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Protein Page:
KIF3A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
KIF3A Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Heterodimer of KIF3A and KIF3B. Interacts with PIFO/C1orf88. Interacts with CLN3. Belongs to the kinesin-like protein family. Kinesin II subfamily. Note: This description may include information from UniProtKB.
Protein type: Microtubule binding protein; Motor protein
Cellular Component: centrosome; synaptic vesicle; neuron projection; spindle microtubule; kinesin II complex; cytosol; photoreceptor connecting cilium
Molecular Function: protein binding; plus-end-directed microtubule motor activity; microtubule binding; ATP binding
Biological Process: smoothened signaling pathway; metabolic process; in utero embryonic development; organelle organization and biogenesis; heart development; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; positive regulation of receptor-mediated endocytosis; anterior/posterior pattern formation; cilium biogenesis; determination of left/right symmetry; blood coagulation; kidney development; dorsoventral neural tube patterning
Reference #:  Q9Y496 (UniProtKB)
Alt. Names/Synonyms: KIF3; KIF3A; kinesin family member 3A; kinesin family protein 3A; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A
Gene Symbols: KIF3A
Molecular weight: 80,041 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KIF3A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K356-a ARINEDPkDALLRQF
0 1 K365-a ALLRQFQkEIEELKK
0 1 S381-p LEEGEEIsGsDIsGs
0 1 S383-p EGEEIsGsDIsGsEE
0 1 S386-p EIsGsDIsGsEEDDD
0 1 S388-p sGsDIsGsEEDDDEE
0 12 S415-p RRGKKKVsPDKMIEM
0 2 K477-a EKLSALEkkVIVGGV
0 2 K478-a KLSALEkkVIVGGVD
0 2 K495-a AKAEEQEkLLEESNM
0 39 Y624-p WQLKCVAyTGNNMRK
0 1 T633 GNNMRKQTPVPDKKE
1 14 S687-p KTGRRKRsAKPETVI
  mouse

 
K356 ARINEDPKDALLRQF
K365 ALLRQFQKEIEELKK
S381 LEEGEEVSGSDISGS
S383 EGEEVSGSDISGSEE
S386 EVSGSDISGSEEDDE
S388 SGSDISGSEEDDEEG
S417-p QAGKKKVsPDKMVEM
K479 EKLSALEKKVIVGGV
K480 KLSALEKKVIVGGVD
K497 AKAEEQEKLLEESNM
Y626 WQLKCVAYTGNNMRK
T635-p GNNMRKQtPVPDKKE
S689-p KMGRRKRsAKPETVI
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