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KIF11 (human)

Overview KIF11 a cytoskeletal protein that belongs to the kinesin-like protein family. BimC subfamily. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Plays a role in chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Phosphorylation regulates its association with the spindle apparatus. Note: This description may include information from UniProtKB. Protein type: Motor protein; Microtubule binding protein Cellular Component: spindle pole; kinesin complex; microtubule; chromatin remodeling complex; spindle microtubule; cytoplasm; spindle; cytosol Molecular Function: microtubule binding; microtubule motor activity; protein kinase binding; ATP binding Biological Process: mitosis; mitotic centrosome separation; mitotic spindle organization and biogenesis; cell division; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; spindle organization and biogenesis; microtubule-based movement Reference #:  P52732 (UniProtKB) Alt. Names/Synonyms: EG5; HKSP; KIF11; kinesin family member 11; kinesin-like 1; Kinesin-like protein 1; Kinesin-like protein KIF11; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; KNSL1; thyroid receptor interacting protein 5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; TRIP5 Gene Symbols: KIF11 Molecular weight: 119,159 Da Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below KIF11 1II6 - A/B=1-368 (human) 1Q0B - A/B=2-368 (human) 1X88 - A/B=10-368 (human) 1YRS - A/B=1-368 (human) 2FKY - A/B=2-368 (human) 2FL2 - A/B=2-368 (human) 2FL6 - A/B=2-368 (human) 2FME - A/B=1-368 (human) 2G1Q - A/B=1-368 (human) 2GM1 - A/B/D/E=1-368 (human) 2IEH - A/B=2-368 (human) 2PG2 - A/B=1-368 (human) 2Q2Y - A/B=2-368 (human) 2Q2Z - A/B=2-368 (human) 2UYI - A/B=1-368 (human) 2UYM - A/B=1-368 (human) 2WOG - A/C/B=1-368 (human) 2X2R - A/C/B=1-368 (human) 2X7C - A/B=1-368 (human) 2X7D - A/B=1-368 (human) 2X7E - A/B=1-368 (human) 2XAE - A/C/B=1-368 (human) 3CJO - A/B=2-368 (human) 3HQD - A/B=1-369 (human) 3K3B - A/B=1-368 (human) 3K5E - A/B=1-368 (human) 3KEN - A=1-369 (human) 3L9H - A/B=1-368 (human) 3ZCW - A=16-363 (human) 4A1Z - A/B=1-368 (human) 4A28 - A/B=1-368 (human) 4A50 - A=1-368 (human) 4A51 - F/A/D/C/G/E/B=1-368 (human) 4A5Y - A/C/B=1-368 (human) 4AP0 - A/D/C/B=1-368 (human) 4AQV - C=1-367 (human) 4AQW - C=1-367 (human) 4AS7 - A=1-368 (human) 4BBG - A=1-368 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4BBG  |  Phospho3D  |  DISEASE  |  Source KIF11 KNSL1  |  GeneCards KIF11 KNSL1  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: T926‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3	_____MASQPNSSAK
0	1		T114-p	TGTGKTFtMEGERsP
0	2		S120-p	FtMEGERsPNEEytW
0	9		Y125-p	ERsPNEEytWEEDPL
0	1		T126-p	RsPNEEytWEEDPLA
0	2		K146-a	TLHQIFEkLTDNGTE
0	3		Y211-p	VHNKDEVyQILEKGA
0	1		T223-p	KGAAKRTtAAtLMNA
0	1		T226-p	AKRTtAAtLMNAyss
0	2		Y231-p	AAtLMNAyssRSHSV
0	2		S232-p	AtLMNAyssRSHSVF
0	2		S233-p	tLMNAyssRSHSVFs
0	1		S240-p	sRSHSVFsVTIHMKE
0	1		S291-p	EAGNINQsLLtLGRV
0	1		T294-p	NINQsLLtLGRVITA
0	1		S323-p	LTRILQDsLGGRTRT
0	1		K372-a	VNQKLTKkALIkEYT
0	1		K376-a	LTKkALIkEYTEEIE
0	110		Y399-p	AREKNGVyIsEENFR
0	1		S401-p	EKNGVyIsEENFRVM
0	11		T458-p	KSDLQNKtQELEttQ
0	1		T463-p	NKtQELEttQKHLQE
0	1		T464-p	KtQELEttQKHLQET
0	20		Y480-p	LQLVKEEyITSALES
0	1		T488	ITSALESTEEKLHDA
0	1		T507-p	LNTVEETtKDVSGLH
0	1		K516	DVSGLHSKLDRKKAV
0	1		K550-u	NNMEELIkDGSSKQK
0	1		T643-p	LEMILSPtVVSILKI
0	1		S652-p	VSILKINsQLKHIFK
0	1		T663-p	HIFKTSLtVADKIED
0	1		S852-p	HNLLEVVsQCCEAsS
0	1		S858-p	VsQCCEAsSSDITEK
0	7		K908-u	TIKIGLTkLNCFLEQ
0	1		T923-p	DLKLDIPtGttPQRK
0	2		T925-p	KLDIPtGttPQRKsy
4	14		T926-p	LDIPtGttPQRKsyL
0	5		S931-p	GttPQRKsyLyPSTL
0	10		Y932-p	ttPQRKsyLyPSTLV
0	1		Y934-p	PQRKsyLyPSTLVRT
0	1		S992	QYTEEPLSQEPSVDA
0	2		T1029-p	KENRGINtLERskVE
1	0		S1033-p	GINtLERskVEETTE
0	9		K1034-u	INtLERskVEETTEH

	mouse
S3-p	_____MAsQPSSLKK
T113	TGTGKTFTMEGERSP
S119	FTMEGERSPNEVyTW
Y124-p	ERSPNEVyTWEEDPL
T125	RSPNEVyTWEEDPLA
K145	TLHQIFEKLTDNGTE
Y210	VHNKDEVYQILEKGA
T222	KGAAKRTTAATLMNA
T225	AKRTTAATLMNAYSS
Y230	AATLMNAYSSRSHSV
S231	ATLMNAYSSRSHSVF
S232	TLMNAYSSRSHSVFS
S239	SRSHSVFSVTIHMKE
S290	EAGNINQSLLTLGRV
T293	NINQSLLTLGRVITA
S322	LTRILQDSLGGRTRT
K371	VNQKLTKKALIKEYT
K375	LTKKALIKEYTEEIE
Y398-p	AREKNGVyISEESFR
S400	EKNGVyISEESFRAM
T457	KSDLQTKTQELETTQ
T462	TKTQELETTQKHLQE
T463	KTQELETTQKHLQET
Y479	LQLVKEEYVSSALER
T487-p	VSSALERtEKTLHDT
T506	LNTVKETTRAVSGLH
K515-a	AVSGLHSkLDRKRAI
K549	NNMEELIKDGSAKQK
S642	LKTIVAPSVVSILNI
K651	VSILNINKQLQHIFR
T662	HIFRASSTVAEKVED
N851	ENLMEFVNGCCKASS
S857	VNGCCKASSSEITKK
K907	TIKTGLTKLNCFLKQ
T922	DLKLDIPTGMtPERK
M924	KLDIPTGMtPERKKY
T925-p	LDIPTGMtPERKKYL
K930	GMtPERKKYLYPTTL
Y931	MtPERKKYLYPTTLV
Y933	PERKKYLYPTTLVRT
S988-p	QCTEELVsPETTEHP
P1025	KENRGLNPVEKYKVE
Y1029	GLNPVEKYKVEEASD
K1030	LNPVEKYKVEEASDL

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