Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SEC31L1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SEC31L1 Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. Abundantly and ubiquitously expressed. Belongs to the WD repeat SEC31 family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; COPII vesicle coat; intracellular membrane-bound organelle; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; ER to Golgi transport vesicle; cytosol
Molecular Function: protein binding; calcium-dependent protein binding
Biological Process: COPII coating of Golgi vesicle; antigen processing and presentation of peptide antigen via MHC class I; protein transport; ER to Golgi vesicle-mediated transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; response to calcium ion
Reference #:  O94979 (UniProtKB)
Alt. Names/Synonyms: ABP125; ABP130; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; Protein transport protein Sec31A; protein-transport protein SEC31; SC31A; SEC31 homolog A (S. cerevisiae); SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; SEC31A; SEC31L1; Web1-like protein; yeast Sec31p homolog
Gene Symbols: SEC31A
Molecular weight: 133,015 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEC31L1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 - gap
0 2 - gap
0 2 K111-u SKIIAGDkEVVIAQN
0 1 S188-p QHILASAsPSGRATV
0 1 K206 RKNEPIIKVSDHSNR
0 1 S251-p WDLRFASsPLRVLEN
0 1 Q423 QGAEQQQQQHHVFIS
0 1 K436 ISQVVTEKEFLSRSD
0 1 K471 ASQTEFEKNVWSFLK
0 2 K488-u FEDDSRGkYLELLGY
0 1 K503 RKEDLGKKIALALNK
0 1 K510 KIALALNKVDGANVA
0 1 S521 ANVALKDSDQVAQsD
0 28 S527-p DSDQVAQsDGEEsPA
0 17 S532-p AQsDGEEsPAAEEQL
0 3 K647-u IVESCDLkNWREALA
0 3 K707 KLVACWTKAQDGSHP
0 1 K723 SLQDLIEKVVILRkA
0 14 K729-u EKVVILRkAVQLTQA
0 2 E792 RLCRAQGEPVAGHEs
0 22 S799-p EPVAGHEsPKIPyEK
0 1 P800 PVAGHEsPKIPyEKQ
0 14 I802 AGHEsPKIPyEKQQL
0 32 Y804-p HEsPKIPyEKQQLPK
0 1 H821 PGPVAGHHQMPRVQT
0 1 R894-m2 TGGSAMYrPQQPVAP
0 1 T1121-p DEHLILKttFEDLIQ
0 1 T1122-p EHLILKttFEDLIQR
0 2 K1156-u RLEFLYDkLREQtLs
0 2 T1161-p YDkLREQtLsPTITS
0 6 S1163-p kLREQtLsPTITSGL
0 1 T1165 REQtLsPTITSGLHN
0 7 K1217-u VVLTQANkLGV____
  SEC31L1 iso5  
T10-p GESDERCtNAGsGCR
S14-p ERCtNAGsGCRRSSP
K106 SKIIAGDKEVVIAQN
S183 QHILASASPSGRATV
K201 RKNEPIIKVSDHSNR
S246 WDLRFASSPLRVLEN
Q418 QGAEQQQQQHHVFIS
K431 ISQVVTEKEFLSRSD
K466 ASQTEFEKNVWSFLK
K483 FEDDSRGKYLELLGY
K498 RKEDLGKKIALALNK
K505 KIALALNKVDGANVA
S516 ANVALKDSDQVAQSD
S522 DSDQVAQSDGEESPA
S527 AQSDGEESPAAEEQL
K642 IVESCDLKNWREALA
K702 KLVACWTKAQDGSHP
K718 SLQDLIEKVVILRKA
K724 EKVVILRKAVQLTQA
E787 RLCRAQGEPVAGHES
S794 EPVAGHESPKIPYEK
P795 PVAGHESPKIPYEKQ
I797 AGHESPKIPYEKQQL
Y799 HESPKIPYEKQQLPK
H816 PGPVAGHHQMPRVQT
R889 TGGSAMYRPQQPVAP
T1101 DEHLILKTTFEDLIQ
T1102 EHLILKTTFEDLIQR
K1136 RLEFLYDKLREQTLS
T1141 YDKLREQTLSPTITS
S1143 KLREQTLSPTITSGL
T1145 REQTLSPTITSGLHN
K1197 VVLTQANKLGV____
  mouse

 
- gap
- gap
K111-u SKIIAGDkEVVIAQK
S188 QHILASASPSGRATV
K206-u RKNEPIIkVSDHSNR
S251 WDLRFASSPLRVLEN
R423-m2 QGAEQQRrQPVFISQ
K435-u ISQVVTEkDFLNRSA
K470-u ASQTEFEkNVWSFLK
K487-u FEEDSRGkYLELLGY
K502-u RKEDLGQkIALALNk
K509-u kIALALNkVDGPDVA
S520-p PDVALKDsDQVAQsD
S526-p DsDQVAQsDGEEsPA
S531-p AQsDGEEsPAAEEQL
K646-u IVESCDLkNWREALA
K706-u RLVACWTkAQDGSSP
K722-u SLQDLIEkVVILRkA
K728-u EkVVILRkAVQLTQA
K791-u RLCKAQGkPVSGQES
S798 kPVSGQESsQsPyER
S799-p PVSGQESsQsPyERQ
S801-p SGQESsQsPyERQPL
Y803-p QESsQsPyERQPLSK
S820-p PGPVAGHsQMPRVQT
R893 TGGAAAYRPQQPVAP
T1131 EEHLILKTTFEDLIQ
T1132 EHLILKTTFEDLIQR
K1166 RLEFLYDKLREQtLs
T1171-p YDKLREQtLsPtIIN
S1173-p KLREQtLsPtIINGL
T1175-p REQtLsPtIINGLHS
K1227 VVLSQASKLGV____
  rat

 
- gap
- gap
K111 SKIIAGDKEVVIAQK
S188 QHILASASPSGRATV
K206 RKNEPIIKVSDHSNR
S251 WDLRFASSPLRVLEN
R423 QGAEQPRRQPVFISQ
K435 ISQVVTEKDFLSRSE
K470 ASQTDFEKNVWSFLK
K487 FEEDSRGKYLELLGY
K502 RREDLGEKIALALNR
R509 KIALALNRVDGSDVA
S520 SDVALKDSDRVAQsD
S526-p DSDRVAQsDGEEsPA
S531-p AQsDGEEsPAEEGQL
K647 IVESCDLKNWREALA
K707 RLVACWTKAQDGSNP
K723 SLQDLIEKVVILRKA
K729 EKVVILRKAVQLTQA
R792 RLCRAQGRSVPGQES
S799 RSVPGQESSRSSYEG
S800 SVPGQESSRSSYEGQ
S802 PGQESSRSSYEGQPL
Y804 QESSRSSYEGQPLPK
P821 PGPLAGHPQVSRVQS
R925 TGGSAVYRPQQPVAP
T1150 DEHLILKTTFEDLIQ
T1151 EHLILKTTFEDLIQR
K1185 RLECLYDKLRDQTLs
T1190 YDKLRDQTLsPtIIS
S1192-p KLRDQTLsPtIISGL
T1194-p RDQTLsPtIISGLHS
K1246 VVLSQASKLGV____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.