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Protein Page:
CrkL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CrkL an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: cytosol; endosome
Molecular Function: signal transducer activity; protein binding; SH3/SH2 adaptor activity
Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; activation of MAPKK activity; positive regulation of signal transduction; nerve growth factor receptor signaling pathway; thymus development; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
Reference #:  P46109 (UniProtKB)
Alt. Names/Synonyms: Crk-like protein; CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Gene Symbols: CRKL
Molecular weight: 33,777 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CrkL

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: Y207‑p
molecular association, regulation: Y207‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 13 S42-p MFLVRDSstCPGDyV
0 15 T43-p FLVRDSstCPGDyVL
0 11 Y48-p SstCPGDyVLSVSEN
0 171 Y92-p LEFYKIHyLDttTLI
0 2 T95-p YKIHyLDttTLIEPA
0 2 T96-p KIHyLDttTLIEPAP
0 1 Y105 LIEPAPRYPsPPMGS
0 5 S107-p EPAPRYPsPPMGSVs
0 2 S112 YPsPPMGSVsAPNLP
0 2 S114-p sPPMGSVsAPNLPTA
0 32 Y127-p TAEDNLEyVRtLyDF
0 6 T130-p DNLEyVRtLyDFPGN
0 124 Y132-p LEyVRtLyDFPGNDA
0 1 K180-ac IPVPYVEkLVRsSPH
0 3 K180-ub IPVPYVEkLVRsSPH
0 2 S184-p YVEkLVRsSPHGKHG
0 226 S195-p GKHGNRNsNsyGIPE
0 97 S197-p HGNRNsNsyGIPEPA
0 279 Y198-p GNRNsNsyGIPEPAH
9 1179 Y207-p IPEPAHAyAQPQttt
0 80 T212-p HAyAQPQtttPLPAV
0 48 T213-p AyAQPQtttPLPAVs
0 18 T214-p yAQPQtttPLPAVsG
0 1 A218 QtttPLPAVsGsPGA
0 22 S220-p ttPLPAVsGsPGAAI
0 1 G221 tPLPAVsGsPGAAIt
0 155 S222-p PLPAVsGsPGAAItP
0 23 T228-p GsPGAAItPLPsTQN
0 1 S232-p AAItPLPsTQNGPVF
0 659 Y251-p QKRVPCAyDktALAL
0 3 K253-ac RVPCAyDktALALEV
0 1 T254-p VPCAyDktALALEVG
0 1 K292-ub LFPFTHVkIFDPQNP
3181 : Phospho-CrkL (Tyr207) Antibody
  mouse

 
S42 MFLVRDSStCPGDyV
T43-p FLVRDSStCPGDyVL
Y48-p SStCPGDyVLSVSEN
Y92-p LEFYKIHyLDTTTLI
T95 YKIHyLDTTTLIEPA
T96 KIHyLDTTTLIEPAP
Y105-p LIEPAPRyPsPPVGs
S107-p EPAPRyPsPPVGsVs
S112-p yPsPPVGsVsAPNLP
S114-p sPPVGsVsAPNLPTA
Y127-p TAEENLEyVRtLyDF
T130-p ENLEyVRtLyDFPGN
Y132-p LEyVRtLyDFPGNDA
K180 IPVPYVEKLVRSSPH
K180-ub IPVPYVEkLVRSSPH
S184 YVEkLVRSSPHGKHG
S195-p GKHGNRNsNsyGIPE
S197-p HGNRNsNsyGIPEPA
Y198-p GNRNsNsyGIPEPAH
Y207-p IPEPAHAyAQPQttt
T212-p HAyAQPQtttPLPtV
T213-p AyAQPQtttPLPtVA
T214-p yAQPQtttPLPtVAs
T218-p QtttPLPtVAstPGA
A220 ttPLPtVAstPGAAI
S221-p tPLPtVAstPGAAIN
T222-p PLPtVAstPGAAINP
N228 stPGAAINPLPSTQN
S232 AAINPLPSTQNGPVF
Y251-p QKRVPCAyDKTALAL
K253 RVPCAyDKTALALEV
T254 VPCAyDKTALALEVG
K292 LFPFTHVKIFDPQNP
3181 : Phospho-CrkL (Tyr207) Antibody
  rat

 
S42 MFLVRDSSTCPGDYV
T43 FLVRDSSTCPGDYVL
Y48 SSTCPGDYVLSVSEN
Y92 LEFYKIHYLDTTTLI
T95 YKIHYLDTTTLIEPA
T96 KIHYLDTTTLIEPAP
Y105 LIEPAPRYPNPPMGS
N107 EPAPRYPNPPMGSVS
S112 YPNPPMGSVSAPNLS
S114 NPPMGSVSAPNLSTA
Y127 TAEENLEYVRTLyDF
T130 ENLEYVRTLyDFPGN
Y132-p LEYVRTLyDFPGNDA
K180 IPVPYVEKLVRSSPH
K180 IPVPYVEKLVRSSPH
S184 YVEKLVRSSPHGKHG
S195 GKHGNRNSNSyGIPE
S197 HGNRNSNSyGIPEPA
Y198-p GNRNSNSyGIPEPAH
Y207-p IPEPAHAyAQPQTTT
T212 HAyAQPQTTTPLPTV
T213 AyAQPQTTTPLPTVA
T214 yAQPQTTTPLPTVAS
T218 QTTTPLPTVASTPGA
A220 TTPLPTVASTPGAAI
S221 TPLPTVASTPGAAIN
T222 PLPTVASTPGAAINP
N228 STPGAAINPLPSTQN
S232 AAINPLPSTQNGPVF
Y251-p QKRVPCAyDKTALAL
K253 RVPCAyDKTALALEV
T254 VPCAyDKTALALEVG
K292 LFPFTHVKIFDPQNP
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