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EFNB1 (human)

Overview EFNB1 a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Note: This description may include information from UniProtKB. Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral Cellular Component: integral to plasma membrane; cytoplasm; synapse; nucleus; lipid raft Molecular Function: protein binding; ephrin receptor binding Biological Process: axon guidance; cell-cell signaling; positive regulation of T cell proliferation; cell adhesion; embryonic pattern specification; neural crest cell migration Reference #:  P98172 (UniProtKB) Alt. Names/Synonyms: CFND; CFNS; EFL-3; EFL3; EFNB1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B1; Ephrin-B1; EPLG2; LERK-2; LERK2; ligand of eph-related kinase 2; MGC8782 Gene Symbols: EFNB1 Molecular weight: 38,007 Da Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states

Select Structure to View Below EFNB1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y79-p	PYEYYKLyLVRPEQA
0	1		K163-u	RTMKIIMkVGQDPNA
0	1		T172-ga	GQDPNAVtPEQLtts
0	1		T177-ga	AVtPEQLttsRPSKE
0	1		T178-ga	VtPEQLttsRPSKEA
0	1		S179-ga	tPEQLttsRPSKEAD
0	1		T188-ga	PSKEADNtVKMATQA
0	1		S201-ga	QAPGSRGsLGDSDGK
0	1		T211-ga	DSDGKHEtVNQEEKs
0	1		S218-p	tVNQEEKsGPGAsGG
0	1		S223-p	EKsGPGAsGGssGDP
0	1		S226-p	GPGAsGGssGDPDGF
0	1		S227-p	PGAsGGssGDPDGFF
0	7		S287-p	LSLSTLAsPkGGSGT
0	6		K289-u	LSTLAsPkGGSGTAG
0	114		Y313-p	LRTTENNyCPHyEKV
0	179		Y317-p	ENNyCPHyEKVsGDy
0	1		K319	NyCPHyEKVsGDyGH
0	14		S321-p	CPHyEKVsGDyGHPV
3	118		Y324-p	yEKVsGDyGHPVyIV
3	113		Y329-p	GDyGHPVyIVQEMPP
1	152		Y343-p	PQSPANIyyKV____
0	30		Y344-p	QSPANIyyKV_____

	mouse
Y79	PYEYYKLYLVRPEQA
K163	RTMKIVMKVGQDPNA
T172	GQDPNAVTPEQLTTS
T177	AVTPEQLTTSRPSKE
T178	VTPEQLTTSRPSKES
S179	TPEQLTTSRPSKESD
T188	PSKESDNTVKTATQA
S200	TQAPGRGSQGDSDGK
T210	DSDGKHETVNQEEKS
S217	TVNQEEKSGPGAGGG
G222	EKSGPGAGGGGSGDS
G225	GPGAGGGGSGDSDSF
S226	PGAGGGGSGDSDSFF
S286-p	LSLSTLAsPkGGSGT
K288-u	LSTLAsPkGGSGTAG
Y312-p	LRTTENNyCPHyEkV
Y316-p	ENNyCPHyEkVsGDy
K318-u	NyCPHyEkVsGDyGH
S320-p	CPHyEkVsGDyGHPV
Y323-p	yEkVsGDyGHPVyIV
Y328-p	GDyGHPVyIVQEMPP
Y342-p	PQSPANIyYKV____
Y343	QSPANIyYKV_____

	rat
Y79	PYEYYKLYLVRPEQA
K163	RTMKIVMKVGQDPNA
T172	GQDPNAVTPEQLTTS
T177	AVTPEQLTTSRPSKE
T178	VTPEQLTTSRPSKES
S179	TPEQLTTSRPSKESD
T188	PSKESDNTVKTATQA
S200	TQAPGRGSQGDSDGK
T210	DSDGKHETVNQQEKS
S217	TVNQQEKSGPGAGGS
G222	EKSGPGAGGSGSGDT
G225	GPGAGGSGSGDTDSF
S226	PGAGGSGSGDTDSFF
S286	LSLSTLASPKGDSGT
K288	LSTLASPKGDSGTAG
Y312	LRTTENNYCPHYEKV
Y316	ENNYCPHYEKVSGDY
K318	NYCPHYEKVSGDYGH
S320	CPHYEKVSGDYGHPV
Y323	YEKVSGDYGHPVYIV
Y328	GDYGHPVYIVQEMPP
Y342	PQSPANIYYKV____
Y343	QSPANIYYKV_____

	chicken
Y75	PYDYYKLYLVKKDQA
K159	RSMKIVMKVGQDPNA
I168	GQDPNAVIPEQLTTS
T173	AVIPEQLTTSRPSKE
T174	VIPEQLTTSRPSKEA
S175	IPEQLTTSRPSKEAD
T184	PSKEADNTVKIVTQS
-	under review
-	under review
G203	VPTVEEPGKPGSVNQ
G212	PGSVNQNGQETQGPS
T215	VNQNGQETQGPSDGF
Q216	NQNGQETQGPSDGFL
S276	LSLSTLASPKCSGNA
K278	LSTLASPKCSGNAGS
Y301	LRTTENNYCPHYEKV
Y305	ENNYCPHYEKVSGDy
K307	NYCPHYEKVSGDyGH
S309	CPHYEKVSGDyGHPV
Y312-p	YEKVSGDyGHPVyIV
Y317-p	GDyGHPVyIVQEMPP
Y331-p	PQSPANIyYKV____
Y332	QSPANIyYKV_____

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