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Protein Page:
KIF11 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KIF11 a cytoskeletal protein that belongs to the kinesin-like protein family. BimC subfamily. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Plays a role in chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Phosphorylation regulates its association with the spindle apparatus. Note: This description may include information from UniProtKB.
Protein type: Microtubule binding protein; Motor protein
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component: spindle pole; kinesin complex; microtubule; membrane; spindle microtubule; cytoplasm; spindle; cytosol
Molecular Function: microtubule binding; protein complex binding; microtubule motor activity; protein kinase binding; ATP binding
Biological Process: mitosis; mitotic centrosome separation; mitotic spindle organization and biogenesis; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; spindle organization and biogenesis; microtubule-based movement
Reference #:  P52732 (UniProtKB)
Alt. Names/Synonyms: EG5; HKSP; KIF11; kinesin family member 11; kinesin-like 1; Kinesin-like protein 1; Kinesin-like protein KIF11; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; KNSL1; thyroid receptor interacting protein 5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; TRIP5
Gene Symbols: KIF11
Molecular weight: 119,159 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KIF11

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: T926‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3 _____MASQPNSSAK
0 1 S36-p NLAERKAsAHSIVEC
0 1 T114-p TGTGKTFtMEGERsP
0 2 S120-p FtMEGERsPNEEytW
0 10 Y125-p ERsPNEEytWEEDPL
0 1 T126-p RsPNEEytWEEDPLA
0 2 K146-ac TLHQIFEkLTDNGTE
0 3 Y211-p VHNKDEVyQILEKGA
0 1 T223-p KGAAKRTtAAtLMNA
0 1 T226-p AKRTtAAtLMNAyss
0 2 Y231-p AAtLMNAyssRSHSV
0 2 S232-p AtLMNAyssRSHSVF
0 2 S233-p tLMNAyssRSHSVFs
0 1 S240-p sRSHSVFsVTIHMKE
0 1 S291-p EAGNINQsLLtLGRV
0 1 T294-p NINQsLLtLGRVITA
0 1 S323-p LTRILQDsLGGRTRT
0 1 K372-ac VNQKLTKkALIkEYT
0 1 K376-ac LTKkALIkEYTEEIE
0 116 Y399-p AREKNGVyIsEENFR
0 2 S401-p EKNGVyIsEENFRVM
0 12 T458-p KSDLQNKtQELEttQ
0 1 T463-p NKtQELEttQKHLQE
0 1 T464-p KtQELEttQKHLQET
0 24 Y480-p LQLVKEEyITSALES
0 1 T488 ITSALESTEEKLHDA
0 1 T507-p LNTVEETtKDVSGLH
0 1 K516 DVSGLHSKLDRKKAV
0 1 S540-p IFGKNLNsLFNNMEE
0 1 K550-ub NNMEELIkDGSSKQK
0 1 T643-p LEMILSPtVVsILKI
0 1 S646-p ILSPtVVsILKINsQ
0 1 S652-p VsILKINsQLKHIFK
0 1 T663-p HIFKTSLtVADKIED
0 1 S852-p HNLLEVVsQCCEAsS
0 1 S858-p VsQCCEAsSSDITEK
0 7 K908-ub TIKIGLTkLNCFLEQ
0 1 T923-p DLKLDIPtGttPQRK
0 3 T925-p KLDIPtGttPQRKsy
5 19 T926-p LDIPtGttPQRKsyL
0 6 S931-p GttPQRKsyLyPsTL
0 13 Y932-p ttPQRKsyLyPsTLV
0 2 Y934-p PQRKsyLyPsTLVRT
0 1 S936-p RKsyLyPsTLVRTEP
0 1 I973 ENNKEETIPDVDVEE
0 2 S992 QYTEEPLSQEPSVDA
0 1 P995 EEPLSQEPSVDAGVD
0 1 S996 EPLSQEPSVDAGVDC
0 5 T1029-p KENRGINtLERskVE
1 3 S1033-p GINtLERskVEETTE
0 9 K1034-ub INtLERskVEETTEH
  mouse

