283-u	QERHFQDkYLFYRFL
0	3	Y348-p	VDDLEIIyDELLHIK
0	1	K631-u	PELEKIVkQISEDAK
0	1	K645	KAPQKKHKVLLQQFN
0	1	K645-u	KAPQKKHkVLLQQFN
0	2	T653-p	VLLQQFNtGDERAQK
0	1	S667	KRQPIRGSDEVLFKV
0	1	Y675	DEVLFKVYCIDHtyt
0	1	T680-p	KVYCIDHtyttIRVP
0	26	Y681-p	VYCIDHtyttIRVPV
0	2	T682-p	YCIDHtyttIRVPVA
0	2	T683-p	CIDHtyttIRVPVAA
0	1	K693-u	VPVAASVkEVISAVA
0	1	T809	GRHNFKKTTANLDLF
0	1	T810	RHNFKKTTANLDLFL
0	24	Y857-p	IAAHCKEyKNLNSFF
0	1	K915-u	AYRLTAAkLEPPLIP
0	1	K950-u	DNLVNFEkMRMIANT
0	1	K978-u	PDAAQANkNHQDVRS
0	1	Y986	NHQDVRSYVRQLNVI

	RAPGEF4 iso3

T121	GESILDNTPRHATIV
Y150	FKALWEKYRQYMAGL
Y153	LWEKYRQYMAGLLAP
K184-u	KENVPSEkILRAGKI
S198	ILRIAILSRAPHMIR
K265	QERHFQDKYLFYRFL
Y330	VDDLEIIYDELLHIK
K613	PELEKIVKQISEDAK
K627	KAPQKKHKVLLQQFN
K627	KAPQKKHKVLLQQFN
T635	VLLQQFNTGDERAQK
S649	KRQPIRGSDEVLFKV
Y657	DEVLFKVYCIDHTYT
T662	KVYCIDHTYTTIRVP
Y663	VYCIDHTYTTIRVPV
T664	YCIDHTYTTIRVPVA
T665	CIDHTYTTIRVPVAA
K675	VPVAASVKEVISAVA
T791	GRHNFKKTTANLDLF
T792	RHNFKKTTANLDLFL
Y839	IAAHCKEYKNLNSFF
K897	AYRLTAAKLEPPLIP
K932	DNLVNFEKMRMIANT
K960	PDAAQANKNHQDVRS
Y968	NHQDVRSYVRQLNVI

	human

T121-p	GESILDNtPRHATIV
Y150-p	FKALWEKyRQyMAGL
Y153-p	LWEKyRQyMAGLLAP
K202	ITKVPSEKILRAGKI
S216-p	ILRNAILsRAPHMIR
K283	QEHHFQDKYLFYRFL
Y348	VDDLEIIYEELLHIK
K631	PELEKIVKQISEDAK
K645-a	KAPQKKHkVLLQQFN
K645	KAPQKKHKVLLQQFN
T653	VLLQQFNTGDERAQK
S667	KRQPIRGSDEVLFKV
Y675-p	DEVLFKVyCMDHTYT
T680	KVyCMDHTYTTIRVP
Y681	VyCMDHTYTTIRVPV
T682	yCMDHTYTTIRVPVA
T683	CMDHTYTTIRVPVAT
K693	VPVATSVKEVISAVA
T809-p	GRHNFKKttANLDLF
T810-p	RHNFKKttANLDLFL
Y857-p	IAAHCKEyKNLNSFF
K915	AYRLTVAKLEPPLIP
K950	DNLVNFEKMRMIANT
K978	PDAAQANKNHQDVRS
Y986-p	NHQDVRSyVRQLNVI

	rat

T121	GESILDNTPRHATIV
Y150	FKALWEKYRQYMAGL
Y153	LWEKYRQYMAGLLAP
K202-u	ITKVPSEkILRAGKI
S216	ILRIAILSRAPHMIR
-	gap
Y306-p	ADDLEIIyDELLHIK
K589	AELEKTVKQISEDAK
K603	KAPQKKHKVLLQQFN
K603	KAPQKKHKVLLQQFN
T611	VLLQQFNTGDERAQK
S625-p	KRQPIRGsDEVLFKV
Y633-p	DEVLFKVyCIDHTyt
T638	KVyCIDHTyttIRVP
Y639-p	VyCIDHTyttIRVPV
T640-p	yCIDHTyttIRVPVA
T641-p	CIDHTyttIRVPVAA
K651	VPVAASVKEVISAVA
T767	GRHNFKKTTANLDLF
T768	RHNFKKTTANLDLFL
Y815	IAAHCKEYKNLNSFF
K873	AYRLTAAKLEPPLIP
K908	DNLVNFEKMRMIANT
K936	PDAAQANKNHQDVRS
Y944	NHQDVRSYVRQLNVI

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