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DAZL (human)

Overview DAZL RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts. Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2. Testis specific. Belongs to the RRM DAZ family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Translation Cellular Component: polysome; cytoplasm; nucleus Molecular Function: identical protein binding; protein binding; translation activator activity; mRNA 3'-UTR binding; RNA binding; nucleotide binding Biological Process: positive regulation of translational initiation; positive regulation of meiosis; multicellular organismal development; spermatogenesis; germ cell development Reference #:  Q92904 (UniProtKB) Alt. Names/Synonyms: DAZ homolog; DAZ-like autosomal; DAZH; DAZL; DAZL1; DAZLA; Deleted in azoospermia-like; Deleted in azoospermia-like 1; deleted in azoospermia-like autosomal; germline specific RNA binding protein; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; SPGYLA Gene Symbols: DAZL Molecular weight: 33,178 Da Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DAZL 2XS2 - A=32-132 (mouse) 2XS5 - A/B=32-117 (mouse) 2XS7 - A=32-117 (mouse) 2XSF - A=35-118 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2-p	______MsTANPETP
0	9		K67-u	FARYGSVkEVKIITD
0	7		K109-u	NFHGKKLkLGPAIRK
0	1		Y276	SVVTQDDYFKDKRVH

	mouse
S2	______MSATTSEAP
K67	FARYGSVKEVKIITD
K109	NFHGKKLKLGPAIRK
Y276-p	SLVTQDDyFKDKRVH

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