 
S3-p _____MAsQPSSLKK
N35 NLAERKANAHSVVEC
T113 TGTGKTFTMEGERSP
S119 FTMEGERSPNEVyTW
Y124-p ERSPNEVyTWEEDPL
T125 RSPNEVyTWEEDPLA
K145 TLHQIFEKLTDNGTE
Y210 VHNKDEVYQILEKGA
T222 KGAAKRTTAATLMNA
T225 AKRTTAATLMNAYSS
Y230 AATLMNAYSSRSHSV
S231 ATLMNAYSSRSHSVF
S232 TLMNAYSSRSHSVFS
S239 SRSHSVFSVTIHMKE
S290 EAGNINQSLLTLGRV
T293 NINQSLLTLGRVITA
S322 LTRILQDSLGGRTRT
K371 VNQKLTKKALIKEYT
K375 LTKKALIKEYTEEIE
Y398-p AREKNGVyISEESFR
S400 EKNGVyISEESFRAM
T457 KSDLQTKTQELETTQ
T462 TKTQELETTQKHLQE
T463 KTQELETTQKHLQET
Y479 LQLVKEEYVSSALER
T487-p VSSALERtEKTLHDT
T506 LNTVKETTRAVSGLH
K515-ac AVSGLHSkLDRKRAI
S539 SFGKNLNSLFNNMEE
K549 NNMEELIKDGSAKQK
S642 LKTIVAPSVVSILNI
S645 IVAPSVVSILNINKQ
K651 VSILNINKQLQHIFR
T662 HIFRASSTVAEKVED
N851 ENLMEFVNGCCKASS
S857 VNGCCKASSSEITKK
K907 TIKTGLTKLNCFLKQ
T922 DLKLDIPTGMtPERK
M924 KLDIPTGMtPERKKY
T925-p LDIPTGMtPERKKYL
K930 GMtPERKKYLYPTTL
Y931 MtPERKKYLYPTTLV
Y933 PERKKYLYPTTLVRT
T935 RKKYLYPTTLVRTEP
S969-p SEASKETsQDMDEER
S988-p QCTEELVsPEttEHP
T991-p EELVsPEttEHPSAD
T992-p ELVsPEttEHPSADC
P1025 KENRGLNPVEKYKVE
Y1029 GLNPVEKYKVEEASD
K1030 LNPVEKYKVEEASDL
  rat

 
S3 _____MASQPSSSSK
N36 NLAERKANAHSVVEC
T114 TGTGKTFTMEGERSP
S120 FTMEGERSPNEVYTW
Y125 ERSPNEVYTWEEDPL
T126 RSPNEVYTWEEDPLA
K146 TLHQIFEKLTDNGTE
Y211 VHNKDEVYQILEKGA
T223 KGAAKRTTAATLMNA
T226 AKRTTAATLMNAYSS
Y231 AATLMNAYSSRSHSV
S232 ATLMNAYSSRSHSVF
S233 TLMNAYSSRSHSVFS
S240 SRSHSVFSVTIHMKE
S291 EAGNINQSLLTLGRV
T294 NINQSLLTLGRVITA
S323 LTRILQDSLGGRTRT
K372 VNQKLTKKALIKEYT
K376 LTKKALIKEYTEEIE
Y399 AREKNGVYISEESFR
S401 EKNGVYISEESFRAM
T458 KSDLQTKTQELETTQ
T463 TKTQELETTQKHLQE
T464 KTQELETTQKHLQET
Y480 LQLVKEEYVSSALER
T488 VSSALERTEKKLHET
T507 LNTVKETTRDVSGLH
K516 DVSGLHSKLDRKRAI
S540 SFGRSLSSLFNNMEE
R550 NNMEELIRDGSEKQK
G643 LKTIIAPGVVSILNI
S646 IIAPGVVSILNINRQ
R652 VSILNINRQLQHIFR
T663 HIFRASVTMAEKVED
N852 QNLMEFVNGCCEASS
S858 VNGCCEASSSEITEK
K908 TIKTGLTKLNCFLQQ
T923 DLKLDIPTGMtPERK
M925 KLDIPTGMtPERKNY
T926-p LDIPTGMtPERKNYL
N931 GMtPERKNYLYPSTL
Y932 MtPERKNYLYPSTLV
Y934 PERKNYLYPSTLVRT
S936 RKNYLYPSTLVRTEP
- under review  
S991 QSTEELVSQEPCVHT
- under review  
- under review  
P1028 KENRGLNPVEKGKVE
- under review  
- under review  
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