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Protein Page:
STX6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STX6 Involved in intracellular vesicle trafficking. Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3. Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. Belongs to the syntaxin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle protein
Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; clathrin-coated vesicle; perinuclear region of cytoplasm; early endosome; integral to membrane; plasma membrane; trans-Golgi network membrane
Molecular Function: SNAP receptor activity; protein binding
Biological Process: vesicle fusion; intracellular protein transport; endosome organization and biogenesis; retrograde transport, endosome to Golgi; Golgi vesicle transport
Reference #:  O43752 (UniProtKB)
Alt. Names/Synonyms: STX6; syntaxin 6; Syntaxin-6
Gene Symbols: STX6
Molecular weight: 29,176 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STX6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S2-p ______MsMEDPFFV
0 1 K16 VVKGEVQKAVNTAQG
0 1 K77-ub IVEANPRkFNLDAtE
0 1 T83-p RkFNLDAtELsIRKA
0 2 S86-p NLDAtELsIRKAFIT
0 1 S107-p RDMKDQMsTSSVQAL
0 1 S110 KDQMsTSSVQALAER
0 3 S127-p RQALLGDsGsQNWSt
0 12 S129-p ALLGDsGsQNWStGT
0 1 T134-p sGsQNWStGTtDkyG
0 1 T137-p QNWStGTtDkyGRLD
0 2 K139-ub WStGTtDkyGRLDRE
0 4 Y140-p StGTtDkyGRLDREL
0 20 S152-p RELQRANsHFIEEQQ
0 1 S205 AVMLEDFSHELESTQ
  mouse

 
S2-p ______MsMEDPFFV
K16-ub VVKGEVQkAVNTAQG
K77 IVEANPRKFNLDATE
T83 RKFNLDATELSIRKA
S86 NLDATELSIRKAFIT
S107 RDMKDQMSASsVQAL
S110-p KDQMSASsVQALAER
S127 RQALLGDSSSQSWNA
S129 ALLGDSSSQSWNAGV
A134 SSSQSWNAGVADRYG
A137 QSWNAGVADRYGRLD
R139 WNAGVADRYGRLDRE
Y140 NAGVADRYGRLDREL
S152 RELQLANSHFIEEQQ
S205-p AVMLDDFsHELESTQ
  rat

 
S2-p ______MsMEDPFFV
K16 VVKGEVQKAVNTAQG
K77 IVEANPRKFNLDATE
T83 RKFNLDATELSIRKA
S86 NLDATELSIRKAFIT
S107 RDMKDQMSASSVQAL
S110 KDQMSASSVQALAER
S127 RQALLGDSSSQNWDA
S129 ALLGDSSSQNWDAGV
A134 SSSQNWDAGVTDRYG
T137 QNWDAGVTDRYGRLD
R139 WDAGVTDRYGRLDRE
Y140 DAGVTDRYGRLDREL
S152 RELQLANSHFIEEQQ
S205 AVMLDDFSHELESTQ
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