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Protein Page:
eIF4B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF4B eukaryotic translation initiation factor 4B. Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Cellular Component: eukaryotic translation initiation factor 4F complex; cytosol
Molecular Function: protein binding; RNA binding; translation initiation factor activity; nucleotide binding
Biological Process: poly(A) tail shortening; cellular protein metabolic process; translation; RNA metabolic process; insulin receptor signaling pathway; translational initiation; gene expression; mRNA metabolic process; mRNA catabolic process, deadenylation-dependent decay; regulation of translational initiation
Reference #:  P23588 (UniProtKB)
Alt. Names/Synonyms: eIF-4B; EIF4B; Eukaryotic translation initiation factor 4B; IF4B; PRO1843
Gene Symbols: EIF4B
Molecular weight: 69,151 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

eIF4B

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
translation, altered: S422‑p
activity, inhibited: S422‑p
molecular association, regulation: S422‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K6-ac __MAASAkKKNKKGK
0 1 S16-p NKKGKTIsLTDFLAE
0 1 Y33-p GTGGGSTyVSKPVsW
0 1 S39-p TyVSKPVsWADETDD
0 2 S57-p DVSTTWHsNDDDVyR
0 59 Y63-p HsNDDDVyRAPPIDr
0 1 R70-m1 yRAPPIDrSILPtAP
0 1 T75-p IDrSILPtAPRAARE
0 44 S93-p DRSRLPKsPPytAFL
0 7 Y96-p RLPKsPPytAFLGNL
0 1 T97-p LPKsPPytAFLGNLP
0 2 Y105-p AFLGNLPyDVTEEsI
0 1 S111-p PyDVTEEsIKEFFRG
0 12 S131-p VRLPREPsNPERLKG
0 2 S183-p DKDRDDRsFGRDRNR
0 7 S192-p GRDRNRDsDKtDtDW
0 2 T195-p RNRDsDKtDtDWRAR
0 1 T197-p RDsDKtDtDWRARPA
0 1 A204 tDWRARPAtDsFDDy
0 3 T205-p DWRARPAtDsFDDyP
0 35 S207-p RARPAtDsFDDyPPR
0 190 Y211-p AtDsFDDyPPRRGDD
0 12 S219-p PPRRGDDsFGDkyRD
0 1 K223-ub GDDsFGDkyRDRyDs
0 15 Y224-p DDsFGDkyRDRyDsD
0 62 Y228-p GDkyRDRyDsDRyRD
0 33 S230-p kyRDRyDsDRyRDGy
0 2 Y233-p DRyDsDRyRDGyRDG
0 6 Y237-p sDRyRDGyRDGyRDG
0 8 Y241-p RDGyRDGyRDGPRRD
0 3 Y252-p PRRDMDRyGGRDRyD
0 31 Y258-p RyGGRDRyDDRGsRD
0 2 S263-p DRyDDRGsRDyDRGy
0 111 Y266-p DDRGsRDyDRGyDsR
0 111 Y270-p sRDyDRGyDsRIGSG
0 5 S272-p DyDRGyDsRIGSGRR
0 8 S283-p SGRRAFGsGyRRDDD
0 11 Y285-p RRAFGsGyRRDDDyR
