Involved in intracellular vesicle trafficking. Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3. Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. Belongs to the syntaxin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle protein
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; clathrin-coated vesicle; perinuclear region of cytoplasm; early endosome; plasma membrane; integral to membrane; trans-Golgi network membrane
Molecular Function: SNAP receptor activity; protein binding
Biological Process: vesicle fusion; intracellular protein transport; endosome organization and biogenesis; retrograde transport, endosome to Golgi; Golgi vesicle transport
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.