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CDH3 (human)

Overview CDH3 Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Cellular Component: cell-cell adherens junction; integral to membrane; plasma membrane Molecular Function: calcium ion binding Biological Process: intercellular junction assembly and maintenance; visual perception; response to stimulus; cell adhesion; homophilic cell adhesion Reference #:  P22223 (UniProtKB) Alt. Names/Synonyms: CADH3; cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; P-cadherin; PCAD; Placental cadherin Gene Symbols: CDH3 Molecular weight: 91,418 Da Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDH3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 114021 225280 601553  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S133-p	QRLNQLKsNKDRDtK
0	1		T139-p	KsNKDRDtKIFySIT
0	1		Y143-p	DRDtKIFySITGPGA
0	1		S492-p	WLAMDPDsGQVTAVG
0	1		K682-u	LLVRKKRkIkEPLLL
0	1		K684-u	VRKKRkIkEPLLLPE
0	1		T694-p	LLLPEDDtRDNVFyy
0	6		Y700-p	DtRDNVFyyGEEGGG
0	22		Y701-p	tRDNVFyyGEEGGGE
0	5		Y713-p	GGEEDQDyDITQLHR
0	3		K818-u	EWGSRFKkLADMyGG
0	25		Y823-p	FKkLADMyGGGEDD_

	mouse
S125	QRLNQLKSNKDRGTK
T131	KSNKDRGTKIFYSIT
Y135	DRGTKIFYSITGPGA
S484	WLAVDPDSGQITAAG
K675	LLVRKKRKVKEPLLL
K677	VRKKRKVKEPLLLPE
T687-p	LLLPEDDtRDNVFYY
Y693	DtRDNVFYYGEEGGG
Y694	tRDNVFYYGEEGGGE
Y706	GGEEDQDYDITQLHR
K811	EWGSRFKKLADMYGG
Y816	FKKLADMYGGGEDD_

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