0 57 Y291-p GyRRDDDyRGGGDRy
0 2 R292 yRRDDDyRGGGDRyE
0 21 Y298-p yRGGGDRyEDRyDRR
0 10 Y302-p GDRyEDRyDRRDDRs
0 1 S309-p yDRRDDRsWssRDDy
0 1 S311-p RRDDRsWssRDDysR
0 2 S312-p RDDRsWssRDDysRD
0 166 Y316-p sWssRDDysRDDyRR
0 27 S317-p WssRDDysRDDyRRD
0 78 Y321-p DDysRDDyRRDDRGP
0 3 S340-p KLNLKPRstPKEDDs
0 2 T341-p LNLKPRstPKEDDss
0 2 S347-p stPKEDDssAstsQs
0 4 S348-p tPKEDDssAstsQsT
0 2 S350-p KEDDssAstsQsTRA
0 1 T351-p EDDssAstsQsTRAA
0 2 S352-p DDssAstsQsTRAAs
0 3 S354-p ssAstsQsTRAAsIF
0 2 T355 sAstsQsTRAAsIFG
0 9 S359-p sQsTRAAsIFGGAkP
0 3 K365-ac AsIFGGAkPVDtAAR
0 1 T369-p GGAkPVDtAAREREV
2 663 S406-p RPRERHPsWRsEEtQ
0 140 S409-p ERHPsWRsEEtQERE
0 17 T412-p PsWRsEEtQERERsR
0 123 S418-p EtQERERsRtGsEss
0 311 T420-p QERERsRtGsEssQt
4 476 S422-p RERsRtGsEssQtGt
0 172 S424-p RsRtGsEssQtGtst
0 319 S425-p sRtGsEssQtGtstt
0 36 T427-p tGsEssQtGtsttss
0 31 T429-p sEssQtGtsttssRN
0 3 S430-p EssQtGtsttssRNA
0 5 T431-p ssQtGtsttssRNAR
0 13 T432-p sQtGtsttssRNARR
0 3 S433-p QtGtsttssRNARRR
0 16 S434-p tGtsttssRNARRRE
0 11 A437 sttssRNARRREsEk
0 203 S442-p RNARRREsEksLENE
0 1 K444-ac ARRREsEksLENEtL
0 68 S445-p RRREsEksLENEtLN
0 8 T450-p EksLENEtLNKEEDC
0 20 S459-p NKEEDCHsPtsKPPK
0 6 T461-p EEDCHsPtsKPPKPD
0 7 S462-p EDCHsPtsKPPKPDQ
0 1 S488-p ENAWVKRssNPPARs
0 10 S489-p NAWVKRssNPPARsQ
0 22 S495-p ssNPPARsQssDtEQ
0 67 S497-p NPPARsQssDtEQQs
0 47 S498-p PPARsQssDtEQQsP
0 10 T500-p ARsQssDtEQQsPtS
1 42 S504-p ssDtEQQsPtSGGGK
0 3 T506-p DtEQQsPtSGGGKVA
0 2 S507 tEQQsPtSGGGKVAP
0 1 S518-p KVAPAQPsEEGPGRK
0 1 D531-ca RKDENKVdGMNAPKG
0 1 S572 KKDQDSRSAPEPKKP
0 1 S585-p KPEENPAskFSSAsK
0 5 K586-ac PEENPAskFSSAsKy
0 1 S591-p AskFSSAsKyAALsV
0 12 Y593-p kFSSAsKyAALsVDG
0 26 S597-p AsKyAALsVDGEDEN
0 109 Y609-p DENEGEDyAE_____
0 6 A610 ENEGEDyAE______
5399 : Phospho-eIF4B (Ser406) Antibody
8151 : Phospho-eIF4B (Ser406) (D1C10) Rabbit mAb
3591 : Phospho-eIF4B (Ser422) Antibody
  mouse

 
K6 __MAASAKKKNKKGK
S16 NKKGKTISLTDFLAE
Y33 GTGGGSTYVPKPVSW
S39 TYVPKPVSWADETDD
S57 DVSTTWHSNDDDVyR
Y63-p HSNDDDVyRAPPIDr
R70-m1 yRAPPIDrSILPTAP
T75 IDrSILPTAPRAARE
S93-p DRSRLPKsPPyTAFL
Y96-p RLPKsPPyTAFLGNL
T97 LPKsPPyTAFLGNLP
Y105-p AFLGNLPyDVTEDSI
S111 PyDVTEDSIKDFFRG
S131 VRLPREPSNPDRLKG
