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Protein Page:
KIF11 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
KIF11 a cytoskeletal protein that belongs to the kinesin-like protein family. BimC subfamily. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Plays a role in chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Phosphorylation regulates its association with the spindle apparatus. Note: This description may include information from UniProtKB.
Protein type: Microtubule binding protein; Motor protein
Cellular Component: spindle pole; kinesin complex; microtubule; spindle microtubule; spindle; cytosol
Molecular Function: microtubule binding; protein complex binding; microtubule motor activity; protein kinase binding; ATP binding
Biological Process: mitosis; mitotic centrosome separation; mitotic spindle organization and biogenesis; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; spindle organization and biogenesis; microtubule-based movement
Reference #:  P52732 (UniProtKB)
Alt. Names/Synonyms: EG5; HKSP; KIF11; kinesin family member 11; kinesin-like 1; Kinesin-like protein 1; Kinesin-like protein KIF11; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; KNSL1; thyroid receptor interacting protein 5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; TRIP5
Gene Symbols: KIF11
Molecular weight: 119,159 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KIF11

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: T926‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3 _____MASQPNSSAK
0 2 S120-p FTMEGERsPNEEyTW
0 9 Y125-p ERsPNEEyTWEEDPL
0 2 K146-a TLHQIFEkLTDNGTE
0 3 Y211-p VHNKDEVyQILEKGA
0 2 Y231-p AATLMNAyssRSHSV
0 2 S232-p ATLMNAyssRSHSVF
0 2 S233-p TLMNAyssRSHSVFS
0 1 S323-p LTRILQDsLGGRTRT
0 110 Y399-p AREKNGVyISEENFR
0 12 T458-p KSDLQNKtQELETTQ
0 20 Y480-p LQLVKEEyITSALES
0 1 T507-p LNTVEETtKDVSGLH
0 1 K550-u NNMEELIkDGSSKQK
0 7 K908-u TIKIGLTkLNCFLEQ
0 1 T923-p DLKLDIPtGttPQRK
0 3 T925-p KLDIPtGttPQRKsy
4 15 T926-p LDIPtGttPQRKsyL
0 5 S931-p GttPQRKsyLYPSTL
0 10 Y932-p ttPQRKsyLYPSTLV
0 1 S992 QYTEEPLSQEPSVDA
0 4 T1029-p KENRGINtLERskVE
1 1 S1033-p GINtLERskVEETTE
0 9 K1034-u INtLERskVEETTEH
  mouse

 
S3-p _____MAsQPSSLKK
S119 FTMEGERSPNEVyTW
Y124-p ERSPNEVyTWEEDPL
K145 TLHQIFEKLTDNGTE
Y210 VHNKDEVYQILEKGA
Y230 AATLMNAYSSRSHSV
S231 ATLMNAYSSRSHSVF
S232 TLMNAYSSRSHSVFS
S322 LTRILQDSLGGRTRT
Y398-p AREKNGVyISEESFR
T457 KSDLQTKTQELETTQ
Y479 LQLVKEEYVSSALER
T506 LNTVKETTRAVSGLH
K549 NNMEELIKDGSAKQK
K907 TIKTGLTKLNCFLKQ
T922 DLKLDIPTGMtPERK
M924 KLDIPTGMtPERKKY
T925-p LDIPTGMtPERKKYL
K930 GMtPERKKYLYPTTL
Y931 MtPERKKYLYPTTLV
S988-p QCTEELVsPETTEHP
P1025 KENRGLNPVEKYKVE
Y1029 GLNPVEKYKVEEASD
K1030 LNPVEKYKVEEASDL
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