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Protein Page:
CDH3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDH3 Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: cell-cell adherens junction; cytoplasm; plasma membrane; integral to membrane
Molecular Function: calcium ion binding
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to drug; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; retinal homeostasis; hair cycle process; negative regulation of transforming growth factor-beta2 production; cell-cell adhesion; negative regulation of catagen; positive regulation of monophenol monooxygenase activity; visual perception; keratinization; homophilic cell adhesion; cell adhesion
Reference #:  P22223 (UniProtKB)
Alt. Names/Synonyms: CADH3; cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; P-cadherin; PCAD; Placental cadherin
Gene Symbols: CDH3
Molecular weight: 91,418 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDH3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S133-p QRLNQLKsNKDRDtK
0 1 T139-p KsNKDRDtKIFySIT
0 1 Y143-p DRDtKIFySITGPGA
0 1 S492-p WLAMDPDsGQVTAVG
0 1 K682-ub LLVRKKRkIkEPLLL
0 1 K684-ub VRKKRkIkEPLLLPE
0 1 T694-p LLLPEDDtRDNVFyy
0 6 Y700-p DtRDNVFyyGEEGGG
0 24 Y701-p tRDNVFyyGEEGGGE
0 5 Y713-p GGEEDQDyDITQLHR
0 3 K818-ub EWGSRFKkLADMyGG
0 28 Y823-p FKkLADMyGGGEDD_
  mouse

 
S125 QRLNQLKSNKDRGTK
T131 KSNKDRGTKIFYSIT
Y135 DRGTKIFYSITGPGA
S484 WLAVDPDSGQITAAG
K675 LLVRKKRKVKEPLLL
K677 VRKKRKVKEPLLLPE
T687-p LLLPEDDtRDNVFYY
Y693 DtRDNVFYYGEEGGG
Y694 tRDNVFYYGEEGGGE
Y706 GGEEDQDYDITQLHR
K811 EWGSRFKKLADMYGG
Y816 FKKLADMYGGGEDD_
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