S183 DKDRDDRSFGRDRNR
S192-p GRDRNRDsDKTDTDW
T195 RNRDsDKTDTDWRAR
T197 RDsDKTDTDWRARPt
T204-p TDWRARPttDsFDDy
T205-p DWRARPttDsFDDyP
S207-p RARPttDsFDDyPPR
Y211-p ttDsFDDyPPRRGDD
S219-p PPRRGDDsFGDKYRD
K223 GDDsFGDKYRDRYDS
Y224 DDsFGDKYRDRYDSD
Y228 GDKYRDRYDSDRYRD
S230 KYRDRYDSDRYRDGY
Y233 DRYDSDRYRDGYRDG
Y237 SDRYRDGYRDGYRDG
Y241 RDGYRDGYRDGPRRD
Y252 PRRDMDRYGGRDRYD
Y258 RYGGRDRYDDRGSRD
S263 DRYDDRGSRDYDRGY
Y266 DDRGSRDYDRGYDSR
Y270 SRDYDRGYDSRIGSG
S272 DYDRGYDSRIGSGRR
S283-p SGRRAFGsGYRRDDD
Y285 RRAFGsGYRRDDDYr
Y291 GYRRDDDYrGGGDRY
R292-m1 YRRDDDYrGGGDRYE
Y298 YrGGGDRYEDRYDRR
Y302 GDRYEDRYDRRDDRS
S309 YDRRDDRSWSSRDDy
S311 RRDDRSWSSRDDySR
S312 RDDRSWSSRDDySRD
Y316-p SWSSRDDySRDDYRR
S317 WSSRDDySRDDYRRD
Y321 DDySRDDYRRDDRGP
S340-p RLNLKPRsAPKEDDA
A341 LNLKPRsAPKEDDAs
A347 sAPKEDDAsASTsQs
S348-p APKEDDAsASTsQss
S350 KEDDAsASTsQssRA
T351 EDDAsASTsQssRAA
S352-p DDAsASTsQssRAAs
S354-p AsASTsQssRAAsIF
S355-p sASTsQssRAAsIFG
S359-p sQssRAAsIFGGAKP
K365 AsIFGGAKPVDTAAR
T369 GGAKPVDTAAREREV
S406-p RPRERHPsWRsEEtQ
S409-p ERHPsWRsEEtQERE
T412-p PsWRsEEtQERERsR
S418-p EtQERERsRtGsEss
T420-p QERERsRtGsEssQt
S422-p RERsRtGsEssQtGA
S424-p RsRtGsEssQtGASA
S425-p sRtGsEssQtGASAT
T427-p tGsEssQtGASATSG
A429 sEssQtGASATSGRN
S430 EssQtGASATSGRNt
A431 ssQtGASATSGRNtR
T432 sQtGASATSGRNtRR
S433 QtGASATSGRNtRRR
G434 tGASATSGRNtRRRE
T437-p SATSGRNtRRREsEK
S442-p RNtRRREsEKsLENE
K444 tRRREsEKsLENEtL
S445-p RRREsEKsLENEtLN
T450-p EKsLENEtLNKEEDC
S459-p NKEEDCHsPtsKPPK
T461-p EEDCHsPtsKPPKPD
S462-p EDCHsPtsKPPKPDQ
S488 ENAWVKRSsNPPARs
S489-p NAWVKRSsNPPARsQ
S495-p SsNPPARsQssDtEQ
S497-p NPPARsQssDtEQPs
S498-p PPARsQssDtEQPsP
T500-p ARsQssDtEQPsPts
S504-p ssDtEQPsPtsGGGK
T506-p DtEQPsPtsGGGKVA
S507-p tEQPsPtsGGGKVAA
P518 KVAAVQPPEEGPSRK
D531 RKDGNKVDVVGATQG
S572-p KKDQDSRsAPEPKKP
S585 KPEENPASKFSSASK
K586 PEENPASKFSSASKY
S591 ASKFSSASKYAALsV
Y593 KFSSASKYAALsVDG
S597-p ASKYAALsVDGEDED
C609 DEDEGDDCtE_____
T610-p EDEGDDCtE______
5399 : Phospho-eIF4B (Ser406) Antibody
8151 : Phospho-eIF4B (Ser406) (D1C10) Rabbit mAb
3591 : Phospho-eIF4B (Ser422) Antibody
  rat

 
K6 __MAASAKKKNKKGK
S16 NKKGKTISLTDFLAE
Y33 GTGGGSTYVPKPVSW
S39 TYVPKPVSWADETDD
S57 DVSTTWHSNDDDVYR
Y63 HSNDDDVYRAPPIDR
