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STX6 (human)

Overview STX6 Involved in intracellular vesicle trafficking. Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3. Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. Belongs to the syntaxin family. Note: This description may include information from UniProtKB. Protein type: Vesicle protein; Membrane protein, integral Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; clathrin-coated vesicle; perinuclear region of cytoplasm; early endosome; plasma membrane; integral to membrane; trans-Golgi network membrane Molecular Function: SNAP receptor activity; protein binding Biological Process: vesicle fusion; intracellular protein transport; endosome organization and biogenesis; retrograde transport, endosome to Golgi; Golgi vesicle transport Reference #:  O43752 (UniProtKB) Alt. Names/Synonyms: STX6; syntaxin 6; Syntaxin-6 Gene Symbols: STX6 Molecular weight: 29,176 Da Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STX6 2NPS - D=169-234 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S2-p	______MsMEDPFFV
0	1		K16	VVKGEVQKAVNTAQG
0	1		K77-u	IVEANPRkFNLDAtE
0	1		T83-p	RkFNLDAtELsIRKA
0	1		S86-p	NLDAtELsIRKAFIT
0	1		S110	KDQMSTSSVQALAER
0	1		S127-p	RQALLGDsGsQNWSt
0	9		S129-p	ALLGDsGsQNWStGT
0	1		T134-p	sGsQNWStGTtDkyG
0	1		T137-p	QNWStGTtDkyGRLD
0	2		K139-u	WStGTtDkyGRLDRE
0	4		Y140-p	StGTtDkyGRLDREL
0	16		S152-p	RELQRANsHFIEEQQ
0	1		S205	AVMLEDFSHELESTQ

	mouse
S2-p	______MsMEDPFFV
K16-u	VVKGEVQkAVNTAQG
K77	IVEANPRKFNLDATE
T83	RKFNLDATELSIRKA
S86	NLDATELSIRKAFIT
S110-p	KDQMSASsVQALAER
S127	RQALLGDSSSQSWNA
S129	ALLGDSSSQSWNAGV
A134	SSSQSWNAGVADRYG
A137	QSWNAGVADRYGRLD
R139	WNAGVADRYGRLDRE
Y140	NAGVADRYGRLDREL
S152	RELQLANSHFIEEQQ
S205-p	AVMLDDFsHELESTQ

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