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CrkL (human)

Overview CrkL an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis Cellular Component: cytosol Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; thymus development; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development Reference #:  P46109 (UniProtKB) Alt. Names/Synonyms: Crk-like protein; CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like Gene Symbols: CRKL Molecular weight: 33,777 Da Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states CST Pathways:  SAPK/JNK Signaling Cascades Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CrkL 2BZX - A=237-303 (human) 2BZY - A/B=237-303 (human) 2DBK - A=220-303 (human) 2EO3 - A=1-104 (human) 2LQN - A=1-303 (human) 2LQW - A=1-303 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2BZX 2BZY 2DBK 2EO3 2LQN 2LQW  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
inhibition: Y207‑p molecular association, regulation: Y207‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	13		S42-p	MFLVRDSstCPGDyV
0	16		T43-p	FLVRDSstCPGDyVL
0	12		Y48-p	SstCPGDyVLSVSEN
0	175		Y92-p	LEFYKIHyLDttTLI
0	2		T95-p	YKIHyLDttTLIEPA
0	2		T96-p	KIHyLDttTLIEPAP
0	3		S107-p	EPAPRYPsPPMGSVs
0	1		S114-p	sPPMGSVsAPNLPTA
0	32		Y127-p	TAEDNLEyVRtLyDF
0	5		T130-p	DNLEyVRtLyDFPGN
0	121		Y132-p	LEyVRtLyDFPGNDA
0	1		K180-a	IPVPYVEkLVRsSPH
0	3		K180-u	IPVPYVEkLVRsSPH
0	2		S184-p	YVEkLVRsSPHGKHG
0	226		S195-p	GKHGNRNsNsyGIPE
0	96		S197-p	HGNRNsNsyGIPEPA
0	278		Y198-p	GNRNsNsyGIPEPAH
9	1191		Y207-p	IPEPAHAyAQPQttt
0	80		T212-p	HAyAQPQtttPLPAV
0	48		T213-p	AyAQPQtttPLPAVs
0	18		T214-p	yAQPQtttPLPAVsG
0	1		A218	QtttPLPAVsGsPGA
0	22		S220-p	ttPLPAVsGsPGAAI
0	1		G221	tPLPAVsGsPGAAIt
0	154		S222-p	PLPAVsGsPGAAItP
0	23		T228-p	GsPGAAItPLPsTQN
0	1		S232-p	AAItPLPsTQNGPVF
0	685		Y251-p	QKRVPCAyDktALAL
0	3		K253-a	RVPCAyDktALALEV
0	1		T254-p	VPCAyDktALALEVG
0	1		K292-u	LFPFTHVkIFDPQNP

	mouse
S42	MFLVRDSStCPGDyV
T43-p	FLVRDSStCPGDyVL
Y48-p	SStCPGDyVLSVSEN
Y92-p	LEFYKIHyLDTTTLI
T95	YKIHyLDTTTLIEPA
T96	KIHyLDTTTLIEPAP
S107-p	EPAPRYPsPPVGSVS
S114	sPPVGSVSAPNLPTA
Y127-p	TAEENLEyVRtLyDF
T130-p	ENLEyVRtLyDFPGN
Y132-p	LEyVRtLyDFPGNDA
K180	IPVPYVEKLVRSSPH
K180-u	IPVPYVEkLVRSSPH
S184	YVEkLVRSSPHGKHG
S195-p	GKHGNRNsNsyGIPE
S197-p	HGNRNsNsyGIPEPA
Y198-p	GNRNsNsyGIPEPAH
Y207-p	IPEPAHAyAQPQttt
T212-p	HAyAQPQtttPLPtV
T213-p	AyAQPQtttPLPtVA
T214-p	yAQPQtttPLPtVAs
T218-p	QtttPLPtVAsTPGA
A220	ttPLPtVAsTPGAAI
S221-p	tPLPtVAsTPGAAIN
T222	PLPtVAsTPGAAINP
N228	sTPGAAINPLPSTQN
S232	AAINPLPSTQNGPVF
Y251-p	QKRVPCAyDKTALAL
K253	RVPCAyDKTALALEV
T254	VPCAyDKTALALEVG
K292	LFPFTHVKIFDPQNP

	rat
S42	MFLVRDSSTCPGDYV
T43	FLVRDSSTCPGDYVL
Y48	SSTCPGDYVLSVSEN
Y92	LEFYKIHYLDTTTLI
T95	YKIHYLDTTTLIEPA
T96	KIHYLDTTTLIEPAP
N107	EPAPRYPNPPMGSVS
S114	NPPMGSVSAPNLSTA
Y127	TAEENLEYVRTLyDF
T130	ENLEYVRTLyDFPGN
Y132-p	LEYVRTLyDFPGNDA
K180	IPVPYVEKLVRSSPH
K180	IPVPYVEKLVRSSPH
S184	YVEKLVRSSPHGKHG
S195	GKHGNRNSNSYGIPE
S197	HGNRNSNSYGIPEPA
Y198	GNRNSNSYGIPEPAH
Y207	IPEPAHAYAQPQTTT
T212	HAYAQPQTTTPLPTV
T213	AYAQPQTTTPLPTVA
T214	YAQPQTTTPLPTVAS
T218	QTTTPLPTVASTPGA
A220	TTPLPTVASTPGAAI
S221	TPLPTVASTPGAAIN
T222	PLPTVASTPGAAINP
N228	STPGAAINPLPSTQN
S232	AAINPLPSTQNGPVF
Y251-p	QKRVPCAyDKTALAL
K253	RVPCAyDKTALALEV
T254	VPCAyDKTALALEVG
K292	LFPFTHVKIFDPQNP

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