R70 YRAPPIDRSILPTAP
T75 IDRSILPTAPRAARE
S93 DRSRLPKSPPYTAFL
Y96 RLPKSPPYTAFLGNL
T97 LPKSPPYTAFLGNLP
Y105 AFLGNLPYDVTEDSI
S111 PYDVTEDSIKDFFRG
S131 VRLPREPSNPDRLKG
S183 DKDRDDRSFGRDRNR
S192 GRDRNRDSDKTDTDW
T195 RNRDSDKTDTDWRAR
T197 RDSDKTDTDWRARPA
A204 TDWRARPATDSFDDY
T205 DWRARPATDSFDDYP
S207 RARPATDSFDDYPPR
Y211 ATDSFDDYPPRRGDD
S219 PPRRGDDSFGDKYRD
K223 GDDSFGDKYRDRYES
Y224 DDSFGDKYRDRYESD
Y228 GDKYRDRYESDRYRD
S230 KYRDRYESDRYRDGY
Y233 DRYESDRYRDGYRDG
Y237 SDRYRDGYRDGYRDG
Y241 RDGYRDGYRDGPRRD
Y252 PRRDMDRYGGRDRYD
Y258 RYGGRDRYDDRGSRD
S263 DRYDDRGSRDYDRGY
Y266 DDRGSRDYDRGYDSR
Y270 SRDYDRGYDSRIGSG
S272 DYDRGYDSRIGSGRR
S283 SGRRAFGSGYRRDDD
Y285 RRAFGSGYRRDDDYR
Y291 GYRRDDDYRGGGDRY
R292 YRRDDDYRGGGDRYE
Y298 YRGGGDRYEDRYDRR
Y302 GDRYEDRYDRRDDRS
S309 YDRRDDRSWSSRDDY
S311 RRDDRSWSSRDDYSR
S312 RDDRSWSSRDDYSRD
Y316 SWSSRDDYSRDDYRR
S317 WSSRDDYSRDDYRRD
Y321 DDYSRDDYRRDDRGP
S340 KLNLKPRSTPKEDDS
T341 LNLKPRSTPKEDDSS
S347 STPKEDDSSASTSQS
S348 TPKEDDSSASTSQSS
S350 KEDDSSASTSQSSRA
T351 EDDSSASTSQSSRAA
S352 DDSSASTSQSSRAAS
S354 SSASTSQSSRAASIF
S355 SASTSQSSRAASIFG
S359 SQSSRAASIFGGAKP
K365 ASIFGGAKPVDTAAR
T369 GGAKPVDTAAREREV
S406-p RPRERHPsWRSEETQ
S409 ERHPsWRSEETQERE
T412 PsWRSEETQERERsR
S418-p ETQERERsRtGsEss
T420-p QERERsRtGsEssQt
S422-p RERsRtGsEssQtGt
S424-p RsRtGsEssQtGtSA
S425-p sRtGsEssQtGtSAT
T427-p tGsEssQtGtSATSG
T429-p sEssQtGtSATSGRN
S430 EssQtGtSATSGRNT
A431 ssQtGtSATSGRNTR
T432 sQtGtSATSGRNTRR
S433 QtGtSATSGRNTRRR
G434 tGtSATSGRNTRRRE
T437 SATSGRNTRRREsEK
S442-p RNTRRREsEKsLENE
K444 TRRREsEKsLENETL
S445-p RRREsEKsLENETLN
T450 EKsLENETLNKEEDC
S459 NKEEDCHSPTSKPPK
T461 EEDCHSPTSKPPKPD
S462 EDCHSPTSKPPKPDQ
S488 ENAWVKRSSNPPARs
S489 NAWVKRSSNPPARsQ
S495-p SSNPPARsQssDtEQ
S497-p NPPARsQssDtEQPs
S498-p PPARsQssDtEQPsP
T500-p ARsQssDtEQPsPTS
S504-p ssDtEQPsPTSGGGK
T506 DtEQPsPTSGGGKVA
S507 tEQPsPTSGGGKVAP
S518 KVAPAQPSEEGPSRK
D531 RKDETKVDGVSTTKG
S572 KKDQDSRSAPEPKKS
S585 KSEENRASKFSSASK
K586 SEENRASKFSSASKY
S591 ASKFSSASKYAALsV
Y593 KFSSASKYAALsVDG
S597-p ASKYAALsVDGEDED
C609 DEDEGDDCtE_____
T610-p EDEGDDCtE______
5399 : Phospho-eIF4B (Ser406) Antibody
8151 : Phospho-eIF4B (Ser406) (D1C10) Rabbit mAb
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