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Protein Page:
EFNB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EFNB1 a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Note: This description may include information from UniProtKB.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; synapse; nucleus; lipid raft
Molecular Function: protein binding; ephrin receptor binding
Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway; positive regulation of T cell proliferation; cell adhesion; embryonic pattern specification; neural crest cell migration
Reference #:  P98172 (UniProtKB)
Alt. Names/Synonyms: CFND; CFNS; EFL-3; EFL3; EFNB1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B1; Ephrin-B1; EPLG2; LERK-2; LERK2; ligand of eph-related kinase 2; MGC8782
Gene Symbols: EFNB1
Molecular weight: 38,007 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Select Structure to View Below

EFNB1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y79-p PYEYYKLyLVRPEQA
0 1 K163-ub RTMKIIMkVGQDPNA
0 1 T172-ga GQDPNAVtPEQLtts
0 1 T177-ga AVtPEQLttsRPSKE
0 1 T178-ga VtPEQLttsRPSKEA
0 1 S179-ga tPEQLttsRPSKEAD
0 1 T188-ga PSKEADNtVKMATQA
0 1 S201-ga QAPGSRGsLGDSDGK
0 1 T211-ga DSDGKHEtVNQEEKs
0 1 S218-p tVNQEEKsGPGAsGG
0 1 S223-p EKsGPGAsGGssGDP
0 1 S226-p GPGAsGGssGDPDGF
0 1 S227-p PGAsGGssGDPDGFF
0 3 S281-p QQRAAALsLsTLAsP
0 1 S283-p RAAALsLsTLAsPkG
0 10 S287-p LsLsTLAsPkGGSGT
0 6 K289-ub LsTLAsPkGGSGTAG
0 123 Y313-p LRTTENNyCPHyEKV
1 190 Y317-p ENNyCPHyEKVsGDy
0 1 K319 NyCPHyEKVsGDyGH
0 17 S321-p CPHyEKVsGDyGHPV
3 130 Y324-p yEKVsGDyGHPVyIV
3 126 Y329-p GDyGHPVyIVQEMPP
1 173 Y343-p PQSPANIyyKV____
0 32 Y344-p QSPANIyyKV_____
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
  mouse

 
Y79 PYEYYKLYLVRPEQA
K163 RTMKIVMKVGQDPNA
T172 GQDPNAVTPEQLTTS
T177 AVTPEQLTTSRPSKE
T178 VTPEQLTTSRPSKES
S179 TPEQLTTSRPSKESD
T188 PSKESDNTVKTATQA
S200 TQAPGRGSQGDSDGK
T210 DSDGKHETVNQEEKS
S217 TVNQEEKSGPGAGGG
- gap
- gap
S226 PGAGGGGSGDSDSFF
S280-p QQRAAALsLSTLAsP
S282 RAAALsLSTLAsPkG
S286-p LsLSTLAsPkGGSGT
K288-ub LSTLAsPkGGSGTAG
Y312-p LRTTENNyCPHyEkV
Y316-p ENNyCPHyEkVsGDy
K318-ub NyCPHyEkVsGDyGH
S320-p CPHyEkVsGDyGHPV
Y323-p yEkVsGDyGHPVyIV
Y328-p GDyGHPVyIVQEMPP
Y342-p PQSPANIyYKV____
Y343 QSPANIyYKV_____
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
  rat

 
Y79 PYEYYKLYLVRPEQA
K163 RTMKIVMKVGQDPNA
T172 GQDPNAVTPEQLTTS
T177 AVTPEQLTTSRPSKE
T178 VTPEQLTTSRPSKES
S179 TPEQLTTSRPSKESD
T188 PSKESDNTVKTATQA
S200 TQAPGRGSQGDSDGK
T210 DSDGKHETVNQQEKS
S217 TVNQQEKSGPGAGGS
- gap
- gap
S226 PGAGGSGSGDTDSFF
S280 QQRAAALSLSTLASP
S282 RAAALSLSTLASPKG
S286 LSLSTLASPKGDSGT
K288 LSTLASPKGDSGTAG
Y312 LRTTENNYCPHYEKV
Y316 ENNYCPHYEKVSGDY
K318 NYCPHYEKVSGDYGH
S320 CPHYEKVSGDYGHPV
Y323 YEKVSGDYGHPVYIV
Y328 GDYGHPVYIVQEMPP
Y342 PQSPANIYYKV____
Y343 QSPANIYYKV_____
  chicken

 
Y75 PYDYYKLYLVKKDQA
K159 RSMKIVMKVGQDPNA
- gap
T173 AVIPEQLTTSRPSKE
T174 VIPEQLTTSRPSKEA
S175 IPEQLTTSRPSKEAD
T184 PSKEADNTVKIVTQS
T198 SPRHKVPTVEEPGKP
S207 EEPGKPGSVNQNGQE
- gap
- gap
T215 VNQNGQETQGPSDGF
- gap
S270 QQRAAALSLSTLASP
S272 RAAALSLSTLASPKC
S276 LSLSTLASPKCSGNA
K278 LSTLASPKCSGNAGS
Y301 LRTTENNYCPHYEKV
Y305 ENNYCPHYEKVSGDy
K307 NYCPHYEKVSGDyGH
S309 CPHYEKVSGDyGHPV
Y312-p YEKVSGDyGHPVyIV
Y317-p GDyGHPVyIVQEMPP
Y331-p PQSPANIyYKV____
Y332 QSPANIyYKV_____
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