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Protein Page:
KIF11 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KIF11 a cytoskeletal protein that belongs to the kinesin-like protein family. BimC subfamily. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Plays a role in chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Phosphorylation regulates its association with the spindle apparatus. Note: This description may include information from UniProtKB.
Protein type: Motor protein; Microtubule binding protein
Cellular Component: spindle pole; kinesin complex; microtubule; membrane; spindle microtubule; cytoplasm; spindle; cytosol
Molecular Function: microtubule binding; protein complex binding; microtubule motor activity; protein kinase binding; ATP binding
Biological Process: mitosis; mitotic spindle organization and biogenesis; mitotic centrosome separation; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; spindle organization and biogenesis; microtubule-based movement
Reference #:  P52732 (UniProtKB)
Alt. Names/Synonyms: EG5; HKSP; KIF11; kinesin family member 11; kinesin-like 1; Kinesin-like protein 1; Kinesin-like protein KIF11; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; KNSL1; thyroid receptor interacting protein 5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; TRIP5
Gene Symbols: KIF11
Molecular weight: 119,159 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KIF11

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: T926‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3 _____MASQPNSSAK
0 1 S36-p NLAERKAsAHSIVEC
0 1 T114-p TGTGKTFtMEGERsP
0 2 S120-p FtMEGERsPNEEytW
0 10 Y125-p ERsPNEEytWEEDPL
0 1 T126-p RsPNEEytWEEDPLA
0 2 K146-ac TLHQIFEkLTDNGTE
0 3 Y211-p VHNKDEVyQILEKGA
0 1 T223-p KGAAKRTtAAtLMNA
0 1 T226-p AKRTtAAtLMNAyss
0 2 Y231-p AAtLMNAyssRSHSV
0 2 S232-p AtLMNAyssRSHSVF
0 2 S233-p tLMNAyssRSHSVFs
0 1 S240-p sRSHSVFsVTIHMKE
0 1 S291-p EAGNINQsLLtLGRV
0 1 T294-p NINQsLLtLGRVITA
0 1 S323-p LTRILQDsLGGRTRT
0 1 K372-ac VNQKLTKkALIkEYT
0 1 K376-ac LTKkALIkEYTEEIE
0 116 Y399-p AREKNGVyIsEENFR
0 2 S401-p EKNGVyIsEENFRVM
0 12 T458-p KSDLQNKtQELEttQ
0 1 T463-p NKtQELEttQKHLQE
0 1 T464-p KtQELEttQKHLQET
0 24 Y480-p LQLVKEEyITSALES
0 1 T488 ITSALESTEEKLHDA
0 1 T507-p LNTVEETtKDVSGLH
0 1 K516 DVSGLHSKLDRKKAV
0 1 S540-p IFGKNLNsLFNNMEE
0 1 K550-ub NNMEELIkDGSSKQK
0 1 T643-p LEMILSPtVVsILKI
0 1 S646-p ILSPtVVsILKINsQ
0 1 S652-p VsILKINsQLKHIFK
0 1 T663-p HIFKTSLtVADKIED
0 1 S852-p HNLLEVVsQCCEAsS
0 1 S858-p VsQCCEAsSSDITEK
0 7 K908-ub TIKIGLTkLNCFLEQ
0 1 T923-p DLKLDIPtGttPQRK
0 3 T925-p KLDIPtGttPQRKsy
4 19 T926-p LDIPtGttPQRKsyL
0 6 S931-p GttPQRKsyLyPsTL
0 13 Y932-p ttPQRKsyLyPsTLV
0 2 Y934-p PQRKsyLyPsTLVRT
0 1 S936-p RKsyLyPsTLVRTEP
0 1 I973 ENNKEETIPDVDVEE
0 2 S992 QYTEEPLSQEPSVDA
0 1 P995 EEPLSQEPSVDAGVD
0 1 S996 EPLSQEPSVDAGVDC
0 5 T1029-p KENRGINtLERskVE
1 3 S1033-p GINtLERskVEETTE
0 9 K1034-ub INtLERskVEETTEH
  mouse

 
S3-p _____MAsQPSSLKK
N35 NLAERKANAHSVVEC
T113 TGTGKTFTMEGERSP
S119 FTMEGERSPNEVyTW
Y124-p ERSPNEVyTWEEDPL
T125 RSPNEVyTWEEDPLA
K145 TLHQIFEKLTDNGTE
Y210 VHNKDEVYQILEKGA
T222 KGAAKRTTAATLMNA
T225 AKRTTAATLMNAYSS
Y230 AATLMNAYSSRSHSV
S231 ATLMNAYSSRSHSVF
S232 TLMNAYSSRSHSVFS
S239 SRSHSVFSVTIHMKE
S290 EAGNINQSLLTLGRV
T293 NINQSLLTLGRVITA
S322 LTRILQDSLGGRTRT
K371 VNQKLTKKALIKEYT
K375 LTKKALIKEYTEEIE
Y398-p AREKNGVyISEESFR
S400 EKNGVyISEESFRAM
T457 KSDLQTKTQELETTQ
T462 TKTQELETTQKHLQE
T463 KTQELETTQKHLQET
Y479 LQLVKEEYVSSALER
T487-p VSSALERtEKTLHDT
T506 LNTVKETTRAVSGLH
K515-ac AVSGLHSkLDRKRAI
S539 SFGKNLNSLFNNMEE
K549 NNMEELIKDGSAKQK
S642 LKTIVAPSVVSILNI
S645 IVAPSVVSILNINKQ
K651 VSILNINKQLQHIFR
T662 HIFRASSTVAEKVED
N851 ENLMEFVNGCCKASS
S857 VNGCCKASSSEITKK
K907 TIKTGLTKLNCFLKQ
T922 DLKLDIPTGMtPERK
M924 KLDIPTGMtPERKKY
T925-p LDIPTGMtPERKKYL
K930 GMtPERKKYLYPTTL
Y931 MtPERKKYLYPTTLV
Y933 PERKKYLYPTTLVRT
T935 RKKYLYPTTLVRTEP
S969-p SEASKETsQDMDEER
S988-p QCTEELVsPEttEHP
T991-p EELVsPEttEHPSAD
T992-p ELVsPEttEHPSADC
P1025 KENRGLNPVEKYKVE
Y1029 GLNPVEKYKVEEASD
K1030 LNPVEKYKVEEASDL
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