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Protein Page:
KIF3A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KIF3A Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Heterodimer of KIF3A and KIF3B. Interacts with PIFO/C1orf88. Interacts with CLN3. Belongs to the kinesin-like protein family. Kinesin II subfamily. Note: This description may include information from UniProtKB.
Protein type: Motor protein; Microtubule binding protein
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: microtubule cytoskeleton; centrosome; synaptic vesicle; neuron projection; spindle microtubule; kinesin II complex; cytosol; photoreceptor connecting cilium
Molecular Function: protein binding; spectrin binding; plus-end-directed microtubule motor activity; microtubule binding; ATP binding
Biological Process: smoothened signaling pathway; metabolic process; in utero embryonic development; organelle organization and biogenesis; heart development; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of receptor-mediated endocytosis; microtubule-based movement; anterior/posterior pattern formation; cilium biogenesis; kidney development; blood coagulation; determination of left/right symmetry; dorsoventral neural tube patterning
Reference #:  Q9Y496 (UniProtKB)
Alt. Names/Synonyms: KIF3; KIF3A; kinesin family member 3A; kinesin family protein 3A; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A
Gene Symbols: KIF3A
Molecular weight: 80,041 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KIF3A

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S687‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K245 NMHVRMGKLHLVDLA
0 1 K259 AGSERQAKTGATGQR
0 1 T316-p SLGGNSKtMMCANIG
0 1 Y327-p ANIGPADyNyDETIS
0 1 Y329-p IGPADyNyDETISTL
0 1 Y338-p ETISTLRyANRAKNI
0 1 K346-ac ANRAKNIkNkARINE
0 1 K348-ac RAKNIkNkARINEDP
0 1 K356-ac ARINEDPkDALLRQF
0 1 K365-ac ALLRQFQkEIEELKK
0 1 K371 QkEIEELKKKLEEGE
0 1 K372 kEIEELKKKLEEGEE
0 1 S381-p LEEGEEIsGsDIsGs
0 1 S383-p EGEEIsGsDIsGsEE
0 1 S386-p EIsGsDIsGsEEDDD
0 1 S388-p sGsDIsGsEEDDDEE
0 13 S415-p RRGKKKVsPDKMIEM
0 1 K431 AKIDEERKALETKLD
0 2 K477-ac EKLSALEkkVIVGGV
0 2 K478-ac KLSALEkkVIVGGVD
0 2 K495-ac AKAEEQEkLLEESNM
0 1 T551 KKLKKVWTMLMAAKS
0 41 Y624-p WQLKCVAyTGNNMRK
0 2 T633-p GNNMRKQtPVPDKKE
1 0 T672 MKLERPRTSKGKARP
1 17 S687-p KTGRRKRsAKPETVI
0 1 T692 KRsAKPETVIDSLLQ
  mouse

 
K245-ac NMHVRMGkLHLVDLA
K259-ac AGSERQAkTGATGQR
T316 SLGGNSKTMMCANIG
Y327 ANIGPADYNYDETIS
Y329 IGPADYNYDETISTL
Y338 ETISTLRYANRAKNI
K346 ANRAKNIKNKARINE
K348 RAKNIKNKARINEDP
K356 ARINEDPKDALLRQF
K365 ALLRQFQKEIEELkk
K371-ac QKEIEELkkKLEEGE
K372-ac KEIEELkkKLEEGEE
S381 LEEGEEVSGSDISGS
S383 EGEEVSGSDISGSEE
S386 EVSGSDISGSEEDDE
S388 SGSDISGSEEDDEEG
S417-p QAGKKKVsPDKMVEM
K433-ac AKIDEERkALETKLD
K479 EKLSALEKKVIVGGV
K480 KLSALEKKVIVGGVD
K497 AKAEEQEKLLEESNM
T553-p KKLKKVWtMLMAAKS
Y626 WQLKCVAYTGNNMRK
T635-p GNNMRKQtPVPDKKE
T674-p MKLERPRtSKGKARP
S689-p KMGRRKRsAKPEtVI
T694-p KRsAKPEtVIDSLLQ
  rat

 
K245 NMHVRMGKLHLVDLA
K259 AGSERQAKTGATGQR
T316 SLGGNSKTMMCANIG
Y327 ANIGPADYNYDETIS
Y329 IGPADYNYDETISTL
Y338 ETISTLRYANRAKNI
K346-ac ANRAKNIkNkARINE
K348-ac RAKNIkNkARINEDP
K356 ARINEDPKDALLRQF
K365 ALLRQFQKEIEELKK
K371 QKEIEELKKKLEEGE
K372 KEIEELKKKLEEGEE
S381-p LEEGEEVsGsDIsGs
S383-p EGEEVsGsDIsGsEE
S386-p EVsGsDIsGsEEDDN
S388-p sGsDIsGsEEDDNEE
S418 QAGKKKVSPDKMMEM
K434 AKIDEERKALETKLD
K480 EKLSALEKKVIVGGV
K481 KLSALEKKVIVGGVD
K498 AKAEEQEKLLEESNM
T554 KKLKKVWTMLMAAKS
Y627 WQLKCVAYTGNNMRK
T636 GNNMRKQTPVPDKKE
T675 MKLERPRTSKGKARP
S690-p KTGRRKRsAKPETVI
T695 KRsAKPETVIDSLLQ
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